5/24/2025
Last update
5/24/2025
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7
USERS' SCORE
Good
Based on 8 Reviews
8.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
320 mg
356%
Calcium (from Calcium Carbonate)
36 mg
3%
Grape Seed Extract (Vitis vinifera) (min. 90% Total Polyphenols)
100 mg
†
Top Medical Research Studies
9
We delved into how vitamin C might influence cancer treatment, focusing on its effects on the immune system. Our findings revealed that vitamin C directly modifies certain proteins, leading to a new type of protein change called vitcylation. This process specifically affects a protein known as STAT1.
By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.
Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.
By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.
Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.
Read More
7
We investigated how calcium treatment, in conjunction with various electroporation methods, affects cancer cell viability. In our study, we used 4T1 breast cancer cells and applied different forms of electroporation, such as reversible and irreversible treatments along with calcium electroporation. We were particularly interested in the bystander effect, where treated cells might affect untreated nearby cells.
By transferring conditioned media from the treated to untreated cells, we observed significant impacts on cell viability. The results showed that after applying calcium electroporation and bleomycin treatments, colony formation plummeted to nearly zero, and metabolic activity dipped as low as 11.62%. Additionally, other assessments, including flow cytometry, confirmed a drastic decrease in cell viability in the presence of calcium therapy.
While the study highlighted calcium’s role in enhancing the effects of electroporation, the combined treatments reduced the overall viability of surrounding cells markedly. We also noticed a delay in wound healing with conditioned media, indicating that calcium treatment could significantly impact not just treated but also neighboring cancer cells. Overall, calcium's combined effects were powerful, emphasizing its utility in cancer treatment strategies.
By transferring conditioned media from the treated to untreated cells, we observed significant impacts on cell viability. The results showed that after applying calcium electroporation and bleomycin treatments, colony formation plummeted to nearly zero, and metabolic activity dipped as low as 11.62%. Additionally, other assessments, including flow cytometry, confirmed a drastic decrease in cell viability in the presence of calcium therapy.
While the study highlighted calcium’s role in enhancing the effects of electroporation, the combined treatments reduced the overall viability of surrounding cells markedly. We also noticed a delay in wound healing with conditioned media, indicating that calcium treatment could significantly impact not just treated but also neighboring cancer cells. Overall, calcium's combined effects were powerful, emphasizing its utility in cancer treatment strategies.
Read More
4
We examined how calcium levels impact the interactions between platelets and cancer cells, as these interactions are crucial for cancer metastasis. Our focus was on specific platelet receptors called integrins, which play vital roles in these interactions.
Throughout our study, we discovered that calcium significantly affects the functionality of these integrins and the overall behavior of platelets. When we reduced calcium levels, we noticed a change in how platelets interacted with breast cancer cells (specifically MDA-MB-231). On the contrary, environments with high calcium levels did not seem to affect these interactions as significantly.
Interestingly, we observed that hypercalcemia, or elevated calcium levels, appeared to enhance cancer cell invasion in the presence of platelets for both breast and lung cancer cells (MDA-MB-231 and A549, respectively). This suggests that rather than obstructing metastatic processes, high calcium may facilitate cancer spread, offering a new perspective on calcium's role in cancer dynamics.
Overall, this study sheds light on how calcium adjustments could be viewed not only as a potential therapeutic strategy but also as a factor impacting cancer progression, especially through platelet interactions.
Throughout our study, we discovered that calcium significantly affects the functionality of these integrins and the overall behavior of platelets. When we reduced calcium levels, we noticed a change in how platelets interacted with breast cancer cells (specifically MDA-MB-231). On the contrary, environments with high calcium levels did not seem to affect these interactions as significantly.
Interestingly, we observed that hypercalcemia, or elevated calcium levels, appeared to enhance cancer cell invasion in the presence of platelets for both breast and lung cancer cells (MDA-MB-231 and A549, respectively). This suggests that rather than obstructing metastatic processes, high calcium may facilitate cancer spread, offering a new perspective on calcium's role in cancer dynamics.
Overall, this study sheds light on how calcium adjustments could be viewed not only as a potential therapeutic strategy but also as a factor impacting cancer progression, especially through platelet interactions.
Read More
Most Useful Reviews
7.5
Reduced hangovers
41 people found this helpful
Reduced my supplement intake greatly—better skin, minimal hangovers: amazing. I have always been a supplement enthusiast, trying various compounds that help combat cell damage and boost energy. Most didn't have noticeable effects, so they were dropped from my routine. Recently, I limited myself to grape seed extract, a multivitamin, and niacin. Grape seed provides a unique 'present' feeling; my skin looks better than with any other combination. Additionally, I have experienced reduced hangovers. I used to suffer severely after more than two drinks, but now symptoms are milder after three drinks. Though not a miracle, this allows me to enjoy moderate drinking again. Grape seed has simplified my regimen, and I prefer the NOW brand for effective, vegetarian capsules.
Read More
9
Skin cancer remedy
33 people found this helpful
Grape Seed Extract combats skin cancer resulting from X-Ray therapy for acne. I underwent several basal cell skin cancer removals due to treatments back in the 70s. A dermatologist informed me that Grape Seed Extract is particularly effective for these conditions. After years of taking it, my skin cancer incidents have nearly vanished—what a relief! While I can't guarantee that this brand is superior, grape seed extract will remain a staple in my supplements.
Read More
9
Vitality boost
6 people found this helpful
I drink it consistently. At the end of my cancer journey, I consulted a second opinion hospital and continue to take cancer research with a prescription from a long-time American university professor. I believe this has been beneficial as I strive to remain energetic despite being given a life expectancy of only three months.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7
- All Researches
9
We delved into how vitamin C might influence cancer treatment, focusing on its effects on the immune system. Our findings revealed that vitamin C directly modifies certain proteins, leading to a new type of protein change called vitcylation. This process specifically affects a protein known as STAT1.
By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.
Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.
By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.
Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.
Read More
8
We explored the impact of calcium and vitamin D supplementation on bone health in young adults after surgery for differentiated thyroid carcinoma (DTC). This study focused on patients under 50 years who had thyroidectomy and were experiencing vitamin D deficiency or insufficiency.
Over the course of one year, we provided patients with daily calcium and vitamin D supplements, monitoring their bone metabolism along the way. After analyzing results from 458 patients, we found that those receiving the supplements had lower levels of parathyroid hormone (PTH) and a notable increase in bone mineral density (BMD) at both the lumbar spine and hip compared to those who did not receive any supplements.
Our findings suggest that calcium, combined with vitamin D, can play a beneficial role in reducing bone loss in young DTC patients suffering from vitamin D malnutrition after thyroid surgery. This could mean improved bone health and a reduced risk of osteoporosis for these patients in the future.
Over the course of one year, we provided patients with daily calcium and vitamin D supplements, monitoring their bone metabolism along the way. After analyzing results from 458 patients, we found that those receiving the supplements had lower levels of parathyroid hormone (PTH) and a notable increase in bone mineral density (BMD) at both the lumbar spine and hip compared to those who did not receive any supplements.
Our findings suggest that calcium, combined with vitamin D, can play a beneficial role in reducing bone loss in young DTC patients suffering from vitamin D malnutrition after thyroid surgery. This could mean improved bone health and a reduced risk of osteoporosis for these patients in the future.
Read More
7
We investigated how calcium treatment, in conjunction with various electroporation methods, affects cancer cell viability. In our study, we used 4T1 breast cancer cells and applied different forms of electroporation, such as reversible and irreversible treatments along with calcium electroporation. We were particularly interested in the bystander effect, where treated cells might affect untreated nearby cells.
By transferring conditioned media from the treated to untreated cells, we observed significant impacts on cell viability. The results showed that after applying calcium electroporation and bleomycin treatments, colony formation plummeted to nearly zero, and metabolic activity dipped as low as 11.62%. Additionally, other assessments, including flow cytometry, confirmed a drastic decrease in cell viability in the presence of calcium therapy.
While the study highlighted calcium’s role in enhancing the effects of electroporation, the combined treatments reduced the overall viability of surrounding cells markedly. We also noticed a delay in wound healing with conditioned media, indicating that calcium treatment could significantly impact not just treated but also neighboring cancer cells. Overall, calcium's combined effects were powerful, emphasizing its utility in cancer treatment strategies.
By transferring conditioned media from the treated to untreated cells, we observed significant impacts on cell viability. The results showed that after applying calcium electroporation and bleomycin treatments, colony formation plummeted to nearly zero, and metabolic activity dipped as low as 11.62%. Additionally, other assessments, including flow cytometry, confirmed a drastic decrease in cell viability in the presence of calcium therapy.
While the study highlighted calcium’s role in enhancing the effects of electroporation, the combined treatments reduced the overall viability of surrounding cells markedly. We also noticed a delay in wound healing with conditioned media, indicating that calcium treatment could significantly impact not just treated but also neighboring cancer cells. Overall, calcium's combined effects were powerful, emphasizing its utility in cancer treatment strategies.
Read More
4
We examined how calcium levels impact the interactions between platelets and cancer cells, as these interactions are crucial for cancer metastasis. Our focus was on specific platelet receptors called integrins, which play vital roles in these interactions.
Throughout our study, we discovered that calcium significantly affects the functionality of these integrins and the overall behavior of platelets. When we reduced calcium levels, we noticed a change in how platelets interacted with breast cancer cells (specifically MDA-MB-231). On the contrary, environments with high calcium levels did not seem to affect these interactions as significantly.
Interestingly, we observed that hypercalcemia, or elevated calcium levels, appeared to enhance cancer cell invasion in the presence of platelets for both breast and lung cancer cells (MDA-MB-231 and A549, respectively). This suggests that rather than obstructing metastatic processes, high calcium may facilitate cancer spread, offering a new perspective on calcium's role in cancer dynamics.
Overall, this study sheds light on how calcium adjustments could be viewed not only as a potential therapeutic strategy but also as a factor impacting cancer progression, especially through platelet interactions.
Throughout our study, we discovered that calcium significantly affects the functionality of these integrins and the overall behavior of platelets. When we reduced calcium levels, we noticed a change in how platelets interacted with breast cancer cells (specifically MDA-MB-231). On the contrary, environments with high calcium levels did not seem to affect these interactions as significantly.
Interestingly, we observed that hypercalcemia, or elevated calcium levels, appeared to enhance cancer cell invasion in the presence of platelets for both breast and lung cancer cells (MDA-MB-231 and A549, respectively). This suggests that rather than obstructing metastatic processes, high calcium may facilitate cancer spread, offering a new perspective on calcium's role in cancer dynamics.
Overall, this study sheds light on how calcium adjustments could be viewed not only as a potential therapeutic strategy but also as a factor impacting cancer progression, especially through platelet interactions.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Reduced hangovers
41 people found this helpful
Reduced my supplement intake greatly—better skin, minimal hangovers: amazing. I have always been a supplement enthusiast, trying various compounds that help combat cell damage and boost energy. Most didn't have noticeable effects, so they were dropped from my routine. Recently, I limited myself to grape seed extract, a multivitamin, and niacin. Grape seed provides a unique 'present' feeling; my skin looks better than with any other combination. Additionally, I have experienced reduced hangovers. I used to suffer severely after more than two drinks, but now symptoms are milder after three drinks. Though not a miracle, this allows me to enjoy moderate drinking again. Grape seed has simplified my regimen, and I prefer the NOW brand for effective, vegetarian capsules.
Read More
9
Skin cancer remedy
33 people found this helpful
Grape Seed Extract combats skin cancer resulting from X-Ray therapy for acne. I underwent several basal cell skin cancer removals due to treatments back in the 70s. A dermatologist informed me that Grape Seed Extract is particularly effective for these conditions. After years of taking it, my skin cancer incidents have nearly vanished—what a relief! While I can't guarantee that this brand is superior, grape seed extract will remain a staple in my supplements.
Read More
9
Vitality boost
6 people found this helpful
I drink it consistently. At the end of my cancer journey, I consulted a second opinion hospital and continue to take cancer research with a prescription from a long-time American university professor. I believe this has been beneficial as I strive to remain energetic despite being given a life expectancy of only three months.
Read More
7.5
Stabilised PSA levels
2 people found this helpful
I’m glad I switched! I was buying my grape seed extract at GNC, but the price kept rising. I take it following prostate surgery and post-surgical radiation treatment because some cancer remains in my body. I have a PSA test every three months, and my PSA reading has not increased significantly in the two years since I began this grape seed extract regimen. I will now purchase it from iHerb, pleased that GNC's price prompted me to seek a reputable alternative online.
Read More
7.5
Post-recovery support
Excellent! A long time ago, I read "What Your Doctor Doesn't Know About Nutrition Could Kill You" and praised grape seed supplements. It took time to find a good product. It helps my wife maintain her levels low after recovering from cancer. I highly recommend it.
Read More
Frequently Asked Questions
7.5
Stabilised PSA levels
2 people found this helpful
I’m glad I switched! I was buying my grape seed extract at GNC, but the price kept rising. I take it following prostate surgery and post-surgical radiation treatment because some cancer remains in my body. I have a PSA test every three months, and my PSA reading has not increased significantly in the two years since I began this grape seed extract regimen. I will now purchase it from iHerb, pleased that GNC's price prompted me to seek a reputable alternative online.
9
Vitality boost
6 people found this helpful
I drink it consistently. At the end of my cancer journey, I consulted a second opinion hospital and continue to take cancer research with a prescription from a long-time American university professor. I believe this has been beneficial as I strive to remain energetic despite being given a life expectancy of only three months.
7.5
Post-recovery support
Excellent! A long time ago, I read "What Your Doctor Doesn't Know About Nutrition Could Kill You" and praised grape seed supplements. It took time to find a good product. It helps my wife maintain her levels low after recovering from cancer. I highly recommend it.
6
Youthful appearance
7 people found this helpful
I love this product! It's kept me looking young. In America, due to being overfed yet undernourished, we're facing various health issues, including cancer and heart disease. This product is phenomenal, especially as I read it has killed leukemia cells and induced apoptosis. I'm not giving medical advice, just sharing my opinion on this remarkable product, which helps maintain youthfulness and tackles free radicals.
9
We delved into how vitamin C might influence cancer treatment, focusing on its effects on the immune system. Our findings revealed that vitamin C directly modifies certain proteins, leading to a new type of protein change called vitcylation. This process specifically affects a protein known as STAT1.
By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.
Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.
By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.
Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.
7
We investigated how calcium treatment, in conjunction with various electroporation methods, affects cancer cell viability. In our study, we used 4T1 breast cancer cells and applied different forms of electroporation, such as reversible and irreversible treatments along with calcium electroporation. We were particularly interested in the bystander effect, where treated cells might affect untreated nearby cells.
By transferring conditioned media from the treated to untreated cells, we observed significant impacts on cell viability. The results showed that after applying calcium electroporation and bleomycin treatments, colony formation plummeted to nearly zero, and metabolic activity dipped as low as 11.62%. Additionally, other assessments, including flow cytometry, confirmed a drastic decrease in cell viability in the presence of calcium therapy.
While the study highlighted calcium’s role in enhancing the effects of electroporation, the combined treatments reduced the overall viability of surrounding cells markedly. We also noticed a delay in wound healing with conditioned media, indicating that calcium treatment could significantly impact not just treated but also neighboring cancer cells. Overall, calcium's combined effects were powerful, emphasizing its utility in cancer treatment strategies.
By transferring conditioned media from the treated to untreated cells, we observed significant impacts on cell viability. The results showed that after applying calcium electroporation and bleomycin treatments, colony formation plummeted to nearly zero, and metabolic activity dipped as low as 11.62%. Additionally, other assessments, including flow cytometry, confirmed a drastic decrease in cell viability in the presence of calcium therapy.
While the study highlighted calcium’s role in enhancing the effects of electroporation, the combined treatments reduced the overall viability of surrounding cells markedly. We also noticed a delay in wound healing with conditioned media, indicating that calcium treatment could significantly impact not just treated but also neighboring cancer cells. Overall, calcium's combined effects were powerful, emphasizing its utility in cancer treatment strategies.
4
We examined how calcium levels impact the interactions between platelets and cancer cells, as these interactions are crucial for cancer metastasis. Our focus was on specific platelet receptors called integrins, which play vital roles in these interactions.
Throughout our study, we discovered that calcium significantly affects the functionality of these integrins and the overall behavior of platelets. When we reduced calcium levels, we noticed a change in how platelets interacted with breast cancer cells (specifically MDA-MB-231). On the contrary, environments with high calcium levels did not seem to affect these interactions as significantly.
Interestingly, we observed that hypercalcemia, or elevated calcium levels, appeared to enhance cancer cell invasion in the presence of platelets for both breast and lung cancer cells (MDA-MB-231 and A549, respectively). This suggests that rather than obstructing metastatic processes, high calcium may facilitate cancer spread, offering a new perspective on calcium's role in cancer dynamics.
Overall, this study sheds light on how calcium adjustments could be viewed not only as a potential therapeutic strategy but also as a factor impacting cancer progression, especially through platelet interactions.
Throughout our study, we discovered that calcium significantly affects the functionality of these integrins and the overall behavior of platelets. When we reduced calcium levels, we noticed a change in how platelets interacted with breast cancer cells (specifically MDA-MB-231). On the contrary, environments with high calcium levels did not seem to affect these interactions as significantly.
Interestingly, we observed that hypercalcemia, or elevated calcium levels, appeared to enhance cancer cell invasion in the presence of platelets for both breast and lung cancer cells (MDA-MB-231 and A549, respectively). This suggests that rather than obstructing metastatic processes, high calcium may facilitate cancer spread, offering a new perspective on calcium's role in cancer dynamics.
Overall, this study sheds light on how calcium adjustments could be viewed not only as a potential therapeutic strategy but also as a factor impacting cancer progression, especially through platelet interactions.
References
- He X, Wang Q, Cheng X, Wang W, Li Y, et al. Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response. Cell. 2025. 10.1016/j.cell.2025.01.043
- Barauskaitė-Šarkinienė N, Novickij V, Šatkauskas S, Ruzgys P. Investigation of the Bystander Effect on Cell Viability After Application of Combined Electroporation-Based Methods. Int J Mol Sci. 2025;26. 10.3390/ijms26052297
- Sun L, Lin X, Li N, Zhang Q, Jiang Y, et al. Effects of vitamin D and calcium supplementation on bone of young adults after thyroidectomy of differentiated thyroid carcinoma. Endocrine. 2025. 10.1007/s12020-025-04195-x
- Morris K, Masri S, Schnoor B, Papa AL. Calcium levels modulate platelet function, platelet-cancer cell interaction, and cancer cell invasion. Sci Rep. 2025;15:7750. 10.1038/s41598-024-79280-8
