Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.7
USERS' SCORE
Good
Based on 6 Reviews
8.2
Supplement Facts
Serving Size: 1 Level Teaspoon (approx. 4 g)
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
4 g
1%**
Dietary Fiber
4 g
14%*
Organic Inulin (FOS) (from Blue Agave)
3.3 g
†
Top Medical Research Studies
8
We explored the effects of inulin supplements on colonic fibrosis caused by radiation therapy for treating pelvic and abdominal cancers. Chronic radiation enteropathy often leads to difficult gastrointestinal issues, and understanding how inulin can help is crucial.
In our study, we found that inulin seems to promote the growth of beneficial bacteria in the gut, which in turn boosts the production of short-chain fatty acids (SCFAs). By conducting experiments on mice with chronic radiation enteropathy, we discovered that when we transplanted gut microbiota and their metabolites from inulin-treated mice, the levels of colonic fibrosis significantly decreased.
Additionally, administering these metabolites led to a drop in the expression of genes related to fibrosis and collagen production in mouse embryonic fibroblast cells. It appears that these inulin-derived metabolites also inhibit the pathways involved in the production of the extracellular matrix. Overall, our findings highlight the promise of inulin as a novel approach to help mitigate chronic radiation-induced colonic fibrosis.
In our study, we found that inulin seems to promote the growth of beneficial bacteria in the gut, which in turn boosts the production of short-chain fatty acids (SCFAs). By conducting experiments on mice with chronic radiation enteropathy, we discovered that when we transplanted gut microbiota and their metabolites from inulin-treated mice, the levels of colonic fibrosis significantly decreased.
Additionally, administering these metabolites led to a drop in the expression of genes related to fibrosis and collagen production in mouse embryonic fibroblast cells. It appears that these inulin-derived metabolites also inhibit the pathways involved in the production of the extracellular matrix. Overall, our findings highlight the promise of inulin as a novel approach to help mitigate chronic radiation-induced colonic fibrosis.
Read More
9.5
We explored how inulin, a type of polysaccharide, can enhance cancer immunotherapy by acting as an adjuvant for nanoparticle vaccines. Our research focused on creating a specific inulin derivative, benzoylated inulin (InBz), through a careful computational approach. This research allowed us to identify InBz as a potent activator of TLR4, a receptor involved in immune responses.
In our experiments, we developed nanoparticle vaccines that combined InBz with a model antigen, ovalbumin (OVA). Testing these InBz-OVA nanoparticles in the lab showed they were effective at activating immune signaling pathways and promoting the maturation of dendritic cells, which are crucial players in the immune system’s response to cancer.
We then moved to live animal models and found that InBz-OVA nanoparticles significantly outperformed traditional aluminum-based adjuvants. The results were quite promising, as they not only generated strong antibody responses but also triggered the production of cytotoxic T lymphocytes that specifically target tumors, leading to notable tumor suppression.
Additionally, we synthesized other inulin derivatives for comparison, which confirmed our computational predictions. This work highlights a new pathway for creating effective vaccine adjuvants using polysaccharides that may improve cancer treatment outcomes.
In our experiments, we developed nanoparticle vaccines that combined InBz with a model antigen, ovalbumin (OVA). Testing these InBz-OVA nanoparticles in the lab showed they were effective at activating immune signaling pathways and promoting the maturation of dendritic cells, which are crucial players in the immune system’s response to cancer.
We then moved to live animal models and found that InBz-OVA nanoparticles significantly outperformed traditional aluminum-based adjuvants. The results were quite promising, as they not only generated strong antibody responses but also triggered the production of cytotoxic T lymphocytes that specifically target tumors, leading to notable tumor suppression.
Additionally, we synthesized other inulin derivatives for comparison, which confirmed our computational predictions. This work highlights a new pathway for creating effective vaccine adjuvants using polysaccharides that may improve cancer treatment outcomes.
Read More
8
We set out to understand how dietary choices and genetics influence the cancer-causing potential of certain bacteria, specifically colibactin-producing E. coli, in a mouse model. By examining mice that were colonized with these bacteria and feeding them various diets, including one that was low in carbohydrates and soluble fiber, we observed some striking results. Mice on the low-carbohydrate diet showed an increase in colonic polyps, which are precursors to cancer.
The study revealed that a lack of soluble fiber led to higher levels of mucosal inflammation, which in turn impaired a key signaling pathway in the colon known as PPAR-γ. This disruption not only boosted the growth of colibactin-producing E. coli but also led to significant DNA damage. However, we discovered that administering inulin, a type of soluble fiber, helped counteract these harmful effects. It reduced inflammation and the number of polyps in the affected mice, highlighting the potential protective quality of inulin.
Additionally, in mice that had deficiencies in DNA mismatch repair, we found that E. coli exacerbated polyp formation through another mechanism involving inflammation. This suggests that dietary fiber, particularly inulin, may play a critical role in preventing inflammation-driven carcinogenesis in the gut. By understanding the interplay between diet, microbiome, and cancer risk, we can better appreciate how something as simple as dietary fiber can help shape our health.
The study revealed that a lack of soluble fiber led to higher levels of mucosal inflammation, which in turn impaired a key signaling pathway in the colon known as PPAR-γ. This disruption not only boosted the growth of colibactin-producing E. coli but also led to significant DNA damage. However, we discovered that administering inulin, a type of soluble fiber, helped counteract these harmful effects. It reduced inflammation and the number of polyps in the affected mice, highlighting the potential protective quality of inulin.
Additionally, in mice that had deficiencies in DNA mismatch repair, we found that E. coli exacerbated polyp formation through another mechanism involving inflammation. This suggests that dietary fiber, particularly inulin, may play a critical role in preventing inflammation-driven carcinogenesis in the gut. By understanding the interplay between diet, microbiome, and cancer risk, we can better appreciate how something as simple as dietary fiber can help shape our health.
Read More
Most Useful Reviews
7.5
Boosts immune system
6 people found this helpful
I chose Inulin over other prebiotics after consulting with my gastroenterologist. It reaches the bowels where beneficial bacteria grow and inhibits certain fats' growth. Inulin serves as a valuable dietary fibre and helps reduce the risk of cancer while enhancing immune functions. If this review has helped you, please give it a thumbs up. Thank you!
Read More
9
Supports intestinal health
5 people found this helpful
Inulin has been proven to increase beneficial intestinal bacteria in the colon, which positively impacts health. It also helps suppress harmful bacteria's reproduction. Daily consumption of 10 grams of inulin can reduce hematocrit in type 2 diabetes patients. I give it to my husband to aid testosterone levels and protect colon cells from cancer. Although inulin may lower blood pressure slightly, those with hypotension should be cautious. Overall, it contributes to good health, which I truly appreciate.
Read More
7.5
Supports gut health
2 people found this helpful
I opted for Inulin rather than other prebiotics after discussing it with a Tequila company owner. Inulin effectively reaches the bowels, promoting beneficial bacteria growth and inhibiting certain fats while serving as dietary fibre. It also helps in reducing the cancer risk and boosts immune function.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.7
- All Researches
9.5
We explored how inulin, a type of polysaccharide, can enhance cancer immunotherapy by acting as an adjuvant for nanoparticle vaccines. Our research focused on creating a specific inulin derivative, benzoylated inulin (InBz), through a careful computational approach. This research allowed us to identify InBz as a potent activator of TLR4, a receptor involved in immune responses.
In our experiments, we developed nanoparticle vaccines that combined InBz with a model antigen, ovalbumin (OVA). Testing these InBz-OVA nanoparticles in the lab showed they were effective at activating immune signaling pathways and promoting the maturation of dendritic cells, which are crucial players in the immune system’s response to cancer.
We then moved to live animal models and found that InBz-OVA nanoparticles significantly outperformed traditional aluminum-based adjuvants. The results were quite promising, as they not only generated strong antibody responses but also triggered the production of cytotoxic T lymphocytes that specifically target tumors, leading to notable tumor suppression.
Additionally, we synthesized other inulin derivatives for comparison, which confirmed our computational predictions. This work highlights a new pathway for creating effective vaccine adjuvants using polysaccharides that may improve cancer treatment outcomes.
In our experiments, we developed nanoparticle vaccines that combined InBz with a model antigen, ovalbumin (OVA). Testing these InBz-OVA nanoparticles in the lab showed they were effective at activating immune signaling pathways and promoting the maturation of dendritic cells, which are crucial players in the immune system’s response to cancer.
We then moved to live animal models and found that InBz-OVA nanoparticles significantly outperformed traditional aluminum-based adjuvants. The results were quite promising, as they not only generated strong antibody responses but also triggered the production of cytotoxic T lymphocytes that specifically target tumors, leading to notable tumor suppression.
Additionally, we synthesized other inulin derivatives for comparison, which confirmed our computational predictions. This work highlights a new pathway for creating effective vaccine adjuvants using polysaccharides that may improve cancer treatment outcomes.
Read More
8
We set out to understand how dietary choices and genetics influence the cancer-causing potential of certain bacteria, specifically colibactin-producing E. coli, in a mouse model. By examining mice that were colonized with these bacteria and feeding them various diets, including one that was low in carbohydrates and soluble fiber, we observed some striking results. Mice on the low-carbohydrate diet showed an increase in colonic polyps, which are precursors to cancer.
The study revealed that a lack of soluble fiber led to higher levels of mucosal inflammation, which in turn impaired a key signaling pathway in the colon known as PPAR-γ. This disruption not only boosted the growth of colibactin-producing E. coli but also led to significant DNA damage. However, we discovered that administering inulin, a type of soluble fiber, helped counteract these harmful effects. It reduced inflammation and the number of polyps in the affected mice, highlighting the potential protective quality of inulin.
Additionally, in mice that had deficiencies in DNA mismatch repair, we found that E. coli exacerbated polyp formation through another mechanism involving inflammation. This suggests that dietary fiber, particularly inulin, may play a critical role in preventing inflammation-driven carcinogenesis in the gut. By understanding the interplay between diet, microbiome, and cancer risk, we can better appreciate how something as simple as dietary fiber can help shape our health.
The study revealed that a lack of soluble fiber led to higher levels of mucosal inflammation, which in turn impaired a key signaling pathway in the colon known as PPAR-γ. This disruption not only boosted the growth of colibactin-producing E. coli but also led to significant DNA damage. However, we discovered that administering inulin, a type of soluble fiber, helped counteract these harmful effects. It reduced inflammation and the number of polyps in the affected mice, highlighting the potential protective quality of inulin.
Additionally, in mice that had deficiencies in DNA mismatch repair, we found that E. coli exacerbated polyp formation through another mechanism involving inflammation. This suggests that dietary fiber, particularly inulin, may play a critical role in preventing inflammation-driven carcinogenesis in the gut. By understanding the interplay between diet, microbiome, and cancer risk, we can better appreciate how something as simple as dietary fiber can help shape our health.
Read More
8
Inulin enhances targeted cancer therapy
We explored the role of inulin in a unique oral drug delivery system designed for colon cancer treatment. By integrating inulin with hyaluronic acid, we aimed to create a targeted approach for delivering chemotherapy, photosensitizers, and agents to relieve tumor hypoxia. This method effectively combines three therapeutic agents: the chemotherapy drug 5-Fluorouracil, the photosensitizer chlorin e6, and the hypoxia reliever metformin into liposomes specifically targeting colon cancer cells.
Our results showed that this combination therapy posed significant advantages over treatments using each agent separately. In fact, when tested in mice, this targeted delivery system resulted in impressive reductions in tumor growth—31 times better than using only 5-Fluorouracil, and similarly, significant improvements compared to either metformin or chlorin e6 alone. Importantly, these liposomes displayed good safety and compliance after oral administration, hinting at their potential in clinical use.
While the specific impact of inulin cannot be isolated fully due to its role within a combination treatment, its function alongside hyaluronic acid appears beneficial in enhancing drug delivery and targeting. Overall, this innovative approach brings hope for more effective colon cancer therapies in the future.
Our results showed that this combination therapy posed significant advantages over treatments using each agent separately. In fact, when tested in mice, this targeted delivery system resulted in impressive reductions in tumor growth—31 times better than using only 5-Fluorouracil, and similarly, significant improvements compared to either metformin or chlorin e6 alone. Importantly, these liposomes displayed good safety and compliance after oral administration, hinting at their potential in clinical use.
While the specific impact of inulin cannot be isolated fully due to its role within a combination treatment, its function alongside hyaluronic acid appears beneficial in enhancing drug delivery and targeting. Overall, this innovative approach brings hope for more effective colon cancer therapies in the future.
Read More
8
Inulin-based curcumin delivery system
We explored a novel approach to improve curcumin’s effectiveness against cancer by encapsulating it in nanoparticles made from stearic acid-grafted inulin. This method was developed to tackle curcumin's well-known issues with solubility and bioavailability.
The inulin-based nanoparticles showed impressive results, significantly enhancing the performance of curcumin in laboratory tests. When we compared the nanoparticles to free curcumin, we found that the nanoparticles had a much lower minimum inhibitory concentration against common bacteria, demonstrating their promising potential.
Additionally, the nanoparticles not only enhanced antioxidant activity but also proved effective in reducing inflammatory cytokine levels and limiting cancer cell growth. Importantly, the study revealed good biocompatibility, indicating that the nanoparticles are safe to use.
Overall, our findings highlight the exciting potential of using inulin as a delivery vehicle for curcumin, a promising candidate in cancer treatment. This innovation offers a fresh perspective on how we can utilize natural compounds more effectively against complex health issues like cancer.
The inulin-based nanoparticles showed impressive results, significantly enhancing the performance of curcumin in laboratory tests. When we compared the nanoparticles to free curcumin, we found that the nanoparticles had a much lower minimum inhibitory concentration against common bacteria, demonstrating their promising potential.
Additionally, the nanoparticles not only enhanced antioxidant activity but also proved effective in reducing inflammatory cytokine levels and limiting cancer cell growth. Importantly, the study revealed good biocompatibility, indicating that the nanoparticles are safe to use.
Overall, our findings highlight the exciting potential of using inulin as a delivery vehicle for curcumin, a promising candidate in cancer treatment. This innovation offers a fresh perspective on how we can utilize natural compounds more effectively against complex health issues like cancer.
Read More
8
We explored the effectiveness of inulin, a natural dietary fiber, as a protective agent against damage from radiation therapy and its potential impact on cancer treatment. In this study, we developed colon-retentive gels made from inulin, aiming to deliver its benefits directly to the gut.
Mice models were used to examine how these gels could protect vital functions affected by radiation, specifically looking at the hematopoietic system and intestinal health. We found that when the gels were administered before and after exposure to radiation, there was a noticeable improvement in blood cell recovery and overall gut health.
Notably, the oral inulin gels enhanced the levels of beneficial gut bacteria and promoted the production of anti-inflammatory cytokines. This improvement in gut homeostasis seemed to enhance radiotherapy effectiveness in a colorectal cancer model while minimizing radiation injury.
These findings highlight the exciting potential of inulin gels as a bioactive material that not only protects against radiation-induced effects but may also support cancer treatment outcomes with fewer side effects.
Mice models were used to examine how these gels could protect vital functions affected by radiation, specifically looking at the hematopoietic system and intestinal health. We found that when the gels were administered before and after exposure to radiation, there was a noticeable improvement in blood cell recovery and overall gut health.
Notably, the oral inulin gels enhanced the levels of beneficial gut bacteria and promoted the production of anti-inflammatory cytokines. This improvement in gut homeostasis seemed to enhance radiotherapy effectiveness in a colorectal cancer model while minimizing radiation injury.
These findings highlight the exciting potential of inulin gels as a bioactive material that not only protects against radiation-induced effects but may also support cancer treatment outcomes with fewer side effects.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Boosts immune system
6 people found this helpful
I chose Inulin over other prebiotics after consulting with my gastroenterologist. It reaches the bowels where beneficial bacteria grow and inhibits certain fats' growth. Inulin serves as a valuable dietary fibre and helps reduce the risk of cancer while enhancing immune functions. If this review has helped you, please give it a thumbs up. Thank you!
Read More
9
Supports intestinal health
5 people found this helpful
Inulin has been proven to increase beneficial intestinal bacteria in the colon, which positively impacts health. It also helps suppress harmful bacteria's reproduction. Daily consumption of 10 grams of inulin can reduce hematocrit in type 2 diabetes patients. I give it to my husband to aid testosterone levels and protect colon cells from cancer. Although inulin may lower blood pressure slightly, those with hypotension should be cautious. Overall, it contributes to good health, which I truly appreciate.
Read More
7.5
Supports gut health
2 people found this helpful
I opted for Inulin rather than other prebiotics after discussing it with a Tequila company owner. Inulin effectively reaches the bowels, promoting beneficial bacteria growth and inhibiting certain fats while serving as dietary fibre. It also helps in reducing the cancer risk and boosts immune function.
Read More
7.5
Post-surgery recovery
I purchased Inulin for my family after my relative's colon cancer surgery. By combining it with lactic acid bacteria, it seems to help ensure comfortable days without difficulties. Its organic form feels safe, and being a powder, it’s easy to adjust the dosage. Just be mindful of humidity.
Read More
7.5
Helps cancer patient
2 people found this helpful
I ordered this for my mother-in-law, who is a cancer patient, and she really enjoys it.
Read More
Frequently Asked Questions
6
Prevents rectal cancer
I initially consumed Inulin for constipation, but I continue to take it because it prevents rectal cancer and is beneficial for the intestines. I have noticed an improvement in my constipation.
7.5
Post-surgery recovery
I purchased Inulin for my family after my relative's colon cancer surgery. By combining it with lactic acid bacteria, it seems to help ensure comfortable days without difficulties. Its organic form feels safe, and being a powder, it’s easy to adjust the dosage. Just be mindful of humidity.
7.5
Boosts immune system
6 people found this helpful
I chose Inulin over other prebiotics after consulting with my gastroenterologist. It reaches the bowels where beneficial bacteria grow and inhibits certain fats' growth. Inulin serves as a valuable dietary fibre and helps reduce the risk of cancer while enhancing immune functions. If this review has helped you, please give it a thumbs up. Thank you!
9
Supports intestinal health
5 people found this helpful
Inulin has been proven to increase beneficial intestinal bacteria in the colon, which positively impacts health. It also helps suppress harmful bacteria's reproduction. Daily consumption of 10 grams of inulin can reduce hematocrit in type 2 diabetes patients. I give it to my husband to aid testosterone levels and protect colon cells from cancer. Although inulin may lower blood pressure slightly, those with hypotension should be cautious. Overall, it contributes to good health, which I truly appreciate.
7.5
Supports gut health
2 people found this helpful
I opted for Inulin rather than other prebiotics after discussing it with a Tequila company owner. Inulin effectively reaches the bowels, promoting beneficial bacteria growth and inhibiting certain fats while serving as dietary fibre. It also helps in reducing the cancer risk and boosts immune function.
8
We set out to understand how dietary choices and genetics influence the cancer-causing potential of certain bacteria, specifically colibactin-producing E. coli, in a mouse model. By examining mice that were colonized with these bacteria and feeding them various diets, including one that was low in carbohydrates and soluble fiber, we observed some striking results. Mice on the low-carbohydrate diet showed an increase in colonic polyps, which are precursors to cancer.
The study revealed that a lack of soluble fiber led to higher levels of mucosal inflammation, which in turn impaired a key signaling pathway in the colon known as PPAR-γ. This disruption not only boosted the growth of colibactin-producing E. coli but also led to significant DNA damage. However, we discovered that administering inulin, a type of soluble fiber, helped counteract these harmful effects. It reduced inflammation and the number of polyps in the affected mice, highlighting the potential protective quality of inulin.
Additionally, in mice that had deficiencies in DNA mismatch repair, we found that E. coli exacerbated polyp formation through another mechanism involving inflammation. This suggests that dietary fiber, particularly inulin, may play a critical role in preventing inflammation-driven carcinogenesis in the gut. By understanding the interplay between diet, microbiome, and cancer risk, we can better appreciate how something as simple as dietary fiber can help shape our health.
The study revealed that a lack of soluble fiber led to higher levels of mucosal inflammation, which in turn impaired a key signaling pathway in the colon known as PPAR-γ. This disruption not only boosted the growth of colibactin-producing E. coli but also led to significant DNA damage. However, we discovered that administering inulin, a type of soluble fiber, helped counteract these harmful effects. It reduced inflammation and the number of polyps in the affected mice, highlighting the potential protective quality of inulin.
Additionally, in mice that had deficiencies in DNA mismatch repair, we found that E. coli exacerbated polyp formation through another mechanism involving inflammation. This suggests that dietary fiber, particularly inulin, may play a critical role in preventing inflammation-driven carcinogenesis in the gut. By understanding the interplay between diet, microbiome, and cancer risk, we can better appreciate how something as simple as dietary fiber can help shape our health.
8
Inulin enhances targeted cancer therapy
We explored the role of inulin in a unique oral drug delivery system designed for colon cancer treatment. By integrating inulin with hyaluronic acid, we aimed to create a targeted approach for delivering chemotherapy, photosensitizers, and agents to relieve tumor hypoxia. This method effectively combines three therapeutic agents: the chemotherapy drug 5-Fluorouracil, the photosensitizer chlorin e6, and the hypoxia reliever metformin into liposomes specifically targeting colon cancer cells.
Our results showed that this combination therapy posed significant advantages over treatments using each agent separately. In fact, when tested in mice, this targeted delivery system resulted in impressive reductions in tumor growth—31 times better than using only 5-Fluorouracil, and similarly, significant improvements compared to either metformin or chlorin e6 alone. Importantly, these liposomes displayed good safety and compliance after oral administration, hinting at their potential in clinical use.
While the specific impact of inulin cannot be isolated fully due to its role within a combination treatment, its function alongside hyaluronic acid appears beneficial in enhancing drug delivery and targeting. Overall, this innovative approach brings hope for more effective colon cancer therapies in the future.
Our results showed that this combination therapy posed significant advantages over treatments using each agent separately. In fact, when tested in mice, this targeted delivery system resulted in impressive reductions in tumor growth—31 times better than using only 5-Fluorouracil, and similarly, significant improvements compared to either metformin or chlorin e6 alone. Importantly, these liposomes displayed good safety and compliance after oral administration, hinting at their potential in clinical use.
While the specific impact of inulin cannot be isolated fully due to its role within a combination treatment, its function alongside hyaluronic acid appears beneficial in enhancing drug delivery and targeting. Overall, this innovative approach brings hope for more effective colon cancer therapies in the future.
8
Patients undergoing colorectal cancer surgery often face the risk of anastomotic leaks (AL), where intestinal contents leak through a poorly healed section of the colon. This study explored whether addressing AL could prevent cancer cells from escaping and leading to recurrences after surgery.
We reviewed data from patients with AL and noted that they had lower survival rates compared to those without complications. Mouse models helped us further investigate the impact of AL on tumor growth, revealing that poorly healed anastomoses resulted in larger tumors.
Interestingly, we found that inulin, when used alongside 5-aminosalicylate (5-ASA), influenced the gut microbiota positively, enhancing the immune response necessary for cancer management. Specifically, both substances seem to support the barrier function of the gut, which is crucial for preventing local tumor growth and metastatic spread.
Overall, our findings suggest that preventing AL is an essential step for improving outcomes after colorectal cancer surgery. The potential of targeting gut health through dietary means, particularly with inulin, offers a promising avenue for reducing cancer recurrence while enhancing healing post-surgery.
We reviewed data from patients with AL and noted that they had lower survival rates compared to those without complications. Mouse models helped us further investigate the impact of AL on tumor growth, revealing that poorly healed anastomoses resulted in larger tumors.
Interestingly, we found that inulin, when used alongside 5-aminosalicylate (5-ASA), influenced the gut microbiota positively, enhancing the immune response necessary for cancer management. Specifically, both substances seem to support the barrier function of the gut, which is crucial for preventing local tumor growth and metastatic spread.
Overall, our findings suggest that preventing AL is an essential step for improving outcomes after colorectal cancer surgery. The potential of targeting gut health through dietary means, particularly with inulin, offers a promising avenue for reducing cancer recurrence while enhancing healing post-surgery.
8
We investigated the role of inulin, a type of soluble fiber, in colorectal cancer (CRC) using mice as our study model. The research involved feeding different groups of mice various fiber-rich diets, including some with high levels of inulin. Our primary aim was to explore how these dietary fibers influenced tumor growth and gut health.
Our findings revealed that a mixed high-fiber diet, which included soluble fibers like inulin, actually increased tumor numbers and sizes in mice exposed to an agent that induces CRC. Notably, when we disrupted the gut bacteria of these mice with antibiotics, the tumor-promoting effects of the fiber-rich diet disappeared. Additionally, when we transferred stools from mice on high-inulin diets to germ-free mice, we saw increased cell proliferation in the colon, which indicates that inulin could potentially accelerate cancer growth.
We discovered that soluble fibers led to significant changes in the gut microbiota—enriching certain harmful bacteria while reducing beneficial ones. This dysbiosis was accompanied by shifts in metabolic markers associated with cancer progression. Essentially, the more inulin present in the diet, the more we observed effects that promoted tumor development.
Overall, our research suggests that high doses of soluble fiber, specifically inulin, can potentially fuel colorectal tumor growth, highlighting important concerns regarding dietary fiber intake and cancer risk.
Our findings revealed that a mixed high-fiber diet, which included soluble fibers like inulin, actually increased tumor numbers and sizes in mice exposed to an agent that induces CRC. Notably, when we disrupted the gut bacteria of these mice with antibiotics, the tumor-promoting effects of the fiber-rich diet disappeared. Additionally, when we transferred stools from mice on high-inulin diets to germ-free mice, we saw increased cell proliferation in the colon, which indicates that inulin could potentially accelerate cancer growth.
We discovered that soluble fibers led to significant changes in the gut microbiota—enriching certain harmful bacteria while reducing beneficial ones. This dysbiosis was accompanied by shifts in metabolic markers associated with cancer progression. Essentially, the more inulin present in the diet, the more we observed effects that promoted tumor development.
Overall, our research suggests that high doses of soluble fiber, specifically inulin, can potentially fuel colorectal tumor growth, highlighting important concerns regarding dietary fiber intake and cancer risk.
References
- Thakur BK, Malaise Y, Choudhury SR, Neustaeter A, Turpin W, et al. Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal cancer. Nat Microbiol. 2025. doi:10.1038/s41564-025-01938-4
- Wang N, Hu J, Jin L, Wang S, Zeng B, et al. Inulin and hyaluronic acid-based oral liposome for enhanced photo-chemotherapy against orthotopic colon cancer and its reversal effects on tumor hypoxia and intestinal microbiota. Int J Biol Macromol. 2025;304:140996. doi:10.1016/j.ijbiomac.2025.140996
- Xie Y, Sun C, Zhang Y, Yang Z, Gao X, et al. Curcumin encapsulation in self-assembled nanoparticles based on amphiphilic stearic acid-grafted inulin: Preparation, characterization, and functional evaluation. Int J Biol Macromol. 2025;301:140302. doi:10.1016/j.ijbiomac.2025.140302
- Cui Z, Shi C, An R, Tang Y, Li Y, et al. In Silico-Guided Discovery of Polysaccharide Derivatives as Adjuvants in Nanoparticle Vaccines for Cancer Immunotherapy. ACS Nano. 2025;19:2099. doi:10.1021/acsnano.4c08898
- Liu D, Wei M, Fang Y, Yuan T, Sun Y, et al. Oral colon-retentive inulin gels protect against radiation-induced hematopoietic and gastrointestinal injury by improving gut homeostasis. Int J Biol Macromol. 2025;292:139199. doi:10.1016/j.ijbiomac.2024.139199
- Sun B, Xie W, Li X, Liu T, Bai J, et al. Inulin enhanced rifaximin-inhibited colon cancer pulmonary metastasis by flora-regulated bile acid pathway. Int J Biol Macromol. 2024;275:133582. doi:10.1016/j.ijbiomac.2024.133582
- Then CK, Paillas S, Moomin A, Misheva MD, Moir RA, et al. Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity. Microbiome. 2024;12:89. doi:10.1186/s40168-024-01804-1
- Li L, He S, Liao B, Wang M, Lin H, et al. Orally Administrated Hydrogel Harnessing Intratumoral Microbiome and Microbiota-Related Immune Responses for Potentiated Colorectal Cancer Treatment. Research (Wash D C). 2024;7:0364. doi:10.34133/research.0364
- Maher S, Elmeligy HA, Aboushousha T, Helal NS, Ossama Y, et al. Synergistic immunomodulatory effect of synbiotics pre- and postoperative resection of pancreatic ductal adenocarcinoma: a randomized controlled study. Cancer Immunol Immunother. 2024;73:109. doi:10.1007/s00262-024-03686-6
- Gutiérrez Salmeán G, Delgadillo González M, Rueda Escalona AA, Leyva Islas JA, Castro-Eguiluz D. Effects of prebiotics, probiotics, and synbiotics on the prevention and treatment of cervical cancer: Mexican consensus and recommendations. Front Oncol. 2024;14:1383258. doi:10.3389/fonc.2024.1383258
- Ji K, Zhang M, Du L, Wang J, Liu Y, et al. Exploring the Role of Inulin in Targeting the Gut Microbiota: An Innovative Strategy for Alleviating Colonic Fibrosis Induced By Irradiation. J Agric Food Chem. 2024;72:5710. doi:10.1021/acs.jafc.3c03432
- Hajjar R, Oliero M, Fragoso G, Ajayi AS, Alaoui AA, et al. Modulating Gut Microbiota Prevents Anastomotic Leak to Reduce Local Implantation and Dissemination of Colorectal Cancer Cells after Surgery. Clin Cancer Res. 2024;30:616. doi:10.1158/1078-0432.CCR-23-1601
- Asim F, Clarke L, Donnelly E, Jamal FR, Piccicacchi LM, et al. How do tumours outside the gastrointestinal tract respond to dietary fibre supplementation?. BMJ Oncol. 2023;2:e000107. doi:10.1136/bmjonc-2023-000107
- Yang J, Wei H, Lin Y, Chu ESH, Zhou Y, et al. High Soluble Fiber Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites in Mice. Gastroenterology. 2024;166:323. doi:10.1053/j.gastro.2023.10.012
