SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.2
USERS' SCORE
Good
Based on 3 Reviews
8.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Folate[5,000 mcg (6S)-5-MTHF**][from Quatrefolic® (6S)-5-MTHF**Glucosamine Salt]
8,333 mcg DFE
2083%
Top Medical Research Studies
9
Folic acid alleviates postpartum anxiety
Gestational Folic Acid Administration Alleviated Maternal Postpartum Emotional and Cognitive Dysfunction in Mice.
Retains significance for maternal health
We explored how folic acid (FA) given during pregnancy influences anxiety and cognitive issues in postpartum mice. By administering FA at different doses, we observed noteworthy improvements in anxiety and cognitive performance among the mice that received a higher dosage.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Read More
7
Folic acid aids ovarian function
Folic Acid Preconditioning Alleviated Radiation-Induced Ovarian Dysfunction in Female Mice.
Highly relevant to reproductive health
We investigated the impact of folic acid (FA) on anxiety and ovarian function in female mice exposed to radiation. By dividing the mice into groups treated with FA and others that weren’t, we observed that those receiving FA showed significantly reduced anxiety levels alongside improvements in ovarian health. The findings highlighted that FA not only supports reproductive performance by preserving ovarian function but may also help manage emotional symptoms linked to radiation exposure. This suggests that folic acid could be a beneficial aid for women undergoing radiation therapy.
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8
Folic acid alleviates pain-induced anxiety
Long-term folic acid treatment relieves chronic inflammatory pain and pain-induced anxiety by reducing MMP2 expression in rats.
Addresses folic acid for anxiety relevance
We investigated the potential effects of folic acid on anxiety arising from chronic inflammatory pain. Using a group of adult rats, we induced inflammatory pain by injecting them with complete Freund's adjuvant into their hindpaw. Pain levels and behaviors were measured through paw withdrawal tests to monitor mechanical and thermal sensitivity.
Our findings revealed that the rats experienced heightened pain levels, correlating with increased expression of Matrix metalloproteinase 2 (MMP2) in certain nerve regions. Most importantly, we discovered that long-term treatment with folic acid not only lowered MMP2 levels but also provided significant relief from the chronic pain. Additionally, this treatment helped reduce anxiety related to pain, showing that folic acid could play a protective role in managing both chronic inflammatory pain and the anxiety that often accompanies it.
The results suggest that folic acid could be a valuable therapeutic option for tackling both pain and the psychological distress that can follow chronic inflammation. This dual benefit opens the door for further exploration of folic acid in pain management strategies.
Our findings revealed that the rats experienced heightened pain levels, correlating with increased expression of Matrix metalloproteinase 2 (MMP2) in certain nerve regions. Most importantly, we discovered that long-term treatment with folic acid not only lowered MMP2 levels but also provided significant relief from the chronic pain. Additionally, this treatment helped reduce anxiety related to pain, showing that folic acid could play a protective role in managing both chronic inflammatory pain and the anxiety that often accompanies it.
The results suggest that folic acid could be a valuable therapeutic option for tackling both pain and the psychological distress that can follow chronic inflammation. This dual benefit opens the door for further exploration of folic acid in pain management strategies.
Read More
Most Useful Reviews
10
Minimises anxiety
This product has truly changed my life. As someone with bipolar disorder and an MTHFR gene mutation, folate has drastically impacted me. My anxiety has significantly diminished, and my mood swings are nearly gone. I feel like myself again and as if I’ve regained my life. I consider these my magic beans!
Read More
9.5
Improves anxiety and sleep
It produced instant results. My wife’s sleep, mood, anxiety, and daily productivity have all improved.
Read More
8.8
Reduces anxiety symptoms
I feel great. After years of struggling with depression, this has helped me immensely. I have more energy for things I enjoy. I highly recommend it for anyone dealing with depression, anxiety, or anger issues. It has transformed my life over the past month, and my skin has also improved.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.2
- All Researches
9
Folic acid alleviates postpartum anxiety
Gestational Folic Acid Administration Alleviated Maternal Postpartum Emotional and Cognitive Dysfunction in Mice.
Retains significance for maternal health
We explored how folic acid (FA) given during pregnancy influences anxiety and cognitive issues in postpartum mice. By administering FA at different doses, we observed noteworthy improvements in anxiety and cognitive performance among the mice that received a higher dosage.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Read More
8
Combination therapy improves anxiety
A combination of chlorzoxazone and folic acid improves recognition memory, anxiety and depression in SCA3-84Q mice.
Significant findings on treatment
We explored the effects of chlorzoxazone and folic acid on anxiety and cognitive functions in mice suffering from spinocerebellar ataxia type 3 (SCA3).
By administering these treatments, we found that while both chlorzoxazone and the combination with folic acid improved motor skills, only the combination significantly reduced anxiety and enhanced memory.
This highlights the potential of combination therapies in addressing both cognitive deficits and emotional symptoms associated with this condition.
By administering these treatments, we found that while both chlorzoxazone and the combination with folic acid improved motor skills, only the combination significantly reduced anxiety and enhanced memory.
This highlights the potential of combination therapies in addressing both cognitive deficits and emotional symptoms associated with this condition.
Read More
8
Folic acid alleviates pain-induced anxiety
Long-term folic acid treatment relieves chronic inflammatory pain and pain-induced anxiety by reducing MMP2 expression in rats.
Addresses folic acid for anxiety relevance
We investigated the potential effects of folic acid on anxiety arising from chronic inflammatory pain. Using a group of adult rats, we induced inflammatory pain by injecting them with complete Freund's adjuvant into their hindpaw. Pain levels and behaviors were measured through paw withdrawal tests to monitor mechanical and thermal sensitivity.
Our findings revealed that the rats experienced heightened pain levels, correlating with increased expression of Matrix metalloproteinase 2 (MMP2) in certain nerve regions. Most importantly, we discovered that long-term treatment with folic acid not only lowered MMP2 levels but also provided significant relief from the chronic pain. Additionally, this treatment helped reduce anxiety related to pain, showing that folic acid could play a protective role in managing both chronic inflammatory pain and the anxiety that often accompanies it.
The results suggest that folic acid could be a valuable therapeutic option for tackling both pain and the psychological distress that can follow chronic inflammation. This dual benefit opens the door for further exploration of folic acid in pain management strategies.
Our findings revealed that the rats experienced heightened pain levels, correlating with increased expression of Matrix metalloproteinase 2 (MMP2) in certain nerve regions. Most importantly, we discovered that long-term treatment with folic acid not only lowered MMP2 levels but also provided significant relief from the chronic pain. Additionally, this treatment helped reduce anxiety related to pain, showing that folic acid could play a protective role in managing both chronic inflammatory pain and the anxiety that often accompanies it.
The results suggest that folic acid could be a valuable therapeutic option for tackling both pain and the psychological distress that can follow chronic inflammation. This dual benefit opens the door for further exploration of folic acid in pain management strategies.
Read More
8
Folic acid aids anxiety treatment
A combination of chlorzoxazone and folic acid improves recognition memory, anxiety and depression in SCA3-84Q mice.
Study shows combined therapy benefits
A recent study explored how a combination of chlorzoxazone and folic acid can influence anxiety and cognitive functions. The research focused on SCA3-84Q mice, which exhibit anxiety, memory decline, and signs of low mood due to a genetic condition known as spinocerebellar ataxia type 3.
We assessed how long-term injections of chlorzoxazone alone, and in combination with folic acid, affected the brain's Purkinje cells and the overall behavior of these mice. While both treatments seemed to enhance certain motor functions, it was notably the combination of chlorzoxazone and folic acid that significantly reduced anxiety and depressed behavior, alongside improving recognition memory.
Our findings suggest that addressing not just motor symptoms but also mood and cognitive functions is crucial in treating conditions like SCA3. This combination therapy could pave the way for more comprehensive treatment strategies for patients dealing with similar conditions.
We assessed how long-term injections of chlorzoxazone alone, and in combination with folic acid, affected the brain's Purkinje cells and the overall behavior of these mice. While both treatments seemed to enhance certain motor functions, it was notably the combination of chlorzoxazone and folic acid that significantly reduced anxiety and depressed behavior, alongside improving recognition memory.
Our findings suggest that addressing not just motor symptoms but also mood and cognitive functions is crucial in treating conditions like SCA3. This combination therapy could pave the way for more comprehensive treatment strategies for patients dealing with similar conditions.
Read More
8
Folic acid eases withdrawal symptoms
Folic Acid Ameliorates Anxiety- and Depressive-Like Behavior Induced by Nicotine Withdrawal Through Restoration of Behavioral and Biochemical Alterations in Adolescent Male Rats.
Moderate relevance due to treatment overlap
We explored the impact of folic acid (FA) on anxiety and depressive-like behaviors in adolescent male rats following nicotine withdrawal. In our study, we divided the rats into groups that received either a nicotine treatment or a vehicle control, then observed their behavior as they experienced withdrawal.
After this period, we introduced various doses of FA and compared their effects on the rats' mood. Our findings indicate that folic acid may help reduce anxiety and depression symptoms linked to nicotine withdrawal.
The study suggested that FA works by inhibiting the activity of an enzyme related to serotonin metabolism, along with balancing oxidative stress and inflammation. While other treatments, like bupropion, were also examined, the potential of FA to improve cognitive issues arising from nicotine withdrawal stands out.
Overall, we observed that folic acid could be a beneficial supplement for addressing anxiety and depression during the challenging withdrawal process from nicotine.
After this period, we introduced various doses of FA and compared their effects on the rats' mood. Our findings indicate that folic acid may help reduce anxiety and depression symptoms linked to nicotine withdrawal.
The study suggested that FA works by inhibiting the activity of an enzyme related to serotonin metabolism, along with balancing oxidative stress and inflammation. While other treatments, like bupropion, were also examined, the potential of FA to improve cognitive issues arising from nicotine withdrawal stands out.
Overall, we observed that folic acid could be a beneficial supplement for addressing anxiety and depression during the challenging withdrawal process from nicotine.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
Minimises anxiety
This product has truly changed my life. As someone with bipolar disorder and an MTHFR gene mutation, folate has drastically impacted me. My anxiety has significantly diminished, and my mood swings are nearly gone. I feel like myself again and as if I’ve regained my life. I consider these my magic beans!
Read More
9.5
Improves anxiety and sleep
It produced instant results. My wife’s sleep, mood, anxiety, and daily productivity have all improved.
8.8
Reduces anxiety symptoms
I feel great. After years of struggling with depression, this has helped me immensely. I have more energy for things I enjoy. I highly recommend it for anyone dealing with depression, anxiety, or anger issues. It has transformed my life over the past month, and my skin has also improved.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
