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SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.5
USERS' SCORE
Good
Based on 11 Reviews
8.3
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Saturated Fat
0.5 g
3%**
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
0.5 g
†
Fish Oil Concentrate
2 g (2,000 mg)
†
Eicosapentaenoic Acid (EPA)
360 mg
†
Docosahexaenoic Acid (DHA)
240 mg
†
Top Medical Research Studies
9
DHA's role in osteoporosis treatment
Comparative study of DHA-enriched phosphatidylcholine and EPA-enriched phosphatidylcholine on ameliorating high bone turnover regulation of the osteogenesis-related Wnt/β-catenin pathway in ovariectomized mice.
Highly relevant study findings
We recently looked into how docosahexaenoic acid (DHA), through its enriched phosphatidylcholine form (DHA-PC), affects osteoporosis. Using a model that simulates the condition in women after ovariectomy, we compared the impact of DHA-PC with eicosapentaenoic acid (EPA) enriched phosphatidylcholine (EPA-PC). Our findings revealed that both DHA-PC and EPA-PC significantly improved the structural quality of trabecular bone, boosted the rate of new bone formation, and elevated bone mineral density, which are crucial factors in combating osteoporosis.
We also discovered that both compounds worked to regulate bone formation by down-regulating the overactive Wnt/β-catenin signaling pathway, which is key to osteogenesis. This means that rather than allowing excessive bone growth, DHA-PC and EPA-PC help bring osteogenesis back to normal levels. Thus, our results suggest that incorporating DHA and EPA phosphatidylcholine could potentially serve as a beneficial strategy in osteoporosis management, highlighting their promising role in health and nutrition.
Overall, this study offers valuable insights into the anti-osteoporotic effects of DHA-PC and EPA-PC and supports their further exploration as functional foods in our diets.
We also discovered that both compounds worked to regulate bone formation by down-regulating the overactive Wnt/β-catenin signaling pathway, which is key to osteogenesis. This means that rather than allowing excessive bone growth, DHA-PC and EPA-PC help bring osteogenesis back to normal levels. Thus, our results suggest that incorporating DHA and EPA phosphatidylcholine could potentially serve as a beneficial strategy in osteoporosis management, highlighting their promising role in health and nutrition.
Overall, this study offers valuable insights into the anti-osteoporotic effects of DHA-PC and EPA-PC and supports their further exploration as functional foods in our diets.
Read More
7
DHA linked to osteoporosis risk
Causal link between docosahexaenoic acid and osteoporosis: A 2-sample Mendelian randomization study.
Study directly addresses DHA effects
We examined the relationship between docosahexaenoic acid (DHA) and osteoporosis using a method called 2-sample Mendelian randomization. This approach allowed us to investigate if higher levels of DHA could be a risk factor for osteoporosis.
Our findings revealed a causal tie: increased blood levels of DHA were indeed linked to a higher risk of developing osteoporosis. Specifically, for each standard deviation increase in DHA levels, the risk for osteoporosis rose by nearly 10%. We found this connection to be statistically significant, with a P-value of 0.033.
However, it's important to point out that the genetic correlation between DHA and osteoporosis was weak, suggesting that this relationship might not be heavily influenced by our genes. While these results indicate that DHA levels are a risk factor for osteoporosis, the underlying mechanisms are still unclear, highlighting the need for further research in this area.
Our findings revealed a causal tie: increased blood levels of DHA were indeed linked to a higher risk of developing osteoporosis. Specifically, for each standard deviation increase in DHA levels, the risk for osteoporosis rose by nearly 10%. We found this connection to be statistically significant, with a P-value of 0.033.
However, it's important to point out that the genetic correlation between DHA and osteoporosis was weak, suggesting that this relationship might not be heavily influenced by our genes. While these results indicate that DHA levels are a risk factor for osteoporosis, the underlying mechanisms are still unclear, highlighting the need for further research in this area.
Read More
9
Eicosapentaenoic acid protects bone health
Eicosapentaenoic acid supplementation modulates the osteoblast/osteoclast balance in inflammatory environments and protects against estrogen deficiency-induced bone loss in mice.
Directly addresses osteoporosis treatment
We evaluated the effects of eicosapentaenoic acid (EPA) on osteoporosis, particularly in how it impacts the balance between osteoblasts (the cells that build bone) and osteoclasts (the cells that break down bone). In an experimental setup, we used mouse bone marrow stem cells and macrophages to study how EPA could counteract the negative effects of inflammation, which can lead to osteoporosis.
By simulating an inflammatory environment with TNF-α, we discovered that EPA helped restore the ability of stem cells to differentiate into osteoblasts, which is crucial for bone formation. Furthermore, we explored how EPA influenced the communication between osteoblasts and osteoclasts, finding that it regulated important factors involved in bone resorption.
When we tested the effects of EPA in a mouse model of estrogen deficiency—an established cause of bone loss in postmenopausal women—we observed significant protective effects against osteoporosis. This suggests that EPA could play a valuable role in maintaining bone health and preventing bone loss related to hormonal changes, providing a promising avenue for future osteoporosis treatments.
By simulating an inflammatory environment with TNF-α, we discovered that EPA helped restore the ability of stem cells to differentiate into osteoblasts, which is crucial for bone formation. Furthermore, we explored how EPA influenced the communication between osteoblasts and osteoclasts, finding that it regulated important factors involved in bone resorption.
When we tested the effects of EPA in a mouse model of estrogen deficiency—an established cause of bone loss in postmenopausal women—we observed significant protective effects against osteoporosis. This suggests that EPA could play a valuable role in maintaining bone health and preventing bone loss related to hormonal changes, providing a promising avenue for future osteoporosis treatments.
Read More
Most Useful Reviews
8.8
Supports joint health
Good omega-3s support joint health and help prevent osteoporosis. The fatty acids relieve inflammation and combat bone loss. I recommend this product.
Read More
8.8
Excellent support
Excellent omega-3 supports joint health, prevents osteoporosis, and fatty acids alleviate inflammation and bone loss.
Read More
8.8
Relieves joint pain
Excellent! Omega-3s maintain joint health, prevent osteoporosis, relieve inflammation, and combat bone loss. They also help reduce joint pain and ease rheumatoid arthritis symptoms.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.5
9
Eicosapentaenoic acid protects bone health
Eicosapentaenoic acid supplementation modulates the osteoblast/osteoclast balance in inflammatory environments and protects against estrogen deficiency-induced bone loss in mice.
Directly addresses osteoporosis treatment
We evaluated the effects of eicosapentaenoic acid (EPA) on osteoporosis, particularly in how it impacts the balance between osteoblasts (the cells that build bone) and osteoclasts (the cells that break down bone). In an experimental setup, we used mouse bone marrow stem cells and macrophages to study how EPA could counteract the negative effects of inflammation, which can lead to osteoporosis.
By simulating an inflammatory environment with TNF-α, we discovered that EPA helped restore the ability of stem cells to differentiate into osteoblasts, which is crucial for bone formation. Furthermore, we explored how EPA influenced the communication between osteoblasts and osteoclasts, finding that it regulated important factors involved in bone resorption.
When we tested the effects of EPA in a mouse model of estrogen deficiency—an established cause of bone loss in postmenopausal women—we observed significant protective effects against osteoporosis. This suggests that EPA could play a valuable role in maintaining bone health and preventing bone loss related to hormonal changes, providing a promising avenue for future osteoporosis treatments.
By simulating an inflammatory environment with TNF-α, we discovered that EPA helped restore the ability of stem cells to differentiate into osteoblasts, which is crucial for bone formation. Furthermore, we explored how EPA influenced the communication between osteoblasts and osteoclasts, finding that it regulated important factors involved in bone resorption.
When we tested the effects of EPA in a mouse model of estrogen deficiency—an established cause of bone loss in postmenopausal women—we observed significant protective effects against osteoporosis. This suggests that EPA could play a valuable role in maintaining bone health and preventing bone loss related to hormonal changes, providing a promising avenue for future osteoporosis treatments.
Read More
9
CFO improves bone density
Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content.
Focus on EPA and DHA
We investigated how concentrated fish oil (CFO), which is rich in eicosapentaenoic acid (EPA) and DHA, impacts bone health, particularly in relation to osteoporosis. In our study, we utilized a group of twelve-month-old female mice and provided them with different dietary options including 1% and 4% CFO, a 4% safflower oil (SFO) diet, and a regular fish oil diet over a span of twelve months.
At the conclusion of the dietary intervention, we measured bone mineral density (BMD) to assess bone health. Our findings indicated that the group consuming the 4% CFO had significantly improved BMD compared to the SFO group, while those on the 1% CFO showed only a mild positive effect. Intriguingly, the 1% CFO group even outperformed the regular fish oil group in terms of BMD.
Additionally, we observed that CFO supplementation led to decreased levels of some markers related to bone loss and inflammation. It encouraged the production of beneficial substances like IL-10 and reduced harmful levels of TNF-α and IL-6. These results suggest that higher concentrations of CFO, especially starting from middle age, could enhance bone health during aging.
At the conclusion of the dietary intervention, we measured bone mineral density (BMD) to assess bone health. Our findings indicated that the group consuming the 4% CFO had significantly improved BMD compared to the SFO group, while those on the 1% CFO showed only a mild positive effect. Intriguingly, the 1% CFO group even outperformed the regular fish oil group in terms of BMD.
Additionally, we observed that CFO supplementation led to decreased levels of some markers related to bone loss and inflammation. It encouraged the production of beneficial substances like IL-10 and reduced harmful levels of TNF-α and IL-6. These results suggest that higher concentrations of CFO, especially starting from middle age, could enhance bone health during aging.
Read More
9
Eicosapentaenoic Acid Benefits Bone Health
Positive correlation between erythrocyte levels of n-3 polyunsaturated fatty acids and bone mass in postmenopausal Korean women with osteoporosis.
Significant correlation found
We explored the relationship between eicosapentaenoic acid (EPA), a type of n-3 polyunsaturated fatty acid, and osteoporosis risk in postmenopausal Korean women. Our study involved fifty women diagnosed with osteoporosis and a control group of one hundred women without the condition. By measuring erythrocyte levels of EPA and examining fish intake, we aimed to see how they correlate with bone mass and the risk of osteoporosis.
The results were promising. We found that higher levels of EPA, as well as other n-3 fatty acids, were positively associated with better bone density, particularly in the femoral neck region. This suggests that incorporating more fish and EPA into the diet may help improve bone health, particularly for women who are postmenopausal and at risk for osteoporosis.
Notably, the findings revealed that while saturated fatty acids negatively impacted bone health, EPA and its companion docosahexaenoic acid (DHA) appeared to protect against osteoporosis. This gives us encouraging insights into how dietary choices can play a significant role in managing bone health.
Overall, our findings highlight the potential benefits of increasing n-3 fatty acid intake, especially EPA, to help reduce osteoporosis risk among postmenopausal women. The connection suggests that a simple dietary change could positively influence bone mass and health.
The results were promising. We found that higher levels of EPA, as well as other n-3 fatty acids, were positively associated with better bone density, particularly in the femoral neck region. This suggests that incorporating more fish and EPA into the diet may help improve bone health, particularly for women who are postmenopausal and at risk for osteoporosis.
Notably, the findings revealed that while saturated fatty acids negatively impacted bone health, EPA and its companion docosahexaenoic acid (DHA) appeared to protect against osteoporosis. This gives us encouraging insights into how dietary choices can play a significant role in managing bone health.
Overall, our findings highlight the potential benefits of increasing n-3 fatty acid intake, especially EPA, to help reduce osteoporosis risk among postmenopausal women. The connection suggests that a simple dietary change could positively influence bone mass and health.
Read More
9
Fish oils may combat osteoporosis
Inhibition of osteoporosis due to restricted food intake by the fish oils DHA and EPA and perilla oil in the rat.
Highlights multiple oil effects
We explored the impact of eicosapentaenoic acid (EPA) and other fish oils on osteoporosis in a study involving female rats. The rats consumed a restricted diet that included triglycerides such as docosahexaenoic acid (DHA), EPA, and perilla oil. This was an interesting approach, particularly because their food intake was cut by half.
The results were encouraging; we observed that the rats receiving EPA and the other oils experienced significant increases in bone mineral density and fracture strength. Additionally, there was a notable decline in urinary calcium and a marker associated with bone breakdown, indicating improved bone health.
While these findings suggest a potential protective effect of fish oils and perilla oil against osteoporosis resulting from restricted diets, it is important to note that the study included multiple oils. This makes it challenging to pinpoint the isolated effect of EPA. However, the depressed excretion of urinary calcium points to a possible mechanism for how these oils could be beneficial in managing osteoporosis.
The results were encouraging; we observed that the rats receiving EPA and the other oils experienced significant increases in bone mineral density and fracture strength. Additionally, there was a notable decline in urinary calcium and a marker associated with bone breakdown, indicating improved bone health.
While these findings suggest a potential protective effect of fish oils and perilla oil against osteoporosis resulting from restricted diets, it is important to note that the study included multiple oils. This makes it challenging to pinpoint the isolated effect of EPA. However, the depressed excretion of urinary calcium points to a possible mechanism for how these oils could be beneficial in managing osteoporosis.
Read More
9
DHA-PC benefits osteoporosis treatment
Docosahexaenoic Acid-Enriched Phosphatidylcholine Exerted Superior Effects to Triglyceride in Ameliorating Obesity-Induced Osteoporosis through Up-Regulating the Wnt/β-Catenin Pathway.
Strong relevance to osteoporosis research
We explored how different forms of docosahexaenoic acid (DHA), particularly DHA-enriched phosphatidylcholine (DHA-PC) and traditional DHA in triglyceride form (DHA-TG), affect obesity-induced osteoporosis. In an experiment with mice that had been induced with osteoporosis, we provided them with DHA-TG and DHA-PC supplements over a 120-day period.
Our findings revealed that DHA-PC significantly improved bone mineral density and biomechanical properties. It also enhanced new bone formation by 55.2% and reduced marrow fat better than DHA-TG. We observed that DHA-PC promoted the differentiation of bone-forming cells while inhibiting fat cell formation, which are both crucial for bone health.
Mechanically, this beneficial effect is linked to the up-regulation of the Wnt/β-catenin signaling pathway in bone marrow stem cells. This pathway plays a vital role in ensuring that these cells become bone-forming cells rather than fat cells. Overall, we see compelling evidence that DHA-PC offers superior effects in combating obesity-related osteoporosis compared to its triglyceride counterpart.
Our findings revealed that DHA-PC significantly improved bone mineral density and biomechanical properties. It also enhanced new bone formation by 55.2% and reduced marrow fat better than DHA-TG. We observed that DHA-PC promoted the differentiation of bone-forming cells while inhibiting fat cell formation, which are both crucial for bone health.
Mechanically, this beneficial effect is linked to the up-regulation of the Wnt/β-catenin signaling pathway in bone marrow stem cells. This pathway plays a vital role in ensuring that these cells become bone-forming cells rather than fat cells. Overall, we see compelling evidence that DHA-PC offers superior effects in combating obesity-related osteoporosis compared to its triglyceride counterpart.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.3
8.8
Supports joint health
Good omega-3s support joint health and help prevent osteoporosis. The fatty acids relieve inflammation and combat bone loss. I recommend this product.
8.8
Excellent support
Excellent omega-3 supports joint health, prevents osteoporosis, and fatty acids alleviate inflammation and bone loss.
8.8
Relieves joint pain
Excellent! Omega-3s maintain joint health, prevent osteoporosis, relieve inflammation, and combat bone loss. They also help reduce joint pain and ease rheumatoid arthritis symptoms.
8.8
Blocks bone loss
EPA and DHA in fish oil help block processes that lead to bone loss and reduce inflammation, relieving joint pain. Daily omega-3 intake is vital for treating osteoporosis.
8.8
Fights inflammation
Super quality. The package was intact. These 200 capsules will last a long time. Omega-3 fatty acids help prevent osteoporosis, maintain joint health, and reduce pain during flare-ups.
