Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 20 Researches
8.3
USERS' SCORE
Moderately Good
Based on 11 Reviews
7.8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Beta-1,3/1,6-D-Glucan Powder (from Saccharomyces cerevisiae)
100 mg
*
Maitake Mushroom Powder (Grifola frondosa)
160 mg
*
Top Medical Research Studies
8
Hydrothermal yeast impacts breast cancer
We investigated the ability of a hydrothermally treated yeast cell wall to fight against MCF-7 breast cancer cells. This innovative method improved solubility and produced a potent anti-proliferative agent.
The treatment significantly reduced cancer cell growth by nearly 59%, even when separated by a plastic barrier.
This suggests that a diffusible factor in the treated yeast contributes to this anti-cancer effect, likely linked to reactive carbon species generated during treatment.
Overall, our findings hint at a promising potential for this approach in cancer therapy development.
The treatment significantly reduced cancer cell growth by nearly 59%, even when separated by a plastic barrier.
This suggests that a diffusible factor in the treated yeast contributes to this anti-cancer effect, likely linked to reactive carbon species generated during treatment.
Overall, our findings hint at a promising potential for this approach in cancer therapy development.
Read More
9
We explored the potential of the maitake mushroom (Grifola frondosa) to fight cancer by examining polysaccharides cultivated in industrial wastewater from Agaricus bisporus. Our research involved optimizing various culture conditions like temperature, shaking speed, and the solubility of the wastewater to maximize fungal growth.
Through our studies, we isolated and analyzed several polysaccharides, discovering that one in particular, NIPGF01, showed promising anticancer properties. We observed that NIPGF01 could significantly inhibit the growth of human gastric and liver cancer cells. The apoptosis rates we measured indicated that as we increased concentrations of NIPGF01, more cancer cells underwent programmed cell death—a positive sign in cancer treatment.
Notably, the study also included methods like UV and molecular weight analysis to ensure the purity and composition of the polysaccharides. These investigations confirmed that NIPGF01 contained pure glucose while showcasing structural features important for its activity. Overall, our findings point towards the maitake mushroom as a promising candidate for cancer research, particularly with the polysaccharides demonstrating strong biological effects.
Through our studies, we isolated and analyzed several polysaccharides, discovering that one in particular, NIPGF01, showed promising anticancer properties. We observed that NIPGF01 could significantly inhibit the growth of human gastric and liver cancer cells. The apoptosis rates we measured indicated that as we increased concentrations of NIPGF01, more cancer cells underwent programmed cell death—a positive sign in cancer treatment.
Notably, the study also included methods like UV and molecular weight analysis to ensure the purity and composition of the polysaccharides. These investigations confirmed that NIPGF01 contained pure glucose while showcasing structural features important for its activity. Overall, our findings point towards the maitake mushroom as a promising candidate for cancer research, particularly with the polysaccharides demonstrating strong biological effects.
Read More
9
We investigated the potential of a polysaccharide extracted from maitake mushrooms in combatting breast cancer. Our research focused on how this natural compound can alter the immune landscape in tumor-bearing mice, particularly by targeting myeloid-derived suppressor cells (MDSCs), which are notorious for promoting cancer growth.
The treatment with maitake mushroom polysaccharide, referred to as GFI, led to a dramatic reduction of MDSCs in the bloodstream and tumor tissues. Importantly, we observed that GFI specifically decreased the levels of PMN-MDSCs in the spleen, while leaving another type, M-MDSCs, mostly unaffected. This selective action indicates a promising therapeutic strategy for enhancing the immune response.
Moreover, GFI treatment not only reduced the presence of these suppressor cells but also helped restore and activate CD8T cells, key players in fighting tumors. This was evidenced by a remarkable increase in Granzyme B levels coupled with a decrease in TIGIT expression. Ultimately, we demonstrated that the polysaccharide treatment significantly inhibited tumor growth in our models. This study reveals the multifaceted role of maitake mushroom polysaccharides in boosting anti-cancer immune activity, making it a noteworthy candidate for further research in breast cancer therapy.
The treatment with maitake mushroom polysaccharide, referred to as GFI, led to a dramatic reduction of MDSCs in the bloodstream and tumor tissues. Importantly, we observed that GFI specifically decreased the levels of PMN-MDSCs in the spleen, while leaving another type, M-MDSCs, mostly unaffected. This selective action indicates a promising therapeutic strategy for enhancing the immune response.
Moreover, GFI treatment not only reduced the presence of these suppressor cells but also helped restore and activate CD8T cells, key players in fighting tumors. This was evidenced by a remarkable increase in Granzyme B levels coupled with a decrease in TIGIT expression. Ultimately, we demonstrated that the polysaccharide treatment significantly inhibited tumor growth in our models. This study reveals the multifaceted role of maitake mushroom polysaccharides in boosting anti-cancer immune activity, making it a noteworthy candidate for further research in breast cancer therapy.
Read More
Most Useful Reviews
9
Major recovery aid
39 people found this helpful
I highly recommend this! As a cancer survivor, I found that chemotherapy weakens the immune system. I am currently very healthy, and I believe that beta glucan has significantly contributed to my recovery and well-being.
Read More
9
Direct cancer impact
11 people found this helpful
An absolute necessity for my daily supplements. I adore this brand, offering 100 mg and 200 mg options. While battling breast cancer, 200 mg greatly benefited me—helping my body detect and eliminate the cancer more effectively. I have blood work to support my experience.
Read More
9
Cancers fought
5 people found this helpful
Five stars! This product effectively fights cancer.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 20 Researches
8.3
- All Researches
9.5
We examined the potential of a specific β-glucan, GFPBW1, derived from maitake mushrooms to enhance the effectiveness of cancer vaccines. The study involved the use of OVA-antigen and a B16-OVA tumor model to see how GFPBW1 might improve immune responses.
Our findings indicated that different doses of GFPBW1 significantly boosted the activation and maturation of immune cells known as antigen presenting cells (APCs). By increasing important markers, we observed greater immune responses, which included higher levels of OVA-specific antibody subtypes like IgG1 and IgG3. This suggests that GFPBW1 could effectively work as an adjuvant, facilitating both Th1 (cell-mediated) and Th2 (humoral) immune responses, which are crucial in fighting cancer.
Additionally, we noted that when GFPBW1 was combined with aluminum, commonly used in vaccines, it led to even higher levels of specific antibodies, creating a balanced immune response. Importantly, the mice that received GFPBW1 with the vaccine did not show any harmful side effects.
In tumor models, GFPBW1 demonstrated remarkable potential in suppressing tumors when used in preventive settings and also enhanced the effects of therapeutic vaccines. The research highlighted a significant increase in targeting immune cells directly to the tumor environment, which illustrates the beneficial role GFPBW1 could play in both vaccine development and cancer therapy.
Our findings indicated that different doses of GFPBW1 significantly boosted the activation and maturation of immune cells known as antigen presenting cells (APCs). By increasing important markers, we observed greater immune responses, which included higher levels of OVA-specific antibody subtypes like IgG1 and IgG3. This suggests that GFPBW1 could effectively work as an adjuvant, facilitating both Th1 (cell-mediated) and Th2 (humoral) immune responses, which are crucial in fighting cancer.
Additionally, we noted that when GFPBW1 was combined with aluminum, commonly used in vaccines, it led to even higher levels of specific antibodies, creating a balanced immune response. Importantly, the mice that received GFPBW1 with the vaccine did not show any harmful side effects.
In tumor models, GFPBW1 demonstrated remarkable potential in suppressing tumors when used in preventive settings and also enhanced the effects of therapeutic vaccines. The research highlighted a significant increase in targeting immune cells directly to the tumor environment, which illustrates the beneficial role GFPBW1 could play in both vaccine development and cancer therapy.
Read More
9
We explored the potential of the maitake mushroom (Grifola frondosa) to fight cancer by examining polysaccharides cultivated in industrial wastewater from Agaricus bisporus. Our research involved optimizing various culture conditions like temperature, shaking speed, and the solubility of the wastewater to maximize fungal growth.
Through our studies, we isolated and analyzed several polysaccharides, discovering that one in particular, NIPGF01, showed promising anticancer properties. We observed that NIPGF01 could significantly inhibit the growth of human gastric and liver cancer cells. The apoptosis rates we measured indicated that as we increased concentrations of NIPGF01, more cancer cells underwent programmed cell death—a positive sign in cancer treatment.
Notably, the study also included methods like UV and molecular weight analysis to ensure the purity and composition of the polysaccharides. These investigations confirmed that NIPGF01 contained pure glucose while showcasing structural features important for its activity. Overall, our findings point towards the maitake mushroom as a promising candidate for cancer research, particularly with the polysaccharides demonstrating strong biological effects.
Through our studies, we isolated and analyzed several polysaccharides, discovering that one in particular, NIPGF01, showed promising anticancer properties. We observed that NIPGF01 could significantly inhibit the growth of human gastric and liver cancer cells. The apoptosis rates we measured indicated that as we increased concentrations of NIPGF01, more cancer cells underwent programmed cell death—a positive sign in cancer treatment.
Notably, the study also included methods like UV and molecular weight analysis to ensure the purity and composition of the polysaccharides. These investigations confirmed that NIPGF01 contained pure glucose while showcasing structural features important for its activity. Overall, our findings point towards the maitake mushroom as a promising candidate for cancer research, particularly with the polysaccharides demonstrating strong biological effects.
Read More
9
Maitake mushroom boosts cancer therapy
We examined how Maitake β-glucan, specifically the MD-Fraction isolated from the maitake mushroom, could improve treatments for HER2-positive breast cancer when combined with trastuzumab, a common anti-HER2 antibody. Our investigation showed that MD-Fraction does not directly kill HER2-positive cancer cells on its own or even alongside trastuzumab in laboratory settings. However, when we looked at mouse models with HER2-positive tumors, the combination of MD-Fraction and trastuzumab proved to be more effective than trastuzumab alone.
We found that immune cells, like natural killer cells and macrophages from mice treated with MD-Fraction, exhibited enhanced capabilities for attacking cancer cells with trastuzumab. Notably, these immune cells showed increased antibody-dependent cellular cytotoxicity (ADCC), which is one way the immune system can help fight cancer. Additionally, when these cells were present in the body’s natural serum, they were able to enhance complement-dependent cytotoxicity (CDCC), another mechanism of tumor cell destruction.
Overall, our findings illustrate that combining MD-Fraction with trastuzumab enhances the effectiveness of the treatment by bolstering these immune responses. This research highlights an exciting avenue for improving therapies for patients with HER2-positive breast cancer, potentially increasing their chances of successful treatment.
We found that immune cells, like natural killer cells and macrophages from mice treated with MD-Fraction, exhibited enhanced capabilities for attacking cancer cells with trastuzumab. Notably, these immune cells showed increased antibody-dependent cellular cytotoxicity (ADCC), which is one way the immune system can help fight cancer. Additionally, when these cells were present in the body’s natural serum, they were able to enhance complement-dependent cytotoxicity (CDCC), another mechanism of tumor cell destruction.
Overall, our findings illustrate that combining MD-Fraction with trastuzumab enhances the effectiveness of the treatment by bolstering these immune responses. This research highlights an exciting avenue for improving therapies for patients with HER2-positive breast cancer, potentially increasing their chances of successful treatment.
Read More
9
We investigated the potential of a polysaccharide extracted from maitake mushrooms in combatting breast cancer. Our research focused on how this natural compound can alter the immune landscape in tumor-bearing mice, particularly by targeting myeloid-derived suppressor cells (MDSCs), which are notorious for promoting cancer growth.
The treatment with maitake mushroom polysaccharide, referred to as GFI, led to a dramatic reduction of MDSCs in the bloodstream and tumor tissues. Importantly, we observed that GFI specifically decreased the levels of PMN-MDSCs in the spleen, while leaving another type, M-MDSCs, mostly unaffected. This selective action indicates a promising therapeutic strategy for enhancing the immune response.
Moreover, GFI treatment not only reduced the presence of these suppressor cells but also helped restore and activate CD8T cells, key players in fighting tumors. This was evidenced by a remarkable increase in Granzyme B levels coupled with a decrease in TIGIT expression. Ultimately, we demonstrated that the polysaccharide treatment significantly inhibited tumor growth in our models. This study reveals the multifaceted role of maitake mushroom polysaccharides in boosting anti-cancer immune activity, making it a noteworthy candidate for further research in breast cancer therapy.
The treatment with maitake mushroom polysaccharide, referred to as GFI, led to a dramatic reduction of MDSCs in the bloodstream and tumor tissues. Importantly, we observed that GFI specifically decreased the levels of PMN-MDSCs in the spleen, while leaving another type, M-MDSCs, mostly unaffected. This selective action indicates a promising therapeutic strategy for enhancing the immune response.
Moreover, GFI treatment not only reduced the presence of these suppressor cells but also helped restore and activate CD8T cells, key players in fighting tumors. This was evidenced by a remarkable increase in Granzyme B levels coupled with a decrease in TIGIT expression. Ultimately, we demonstrated that the polysaccharide treatment significantly inhibited tumor growth in our models. This study reveals the multifaceted role of maitake mushroom polysaccharides in boosting anti-cancer immune activity, making it a noteworthy candidate for further research in breast cancer therapy.
Read More
9
Maitake mushroom aids cancer treatment
We explored the potential of the Grifola frondosa polysaccharide-protein complex, commonly known as maitake mushroom, to combat cancer, particularly liver cancer.
In an insightful study, we compared two different extraction methods for this complex: one using cold water and another using boiling water. The results unveiled that the cold-extracted version displayed significantly stronger anti-cancer effects. The focus was on how these compounds influence liver cancer cells and gut health in mice with H22 tumors.
Our findings highlighted that the cold-extracted complex not only inhibited tumor growth but also positively impacted gut microbiota. We observed that it activated important signaling pathways related to immune response, which are crucial in the fight against cancer. Moreover, this version boosted the production of beneficial short-chain fatty acids, contributing to better gut health and possibly enhancing overall well-being.
Ultimately, our research indicates that maitake mushroom could serve as a promising natural treatment for liver cancer and supports the idea that diet and gut health may play important roles in cancer therapy.
In an insightful study, we compared two different extraction methods for this complex: one using cold water and another using boiling water. The results unveiled that the cold-extracted version displayed significantly stronger anti-cancer effects. The focus was on how these compounds influence liver cancer cells and gut health in mice with H22 tumors.
Our findings highlighted that the cold-extracted complex not only inhibited tumor growth but also positively impacted gut microbiota. We observed that it activated important signaling pathways related to immune response, which are crucial in the fight against cancer. Moreover, this version boosted the production of beneficial short-chain fatty acids, contributing to better gut health and possibly enhancing overall well-being.
Ultimately, our research indicates that maitake mushroom could serve as a promising natural treatment for liver cancer and supports the idea that diet and gut health may play important roles in cancer therapy.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 11 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Major recovery aid
39 people found this helpful
I highly recommend this! As a cancer survivor, I found that chemotherapy weakens the immune system. I am currently very healthy, and I believe that beta glucan has significantly contributed to my recovery and well-being.
Read More
9
Direct cancer impact
11 people found this helpful
An absolute necessity for my daily supplements. I adore this brand, offering 100 mg and 200 mg options. While battling breast cancer, 200 mg greatly benefited me—helping my body detect and eliminate the cancer more effectively. I have blood work to support my experience.
Read More
9
Cancers fought
5 people found this helpful
Five stars! This product effectively fights cancer.
Read More
6
Unexpected allergy relief
71 people found this helpful
After learning about clinical research on this compound, I began taking these pills as a former cancer patient. The reported anti-tumour and immune-stimulating effects intrigued me. After a month, I noticed my static allergies had disappeared—an unexpected, welcome benefit. I will continue to buy this brand.
Read More
7.5
Restored immunity
33 people found this helpful
Excellent product! It helped me to restore my immune system after cancer.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Kim S, Kang J, An D, Seo J, Oh DB. Lysosome-Targeting Chimera Using Mannose-6-Phosphate Glycans Derived from Glyco-Engineered Yeast. Bioconjug Chem. 2025;36:424. 10.1021/acs.bioconjchem.4c00512
- Kitagawa T. Hydrothermal treatment of yeast cell wall generates potent anti-proliferative agents targeting MCF7 breast cancer cells effectively even under culture conditions separated by a plastic wall. PLoS One. 2025;20:e0313379. 10.1371/journal.pone.0313379
- Wu J, Ji K, Kang G, Zhang M, Wang J, et al. Butyrate-engineered yeast activates Nppa and Sgcg genes and reduces radiation-induced heart damage via the gut-heart axis. Pharmacol Res. 2025;213:107642. 10.1016/j.phrs.2025.107642
- Jia D, Chen S. Yeast paves the way for cancer immunotherapy. Cell Chem Biol. 2025;32:9. 10.1016/j.chembiol.2024.12.011
- Pan T, Huang J. Polysaccharide with anticancer activity from Grifola frondosa cultured in industrial wastewater of Agaricus bisporus. Int J Biol Macromol. 2024;283:137489. 10.1016/j.ijbiomac.2024.137489
- Xu Y, Huang C, Xu T, Xiang X, Amakye WK, et al. A Water Polysaccharide-Protein Complex from Grifola frondosa Inhibit the Growth of Subcutaneous but Not Peritoneal Colon Tumor under Fasting Condition. Mol Nutr Food Res. 2024;68:e2400023. 10.1002/mnfr.202400023
- He X, Lu JL, Liao WF, Long YR, Zhang X, et al. GFPBW1, a β-glucan from Grifola frondosa as vaccine adjuvant: APCs activation and maturation. Acta Pharmacol Sin. 2024;45:2394. 10.1038/s41401-024-01330-8
- Masuda Y, Yamashita S, Nakayama Y, Shimizu R, Konishi M. Maitake Beta-Glucan Enhances the Therapeutic Effect of Trastuzumab via Antibody-Dependent Cellular Cytotoxicity and Complement-Dependent Cytotoxicity. Biol Pharm Bull. 2024;47:840. 10.1248/bpb.b23-00802
- Abosharaf HA, Gebreel DT, Allam S, El-Atrash A, Tousson E. Ehrlich ascites carcinoma provokes renal toxicity and DNA injury in mice: Therapeutic impact of chitosan and maitake nanoparticles. Basic Clin Pharmacol Toxicol. 2024;134:472. 10.1111/bcpt.13988
- Li X, Ruan Q, Yang W, Tian H, Wu N, et al. Polysaccharide isolated from eliminates myeloid-derived suppressor cells and inhibits tumor growth by enhancing T cells responses. Int J Biol Sci. 2024;20:664. 10.7150/ijbs.85276
- Zhao J, He R, Zhong H, Liu S, Liu X, et al. A cold-water extracted polysaccharide-protein complex from Grifola frondosa exhibited anti-tumor activity via TLR4-NF-κB signaling activation and gut microbiota modification in H22 tumor-bearing mice. Int J Biol Macromol. 2023;239:124291. 10.1016/j.ijbiomac.2023.124291
- Abdellaoui M, Kadi A, Abrazi Y, Kadi Y, Gary A, et al. Oral Intake of Combined Natural Immunostimulants Suppresses the 7,12-DMBA/ Croton Oil Induced Two-step Skin Carcinogenesis in Swiss Albino Mice. Gulf J Oncolog. 2023;1:32.
- Masuda Y, Nakayama Y, Shimizu R, Naito K, Miyamoto E, et al. Maitake α-glucan promotes differentiation of monocytic myeloid-derived suppressor cells into M1 macrophages. Life Sci. 2023;317:121453. 10.1016/j.lfs.2023.121453
- Zhang H, Dong X, Ji H, Yu J, Liu A. Preparation and structural characterization of acid-extracted polysaccharide from Grifola frondosa and antitumor activity on S180 tumor-bearing mice. Int J Biol Macromol. 2023;234:123302. 10.1016/j.ijbiomac.2023.123302
- Aguilera-Braico DM, Balogh GA. CD3Ɛ immune restorative ability induced by Maitake Pro4x in immunosupressed BALBc mice. BMC Res Notes. 2022;15:307. 10.1186/s13104-022-06201-1
- Hu Q, Xie B. Effect of Maitake D-fraction in advanced laryngeal and pharyngeal cancers during concurrent chemoradiotherapy: A randomized clinical trial. Acta Biochim Pol. 2022;69:625. 10.18388/abp.2020_5996
- Zhao F, Guo Z, Ma ZR, Ma LL, Zhao J. Antitumor activities of Grifola frondosa (Maitake) polysaccharide: A meta-analysis based on preclinical evidence and quality assessment. J Ethnopharmacol. 2021;280:114395. 10.1016/j.jep.2021.114395
- Liu C, Ji HY, Wu P, Yu J, Liu AJ. The preparation of a cold-water soluble polysaccharide from Grifola frondosa and its inhibitory effects on MKN-45 cells. Glycoconj J. 2020;37:413. 10.1007/s10719-020-09932-0
- Masuda Y, Nakayama Y, Mukae T, Tanaka A, Naito K, et al. Maturation of dendritic cells by maitake α-glucan enhances anti-cancer effect of dendritic cell vaccination. Int Immunopharmacol. 2019;67:408. 10.1016/j.intimp.2018.12.039
- Alonso EN, Ferronato MJ, Fermento ME, Gandini NA, Romero AL, et al. Antitumoral and antimetastatic activity of Maitake D-Fraction in triple-negative breast cancer cells. Oncotarget. 2018;9:23396. 10.18632/oncotarget.25174
