Behavioral and cognitive effects of docosahexaenoic acid in drug-naïve children with attention-deficit/hyperactivity disorder: a randomized, placebo-controlled clinical trial.
We evaluated the effects of docosahexaenoic acid (DHA) supplementation on behavior and cognition in children aged 7 to 14 with ADHD. Over six months, 50 participants were randomly assigned to receive either DHA or a placebo in a controlled clinical trial.
While DHA showed some minor positive effects on psychosocial functioning and attention, it did not significantly improve primary ADHD symptoms. Importantly, no side effects were reported, suggesting that further research into DHA's potential benefits for ADHD-related difficulties is worthwhile.
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1
No benefits of DHA found
The Influence of Prenatal DHA Supplementation on Individual Domains of Behavioral Functioning in School-Aged Children: Follow-Up of a Randomized Controlled Trial.
We conducted a randomized controlled trial to see how prenatal DHA supplementation affects children’s behavior. Pregnant women received either 800 mg of DHA or a placebo until birth. When the children turned seven, we asked their parents to complete several behavior assessments.
Surprisingly, the results showed that children in the DHA group performed worse on various behavior scales compared to those in the placebo group. This suggests that prenatal DHA may not only fail to improve behavior in children but could potentially lead to adverse effects instead.
Read More
8
DHA shows limited ADHD benefits
Randomized open-label trial of docosahexaenoic acid-enriched fish oil and fish meal on cognitive and behavioral functioning in Omani children.
We explored how DHA-enriched fish oil and grilled fish impacted attention-deficit/hyperactivity disorder (ADHD) symptoms in Omani children aged 9 to 10. Over 12 weeks, participants received either a fish oil supplement or grilled fish daily.
While DHA levels significantly rose, changes in cognitive function were mixed. The Trail Making Test showed notable improvement in the fish oil group, as did behavioral assessments using the Vanderbilt scales. Despite these positive highlights, the overall benefits on ADHD were limited.
The findings suggest considering DHA fortification in dietary policies for child health improvement.
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Most Useful Reviews
7.5
Improved reasoning
7 people found this helpful
Great! ADHD, best of all. Natal - Rio Grande do Norte, Brazil, all my products took 7 consecutive days to arrive at my house. Very good, I often forgot things, but after taking it for over 5 months, I’m now writing. My reasoning has improved significantly; I’m still on this journey, taking 2 a day, equivalent to 1000 DHA. The doctor recommended a maximum of 3, but it is costly. Congratulations.
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7.5
High DHA dosage
1 people found this helpful
Excellent product! Due to my ADHD, I require a high dose of DHA. This 500mg dose enables me to reach 1000mg with just two capsules. Though the capsules are large, they are soft and easy to swallow. The quality-price ratio is excellent.
Read More
7.5
Supports ADHD well
1 people found this helpful
First of all, I love Now's products; this omega helps with my ADHD. We purchase this product repeatedly. If my review helped you, please give me a thumbs up. Thanks! 👍🙏☺️❤️
We explored how DHA-enriched fish oil and grilled fish impacted attention-deficit/hyperactivity disorder (ADHD) symptoms in Omani children aged 9 to 10. Over 12 weeks, participants received either a fish oil supplement or grilled fish daily.
While DHA levels significantly rose, changes in cognitive function were mixed. The Trail Making Test showed notable improvement in the fish oil group, as did behavioral assessments using the Vanderbilt scales. Despite these positive highlights, the overall benefits on ADHD were limited.
The findings suggest considering DHA fortification in dietary policies for child health improvement.
Read More
8
Omega-3s improve ADHD symptoms
Omega-3 Polyunsaturated Fatty Acids in Youths with Attention Deficit Hyperactivity Disorder: a Systematic Review and Meta-Analysis of Clinical Trials and Biological Studies.
We examined the effectiveness of omega-3 polyunsaturated fatty acids (n-3 PUFAs) for treating ADHD in children and adolescents. Our analysis included randomized controlled trials, which revealed that n-3 PUFAs significantly improve both ADHD symptoms and cognitive function.
Additionally, our findings showed that youth with ADHD generally have lower levels of these beneficial fats in their bodies. Overall, our research supports the idea that omega-3 supplementation can be a valuable treatment for ADHD.
Read More
7
Omega-3 reduces ADHD impulsiveness
Impulsiveness in children with attention-deficit/hyperactivity disorder after an 8-week intervention with the Mediterranean diet and/or omega-3 fatty acids: a randomised clinical trial.
We explored the impact of an 8-week dietary intervention on impulsive behavior in children with ADHD.
In a study involving 60 children from Madrid, participants were divided into four groups: a control without intervention, and three groups receiving either the Mediterranean diet, omega-3 supplementation, or both.
Our findings suggest that daily intake of omega-3 fatty acids may reduce impulsiveness, as indicated by the Barratt Impulsiveness Scale. However, the overall evidence regarding the Mediterranean diet’s effectiveness remains inconclusive.
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7
Dietary changes may reduce impulsiveness
Impulsiveness in children with attention-deficit/hyperactivity disorder after an 8-week intervention with the Mediterranean diet and/or omega-3 fatty acids: A randomised clinical trial.
We examined how an 8-week dietary intervention—featuring a Mediterranean diet and/or omega-3 fatty acid supplements—affects impulsive behavior in children with ADHD. Our study involved 60 children from Madrid, divided into groups receiving different dietary treatments.
The findings suggest that children taking 550mg of EPA and 225mg of DHA daily showed reduced impulsiveness. However, while the Mediterranean diet also seemed to help, we couldn't reach definitive conclusions regarding its overall effectiveness in this specific group.
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7
EPA improves attention in ADHD
High-dose eicosapentaenoic acid (EPA) improves attention and vigilance in children and adolescents with attention deficit hyperactivity disorder (ADHD) and low endogenous EPA levels.
Great! ADHD, best of all. Natal - Rio Grande do Norte, Brazil, all my products took 7 consecutive days to arrive at my house. Very good, I often forgot things, but after taking it for over 5 months, I’m now writing. My reasoning has improved significantly; I’m still on this journey, taking 2 a day, equivalent to 1000 DHA. The doctor recommended a maximum of 3, but it is costly. Congratulations.
Read More
7.5
High DHA dosage
1 people found this helpful
Excellent product! Due to my ADHD, I require a high dose of DHA. This 500mg dose enables me to reach 1000mg with just two capsules. Though the capsules are large, they are soft and easy to swallow. The quality-price ratio is excellent.
Read More
7.5
Supports ADHD well
1 people found this helpful
First of all, I love Now's products; this omega helps with my ADHD. We purchase this product repeatedly. If my review helped you, please give me a thumbs up. Thanks! 👍🙏☺️❤️
Read More
7.5
Increases dopamine supply
1 people found this helpful
Used for a teenager with ADHD. DHA nourishes brain tissue when taken alongside Phosphatidylserine 100mg. It effectively boosts dopamine levels, which are typically lacking in individuals with ADHD.
Read More
9
Boosts brain function
Best omega-3 fat for the brain! DHA provides numerous benefits, particularly for cognitive tasks, aiding concentration in those with ADHD, helping to form synapses, and possibly reducing the risk of depression. It also supports heart health and muscle recovery. These capsules are well-dosed, and I haven't experienced any reflux from them. Highly recommend!
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition characterized by a persistent pattern of inattention and/or hyperactivity-impulsivity that interferes with functioning or development. The symptoms typically present in early childhood and can continue into adolescence and adulthood. Individuals with ADHD may find it challenging to focus, organize tasks, follow through on instructions, and regulate their emotions. Hyperactivity can manifest as excessive fidgeting or an inability to remain seated in structured environments, while impulsivity may lead to hasty actions without considering the consequences.
Diagnosis of ADHD involves comprehensive assessments, often including behavioral evaluations and standardized rating scales, to determine how symptoms impact the individual’s daily life. Treatment can vary widely and may include behavioral therapy, psychoeducation, and medications such as stimulants or non-stimulants, aimed at improving attention span and impulse control. Understanding ADHD is crucial, not only for effective management but also for reducing stigma and promoting awareness. As our understanding of neurodiversity expands, more resources and support systems are becoming available to help those with ADHD thrive in both academic and social settings.
DHA, or docosahexaenoic acid, is an omega-3 fatty acid that is crucial for various bodily functions, particularly in brain health and development. Found abundantly in fish oil, algae, and certain other marine sources, DHA plays a significant role in building and maintaining the structure of brain cell membranes. As a primary structural component of the cerebral cortex, retina, and sperm cells, adequate levels of DHA are essential for optimal neurological functioning and overall cognitive health.
Research indicates that DHA supports brain development in infants and children, making it a vital nutrient during pregnancy and breastfeeding. Furthermore, DHA has been linked to various health benefits, including a potential reduction in the risk of Alzheimer's disease, improved heart health, and anti-inflammatory effects. While our bodies can convert some ALA (alpha-linolenic acid) — another omega-3 fatty acid — into DHA, dietary sources like fatty fish, fish oil supplements, or algae-based supplements can help individuals, especially those who do not consume fish, to achieve sufficient DHA intake for their health needs.
Research suggests that DHA (docosahexaenoic acid), an omega-3 fatty acid known for its role in brain health, may have potential benefits for individuals with ADHD (Attention Deficit Hyperactivity Disorder). Some studies indicate that supplementation with omega-3 fatty acids, particularly DHA and EPA (eicosapentaenoic acid), can lead to improvements in attention, hyperactivity, and overall behavior in children diagnosed with ADHD. However, the evidence remains somewhat mixed, and more research is necessary to conclusively determine the effectiveness of DHA on ADHD symptoms.
It is important to note that while DHA may complement traditional treatments for ADHD, it should not replace prescribed medications or therapeutic interventions. If you are considering incorporating DHA or omega-3 supplements into your or your child's routine, it is advisable to consult with a healthcare professional to determine the appropriate dosage and ensure it aligns with your overall treatment plan.
Based on user reviews, the timeline for observing results from taking this DHA supplement for ADHD can vary significantly. Some users report noticing improvements relatively quickly, often within a few weeks to a couple of months. For instance, one user mentioned feeling a significant enhancement in reasoning skills after taking the supplement for over five months, while others noted improvements in memory and overall functioning within just weeks of starting supplementation Read ReviewRead Review.
Overall, while individual experiences may differ, it appears that many users may start to see some benefits within a few weeks, with continued improvement over several months of consistent use. Users also emphasize the importance of adhering to recommended dosages to maximize effects on ADHD symptoms Read Review.
When it comes to the use of omega-3 supplements for managing ADHD, the scientific research presents a mixed picture. Some studies indicate potential benefits, particularly with long-term use. For example, a meta-analysis of randomized controlled trials found that while omega-3 polyunsaturated fatty acids (PUFAs) did not significantly improve ADHD symptoms overall compared to placebo, those studies with a duration of at least four months showed a significant improvement (see [1]). Similarly, other studies have observed minor improvements in behavior and cognitive function associated with omega-3 supplementation, especially in specific cases or with particular doses (see [12] and [8]).
However, not all research supports the efficacy of omega-3s for ADHD. A 12-month trial using Omega-3/6 dietary supplements found no significant improvement in symptoms among children with inattentive ADHD when compared to a placebo (see [2]). Furthermore, a study examining prenatal DHA levels suggested potential adverse effects on children's behavior (see [4]). Overall, while there may be some promise in using omega-3 fatty acids for managing ADHD symptoms, the evidence is not consistently favorable, emphasizing the need for further research.
Based on user reviews, many individuals report significant improvements in their ADHD symptoms after using this DHA supplement. Users have noted enhancements in cognitive functions such as memory and reasoning skills, with one reviewer mentioning that after over five months of use, they have experienced a remarkable boost in their ability to write and reason effectively Read Review. Additionally, some users highlight improved focus and reduced mental stress, indicating that the supplement may help in managing daily tasks better Read Review.
Anecdotal evidence suggests that users find the supplement beneficial for both children and adults with ADHD, reporting calmer behaviors and better concentration when taken consistently. For instance, one parent observed a calmer demeanor in their teenager after starting the DHA supplement Read Review. While these experiences offer promising insights into the supplement's potential, it's important to note that individual results can vary widely, and the effectiveness may depend on several factors including dosage and individual health conditions. Overall, the reviews collectively convey a positive outlook on the cognitive benefits associated with this DHA supplement for those coping with ADHD.
Based on user reviews, many individuals report positive experiences when combining this DHA supplement with other products, particularly for managing ADHD symptoms. One user noted that when taken alongside Phosphatidylserine, it effectively boosts dopamine levels, which are often lacking in individuals with ADHD Read Review. This combination seems to enhance cognitive function and has garnered favorable feedback, with parents also observing improvements in their children's focus and calmness Read Review.
Moreover, users highlight that the DHA supplement is versatile and can be easily incorporated into daily routines without significant drawbacks. Many have mentioned taking it consistently along with other dietary supplements, contributing to overall improved cognitive performance and an easier manageability of ADHD symptoms Read ReviewRead Review. While individual responses may vary, the consensus among users appears to favor the combination approach for achieving better outcomes in handling ADHD.
Users report varying effective doses for DHA when treating ADHD, with many finding success at a daily intake of around 1000mg. For instance, one reviewer mentions taking 2 capsules, which amounts to 1000mg of DHA, and notes significant improvements in reasoning and daily functioning after over five months of use Read Review. Another user, who emphasized the need for a higher dose due to ADHD, also noted that two 500mg capsules provide an efficient way to reach the desired dosage Read Review.
Other users such as those with children diagnosed with ADHD have reported positive outcomes when combining DHA with other supplements like Phosphatidylserine Read Review. Generally, a consistent dosage of two capsules daily seems to be a common choice among users seeking to manage ADHD symptoms effectively, underscoring its potential in enhancing cognitive function and concentration Read Review.
7.5
Improved reasoning
7 people found this helpful
Great! ADHD, best of all. Natal - Rio Grande do Norte, Brazil, all my products took 7 consecutive days to arrive at my house. Very good, I often forgot things, but after taking it for over 5 months, I’m now writing. My reasoning has improved significantly; I’m still on this journey, taking 2 a day, equivalent to 1000 DHA. The doctor recommended a maximum of 3, but it is costly. Congratulations.
9
Memory improvement
I have ADHD and take this once a day. It certainly helps me function better, and my memory has improved.
7.5
Supports ADHD well
1 people found this helpful
First of all, I love Now's products; this omega helps with my ADHD. We purchase this product repeatedly. If my review helped you, please give me a thumbs up. Thanks! 👍🙏☺️❤️
7.5
Useful during stress
Okay, this is a very good omega-3 for the brain. It contains twice as much of the essential acid and is beneficial for managing mental stress and ADHD.
7.5
Calm behaviour
Excellent! An excellent fish oil supplement. I give it to a teenager with ADHD, and I believe he has become calmer.
7.5
Increases dopamine supply
1 people found this helpful
Used for a teenager with ADHD. DHA nourishes brain tissue when taken alongside Phosphatidylserine 100mg. It effectively boosts dopamine levels, which are typically lacking in individuals with ADHD.
7.5
High DHA dosage
1 people found this helpful
Excellent product! Due to my ADHD, I require a high dose of DHA. This 500mg dose enables me to reach 1000mg with just two capsules. Though the capsules are large, they are soft and easy to swallow. The quality-price ratio is excellent.
7
Cognitive support
Great! I have been using NOW DHA for many years. This product is beneficial for cognition and can aid those with ADD and ADHD. I usually take two capsules daily.
4
Omega-3s show limited ADHD effects
Omega-3 Polyunsaturated Fatty Acids for Core Symptoms of Attention-Deficit/Hyperactivity Disorder: A Meta-Analysis of Randomized Controlled Trials.
We investigated the impact of omega-3 polyunsaturated fatty acids (PUFAs) on ADHD symptoms through a meta-analysis of randomized controlled trials. Our analysis included 22 studies with 1,789 participants, revealing that omega-3 PUFAs did not significantly improve ADHD symptoms overall compared to a placebo.
However, we noted a silver lining: for studies with treatment durations of at least four months, there was a significant improvement over the placebo. Still, higher doses of eicosapentaenoic acid (EPA) didn't seem to enhance results. This suggests that while omega-3s may not be a cure-all, long-term use could hold promise for some.
8
Omega-3s improve ADHD symptoms
Omega-3 Polyunsaturated Fatty Acids in Youths with Attention Deficit Hyperactivity Disorder: a Systematic Review and Meta-Analysis of Clinical Trials and Biological Studies.
We examined the effectiveness of omega-3 polyunsaturated fatty acids (n-3 PUFAs) for treating ADHD in children and adolescents. Our analysis included randomized controlled trials, which revealed that n-3 PUFAs significantly improve both ADHD symptoms and cognitive function.
Additionally, our findings showed that youth with ADHD generally have lower levels of these beneficial fats in their bodies. Overall, our research supports the idea that omega-3 supplementation can be a valuable treatment for ADHD.
7
Omega-3 PUFAs can aid ADHD
Early monitoring of fatty acid profile in children with attention deficit and/or hyperactivity disorder under treatment with omega-3 polyunsaturated fatty acids.
We explored the effects of omega-3 fatty acids, specifically DHA and EPA, in combination with methylphenidate (MPH) for children with ADHD. Over a month, 40 children aged 7 to 15 received this treatment, followed by assessments of their attention scores and fatty acid profiles.
Our findings showed notable improvements in attention quality and a reduction in certain adverse fatty acids. Importantly, no severe side effects were reported, signaling that omega-3 PUFAs could be a safe addition to ADHD treatment. However, more research is needed to confirm these effects over the long term.
2
No clinical benefit from Omega-3/6
Omega-3/6 supplementation for mild to moderate inattentive ADHD: a randomised, double-blind, placebo-controlled efficacy study in Italian children.
We explored the effects of Omega-3/6 dietary supplements on children with inattentive ADHD. Conducting a rigorous trial with 160 participants, we compared the supplement against a placebo over 12 months.
Surprisingly, the results indicated no significant improvement in ADHD symptoms for the group receiving the Omega-3/6 supplement compared to the placebo group. While some minor changes in blood levels of fatty acids were noted, there was no clinically meaningful benefit observed in alleviating inattentive symptoms.
This suggests that Omega-3/6 dietary products may have a limited role in the treatment of mild inattentive ADHD in children.
1
No benefits of DHA found
The Influence of Prenatal DHA Supplementation on Individual Domains of Behavioral Functioning in School-Aged Children: Follow-Up of a Randomized Controlled Trial.
We conducted a randomized controlled trial to see how prenatal DHA supplementation affects children’s behavior. Pregnant women received either 800 mg of DHA or a placebo until birth. When the children turned seven, we asked their parents to complete several behavior assessments.
Surprisingly, the results showed that children in the DHA group performed worse on various behavior scales compared to those in the placebo group. This suggests that prenatal DHA may not only fail to improve behavior in children but could potentially lead to adverse effects instead.
References
Liu TH, Wu JY, Huang PY, Lai CC, Chang JP, et al. Omega-3 Polyunsaturated Fatty Acids for Core Symptoms of Attention-Deficit/Hyperactivity Disorder: A Meta-Analysis of Randomized Controlled Trials. J Clin Psychiatry. 2023;84. 10.4088/JCP.22r14772
Carucci S, Romaniello R, Demuru G, Curatolo P, Grelloni C, et al. Omega-3/6 supplementation for mild to moderate inattentive ADHD: a randomised, double-blind, placebo-controlled efficacy study in Italian children. Eur Arch Psychiatry Clin Neurosci. 2022;272:1453. 10.1007/s00406-022-01428-2
San Mauro Martin I, Sanz Rojo S, González Cosano L, Conty de la Campa R, Garicano Vilar E, et al. Impulsiveness in children with attention-deficit/hyperactivity disorder after an 8-week intervention with the Mediterranean diet and/or omega-3 fatty acids: a randomised clinical trial. Neurologia (Engl Ed). 2022;37:513. 10.1016/j.nrleng.2019.09.009
Gould JF, Anderson PJ, Yelland LN, Gibson RA, Makrides M. The Influence of Prenatal DHA Supplementation on Individual Domains of Behavioral Functioning in School-Aged Children: Follow-Up of a Randomized Controlled Trial. Nutrients. 2021;13. 10.3390/nu13092996
San Mauro Martin I, Sanz Rojo S, González Cosano L, Conty de la Campa R, Garicano Vilar E, et al. Impulsiveness in children with attention-deficit/hyperactivity disorder after an 8-week intervention with the Mediterranean diet and/or omega-3 fatty acids: A randomised clinical trial. Neurologia (Engl Ed). 2022;37:513. 10.1016/j.nrl.2019.09.007
Chang JP, Su KP, Mondelli V, Satyanarayanan SK, Yang HT, et al. High-dose eicosapentaenoic acid (EPA) improves attention and vigilance in children and adolescents with attention deficit hyperactivity disorder (ADHD) and low endogenous EPA levels. Transl Psychiatry. 2019;9:303. 10.1038/s41398-019-0633-0
Martins BP, Bandarra NM, Figueiredo-Braga M. The role of marine omega-3 in human neurodevelopment, including Autism Spectrum Disorders and Attention-Deficit/Hyperactivity Disorder - a review. Crit Rev Food Sci Nutr. 2020;60:1431. 10.1080/10408398.2019.1573800
Checa-Ros A, Haro-García A, Seiquer I, Molina-Carballo A, Uberos-Fernández J, et al. Early monitoring of fatty acid profile in children with attention deficit and/or hyperactivity disorder under treatment with omega-3 polyunsaturated fatty acids. Minerva Pediatr. 2019;71:313. 10.23736/S0026-4946.18.04975-7
Crippa A, Tesei A, Sangiorgio F, Salandi A, Trabattoni S, et al. Behavioral and cognitive effects of docosahexaenoic acid in drug-naïve children with attention-deficit/hyperactivity disorder: a randomized, placebo-controlled clinical trial. Eur Child Adolesc Psychiatry. 2019;28:571. 10.1007/s00787-018-1223-z
Al-Ghannami SS, Al-Adawi S, Ghebremeskel K, Hussein IS, Min Y, et al. Randomized open-label trial of docosahexaenoic acid-enriched fish oil and fish meal on cognitive and behavioral functioning in Omani children. Nutrition. 2019;57:167. 10.1016/j.nut.2018.04.008
Yonezawa K, Nonaka S, Iwakura Y, Kusano Y, Funamoto Y, et al. Investigation into the plasma concentration of ω3 polyunsaturated fatty acids in Japanese attention-deficit hyperactivity disorder patients. J Neural Transm (Vienna). 2018;125:1395. 10.1007/s00702-018-1895-z
Chang JP, Su KP, Mondelli V, Pariante CM. Omega-3 Polyunsaturated Fatty Acids in Youths with Attention Deficit Hyperactivity Disorder: a Systematic Review and Meta-Analysis of Clinical Trials and Biological Studies. Neuropsychopharmacology. 2018;43:534. 10.1038/npp.2017.160
Ramakrishnan U, Gonzalez-Casanova I, Schnaas L, DiGirolamo A, Quezada AD, et al. Prenatal supplementation with DHA improves attention at 5 y of age: a randomized controlled trial. Am J Clin Nutr. 2016;104:1075.
Bonvicini C, Faraone SV, Scassellati C. Attention-deficit hyperactivity disorder in adults: A systematic review and meta-analysis of genetic, pharmacogenetic and biochemical studies. Mol Psychiatry. 2016;21:872. 10.1038/mp.2016.74
Wu Q, Zhou T, Ma L, Yuan D, Peng Y. Protective effects of dietary supplementation with natural ω-3 polyunsaturated fatty acids on the visual acuity of school-age children with lower IQ or attention-deficit hyperactivity disorder. Nutrition. 2015;31:935. 10.1016/j.nut.2014.12.026
Bos DJ, Oranje B, Veerhoek ES, Van Diepen RM, Weusten JM, et al. Reduced Symptoms of Inattention after Dietary Omega-3 Fatty Acid Supplementation in Boys with and without Attention Deficit/Hyperactivity Disorder. Neuropsychopharmacology. 2015;40:2298. 10.1038/npp.2015.73