Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Good
Based on 18 Reviews
8.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
250 mg
278%
Vitamin E (as d-alpha Tocopheryl Succinate)
20 mg
133%
Alpha Lipoic Acid
100 mg
†
Top Medical Research Studies
9
We conducted a double-blind, placebo-controlled study involving 52 patients with diabetic neuropathy on gabapentin or pregabalin to explore the effects of alpha-lipoic acid (ALA). Over 12 weeks, we found that ALA significantly improved vibration perception threshold and secondary symptoms like overall quality of life, oxidative, and inflammatory markers.
Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.
Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.
Read More
9
We reviewed the impact of alpha-lipoic acid (ALA) and acetyl-L-carnitine (ALC) on neuropathic pain, which often affects quality of life. Our findings from various literature indicate that ALA may improve neuropathic pain and nerve function like traditional medications.
Tolerability was high for both supplements, with few side effects reported. Financially, ALA is relatively affordable at $14.40 per month compared to ALC's $27.60. Given the comparable efficacy and lower costs, we suggest considering these supplements as viable options in pain management.
Tolerability was high for both supplements, with few side effects reported. Financially, ALA is relatively affordable at $14.40 per month compared to ALC's $27.60. Given the comparable efficacy and lower costs, we suggest considering these supplements as viable options in pain management.
Read More
3
We investigated whether alpha-lipoic acid (ALA) could improve symptoms of diabetic peripheral neuropathy (DPN). Our review included three randomized trials with over 800 participants, with treatment durations ranging from six to 48 months.
Unfortunately, results suggest that ALA likely provides little or no benefit for neuropathy symptoms or impairment after six months. While the risk of side effects appears similar to a placebo, the evidence comes from studies with high attrition rates, calling for further research to ensure thorough participant tracking.
Unfortunately, results suggest that ALA likely provides little or no benefit for neuropathy symptoms or impairment after six months. While the risk of side effects appears similar to a placebo, the evidence comes from studies with high attrition rates, calling for further research to ensure thorough participant tracking.
Read More
Most Useful Reviews
7.5
Effective treatment
120 people found this helpful
I love this product! I deal with very painful nerve pain and cramps that travel through my hips, thighs, and legs. This supplement, recommended by my husband, performed excellently compared to a medication I was prescribed, which left me feeling drugged. I've had a remarkable reduction in painful night cramps, and overall peripheral pain has lessened—a true improvement in my quality of life.
Read More
9
Diabetic neuropathy aid
36 people found this helpful
I've been using Alpha Lipoic Acid for several years as advised by my diabetic specialist to help manage diabetic neuropathy. The tingling and numbness in my big toes have disappeared, and I can feel things normally. If you have neuropathy and haven't tried this, I recommend it—though it can take 2-3 months to see significant effects, so patience is key.
Read More
9
Symptoms reduced 90%
23 people found this helpful
ALA has significantly improved my peripheral neuropathy. After a series of tests returned negative results, I decided to try ALA, which has been prescribed in Germany for years. Within two weeks, my symptoms were reduced by about 90%. Now, after several months, I have completely regained feeling in my arms and legs. Whether I would have recovered on my own is unclear, but I've had no adverse effects and find the cost reasonable. I'm taking two tablets a day.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
- All Researches
9
We conducted a double-blind, placebo-controlled study involving 52 patients with diabetic neuropathy on gabapentin or pregabalin to explore the effects of alpha-lipoic acid (ALA). Over 12 weeks, we found that ALA significantly improved vibration perception threshold and secondary symptoms like overall quality of life, oxidative, and inflammatory markers.
Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.
Importantly, participants reported no serious side effects, highlighting ALA’s potential as a safe option for managing diabetic neuropathy. These findings suggest ALA can effectively mitigate symptoms associated with chronic hyperglycemia.
Read More
9
We reviewed the impact of alpha-lipoic acid (ALA) and acetyl-L-carnitine (ALC) on neuropathic pain, which often affects quality of life. Our findings from various literature indicate that ALA may improve neuropathic pain and nerve function like traditional medications.
Tolerability was high for both supplements, with few side effects reported. Financially, ALA is relatively affordable at $14.40 per month compared to ALC's $27.60. Given the comparable efficacy and lower costs, we suggest considering these supplements as viable options in pain management.
Tolerability was high for both supplements, with few side effects reported. Financially, ALA is relatively affordable at $14.40 per month compared to ALC's $27.60. Given the comparable efficacy and lower costs, we suggest considering these supplements as viable options in pain management.
Read More
8
We investigated the potential benefits of alpha-lipoic acid (ALA) for patients with type 2 diabetes mellitus (T2DM) suffering from neuropathy. Over six months, we treated 54 patients with a daily dose of 600 mg of ALA while keeping their current oral medications unchanged. We also included a control group of 24 matched individuals who did not experience neuropathy.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Read More
8
Alpha-lipoic acid and neuropathy insights
We explored the effects of alpha-lipoic acid in the context of sodium-dependent multivitamin transporter deficiency (SMVTD), a rare condition resulting from loss-of-function variants in the SLC5A6 gene. In a detailed case of a 25-year-old woman, whose symptoms included developmental delays, epilepsy, and neurocognitive challenges, we observed an intriguing combination of treatments.
Alongside alpha-lipoic acid, her therapy incorporated biotin and pantothenic acid, which collectively enhanced her overall metabolic control and neurocognitive function. While our findings do highlight the improvement in her condition, they make it difficult to draw strong conclusions about the isolated effect of alpha-lipoic acid on neuropathy alone.
Ultimately, this case points towards a promising domain for further research. It emphasizes the importance of considering how combined vitamin treatments may yield benefits for individuals affected by neuropathies associated with unique metabolic disorders.
Alongside alpha-lipoic acid, her therapy incorporated biotin and pantothenic acid, which collectively enhanced her overall metabolic control and neurocognitive function. While our findings do highlight the improvement in her condition, they make it difficult to draw strong conclusions about the isolated effect of alpha-lipoic acid on neuropathy alone.
Ultimately, this case points towards a promising domain for further research. It emphasizes the importance of considering how combined vitamin treatments may yield benefits for individuals affected by neuropathies associated with unique metabolic disorders.
Read More
8
We explored the impact of genome sequencing on diagnosing and treating SLC5A6-related neuropathy. In this study, we observed that thirteen individuals with specific genetic variants experienced various symptoms, including childhood-onset peripheral motor neuropathy.
Interestingly, a targeted treatment approach using biotin, pantothenic acid, and alpha-lipoic acid showed promising clinical improvements in one case. The findings highlight the critical role of genetic testing in identifying conditions early, potentially saving both time and costs for families seeking answers.
Interestingly, a targeted treatment approach using biotin, pantothenic acid, and alpha-lipoic acid showed promising clinical improvements in one case. The findings highlight the critical role of genetic testing in identifying conditions early, potentially saving both time and costs for families seeking answers.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Effective treatment
120 people found this helpful
I love this product! I deal with very painful nerve pain and cramps that travel through my hips, thighs, and legs. This supplement, recommended by my husband, performed excellently compared to a medication I was prescribed, which left me feeling drugged. I've had a remarkable reduction in painful night cramps, and overall peripheral pain has lessened—a true improvement in my quality of life.
Read More
9
Diabetic neuropathy aid
36 people found this helpful
I've been using Alpha Lipoic Acid for several years as advised by my diabetic specialist to help manage diabetic neuropathy. The tingling and numbness in my big toes have disappeared, and I can feel things normally. If you have neuropathy and haven't tried this, I recommend it—though it can take 2-3 months to see significant effects, so patience is key.
Read More
9
Symptoms reduced 90%
23 people found this helpful
ALA has significantly improved my peripheral neuropathy. After a series of tests returned negative results, I decided to try ALA, which has been prescribed in Germany for years. Within two weeks, my symptoms were reduced by about 90%. Now, after several months, I have completely regained feeling in my arms and legs. Whether I would have recovered on my own is unclear, but I've had no adverse effects and find the cost reasonable. I'm taking two tablets a day.
Read More
10
Neuropathy is gone
12 people found this helpful
It must be magic. After reading the customer feedback, I had to try this supplement. I was amazed to see strong, perfect fingernails shortly after starting the one capsule daily. My fingernails were previously weak and peeling! Moreover, my neuropathy, foot pain, and nighttime leg cramps have vanished.
Read More
9
Alleviates pain
10 people found this helpful
Alpha Lipoic Acid helps with my neuropathy in my feet. I take it daily, and it genuinely alleviates some of the pain associated with this condition! My doctor actually encouraged me to start taking it.
Read More
Frequently Asked Questions
8
We investigated the potential benefits of alpha-lipoic acid (ALA) for patients with type 2 diabetes mellitus (T2DM) suffering from neuropathy. Over six months, we treated 54 patients with a daily dose of 600 mg of ALA while keeping their current oral medications unchanged. We also included a control group of 24 matched individuals who did not experience neuropathy.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
Our findings showed a significant decrease in advanced glycation end products (AGEs), which are harmful compounds that can worsen diabetes complications. The levels of AGEs dropped from 11.89 to 10.95 AU/μg, reflecting the positive impact ALA treatment can have. Interestingly, while the levels of soluble receptor for AGEs (sRAGE) and the AGEs/sRAGE ratio did not show changes with ALA treatment, we did observe correlations between the reduction of AGEs and improvements in neuropathic symptoms and endothelial function.
Overall, our study supports the idea that ALA can effectively lower AGEs in T2DM patients with neuropathy, which could help improve their nerve function and overall health. This offers a promising avenue for managing such complications in diabetes.
7
Alpha-lipoic acid shows promise
The study focused on examining the effects of alpha-lipoic acid specifically on diabetic peripheral neuropathy, an often painful condition affecting many people with diabetes. We explored how this supplement could potentially ease symptoms and improve overall nerve health.
The research was designed meticulously to isolate the impacts of alpha-lipoic acid, with proper control measures in place. As we delved into the results, we found promising signs that this antioxidant might provide relief from neuropathy symptoms.
Participants in the study reported improvements in pain levels and other sensations associated with nerve damage, suggesting that alpha-lipoic acid has beneficial effects. However, while the benefits were noted, more extensive studies are needed to fully understand the long-term impact and effectiveness of this treatment.
Overall, adding alpha-lipoic acid to treatment routines for diabetic neuropathy could be a worthwhile consideration. It presents a potential opportunity for those seeking relief from this challenging condition.
The research was designed meticulously to isolate the impacts of alpha-lipoic acid, with proper control measures in place. As we delved into the results, we found promising signs that this antioxidant might provide relief from neuropathy symptoms.
Participants in the study reported improvements in pain levels and other sensations associated with nerve damage, suggesting that alpha-lipoic acid has beneficial effects. However, while the benefits were noted, more extensive studies are needed to fully understand the long-term impact and effectiveness of this treatment.
Overall, adding alpha-lipoic acid to treatment routines for diabetic neuropathy could be a worthwhile consideration. It presents a potential opportunity for those seeking relief from this challenging condition.
8
Alpha-lipoic acid and neuropathy insights
We explored the effects of alpha-lipoic acid in the context of sodium-dependent multivitamin transporter deficiency (SMVTD), a rare condition resulting from loss-of-function variants in the SLC5A6 gene. In a detailed case of a 25-year-old woman, whose symptoms included developmental delays, epilepsy, and neurocognitive challenges, we observed an intriguing combination of treatments.
Alongside alpha-lipoic acid, her therapy incorporated biotin and pantothenic acid, which collectively enhanced her overall metabolic control and neurocognitive function. While our findings do highlight the improvement in her condition, they make it difficult to draw strong conclusions about the isolated effect of alpha-lipoic acid on neuropathy alone.
Ultimately, this case points towards a promising domain for further research. It emphasizes the importance of considering how combined vitamin treatments may yield benefits for individuals affected by neuropathies associated with unique metabolic disorders.
Alongside alpha-lipoic acid, her therapy incorporated biotin and pantothenic acid, which collectively enhanced her overall metabolic control and neurocognitive function. While our findings do highlight the improvement in her condition, they make it difficult to draw strong conclusions about the isolated effect of alpha-lipoic acid on neuropathy alone.
Ultimately, this case points towards a promising domain for further research. It emphasizes the importance of considering how combined vitamin treatments may yield benefits for individuals affected by neuropathies associated with unique metabolic disorders.
References
- Csiha S, Hernyák M, Molnár Á, Lőrincz H, Katkó M, et al. Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy. Biomedicines. 2025;13. doi:10.3390/biomedicines13020438
- Abuali SM, Frasca DJ. Alpha-Lipoic Acid for Diabetic Peripheral Neuropathy. Am Fam Physician. 2025;111:119.
- Walimbe AS, Waskow E, Mackay L, Miller M, Gijavanekar C, et al. Expanded Clinical Phenotype and the Role of Untargeted Metabolomics Analysis in Confirming the Diagnosis of Sodium-Dependent Multivitamin Transporter Deficiency. Am J Med Genet A. 2025. doi:10.1002/ajmg.a.64014
- Hernyák M, Tóth LI, Csiha S, Molnár Á, Lőrincz H, et al. Kallistatin as a Potential Marker of Therapeutic Response During Alpha-Lipoic Acid Treatment in Diabetic Patients with Sensorimotor Polyneuropathy. Int J Mol Sci. 2024;25. doi:10.3390/ijms252413276
- Pingali U, Sravanasandya P, Mekala P, Yareeda S, Sireesha K, et al. A randomized, double-blind, placebo controlled study to evaluate the effect of alpha-lipoic acid on inhibition of ADP-and collagen-induced platelet aggregation ex vivo in diabetic neuropathy patients on gabapentin or pregabalin. J Postgrad Med. 2024;70:191. doi:10.4103/jpgm.jpgm_310_24
- Wang Q, Xie H, Wang Z, Huang R, Xu M, et al. Comparative efficacy and safety of Chinese patent medicines as an adjunctive therapy for diabetic peripheral neuropathy: systematic review and network meta-analysis of randomized controlled trials. Pharm Biol. 2024;62:833. doi:10.1080/13880209.2024.2422084
- Pingali U, Kammila S, Mekala P, Yareeda S, Penugonda S. A Study to Evaluate the Effect of Alpha-Lipoic Acid on Neuropathic Symptoms in Diabetic Neuropathy Patients on Gabapentin or Pregabalin. Cureus. 2024;16:e70299. doi:10.7759/cureus.70299
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. doi:10.3390/nu16183045
- Aldendail CF, Chen P, Dibble HS, Baute Penry V. A Comprehensive Review of Safety, Efficacy, and Indications for the Use of Alpha-Lipoic Acid and Acetyl-L-Carnitine in Neuropathic Pain. Integr Med (Encinitas). 2024;23:32.
- Riley LG, Sabui S, Said HM, Niaz A, Girisha KM, et al. Genome sequencing enables diagnosis and treatment of SLC5A6 neuropathy. Eur J Hum Genet. 2024;32:947. doi:10.1038/s41431-024-01641-8
- Ran GL, Li YP, Lu LC, Lan SH. Disease-modifying therapies for diabetic peripheral neuropathy: A systematic review and meta-analysis of randomized controlled trials. J Diabetes Complications. 2024;38:108691. doi:10.1016/j.jdiacomp.2024.108691
- Prado MB, Adiao KJB. Ranking Alpha Lipoic Acid and Gamma Linolenic Acid in Terms of Efficacy and Safety in the Management of Adults With Diabetic Peripheral Neuropathy: A Systematic Review and Network Meta-analysis. Can J Diabetes. 2024;48:233. doi:10.1016/j.jcjd.2024.01.007
- Lee DW, Park HC, Kim DH. Protective effect of alpha-lipoic acid and epalrestat on oxaliplatin-induced peripheral neuropathy in zebrafish. Muscle Nerve. 2024;69:498. doi:10.1002/mus.28047
- Ziegler D. Pathogenetic treatments for diabetic peripheral neuropathy. Diabetes Res Clin Pract. 2023;206 Suppl 1:110764. doi:10.1016/j.diabres.2023.110764
- Baicus C, Purcarea A, von Elm E, Delcea C, Furtunescu FL. Alpha-lipoic acid for diabetic peripheral neuropathy. Cochrane Database Syst Rev. 2024;1:CD012967. doi:10.1002/14651858.CD012967.pub2
- Li Y, Jia Y. Effect of miR-146a polymorphism on lipoic acid therapy in patients with T2DM peripheral polyneuropthy. Cell Mol Biol (Noisy-le-grand). 2023;69:38. doi:10.14715/cmb/2023.69.12.7
