' 
![]()
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7
USERS' SCORE
Good
Based on 9 Reviews
8.7
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
9
DHA shows promise in Alzheimer's
Nose-to-brain delivery of DHA-loaded nanoemulsions: A promising approach against Alzheimer's disease.
Direct focus on DHA's effects
We investigated the potential benefits of docosahexaenoic acid (DHA) in fighting Alzheimer's disease (AD) through a novel intranasal administration method. By using a specially formulated nanoemulsion that protects DHA from oxidation, we aimed to enhance its delivery to the brain. In our study, we administered this DHA-rich nanoemulsion to J20 mice, a well-known transgenic model for AD.
The results were promising. After treatment, the mice showed notable improvements in their well-being and memory performance, which we measured through their ability to navigate spatial tasks. Additionally, we observed a significant reduction in harmful amyloid deposits, oxidative stress, and neuroinflammation within their brain tissues. This positive outcome could potentially stem from DHA's ability to affect specific processes in the brain, such as the inactivation of GSK3β, a kinase associated with AD.
Overall, our findings suggest that intranasal DHA treatment not only has therapeutic effects but may also modify the progression of Alzheimer's disease. Considering that DHA has already demonstrated safety in humans, we believe there is a strong case for conducting clinical trials to explore this approach further for Alzheimer's patients.
The results were promising. After treatment, the mice showed notable improvements in their well-being and memory performance, which we measured through their ability to navigate spatial tasks. Additionally, we observed a significant reduction in harmful amyloid deposits, oxidative stress, and neuroinflammation within their brain tissues. This positive outcome could potentially stem from DHA's ability to affect specific processes in the brain, such as the inactivation of GSK3β, a kinase associated with AD.
Overall, our findings suggest that intranasal DHA treatment not only has therapeutic effects but may also modify the progression of Alzheimer's disease. Considering that DHA has already demonstrated safety in humans, we believe there is a strong case for conducting clinical trials to explore this approach further for Alzheimer's patients.
Read More
8
Eicosapentaenoic Acid aids Alzheimer's treatment
N-3 polyunsaturated fatty acids attenuate amyloid-beta-induced toxicity in AD transgenic Caenorhabditis elegans via promotion of proteasomal activity and activation of PPAR-gamma.
Highly relevant study on Alzheimer's
We investigated how eicosapentaenoic acid (EPA), an n-3 polyunsaturated fatty acid, affects the toxicity linked to Alzheimer’s disease. Using a model of transgenic Caenorhabditis elegans, we observed that treating these worms with EPA led to a decrease in the harmful effects caused by beta-amyloid (Aβ) accumulation, a key contributor to cognitive decline in Alzheimer’s.
Notably, we found that EPA not only reduced the signs of paralysis associated with Aβ but also lowered the production of reactive oxygen species, which are harmful compounds that can damage cells. Additionally, our findings suggested that EPA restored proteasomal activity, helping clear the Aβ build-up.
We further explored the role of PPAR-gamma, a receptor that appears to be crucial for EPA's protective effects. When we used an inhibitor to block PPAR-gamma, the positive outcomes of EPA treatment were no longer evident. This suggests that EPA’s beneficial effects in fighting Aβ-induced toxicity are linked to its ability to activate PPAR-gamma.
Overall, our research underscores the potential of eicosapentaenoic acid as a promising therapeutic option for mitigating Alzheimer's symptoms by enhancing cellular functions.
Notably, we found that EPA not only reduced the signs of paralysis associated with Aβ but also lowered the production of reactive oxygen species, which are harmful compounds that can damage cells. Additionally, our findings suggested that EPA restored proteasomal activity, helping clear the Aβ build-up.
We further explored the role of PPAR-gamma, a receptor that appears to be crucial for EPA's protective effects. When we used an inhibitor to block PPAR-gamma, the positive outcomes of EPA treatment were no longer evident. This suggests that EPA’s beneficial effects in fighting Aβ-induced toxicity are linked to its ability to activate PPAR-gamma.
Overall, our research underscores the potential of eicosapentaenoic acid as a promising therapeutic option for mitigating Alzheimer's symptoms by enhancing cellular functions.
Read More
8
EPA disrupts Aβ fibrils
Destabilization of Aβ fibrils by omega-3 polyunsaturated fatty acids: a molecular dynamics study.
Direct focus on Alzheimer's treatment
We explored the potential of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, in destabilizing the toxic aggregates of the Aβ protein that form plaques in Alzheimer's disease. The study utilized advanced molecular dynamics simulations to assess how EPA interacts with these fibrils over time.
Throughout the analysis, we observed that EPA not only binds to the Aβ fibrils but also disrupts their structure. As a result, we noted increased root mean square deviation, radius of gyration, and surface area while the number of hydrogen bonds and β-sheet content decreased. This indicates that EPA interferes with the fibrils' stability, potentially paving the way for therapeutic applications in Alzheimer’s treatment.
Importantly, the interactions demonstrated that the polar head of EPA aligns with positively charged residues in the fibril, showcasing a clear mechanism behind its destabilizing effects. The hydrophobic tail of EPA competes with the natural hydrophobic interactions within the fibrils, ultimately leading to their destabilization. Overall, our findings suggest that EPA could be a promising candidate for further drug development aimed at combating Alzheimer’s disease.
Throughout the analysis, we observed that EPA not only binds to the Aβ fibrils but also disrupts their structure. As a result, we noted increased root mean square deviation, radius of gyration, and surface area while the number of hydrogen bonds and β-sheet content decreased. This indicates that EPA interferes with the fibrils' stability, potentially paving the way for therapeutic applications in Alzheimer’s treatment.
Importantly, the interactions demonstrated that the polar head of EPA aligns with positively charged residues in the fibril, showcasing a clear mechanism behind its destabilizing effects. The hydrophobic tail of EPA competes with the natural hydrophobic interactions within the fibrils, ultimately leading to their destabilization. Overall, our findings suggest that EPA could be a promising candidate for further drug development aimed at combating Alzheimer’s disease.
Read More
Most Useful Reviews
9.5
Supports brain health
Excellent! DHA is vital for brain health, particularly for those with a family history of Alzheimer's. I appreciate this NOW product as it contains 500mg of DHA per capsule.
Read More
9.5
Promotes brain function
In the elderly, DHA levels are often low, risking memory loss. Supplementing with DHA is wise for brain and eye development, decreasing the chances of Alzheimer's, dementia, and related issues. It also lowers inflammation and aids in chronic disease management.
Read More
9.5
Essential nutrition
Very good, very good! This is essential nutrition for preventing Alzheimer's disease.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7
9
DHA's role in Alzheimer's management
Cosupplementation with DHA and medium-chain triglycerides ameliorates NAFLD and reduces amyloid-β accumulation by modulating hepatic lipid metabolism in APP/PS1 mice.
DHA's combined effect with MCTs
We aimed to uncover how docosahexaenoic acid (DHA) might affect Alzheimer's disease, particularly in relation to nonalcoholic fatty liver disease (NAFLD). Our study involved 40 three-month-old male APP/PS1 mice, which are commonly used in Alzheimer's research, divided into four groups. These groups ate different diets—one with DHA, one with medium-chain triglycerides (MCTs), one with both, and one control—as we observed their impacts on liver health and amyloid-β (Aβ) accumulations over eight months.
Our findings showed that mice with Alzheimer's displayed both NAFLD and increased levels of Aβ in their brains. Interestingly, the combination of DHA and MCTs led to lower blood and liver lipids. It also alleviated fat buildup in the liver and reduced Aβ levels in both the brain and serum. Moreover, it effectively raised the levels of proteins linked to Aβ clearance while altering the expression of key enzymes related to liver lipid metabolism.
In essence, our research suggests that DHA, particularly when paired with MCTs, may offer protective benefits against the progression of NAFLD and simultaneously reduce Aβ accumulation. This could indicate a more significant response to metabolic changes in APP/PS1 mice compared to normal mice. Our study adds to the understanding of DHA's potential role in managing Alzheimer's disease through its effects on liver metabolism and Aβ processing.
Our findings showed that mice with Alzheimer's displayed both NAFLD and increased levels of Aβ in their brains. Interestingly, the combination of DHA and MCTs led to lower blood and liver lipids. It also alleviated fat buildup in the liver and reduced Aβ levels in both the brain and serum. Moreover, it effectively raised the levels of proteins linked to Aβ clearance while altering the expression of key enzymes related to liver lipid metabolism.
In essence, our research suggests that DHA, particularly when paired with MCTs, may offer protective benefits against the progression of NAFLD and simultaneously reduce Aβ accumulation. This could indicate a more significant response to metabolic changes in APP/PS1 mice compared to normal mice. Our study adds to the understanding of DHA's potential role in managing Alzheimer's disease through its effects on liver metabolism and Aβ processing.
Read More
9
DHA shows promise in Alzheimer's
Nose-to-brain delivery of DHA-loaded nanoemulsions: A promising approach against Alzheimer's disease.
Direct focus on DHA's effects
We investigated the potential benefits of docosahexaenoic acid (DHA) in fighting Alzheimer's disease (AD) through a novel intranasal administration method. By using a specially formulated nanoemulsion that protects DHA from oxidation, we aimed to enhance its delivery to the brain. In our study, we administered this DHA-rich nanoemulsion to J20 mice, a well-known transgenic model for AD.
The results were promising. After treatment, the mice showed notable improvements in their well-being and memory performance, which we measured through their ability to navigate spatial tasks. Additionally, we observed a significant reduction in harmful amyloid deposits, oxidative stress, and neuroinflammation within their brain tissues. This positive outcome could potentially stem from DHA's ability to affect specific processes in the brain, such as the inactivation of GSK3β, a kinase associated with AD.
Overall, our findings suggest that intranasal DHA treatment not only has therapeutic effects but may also modify the progression of Alzheimer's disease. Considering that DHA has already demonstrated safety in humans, we believe there is a strong case for conducting clinical trials to explore this approach further for Alzheimer's patients.
The results were promising. After treatment, the mice showed notable improvements in their well-being and memory performance, which we measured through their ability to navigate spatial tasks. Additionally, we observed a significant reduction in harmful amyloid deposits, oxidative stress, and neuroinflammation within their brain tissues. This positive outcome could potentially stem from DHA's ability to affect specific processes in the brain, such as the inactivation of GSK3β, a kinase associated with AD.
Overall, our findings suggest that intranasal DHA treatment not only has therapeutic effects but may also modify the progression of Alzheimer's disease. Considering that DHA has already demonstrated safety in humans, we believe there is a strong case for conducting clinical trials to explore this approach further for Alzheimer's patients.
Read More
9
DHA shows potential in AD treatment
Up-regulation of myelin-associated glycoprotein is associated with the ameliorating effect of omega-3 polyunsaturated fatty acids on Alzheimer's disease progression in APP-PS1 transgenic mice.
Study shows moderate relevance
We examined how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, could influence Alzheimer's disease (AD) progression. To do this, we crossed special mice known for their ability to produce higher levels of omega-3s with another group genetically predisposed to develop AD. The goal was to see if increased DHA in their brains would improve their cognition and reduce harmful protein levels associated with AD.
Our findings were compelling. Mice with elevated DHA levels showed fewer cognitive deficits and lower levels of amyloid-beta, the protein linked to AD, compared to those that lacked this enhancement. We also found that this improvement was associated with higher expression of myelin-associated glycoprotein (MAG) in key brain areas involved in learning and memory. This suggests a potential mechanism through which DHA exerts its protective effects.
Additionally, our analysis indicated that the protective properties of DHA were compromised when MAG expression was inhibited. This reinforces the idea that up-regulation of MAG is crucial for DHA’s beneficial effects against AD. Overall, our research highlights DHA as a promising avenue for Alzheimer's treatment due to its ability to enhance MAG expression and support cognitive function.
Our findings were compelling. Mice with elevated DHA levels showed fewer cognitive deficits and lower levels of amyloid-beta, the protein linked to AD, compared to those that lacked this enhancement. We also found that this improvement was associated with higher expression of myelin-associated glycoprotein (MAG) in key brain areas involved in learning and memory. This suggests a potential mechanism through which DHA exerts its protective effects.
Additionally, our analysis indicated that the protective properties of DHA were compromised when MAG expression was inhibited. This reinforces the idea that up-regulation of MAG is crucial for DHA’s beneficial effects against AD. Overall, our research highlights DHA as a promising avenue for Alzheimer's treatment due to its ability to enhance MAG expression and support cognitive function.
Read More
9
Cognitive enhancement in Alzheimer’s models
Gut microbiota and inflammation analyses reveal the protective effect of medium-chain triglycerides combined with docosahexaenoic acid on cognitive function in APP/PS1 and SAMP8 mice.
Combined effects obscured specific impacts
We delved into how docosahexaenoic acid (DHA), when combined with medium-chain triglycerides (MCTs), influences cognitive function, particularly in the context of Alzheimer's disease. In our study, we used two mouse models known for neurodegenerative research, which helped us assess the impact of DHA and MCTs on not just cognitive abilities, but also inflammation and gut microbiota.
The findings revealed that the combination of MCTs and DHA significantly improved spatial learning, memory, and exploratory behavior in these mice. Notably, we observed a reduction in specific inflammation markers and a positive shift in gut microbiota composition, with a decrease in harmful bacteria levels.
Moreover, this dual supplementation outperformed either MCTs or DHA alone, showcasing a unique synergy that could offer new insights into potential dietary interventions aimed at improving cognitive health in Alzheimer's. Overall, our study indicates that the combined effects of MCTs and DHA are promising and could be key in finding new avenues for cognitive enhancement in neurodegenerative conditions.
The findings revealed that the combination of MCTs and DHA significantly improved spatial learning, memory, and exploratory behavior in these mice. Notably, we observed a reduction in specific inflammation markers and a positive shift in gut microbiota composition, with a decrease in harmful bacteria levels.
Moreover, this dual supplementation outperformed either MCTs or DHA alone, showcasing a unique synergy that could offer new insights into potential dietary interventions aimed at improving cognitive health in Alzheimer's. Overall, our study indicates that the combined effects of MCTs and DHA are promising and could be key in finding new avenues for cognitive enhancement in neurodegenerative conditions.
Read More
9
DHA may improve Alzheimer's-related dysfunctions
Increasing the Survival of a Neuronal Model of Alzheimer's Disease Using Docosahexaenoic Acid, Restoring Endolysosomal Functioning by Modifying the Interactions between the Membrane Proteins C99 and Rab5.
High relevance for Alzheimer's research
We set out to explore the influence of docosahexaenoic acid, or DHA, on problems associated with Alzheimer's disease (AD). By using human neuroblastoma cells that express a form of the amyloid precursor protein commonly linked to AD, we observed significant endolysosomal abnormalities. These included enlarged endosomes, a decrease in exosome secretion, and an increase in cell death, supporting the relevance of our model for studying Alzheimer’s mechanisms.
Our findings revealed that DHA treatment seemed to offer neuroprotection. Specifically, we found that DHA helped reduce the interaction between the C99 fragment of the amyloid precursor protein and a protein called Rab5, which plays a crucial role in endosomal function. We also noted effects like smaller endosome sizes, improved exosome production, and decreased apoptosis in the cells treated with DHA.
Overall, our study suggests that DHA may have the potential to correct the dysfunctional interactions and processes within neurons that are characteristic of Alzheimer's disease. This highlights an exciting avenue for further research into nutritional interventions for AD.
Our findings revealed that DHA treatment seemed to offer neuroprotection. Specifically, we found that DHA helped reduce the interaction between the C99 fragment of the amyloid precursor protein and a protein called Rab5, which plays a crucial role in endosomal function. We also noted effects like smaller endosome sizes, improved exosome production, and decreased apoptosis in the cells treated with DHA.
Overall, our study suggests that DHA may have the potential to correct the dysfunctional interactions and processes within neurons that are characteristic of Alzheimer's disease. This highlights an exciting avenue for further research into nutritional interventions for AD.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.7
9.5
Supports brain health
Excellent! DHA is vital for brain health, particularly for those with a family history of Alzheimer's. I appreciate this NOW product as it contains 500mg of DHA per capsule.
9.5
Promotes brain function
In the elderly, DHA levels are often low, risking memory loss. Supplementing with DHA is wise for brain and eye development, decreasing the chances of Alzheimer's, dementia, and related issues. It also lowers inflammation and aids in chronic disease management.
9.5
Essential nutrition
Very good, very good! This is essential nutrition for preventing Alzheimer's disease.
9.3
Improves brain function
I love this product! DHA is vital for skin and eye health. It supports children's brain development and adult brain function. A deficiency can lead to issues later in life, including learning difficulties and increasing Alzheimer’s risk. DHA also lowers cardiovascular disease risks.
Read More
8.8
Protects against alzheimer
DHA is crucial for the central nervous system. A deficiency can diminish mental performance and memory while increasing the risk of conditions like Alzheimer's. It also aids in forming the myelin sheath of nerves, ensuring effective nerve impulse conduction. I highly recommend it!
Read More
