SCIENTIFIC SCORE
Questionable
Based on 27 Researches
6.9
USERS' SCORE
Good
Based on 3 Reviews
8.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Folate[5,000 mcg (6S)-5-MTHF**][from Quatrefolic® (6S)-5-MTHF**Glucosamine Salt]
8,333 mcg DFE
2083%

Top Medical Research Studies

9.5
Family education improves anemia treatment
Family-centered Health Education Intervention for Improving Iron-folic Acid Adherence and Anemia Reduction among Antenatal Mothers in Rural Jodhpur: A Quasi-experimental Study.
Significant findings on anemia management
We investigated how family-centered health education influences adherence to iron-folic acid supplements and improves anemia among pregnant women. Through a quasi-experimental trial, we compared results from intervention and control groups, focusing on women aged 14-16 weeks with anemia.

Our findings showed that this educational approach led to notable increases in participants' knowledge and practices regarding anemia management. Significant drops in moderate and mild anemia rates were observed, along with improvements in hemoglobin and ferritin levels. This suggests that better education can effectively enhance anemia status in expectant mothers.
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9
Folate supplementation improves anemia
Effect of School-Based Weekly Iron and Folic Acid Supplementation Program on the Serum Folate Status of Adolescent Girls in Sidama Region, Southern Ethiopia: Comparative Cross-Sectional Study.
Study shows significant benefits
We conducted a study to understand how a school-based program offering weekly iron and folic acid supplements affects anemia, particularly focusing on the serum folate levels in adolescent girls aged 10 to 19 in the Sidama Region of Southern Ethiopia.

Our research compared 165 girls from schools participating in the supplementation program to 165 girls from schools without this initiative. We measured the serum folate levels, alongside hemoglobin concentrations, to get a clearer picture of the program's effectiveness.

The results were promising. We observed that the girls receiving the supplements had a significantly higher mean serum folate concentration of 9.76 ng/mL compared to 7.38 ng/mL in those who did not receive the supplementation. Additionally, the hemoglobin levels were higher in the supplemented group, suggesting a positive effect on overall health.

This highlights the importance of the WIFAS program not just for iron levels but also for folate status, indicating a crucial step in tackling anemia in vulnerable populations. We are optimistic that this evidence can help advocate for the program's expansion in areas facing deficiencies in both iron and folate.
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9
Folate's role in cancer anemia
Functionalized Iron Oxide Nanoparticles for Both Dual-Modal Imaging and Erythropoiesis.
Study highlights folate's impact
We explored how functionalized iron oxide nanoparticles, specifically those enhanced with folate, can play a crucial role in improving anemia related to cancer. This innovative approach aimed at offering both effective imaging solutions for tumors as well as addressing cancer-related anemia in patients.

Our focus was on nanoparticles modified with protoporphyrin IX and folate, which allowed for both magnetic resonance imaging and fluorescence imaging to assist in cancer diagnostics. The study showed that the nanoparticles collected in targeted tumor areas efficiently, which is helpful for imaging and treatment purposes. Interestingly, we also observed a significant improvement in erythropoiesis, with an increase of up to 20% in red blood cell counts and hemoglobin levels in mice suffering from cancer-related anemia.

This finding provides a potential alternative to traditional blood transfusions, which can be burdensome for patients requiring frequent treatments. While we recognize that the isolated effects of folate itself may not be easily determined due to the combined treatment methods, the contribution of folate in this context relates directly to our quest to understand how to effectively combat anemia in cancer patients. Overall, this study positions functionalized iron oxide nanoparticles as a promising tool in the intersection of cancer treatment and anemia management.
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Most Useful Reviews

9.5
Increased energy achieved
This product works great for my medical condition. I have Pernicious Anemia and must take B12 injections every two weeks for life, along with Folic Acid due to low folate levels. After trying Folic Acid for six months with no improvement, I switched to MethylFolate, which my doctor suggested due to its better absorption process. I noticed a difference on the very first day of taking this product, experiencing increased energy and reduced brain fog. I am purchasing it again.
Read More
9.5
Helpful for anemia
Helpful. Definitely helped my anemia.
Read More
8.8
Notable difference felt
This helps me feel better. I suffer from numerous health issues that make me feel older than I am. I have chronic anemia, and despite taking a lot of iron, it isn’t absorbed unless I also take B12 and Folate. I’ve tried many brands, but this is the first Folate that has actually helped me FEEL a difference. I take about three to five of these alongside my B12 and iron, and within an hour, I notice significant improvement in both my emotional and physical wellbeing.
Read More

Medical Researches

SCIENTIFIC SCORE
Questionable
Based on 27 Researches
6.9
  • All Researches
9.5
Nutrition education reduces anemia rates
Effect of nutrition education and iron-folic acid supplementation on anemia among pregnant women in Ethiopia: a quasi-experimental study.
Important for maternal health improvements.
We assessed how nutrition education, combined with iron-folic acid supplementation, impacts hemoglobin levels and adherence to supplementation among pregnant women in Ethiopia. Over three months, pregnant women received community-based education and were given supplements for six weeks.

The results were promising! After the intervention, anemia rates fell significantly from 27.8% to 7.2% among those who received education. Moreover, those participants showed much higher adherence to the supplementation compared to those who did not, suggesting that combining education with iron-folic acid intake can effectively improve health outcomes for pregnant women.
Read More
9.5
Family education improves anemia treatment
Family-centered Health Education Intervention for Improving Iron-folic Acid Adherence and Anemia Reduction among Antenatal Mothers in Rural Jodhpur: A Quasi-experimental Study.
Significant findings on anemia management
We investigated how family-centered health education influences adherence to iron-folic acid supplements and improves anemia among pregnant women. Through a quasi-experimental trial, we compared results from intervention and control groups, focusing on women aged 14-16 weeks with anemia.

Our findings showed that this educational approach led to notable increases in participants' knowledge and practices regarding anemia management. Significant drops in moderate and mild anemia rates were observed, along with improvements in hemoglobin and ferritin levels. This suggests that better education can effectively enhance anemia status in expectant mothers.
Read More
9.5
Nutrition education reduces anemia
Effect of nutrition education and iron-folic acid supplementation on anemia among pregnant women in Ethiopia: a quasi-experimental study.
Effectiveness in anemia reduction
We observed the influence of nutrition education and iron-folic acid (IFA) supplementation on the levels of anemia among pregnant women in Butajira, Ethiopia. Through a quasi-experimental design over three months, we provided pregnant women with health education based on the Health Belief Model, alongside IFA supplements over a six-week period.

At the end of the study, we noticed a remarkable improvement. The proportion of anemia in women receiving the intervention dropped significantly from 27.8% to just 7.2%. Additionally, the knowledge about IFA supplementation improved notably in the intervention group compared to those who did not receive the same level of education, showing a clear connection between education, adherence to supplementation, and overall hemoglobin levels.

We found that participants who engaged in the educational interventions were more likely to adhere to their IFA supplement regimen—2.26 times more so than those who did not participate. This highlights the vital role that combining community-based education and supplementation can play in tackling anemia during pregnancy and improving maternal health outcomes effectively.
Read More
9.5
Folate's limited role in anemia
An Unusual Case of Hemolytic Anemia: A Case Report.
Moderate connection to folate research
Our exploration centered on how folate impacts anemia, specifically in cases of vitamin B12 deficiency. We observed that while vitamin B12 is often the star player in reversing anemia symptoms, folate also plays a critical support role.

Despite this, the data from related cases indicated that isolated folate treatment did not provide significant benefits in correcting anemia. The connection between folate and hemolytic anemia became clear, yet treatment focused primarily on reintroducing vitamin B12, suggesting that folate’s contribution might not be as decisive on its own.

This finding emphasizes the importance of comprehensive treatment approaches and the need for health care providers to consider both vitamins in managing anemia. Ultimately, the positive outcomes we identified were closely tied to vitamin B12 administration rather than folate acting independently.
Read More
9
Grassroots program improves compliance
Evaluating the Impact of an Iron Supplementation Program for Combating Anemia in School-Age and Adolescent Females by a Grassroots Organization in India.
Folate's impact on anemia unclear
We evaluated the effectiveness of a grassroots organization’s iron and folic acid (IFA) supplementation program aimed at improving anemia levels among school-age and adolescent females in India. The program implemented a peer network approach to educate young females about anemia and encourage compliance with supplementation.

Participants in the study received a one-time anti-helminthic treatment, followed by weekly IFA tablets containing varying amounts of elemental iron and folic acid, based on age groups. Over the four-month period, we assessed hemoglobin levels before and after supplementation to determine its impact.

While the combination of iron and folic acid treatments has been recognized for its beneficial effects in fighting anemia, this specific program highlights the vital role of community-driven initiatives in enhancing health outcomes. Our findings suggest that while iron supplementation alone can have noticeable effects, isolating the specific benefits of folic acid within this context remains challenging.

Ultimately, we believe the involvement of grassroots organizations is crucial in raising awareness and improving compliance with nutritional supplementation programs, thereby helping to combat anemia effectively among children.
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User Reviews

USERS' SCORE
Good
Based on 3 Reviews
8.6
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9.5
Increased energy achieved
This product works great for my medical condition. I have Pernicious Anemia and must take B12 injections every two weeks for life, along with Folic Acid due to low folate levels. After trying Folic Acid for six months with no improvement, I switched to MethylFolate, which my doctor suggested due to its better absorption process. I noticed a difference on the very first day of taking this product, experiencing increased energy and reduced brain fog. I am purchasing it again.
Read More
9.5
Helpful for anemia
Helpful. Definitely helped my anemia.
8.8
Notable difference felt
This helps me feel better. I suffer from numerous health issues that make me feel older than I am. I have chronic anemia, and despite taking a lot of iron, it isn’t absorbed unless I also take B12 and Folate. I’ve tried many brands, but this is the first Folate that has actually helped me FEEL a difference. I take about three to five of these alongside my B12 and iron, and within an hour, I notice significant improvement in both my emotional and physical wellbeing.
Read More

Frequently Asked Questions

No FAQs are available for this product and symptom.
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