' 
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 18 Reviews
8.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
250 mg
278%
Vitamin E (as d-alpha Tocopheryl Succinate)
20 mg
133%
Alpha Lipoic Acid
100 mg
†
Top Medical Research Studies
8
Alpha-lipoic acid reduces AGEs
Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy.
Direct effect on T2DM neuropathy
We investigated the potential benefits of alpha-lipoic acid (ALA) for patients with type 2 diabetes mellitus (T2DM) suffering from neuropathy. Over six months, we treated 54 patients with a daily dose of 600 mg of ALA while keeping their current oral medications unchanged. We also included a control group of 24 matched individuals who did not experience neuropathy.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Read More
7
Alpha-lipoic acid shows promise
Alpha-Lipoic Acid for Diabetic Peripheral Neuropathy.
Highly relevant to neuropathy treatment
The study focused on examining the effects of alpha-lipoic acid specifically on diabetic peripheral neuropathy, an often painful condition affecting many people with diabetes. We explored how this supplement could potentially ease symptoms and improve overall nerve health.
The research was designed meticulously to isolate the impacts of alpha-lipoic acid, with proper control measures in place. As we delved into the results, we found promising signs that this antioxidant might provide relief from neuropathy symptoms.
Participants in the study reported improvements in pain levels and other sensations associated with nerve damage, suggesting that alpha-lipoic acid has beneficial effects. However, while the benefits were noted, more extensive studies are needed to fully understand the long-term impact and effectiveness of this treatment.
Overall, adding alpha-lipoic acid to treatment routines for diabetic neuropathy could be a worthwhile consideration. It presents a potential opportunity for those seeking relief from this challenging condition.
The research was designed meticulously to isolate the impacts of alpha-lipoic acid, with proper control measures in place. As we delved into the results, we found promising signs that this antioxidant might provide relief from neuropathy symptoms.
Participants in the study reported improvements in pain levels and other sensations associated with nerve damage, suggesting that alpha-lipoic acid has beneficial effects. However, while the benefits were noted, more extensive studies are needed to fully understand the long-term impact and effectiveness of this treatment.
Overall, adding alpha-lipoic acid to treatment routines for diabetic neuropathy could be a worthwhile consideration. It presents a potential opportunity for those seeking relief from this challenging condition.
Read More
8
Alpha-lipoic acid and neuropathy insights
Expanded Clinical Phenotype and the Role of Untargeted Metabolomics Analysis in Confirming the Diagnosis of Sodium-Dependent Multivitamin Transporter Deficiency.
Moderate relevance to neuropathy treatment
We explored the effects of alpha-lipoic acid in the context of sodium-dependent multivitamin transporter deficiency (SMVTD), a rare condition resulting from loss-of-function variants in the SLC5A6 gene. In a detailed case of a 25-year-old woman, whose symptoms included developmental delays, epilepsy, and neurocognitive challenges, we observed an intriguing combination of treatments.
Alongside alpha-lipoic acid, her therapy incorporated biotin and pantothenic acid, which collectively enhanced her overall metabolic control and neurocognitive function. While our findings do highlight the improvement in her condition, they make it difficult to draw strong conclusions about the isolated effect of alpha-lipoic acid on neuropathy alone.
Ultimately, this case points towards a promising domain for further research. It emphasizes the importance of considering how combined vitamin treatments may yield benefits for individuals affected by neuropathies associated with unique metabolic disorders.
Alongside alpha-lipoic acid, her therapy incorporated biotin and pantothenic acid, which collectively enhanced her overall metabolic control and neurocognitive function. While our findings do highlight the improvement in her condition, they make it difficult to draw strong conclusions about the isolated effect of alpha-lipoic acid on neuropathy alone.
Ultimately, this case points towards a promising domain for further research. It emphasizes the importance of considering how combined vitamin treatments may yield benefits for individuals affected by neuropathies associated with unique metabolic disorders.
Read More
Most Useful Reviews
8.8
Effective treatment
I love this product! I deal with very painful nerve pain and cramps that travel through my hips, thighs, and legs. This supplement, recommended by my husband, performed excellently compared to a medication I was prescribed, which left me feeling drugged. I've had a remarkable reduction in painful night cramps, and overall peripheral pain has lessened—a true improvement in my quality of life.
Read More
9.5
Diabetic neuropathy aid
I've been using Alpha Lipoic Acid for several years as advised by my diabetic specialist to help manage diabetic neuropathy. The tingling and numbness in my big toes have disappeared, and I can feel things normally. If you have neuropathy and haven't tried this, I recommend it—though it can take 2-3 months to see significant effects, so patience is key.
Read More
9.5
Symptoms reduced 90%
ALA has significantly improved my peripheral neuropathy. After a series of tests returned negative results, I decided to try ALA, which has been prescribed in Germany for years. Within two weeks, my symptoms were reduced by about 90%. Now, after several months, I have completely regained feeling in my arms and legs. Whether I would have recovered on my own is unclear, but I've had no adverse effects and find the cost reasonable. I'm taking two tablets a day.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
- All Researches
8
Alpha-lipoic acid reduces AGEs
Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy.
Direct effect on T2DM neuropathy
We investigated the potential benefits of alpha-lipoic acid (ALA) for patients with type 2 diabetes mellitus (T2DM) suffering from neuropathy. Over six months, we treated 54 patients with a daily dose of 600 mg of ALA while keeping their current oral medications unchanged. We also included a control group of 24 matched individuals who did not experience neuropathy.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Read More
8
Alpha-lipoic acid and neuropathy insights
Expanded Clinical Phenotype and the Role of Untargeted Metabolomics Analysis in Confirming the Diagnosis of Sodium-Dependent Multivitamin Transporter Deficiency.
Moderate relevance to neuropathy treatment
We explored the effects of alpha-lipoic acid in the context of sodium-dependent multivitamin transporter deficiency (SMVTD), a rare condition resulting from loss-of-function variants in the SLC5A6 gene. In a detailed case of a 25-year-old woman, whose symptoms included developmental delays, epilepsy, and neurocognitive challenges, we observed an intriguing combination of treatments.
Alongside alpha-lipoic acid, her therapy incorporated biotin and pantothenic acid, which collectively enhanced her overall metabolic control and neurocognitive function. While our findings do highlight the improvement in her condition, they make it difficult to draw strong conclusions about the isolated effect of alpha-lipoic acid on neuropathy alone.
Ultimately, this case points towards a promising domain for further research. It emphasizes the importance of considering how combined vitamin treatments may yield benefits for individuals affected by neuropathies associated with unique metabolic disorders.
Alongside alpha-lipoic acid, her therapy incorporated biotin and pantothenic acid, which collectively enhanced her overall metabolic control and neurocognitive function. While our findings do highlight the improvement in her condition, they make it difficult to draw strong conclusions about the isolated effect of alpha-lipoic acid on neuropathy alone.
Ultimately, this case points towards a promising domain for further research. It emphasizes the importance of considering how combined vitamin treatments may yield benefits for individuals affected by neuropathies associated with unique metabolic disorders.
Read More
7
Alpha-lipoic acid shows promise
Alpha-Lipoic Acid for Diabetic Peripheral Neuropathy.
Highly relevant to neuropathy treatment
The study focused on examining the effects of alpha-lipoic acid specifically on diabetic peripheral neuropathy, an often painful condition affecting many people with diabetes. We explored how this supplement could potentially ease symptoms and improve overall nerve health.
The research was designed meticulously to isolate the impacts of alpha-lipoic acid, with proper control measures in place. As we delved into the results, we found promising signs that this antioxidant might provide relief from neuropathy symptoms.
Participants in the study reported improvements in pain levels and other sensations associated with nerve damage, suggesting that alpha-lipoic acid has beneficial effects. However, while the benefits were noted, more extensive studies are needed to fully understand the long-term impact and effectiveness of this treatment.
Overall, adding alpha-lipoic acid to treatment routines for diabetic neuropathy could be a worthwhile consideration. It presents a potential opportunity for those seeking relief from this challenging condition.
The research was designed meticulously to isolate the impacts of alpha-lipoic acid, with proper control measures in place. As we delved into the results, we found promising signs that this antioxidant might provide relief from neuropathy symptoms.
Participants in the study reported improvements in pain levels and other sensations associated with nerve damage, suggesting that alpha-lipoic acid has beneficial effects. However, while the benefits were noted, more extensive studies are needed to fully understand the long-term impact and effectiveness of this treatment.
Overall, adding alpha-lipoic acid to treatment routines for diabetic neuropathy could be a worthwhile consideration. It presents a potential opportunity for those seeking relief from this challenging condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Effective treatment
I love this product! I deal with very painful nerve pain and cramps that travel through my hips, thighs, and legs. This supplement, recommended by my husband, performed excellently compared to a medication I was prescribed, which left me feeling drugged. I've had a remarkable reduction in painful night cramps, and overall peripheral pain has lessened—a true improvement in my quality of life.
Read More
9.5
Diabetic neuropathy aid
I've been using Alpha Lipoic Acid for several years as advised by my diabetic specialist to help manage diabetic neuropathy. The tingling and numbness in my big toes have disappeared, and I can feel things normally. If you have neuropathy and haven't tried this, I recommend it—though it can take 2-3 months to see significant effects, so patience is key.
Read More
9.5
Symptoms reduced 90%
ALA has significantly improved my peripheral neuropathy. After a series of tests returned negative results, I decided to try ALA, which has been prescribed in Germany for years. Within two weeks, my symptoms were reduced by about 90%. Now, after several months, I have completely regained feeling in my arms and legs. Whether I would have recovered on my own is unclear, but I've had no adverse effects and find the cost reasonable. I'm taking two tablets a day.
Read More
10
Neuropathy is gone
It must be magic. After reading the customer feedback, I had to try this supplement. I was amazed to see strong, perfect fingernails shortly after starting the one capsule daily. My fingernails were previously weak and peeling! Moreover, my neuropathy, foot pain, and nighttime leg cramps have vanished.
Read More
9.5
Alleviates pain
Alpha Lipoic Acid helps with my neuropathy in my feet. I take it daily, and it genuinely alleviates some of the pain associated with this condition! My doctor actually encouraged me to start taking it.
