Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.8
USERS' SCORE
Good
Based on 3 Reviews
8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Choline (from 630 mg Choline Bitartrate)
250 mg
45%
Inositol
250 mg
†
Top Medical Research Studies
9
Inositol extract curbs atherosclerosis inflammation
We investigated how inositol, a key component found in an edible fruit extract, affects the early stages of arteriosclerosis—specifically, monocyte adhesion to endothelial cells, which is crucial in the development of cardiovascular diseases. Using human umbilical vein endothelial cells stimulated with tumor necrosis factor (TNF), we discovered that the inositol-rich extract substantially reduced the expression of vascular cell adhesion molecule-1 (VCAM-1). This reduction is important because VCAM-1 is a protein that facilitates monocyte attachment to blood vessel walls.
Our findings revealed that, through complex signaling pathways, the extract upregulated a protein called phosphatase and tensin homolog (PTEN). This process helped inhibit the activation of AKT and glycogen synthase kinase 3 (GSK-3), which are involved in inflammatory responses. Interestingly, we also saw that the extract interfered with the activation of the nuclear factor kappa B (NF-κB) pathway, further decreasing the expression of various pro-inflammatory genes.
In animal studies, the oral administration of this extract notably decreased VCAM-1 expression and monocyte infiltration in mouse models of arteriosclerosis. These compelling results point to the potential of using inositol as a nutraceutical aimed at preventing the onset of arteriosclerosis by addressing its initial inflammatory processes.
Our findings revealed that, through complex signaling pathways, the extract upregulated a protein called phosphatase and tensin homolog (PTEN). This process helped inhibit the activation of AKT and glycogen synthase kinase 3 (GSK-3), which are involved in inflammatory responses. Interestingly, we also saw that the extract interfered with the activation of the nuclear factor kappa B (NF-κB) pathway, further decreasing the expression of various pro-inflammatory genes.
In animal studies, the oral administration of this extract notably decreased VCAM-1 expression and monocyte infiltration in mouse models of arteriosclerosis. These compelling results point to the potential of using inositol as a nutraceutical aimed at preventing the onset of arteriosclerosis by addressing its initial inflammatory processes.
Read More
9
Our study dives into how pinitol, a naturally occurring substance related to inositol, affects the inflammation and dysfunction of endothelial cells, which are crucial players in atherosclerosis. We found that pinitol has a strong protective effect against oxidized low-density lipoprotein (ox-LDL), a harmful substance that contributes to the progression of atherosclerosis.
Through our experiments, we were pleased to discover that pinitol reduces harmful processes triggered by ox-LDL. This included decreasing the production of reactive oxygen species, a significant contributor to oxidative stress. We also observed a notable drop in the levels of pro-inflammatory molecules such as IL-6 and monocyte chemoattractant protein-1.
Additionally, pinitol successfully inhibited the attachment of THP-1 monocytes to endothelial cells, which is important because excessive monocyte attachment can worsen inflammation and contribute to artery blockages. This was shown through the downregulation of specific adhesion molecules.
Finally, we noted that pinitol also reduced the levels of LOX-1, a receptor that drives atherogenesis, while restoring the protective expression of KLF2, a key factor against atherosclerosis. This research highlights the promising potential of pinitol not just in treating, but possibly preventing atherosclerosis, which remains a pressing health concern worldwide.
Through our experiments, we were pleased to discover that pinitol reduces harmful processes triggered by ox-LDL. This included decreasing the production of reactive oxygen species, a significant contributor to oxidative stress. We also observed a notable drop in the levels of pro-inflammatory molecules such as IL-6 and monocyte chemoattractant protein-1.
Additionally, pinitol successfully inhibited the attachment of THP-1 monocytes to endothelial cells, which is important because excessive monocyte attachment can worsen inflammation and contribute to artery blockages. This was shown through the downregulation of specific adhesion molecules.
Finally, we noted that pinitol also reduced the levels of LOX-1, a receptor that drives atherogenesis, while restoring the protective expression of KLF2, a key factor against atherosclerosis. This research highlights the promising potential of pinitol not just in treating, but possibly preventing atherosclerosis, which remains a pressing health concern worldwide.
Read More
9
We explored the role of a significant player called IRE1 in the context of atherosclerosis, a serious condition linked to heart disease. This research focused on understanding how the inhibition of IRE1 affects inflammation and plaque formation within blood vessels, a key issue that arises from something called metaflammation, which is a low-grade, chronic inflammation often tied to obesity and diabetes.
By studying macrophages—cells that contribute to the inflammation—we found that when IRE1 was inhibited, it dampened the production of certain inflammatory proteins that can promote atherosclerosis. In experimental models, these IRE1 inhibitors successfully reduced the size of atherosclerotic plaques in mice without altering their lipid levels, indicating that it may be possible to combat this disease without affecting cholesterol levels.
Importantly, while the findings highlight the potential of targeting IRE1 to help manage atherosclerosis, the specifics of inositol’s role were not clearly outlined in the study. Therefore, while we can appreciate the inspiring approach taken here, we must acknowledge that the direct benefits of inositol treatment on arteriosclerosis remain unexamined.
By studying macrophages—cells that contribute to the inflammation—we found that when IRE1 was inhibited, it dampened the production of certain inflammatory proteins that can promote atherosclerosis. In experimental models, these IRE1 inhibitors successfully reduced the size of atherosclerotic plaques in mice without altering their lipid levels, indicating that it may be possible to combat this disease without affecting cholesterol levels.
Importantly, while the findings highlight the potential of targeting IRE1 to help manage atherosclerosis, the specifics of inositol’s role were not clearly outlined in the study. Therefore, while we can appreciate the inspiring approach taken here, we must acknowledge that the direct benefits of inositol treatment on arteriosclerosis remain unexamined.
Read More
Most Useful Reviews
6
Weight loss aid
47 people found this helpful
As expected, my cholesterol levels had risen, and I was diagnosed with hyperlipidaemia for several years. However, my doctor was serious about preventing arteriosclerosis, and after four months, I lost 10kg. I realised that I also needed supplements, so I searched for anti-bite options and found one that looked good. After taking it, I felt it was beneficial for me. At night, it calmed my spirit and allowed me to sleep peacefully. I usually don’t cope well with stress. The autonomic nerve feels broken, and alongside taking DHA, I believe choline and inositol will be my saviours. The product is remarkably effective and balances my mental and physical state. I even prepare it as a refreshing drink like lemon water.
Read More
7.5
Mental clarity improvement
1 people found this helpful
I heard this has become an essential nutrient in the United States. It converts to acetylcholine and is said to improve arteriosclerosis. After using it, I feel like my head is clearer.
Read More
7.5
Nervous system support
This product helps protect the nervous system, and myo-inositol is beneficial for preventing arteriosclerosis. It combines with choline to synthesise lecithin, aiding in lowering blood cholesterol levels. I have also learned that creatine supplementation is beneficial for those with muscle deficiencies, as studies show it enhances physical strength and explosive power, making it popular in athletic and bodybuilding circles.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.8
- All Researches
9
Inositol extract curbs atherosclerosis inflammation
We investigated how inositol, a key component found in an edible fruit extract, affects the early stages of arteriosclerosis—specifically, monocyte adhesion to endothelial cells, which is crucial in the development of cardiovascular diseases. Using human umbilical vein endothelial cells stimulated with tumor necrosis factor (TNF), we discovered that the inositol-rich extract substantially reduced the expression of vascular cell adhesion molecule-1 (VCAM-1). This reduction is important because VCAM-1 is a protein that facilitates monocyte attachment to blood vessel walls.
Our findings revealed that, through complex signaling pathways, the extract upregulated a protein called phosphatase and tensin homolog (PTEN). This process helped inhibit the activation of AKT and glycogen synthase kinase 3 (GSK-3), which are involved in inflammatory responses. Interestingly, we also saw that the extract interfered with the activation of the nuclear factor kappa B (NF-κB) pathway, further decreasing the expression of various pro-inflammatory genes.
In animal studies, the oral administration of this extract notably decreased VCAM-1 expression and monocyte infiltration in mouse models of arteriosclerosis. These compelling results point to the potential of using inositol as a nutraceutical aimed at preventing the onset of arteriosclerosis by addressing its initial inflammatory processes.
Our findings revealed that, through complex signaling pathways, the extract upregulated a protein called phosphatase and tensin homolog (PTEN). This process helped inhibit the activation of AKT and glycogen synthase kinase 3 (GSK-3), which are involved in inflammatory responses. Interestingly, we also saw that the extract interfered with the activation of the nuclear factor kappa B (NF-κB) pathway, further decreasing the expression of various pro-inflammatory genes.
In animal studies, the oral administration of this extract notably decreased VCAM-1 expression and monocyte infiltration in mouse models of arteriosclerosis. These compelling results point to the potential of using inositol as a nutraceutical aimed at preventing the onset of arteriosclerosis by addressing its initial inflammatory processes.
Read More
9
Our study dives into how pinitol, a naturally occurring substance related to inositol, affects the inflammation and dysfunction of endothelial cells, which are crucial players in atherosclerosis. We found that pinitol has a strong protective effect against oxidized low-density lipoprotein (ox-LDL), a harmful substance that contributes to the progression of atherosclerosis.
Through our experiments, we were pleased to discover that pinitol reduces harmful processes triggered by ox-LDL. This included decreasing the production of reactive oxygen species, a significant contributor to oxidative stress. We also observed a notable drop in the levels of pro-inflammatory molecules such as IL-6 and monocyte chemoattractant protein-1.
Additionally, pinitol successfully inhibited the attachment of THP-1 monocytes to endothelial cells, which is important because excessive monocyte attachment can worsen inflammation and contribute to artery blockages. This was shown through the downregulation of specific adhesion molecules.
Finally, we noted that pinitol also reduced the levels of LOX-1, a receptor that drives atherogenesis, while restoring the protective expression of KLF2, a key factor against atherosclerosis. This research highlights the promising potential of pinitol not just in treating, but possibly preventing atherosclerosis, which remains a pressing health concern worldwide.
Through our experiments, we were pleased to discover that pinitol reduces harmful processes triggered by ox-LDL. This included decreasing the production of reactive oxygen species, a significant contributor to oxidative stress. We also observed a notable drop in the levels of pro-inflammatory molecules such as IL-6 and monocyte chemoattractant protein-1.
Additionally, pinitol successfully inhibited the attachment of THP-1 monocytes to endothelial cells, which is important because excessive monocyte attachment can worsen inflammation and contribute to artery blockages. This was shown through the downregulation of specific adhesion molecules.
Finally, we noted that pinitol also reduced the levels of LOX-1, a receptor that drives atherogenesis, while restoring the protective expression of KLF2, a key factor against atherosclerosis. This research highlights the promising potential of pinitol not just in treating, but possibly preventing atherosclerosis, which remains a pressing health concern worldwide.
Read More
9
We explored the role of a significant player called IRE1 in the context of atherosclerosis, a serious condition linked to heart disease. This research focused on understanding how the inhibition of IRE1 affects inflammation and plaque formation within blood vessels, a key issue that arises from something called metaflammation, which is a low-grade, chronic inflammation often tied to obesity and diabetes.
By studying macrophages—cells that contribute to the inflammation—we found that when IRE1 was inhibited, it dampened the production of certain inflammatory proteins that can promote atherosclerosis. In experimental models, these IRE1 inhibitors successfully reduced the size of atherosclerotic plaques in mice without altering their lipid levels, indicating that it may be possible to combat this disease without affecting cholesterol levels.
Importantly, while the findings highlight the potential of targeting IRE1 to help manage atherosclerosis, the specifics of inositol’s role were not clearly outlined in the study. Therefore, while we can appreciate the inspiring approach taken here, we must acknowledge that the direct benefits of inositol treatment on arteriosclerosis remain unexamined.
By studying macrophages—cells that contribute to the inflammation—we found that when IRE1 was inhibited, it dampened the production of certain inflammatory proteins that can promote atherosclerosis. In experimental models, these IRE1 inhibitors successfully reduced the size of atherosclerotic plaques in mice without altering their lipid levels, indicating that it may be possible to combat this disease without affecting cholesterol levels.
Importantly, while the findings highlight the potential of targeting IRE1 to help manage atherosclerosis, the specifics of inositol’s role were not clearly outlined in the study. Therefore, while we can appreciate the inspiring approach taken here, we must acknowledge that the direct benefits of inositol treatment on arteriosclerosis remain unexamined.
Read More
8
SNF472 slows cardiovascular calcification
We conducted a study to explore how SNF472, a type of myo-inositol hexaphosphate, may influence cardiovascular calcification in patients with end-stage kidney disease undergoing hemodialysis. This double-blind, placebo-controlled trial involved nearly 300 participants who were randomly assigned to receive either SNF472 at two different doses or a placebo, administered three times a week over a year.
Our key focus was on measuring changes in coronary artery calcium scores, a crucial indicator of heart health. We discovered that SNF472 significantly slowed the progression of coronary artery calcium and aortic valve calcification compared to those who received the placebo alongside standard care.
These findings suggest that SNF472 could play a beneficial role in managing cardiovascular calcification in these vulnerable patients. However, further research is warranted to investigate its potential impact on actual cardiovascular events in the future.
Our key focus was on measuring changes in coronary artery calcium scores, a crucial indicator of heart health. We discovered that SNF472 significantly slowed the progression of coronary artery calcium and aortic valve calcification compared to those who received the placebo alongside standard care.
These findings suggest that SNF472 could play a beneficial role in managing cardiovascular calcification in these vulnerable patients. However, further research is warranted to investigate its potential impact on actual cardiovascular events in the future.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
6
Weight loss aid
47 people found this helpful
As expected, my cholesterol levels had risen, and I was diagnosed with hyperlipidaemia for several years. However, my doctor was serious about preventing arteriosclerosis, and after four months, I lost 10kg. I realised that I also needed supplements, so I searched for anti-bite options and found one that looked good. After taking it, I felt it was beneficial for me. At night, it calmed my spirit and allowed me to sleep peacefully. I usually don’t cope well with stress. The autonomic nerve feels broken, and alongside taking DHA, I believe choline and inositol will be my saviours. The product is remarkably effective and balances my mental and physical state. I even prepare it as a refreshing drink like lemon water.
Read More
7.5
Mental clarity improvement
1 people found this helpful
I heard this has become an essential nutrient in the United States. It converts to acetylcholine and is said to improve arteriosclerosis. After using it, I feel like my head is clearer.
Read More
7.5
Nervous system support
This product helps protect the nervous system, and myo-inositol is beneficial for preventing arteriosclerosis. It combines with choline to synthesise lecithin, aiding in lowering blood cholesterol levels. I have also learned that creatine supplementation is beneficial for those with muscle deficiencies, as studies show it enhances physical strength and explosive power, making it popular in athletic and bodybuilding circles.
Read More
Frequently Asked Questions
6
Weight loss aid
47 people found this helpful
As expected, my cholesterol levels had risen, and I was diagnosed with hyperlipidaemia for several years. However, my doctor was serious about preventing arteriosclerosis, and after four months, I lost 10kg. I realised that I also needed supplements, so I searched for anti-bite options and found one that looked good. After taking it, I felt it was beneficial for me. At night, it calmed my spirit and allowed me to sleep peacefully. I usually don’t cope well with stress. The autonomic nerve feels broken, and alongside taking DHA, I believe choline and inositol will be my saviours. The product is remarkably effective and balances my mental and physical state. I even prepare it as a refreshing drink like lemon water.
7.5
Mental clarity improvement
1 people found this helpful
I heard this has become an essential nutrient in the United States. It converts to acetylcholine and is said to improve arteriosclerosis. After using it, I feel like my head is clearer.
7.5
Nervous system support
This product helps protect the nervous system, and myo-inositol is beneficial for preventing arteriosclerosis. It combines with choline to synthesise lecithin, aiding in lowering blood cholesterol levels. I have also learned that creatine supplementation is beneficial for those with muscle deficiencies, as studies show it enhances physical strength and explosive power, making it popular in athletic and bodybuilding circles.
9
Inositol extract curbs atherosclerosis inflammation
We investigated how inositol, a key component found in an edible fruit extract, affects the early stages of arteriosclerosis—specifically, monocyte adhesion to endothelial cells, which is crucial in the development of cardiovascular diseases. Using human umbilical vein endothelial cells stimulated with tumor necrosis factor (TNF), we discovered that the inositol-rich extract substantially reduced the expression of vascular cell adhesion molecule-1 (VCAM-1). This reduction is important because VCAM-1 is a protein that facilitates monocyte attachment to blood vessel walls.
Our findings revealed that, through complex signaling pathways, the extract upregulated a protein called phosphatase and tensin homolog (PTEN). This process helped inhibit the activation of AKT and glycogen synthase kinase 3 (GSK-3), which are involved in inflammatory responses. Interestingly, we also saw that the extract interfered with the activation of the nuclear factor kappa B (NF-κB) pathway, further decreasing the expression of various pro-inflammatory genes.
In animal studies, the oral administration of this extract notably decreased VCAM-1 expression and monocyte infiltration in mouse models of arteriosclerosis. These compelling results point to the potential of using inositol as a nutraceutical aimed at preventing the onset of arteriosclerosis by addressing its initial inflammatory processes.
Our findings revealed that, through complex signaling pathways, the extract upregulated a protein called phosphatase and tensin homolog (PTEN). This process helped inhibit the activation of AKT and glycogen synthase kinase 3 (GSK-3), which are involved in inflammatory responses. Interestingly, we also saw that the extract interfered with the activation of the nuclear factor kappa B (NF-κB) pathway, further decreasing the expression of various pro-inflammatory genes.
In animal studies, the oral administration of this extract notably decreased VCAM-1 expression and monocyte infiltration in mouse models of arteriosclerosis. These compelling results point to the potential of using inositol as a nutraceutical aimed at preventing the onset of arteriosclerosis by addressing its initial inflammatory processes.
9
Our study dives into how pinitol, a naturally occurring substance related to inositol, affects the inflammation and dysfunction of endothelial cells, which are crucial players in atherosclerosis. We found that pinitol has a strong protective effect against oxidized low-density lipoprotein (ox-LDL), a harmful substance that contributes to the progression of atherosclerosis.
Through our experiments, we were pleased to discover that pinitol reduces harmful processes triggered by ox-LDL. This included decreasing the production of reactive oxygen species, a significant contributor to oxidative stress. We also observed a notable drop in the levels of pro-inflammatory molecules such as IL-6 and monocyte chemoattractant protein-1.
Additionally, pinitol successfully inhibited the attachment of THP-1 monocytes to endothelial cells, which is important because excessive monocyte attachment can worsen inflammation and contribute to artery blockages. This was shown through the downregulation of specific adhesion molecules.
Finally, we noted that pinitol also reduced the levels of LOX-1, a receptor that drives atherogenesis, while restoring the protective expression of KLF2, a key factor against atherosclerosis. This research highlights the promising potential of pinitol not just in treating, but possibly preventing atherosclerosis, which remains a pressing health concern worldwide.
Through our experiments, we were pleased to discover that pinitol reduces harmful processes triggered by ox-LDL. This included decreasing the production of reactive oxygen species, a significant contributor to oxidative stress. We also observed a notable drop in the levels of pro-inflammatory molecules such as IL-6 and monocyte chemoattractant protein-1.
Additionally, pinitol successfully inhibited the attachment of THP-1 monocytes to endothelial cells, which is important because excessive monocyte attachment can worsen inflammation and contribute to artery blockages. This was shown through the downregulation of specific adhesion molecules.
Finally, we noted that pinitol also reduced the levels of LOX-1, a receptor that drives atherogenesis, while restoring the protective expression of KLF2, a key factor against atherosclerosis. This research highlights the promising potential of pinitol not just in treating, but possibly preventing atherosclerosis, which remains a pressing health concern worldwide.
References
- Lee J, Park J, Song KM, Lee YG, Choi HK. Extract Containing -Inositol Suppresses TNF--Induced VCAM-1 Expression and Monocyte Adhesion to Endothelial Cells via Inhibition of the PTEN/Akt/GSK-3 and NF-B Signaling Pathways. J Med Food. 2024;27:419. doi:10.1089/jmf.2023.K.0326
- Chen XH, Tan Y, Yu S, Lu L, Deng Y. Pinitol Protects Against Ox-Low-Density Lipoprotein-Induced Endothelial Inflammation and Monocytes Attachment. J Cardiovasc Pharmacol. 2022;79:368. doi:10.1097/FJC.0000000000001190
- Raggi P, Bellasi A, Bushinsky D, Bover J, Rodriguez M, et al. Slowing Progression of Cardiovascular Calcification With SNF472 in Patients on Hemodialysis: Results of a Randomized Phase 2b Study. Circulation. 2020;141:728. doi:10.1161/CIRCULATIONAHA.119.044195
- Tufanli O, Telkoparan Akillilar P, Acosta-Alvear D, Kocaturk B, Onat UI, et al. Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proc Natl Acad Sci U S A. 2017;114:E1395. doi:10.1073/pnas.1621188114
