' 
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Choline (from 630 mg Choline Bitartrate)
250 mg
45%
Inositol
250 mg
†
Top Medical Research Studies
9
Myo-inositol affects prostate cancer cells
Proteomic Analysis of Anticancer Effect of Myo-inositol in Human Prostate Cancer (DU-145) Cell Line.
Direct investigation of Myo-inositol
We investigated the potential benefits of Myo-inositol, a naturally occurring sugar alcohol, on DU-145 prostate cancer cells. By treating these cancer cells with various doses of Myo-inositol, we determined its half-maximal inhibitory concentration (IC50) using a simple method that measures cell viability.
Our findings revealed that Myo-inositol significantly decreased the viability of DU-145 cells, showing an IC50 of 0.06 mg/ml. This suggests that Myo-inositol may effectively inhibit cancer cell growth.
Furthermore, we performed a detailed proteomic analysis using advanced techniques to explore how Myo-inositol changes protein expression. We found notable differences in protein levels between treated and untreated cells, particularly in areas linked to key cellular functions like cytoskeletal regulation, apoptosis (cell death), and stress responses. For instance, certain proteins tied to tumor suppression were upregulated in response to Myo-inositol treatment.
Overall, these observations highlight Myo-inositol's potential as a therapeutic option. However, further studies are necessary to unravel the underlying mechanisms and assess its effectiveness in combination with other treatments for managing prostate cancer, especially castration-resistant prostate cancer (CRPC).
Our findings revealed that Myo-inositol significantly decreased the viability of DU-145 cells, showing an IC50 of 0.06 mg/ml. This suggests that Myo-inositol may effectively inhibit cancer cell growth.
Furthermore, we performed a detailed proteomic analysis using advanced techniques to explore how Myo-inositol changes protein expression. We found notable differences in protein levels between treated and untreated cells, particularly in areas linked to key cellular functions like cytoskeletal regulation, apoptosis (cell death), and stress responses. For instance, certain proteins tied to tumor suppression were upregulated in response to Myo-inositol treatment.
Overall, these observations highlight Myo-inositol's potential as a therapeutic option. However, further studies are necessary to unravel the underlying mechanisms and assess its effectiveness in combination with other treatments for managing prostate cancer, especially castration-resistant prostate cancer (CRPC).
Read More
9
Isogarcinol suppresses breast cancer growth
Isogarcinol Reduces MARS Levels and Deactivates the PI3K/AKT Pathway to Suppress the Malignant Properties of Breast Cancer Cells.
Highly relevant to cancer treatments
We investigated how isogarcinol (ISO) influences breast cancer cells and what mechanisms are at play. Through lab tests, we found that ISO at 13 μM effectively lowered cell growth and movement. In living subjects, doses of 5 to 15 mg/kg showed a significant reduction in tumor activity.
We observed that ISO achieves its tumor-suppressing effects by lowering the levels of a protein called methionyl-tRNA synthetase (MARS) and deactivating key pathways involved in cancer progression. These findings suggest ISO could be a valuable addition to breast cancer treatment strategies.
We observed that ISO achieves its tumor-suppressing effects by lowering the levels of a protein called methionyl-tRNA synthetase (MARS) and deactivating key pathways involved in cancer progression. These findings suggest ISO could be a valuable addition to breast cancer treatment strategies.
Read More
7
Vitamin E Succinate enhances autophagy
[The role of endoplasmic reticulum IP(3)R calcium channel in vitamin E succinate induced autophagy of human gastric cancer cell].
High relevance to gastric cancer treatment
We examined how vitamin E succinate (VES) affects autophagy in human gastric cancer cells by activating a calcium signaling pathway. Our study involved cultured gastric cancer cell lines treated with various doses of VES. We noted that VES significantly reduced cell proliferation and enhanced the formation of autophagosomes, indicating increased autophagy.
However, when we inhibited the calcium channel involved, the positive effects of VES diminished, suggesting the importance of this pathway in its action. Overall, while VES shows promise in promoting autophagy, further research is needed to understand its full potential in cancer treatment.
However, when we inhibited the calcium channel involved, the positive effects of VES diminished, suggesting the importance of this pathway in its action. Overall, while VES shows promise in promoting autophagy, further research is needed to understand its full potential in cancer treatment.
Read More
Most Useful Reviews
2
Conflicting effects noted
SIDE EFFECTS!!! Although choline deficiencies can lead to adverse health effects, excessive choline can cause issues like hypotension, sweating, and vomiting. Inositol is said to potentially have an anti-cancer effect while also possibly exacerbating growths. It may induce nausea, stomach pain, tiredness, headaches, and dizziness. Other side effects include anxiety, jitteriness, and insomnia. It's crucial to consider all side effects and drug interactions when taking supplements, and to devise a regimen that avoids harmful combinations while favouring beneficial ones.
Read More
7.5
Positive recovery addition
Good addition When my husband had cancer treatment, I gave him this supplement along with others. It was a good addition to his energy and recovery.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
- All Researches
9
Myo-inositol affects prostate cancer cells
Proteomic Analysis of Anticancer Effect of Myo-inositol in Human Prostate Cancer (DU-145) Cell Line.
Direct investigation of Myo-inositol
We investigated the potential benefits of Myo-inositol, a naturally occurring sugar alcohol, on DU-145 prostate cancer cells. By treating these cancer cells with various doses of Myo-inositol, we determined its half-maximal inhibitory concentration (IC50) using a simple method that measures cell viability.
Our findings revealed that Myo-inositol significantly decreased the viability of DU-145 cells, showing an IC50 of 0.06 mg/ml. This suggests that Myo-inositol may effectively inhibit cancer cell growth.
Furthermore, we performed a detailed proteomic analysis using advanced techniques to explore how Myo-inositol changes protein expression. We found notable differences in protein levels between treated and untreated cells, particularly in areas linked to key cellular functions like cytoskeletal regulation, apoptosis (cell death), and stress responses. For instance, certain proteins tied to tumor suppression were upregulated in response to Myo-inositol treatment.
Overall, these observations highlight Myo-inositol's potential as a therapeutic option. However, further studies are necessary to unravel the underlying mechanisms and assess its effectiveness in combination with other treatments for managing prostate cancer, especially castration-resistant prostate cancer (CRPC).
Our findings revealed that Myo-inositol significantly decreased the viability of DU-145 cells, showing an IC50 of 0.06 mg/ml. This suggests that Myo-inositol may effectively inhibit cancer cell growth.
Furthermore, we performed a detailed proteomic analysis using advanced techniques to explore how Myo-inositol changes protein expression. We found notable differences in protein levels between treated and untreated cells, particularly in areas linked to key cellular functions like cytoskeletal regulation, apoptosis (cell death), and stress responses. For instance, certain proteins tied to tumor suppression were upregulated in response to Myo-inositol treatment.
Overall, these observations highlight Myo-inositol's potential as a therapeutic option. However, further studies are necessary to unravel the underlying mechanisms and assess its effectiveness in combination with other treatments for managing prostate cancer, especially castration-resistant prostate cancer (CRPC).
Read More
9
Isogarcinol suppresses breast cancer growth
Isogarcinol Reduces MARS Levels and Deactivates the PI3K/AKT Pathway to Suppress the Malignant Properties of Breast Cancer Cells.
Highly relevant to cancer treatments
We investigated how isogarcinol (ISO) influences breast cancer cells and what mechanisms are at play. Through lab tests, we found that ISO at 13 μM effectively lowered cell growth and movement. In living subjects, doses of 5 to 15 mg/kg showed a significant reduction in tumor activity.
We observed that ISO achieves its tumor-suppressing effects by lowering the levels of a protein called methionyl-tRNA synthetase (MARS) and deactivating key pathways involved in cancer progression. These findings suggest ISO could be a valuable addition to breast cancer treatment strategies.
We observed that ISO achieves its tumor-suppressing effects by lowering the levels of a protein called methionyl-tRNA synthetase (MARS) and deactivating key pathways involved in cancer progression. These findings suggest ISO could be a valuable addition to breast cancer treatment strategies.
Read More
7
Vitamin E Succinate enhances autophagy
[The role of endoplasmic reticulum IP(3)R calcium channel in vitamin E succinate induced autophagy of human gastric cancer cell].
High relevance to gastric cancer treatment
We examined how vitamin E succinate (VES) affects autophagy in human gastric cancer cells by activating a calcium signaling pathway. Our study involved cultured gastric cancer cell lines treated with various doses of VES. We noted that VES significantly reduced cell proliferation and enhanced the formation of autophagosomes, indicating increased autophagy.
However, when we inhibited the calcium channel involved, the positive effects of VES diminished, suggesting the importance of this pathway in its action. Overall, while VES shows promise in promoting autophagy, further research is needed to understand its full potential in cancer treatment.
However, when we inhibited the calcium channel involved, the positive effects of VES diminished, suggesting the importance of this pathway in its action. Overall, while VES shows promise in promoting autophagy, further research is needed to understand its full potential in cancer treatment.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
2
Conflicting effects noted
SIDE EFFECTS!!! Although choline deficiencies can lead to adverse health effects, excessive choline can cause issues like hypotension, sweating, and vomiting. Inositol is said to potentially have an anti-cancer effect while also possibly exacerbating growths. It may induce nausea, stomach pain, tiredness, headaches, and dizziness. Other side effects include anxiety, jitteriness, and insomnia. It's crucial to consider all side effects and drug interactions when taking supplements, and to devise a regimen that avoids harmful combinations while favouring beneficial ones.
Read More
7.5
Positive recovery addition
Good addition When my husband had cancer treatment, I gave him this supplement along with others. It was a good addition to his energy and recovery.
