' 
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 7 Reviews
8.1
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Choline (from 630 mg Choline Bitartrate)
250 mg
45%
Inositol
250 mg
†
Top Medical Research Studies
8
BZYQD enhances motility and reduces inflammation
Buzhongyiqi Decoction Protects Against Loperamide-Induced Constipation by Regulating the Arachidonic Acid Pathway in Rats.
Moderate relevance to inositol's role
We aimed to understand the effects of Buzhongyiqi decoction (BZYQD) on constipation, particularly how it influences various metabolic pathways. In our exploration, we conducted experiments on rats experiencing loperamide-induced constipation. Following treatment with BZYQD, we observed a notable increase in the small intestinal transit rate, suggesting improved digestive movement.
Our findings also revealed that BZYQD helped to reduce pathological damage in the colon. Interestingly, one of the key factors we looked at was inositol, a metabolite whose levels were significantly affected by the treatment. We discovered that BZYQD not only increased serum levels of inositol but also enhanced the levels of motilin and gastrin, hormones that play important roles in regulating gastrointestinal motility.
Additionally, our analysis showed that BZYQD impacted inflammatory pathways by reducing the production of pro-inflammatory mediators and down-regulating markers like cyclooxygenase-2. These effects suggest a comprehensive approach to managing constipation might involve multiple metabolic pathways, with inositol being a notable component. Overall, our study suggests that BZYQD can protect against constipation, with inositol contributing to this beneficial effect, though further studies are needed to isolate its specific impact.
Our findings also revealed that BZYQD helped to reduce pathological damage in the colon. Interestingly, one of the key factors we looked at was inositol, a metabolite whose levels were significantly affected by the treatment. We discovered that BZYQD not only increased serum levels of inositol but also enhanced the levels of motilin and gastrin, hormones that play important roles in regulating gastrointestinal motility.
Additionally, our analysis showed that BZYQD impacted inflammatory pathways by reducing the production of pro-inflammatory mediators and down-regulating markers like cyclooxygenase-2. These effects suggest a comprehensive approach to managing constipation might involve multiple metabolic pathways, with inositol being a notable component. Overall, our study suggests that BZYQD can protect against constipation, with inositol contributing to this beneficial effect, though further studies are needed to isolate its specific impact.
Read More
9
Laxative effects of Spicatoside A
Spicatoside A in red Liriope platyphylla displays a laxative effect in a constipation rat model via regulating mAChRs and ER stress signaling.
Indirect inositol assessment noted
We examined the effects of an extract from Red Liriope platyphylla (EtRLP) on constipation in rats. Our study compared two groups of Sprague Dawley rats: one received loperamide to induce constipation while the other was treated with EtRLP alongside loperamide.
We noticed that the rats treated with EtRLP had significantly better outcomes. They experienced increased excretion of urine and stool, despite their food intake remaining the same. Histological evaluations showed improvements in the cellular structure of the transverse colon and enhanced mucin secretion.
A key component of the extract, known as Spicatoside A, appeared to play a crucial role. We observed that it helped restore important signaling pathways related to muscarinic acetylcholine receptors (mAChRs) and the endoplasmic reticulum stress response, which are crucial for digestive health.
However, while we noted the involvement of inositol through its pathways, we did not specifically isolate its effects, meaning that further research would be needed to fully understand its role in relieving constipation. Overall, our findings suggest that EtRLP could be a valuable option for alleviating constipation, primarily through the actions of Spicatoside A.
We noticed that the rats treated with EtRLP had significantly better outcomes. They experienced increased excretion of urine and stool, despite their food intake remaining the same. Histological evaluations showed improvements in the cellular structure of the transverse colon and enhanced mucin secretion.
A key component of the extract, known as Spicatoside A, appeared to play a crucial role. We observed that it helped restore important signaling pathways related to muscarinic acetylcholine receptors (mAChRs) and the endoplasmic reticulum stress response, which are crucial for digestive health.
However, while we noted the involvement of inositol through its pathways, we did not specifically isolate its effects, meaning that further research would be needed to fully understand its role in relieving constipation. Overall, our findings suggest that EtRLP could be a valuable option for alleviating constipation, primarily through the actions of Spicatoside A.
Read More
Most Useful Reviews
8.8
Bowels regulated
I tested it on myself and my mother. This is not my first time using it. I noticed that it helps to establish bowel movements and eliminates constipation. However, it's challenging to isolate the rest of the effects since we take various supplements. Gradually, I’ve noticed my weight decreasing.
Read More
8.3
Relieved constipation
I felt quite low and lacked appetite, so I continued taking this supplement. Gradually, I started to feel better and my anxiety diminished. It seems effective for concentration. To my surprise, the constipation vanished. However, those with a tendency to have loose bowels should be cautious.
Read More
9.5
Stimulates intestines
I take it with oecetine and I’m delighted. It's a good supplement that stimulates the intestines, particularly beneficial for those experiencing constipation.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
- All Researches
9
Laxative effects of Spicatoside A
Spicatoside A in red Liriope platyphylla displays a laxative effect in a constipation rat model via regulating mAChRs and ER stress signaling.
Indirect inositol assessment noted
We examined the effects of an extract from Red Liriope platyphylla (EtRLP) on constipation in rats. Our study compared two groups of Sprague Dawley rats: one received loperamide to induce constipation while the other was treated with EtRLP alongside loperamide.
We noticed that the rats treated with EtRLP had significantly better outcomes. They experienced increased excretion of urine and stool, despite their food intake remaining the same. Histological evaluations showed improvements in the cellular structure of the transverse colon and enhanced mucin secretion.
A key component of the extract, known as Spicatoside A, appeared to play a crucial role. We observed that it helped restore important signaling pathways related to muscarinic acetylcholine receptors (mAChRs) and the endoplasmic reticulum stress response, which are crucial for digestive health.
However, while we noted the involvement of inositol through its pathways, we did not specifically isolate its effects, meaning that further research would be needed to fully understand its role in relieving constipation. Overall, our findings suggest that EtRLP could be a valuable option for alleviating constipation, primarily through the actions of Spicatoside A.
We noticed that the rats treated with EtRLP had significantly better outcomes. They experienced increased excretion of urine and stool, despite their food intake remaining the same. Histological evaluations showed improvements in the cellular structure of the transverse colon and enhanced mucin secretion.
A key component of the extract, known as Spicatoside A, appeared to play a crucial role. We observed that it helped restore important signaling pathways related to muscarinic acetylcholine receptors (mAChRs) and the endoplasmic reticulum stress response, which are crucial for digestive health.
However, while we noted the involvement of inositol through its pathways, we did not specifically isolate its effects, meaning that further research would be needed to fully understand its role in relieving constipation. Overall, our findings suggest that EtRLP could be a valuable option for alleviating constipation, primarily through the actions of Spicatoside A.
Read More
8
BZYQD enhances motility and reduces inflammation
Buzhongyiqi Decoction Protects Against Loperamide-Induced Constipation by Regulating the Arachidonic Acid Pathway in Rats.
Moderate relevance to inositol's role
We aimed to understand the effects of Buzhongyiqi decoction (BZYQD) on constipation, particularly how it influences various metabolic pathways. In our exploration, we conducted experiments on rats experiencing loperamide-induced constipation. Following treatment with BZYQD, we observed a notable increase in the small intestinal transit rate, suggesting improved digestive movement.
Our findings also revealed that BZYQD helped to reduce pathological damage in the colon. Interestingly, one of the key factors we looked at was inositol, a metabolite whose levels were significantly affected by the treatment. We discovered that BZYQD not only increased serum levels of inositol but also enhanced the levels of motilin and gastrin, hormones that play important roles in regulating gastrointestinal motility.
Additionally, our analysis showed that BZYQD impacted inflammatory pathways by reducing the production of pro-inflammatory mediators and down-regulating markers like cyclooxygenase-2. These effects suggest a comprehensive approach to managing constipation might involve multiple metabolic pathways, with inositol being a notable component. Overall, our study suggests that BZYQD can protect against constipation, with inositol contributing to this beneficial effect, though further studies are needed to isolate its specific impact.
Our findings also revealed that BZYQD helped to reduce pathological damage in the colon. Interestingly, one of the key factors we looked at was inositol, a metabolite whose levels were significantly affected by the treatment. We discovered that BZYQD not only increased serum levels of inositol but also enhanced the levels of motilin and gastrin, hormones that play important roles in regulating gastrointestinal motility.
Additionally, our analysis showed that BZYQD impacted inflammatory pathways by reducing the production of pro-inflammatory mediators and down-regulating markers like cyclooxygenase-2. These effects suggest a comprehensive approach to managing constipation might involve multiple metabolic pathways, with inositol being a notable component. Overall, our study suggests that BZYQD can protect against constipation, with inositol contributing to this beneficial effect, though further studies are needed to isolate its specific impact.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Bowels regulated
I tested it on myself and my mother. This is not my first time using it. I noticed that it helps to establish bowel movements and eliminates constipation. However, it's challenging to isolate the rest of the effects since we take various supplements. Gradually, I’ve noticed my weight decreasing.
Read More
8.3
Relieved constipation
I felt quite low and lacked appetite, so I continued taking this supplement. Gradually, I started to feel better and my anxiety diminished. It seems effective for concentration. To my surprise, the constipation vanished. However, those with a tendency to have loose bowels should be cautious.
Read More
9.5
Stimulates intestines
I take it with oecetine and I’m delighted. It's a good supplement that stimulates the intestines, particularly beneficial for those experiencing constipation.
2.5
Became constipated
I felt positive effects initially, but I stopped taking it as I became constipated.
8
Improves constipation
This supplement, ranked No. 1 among similar products, has 100 vegetarian capsules. I found that choline and inositol improve fatty liver, protect nervous system health, assist nerve transmission, and aid fat metabolism. Inositol can also address constipation and other disorders. I take one capsule daily with food without any unpleasant odour.
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