Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
9
DHA's role in osteoporosis treatment
We recently looked into how docosahexaenoic acid (DHA), through its enriched phosphatidylcholine form (DHA-PC), affects osteoporosis. Using a model that simulates the condition in women after ovariectomy, we compared the impact of DHA-PC with eicosapentaenoic acid (EPA) enriched phosphatidylcholine (EPA-PC). Our findings revealed that both DHA-PC and EPA-PC significantly improved the structural quality of trabecular bone, boosted the rate of new bone formation, and elevated bone mineral density, which are crucial factors in combating osteoporosis.
We also discovered that both compounds worked to regulate bone formation by down-regulating the overactive Wnt/β-catenin signaling pathway, which is key to osteogenesis. This means that rather than allowing excessive bone growth, DHA-PC and EPA-PC help bring osteogenesis back to normal levels. Thus, our results suggest that incorporating DHA and EPA phosphatidylcholine could potentially serve as a beneficial strategy in osteoporosis management, highlighting their promising role in health and nutrition.
Overall, this study offers valuable insights into the anti-osteoporotic effects of DHA-PC and EPA-PC and supports their further exploration as functional foods in our diets.
We also discovered that both compounds worked to regulate bone formation by down-regulating the overactive Wnt/β-catenin signaling pathway, which is key to osteogenesis. This means that rather than allowing excessive bone growth, DHA-PC and EPA-PC help bring osteogenesis back to normal levels. Thus, our results suggest that incorporating DHA and EPA phosphatidylcholine could potentially serve as a beneficial strategy in osteoporosis management, highlighting their promising role in health and nutrition.
Overall, this study offers valuable insights into the anti-osteoporotic effects of DHA-PC and EPA-PC and supports their further exploration as functional foods in our diets.
Read More
7
We examined the relationship between docosahexaenoic acid (DHA) and osteoporosis using a method called 2-sample Mendelian randomization. This approach allowed us to investigate if higher levels of DHA could be a risk factor for osteoporosis.
Our findings revealed a causal tie: increased blood levels of DHA were indeed linked to a higher risk of developing osteoporosis. Specifically, for each standard deviation increase in DHA levels, the risk for osteoporosis rose by nearly 10%. We found this connection to be statistically significant, with a P-value of 0.033.
However, it's important to point out that the genetic correlation between DHA and osteoporosis was weak, suggesting that this relationship might not be heavily influenced by our genes. While these results indicate that DHA levels are a risk factor for osteoporosis, the underlying mechanisms are still unclear, highlighting the need for further research in this area.
Our findings revealed a causal tie: increased blood levels of DHA were indeed linked to a higher risk of developing osteoporosis. Specifically, for each standard deviation increase in DHA levels, the risk for osteoporosis rose by nearly 10%. We found this connection to be statistically significant, with a P-value of 0.033.
However, it's important to point out that the genetic correlation between DHA and osteoporosis was weak, suggesting that this relationship might not be heavily influenced by our genes. While these results indicate that DHA levels are a risk factor for osteoporosis, the underlying mechanisms are still unclear, highlighting the need for further research in this area.
Read More
9
DHA-PC benefits osteoporosis treatment
We explored how different forms of docosahexaenoic acid (DHA), particularly DHA-enriched phosphatidylcholine (DHA-PC) and traditional DHA in triglyceride form (DHA-TG), affect obesity-induced osteoporosis. In an experiment with mice that had been induced with osteoporosis, we provided them with DHA-TG and DHA-PC supplements over a 120-day period.
Our findings revealed that DHA-PC significantly improved bone mineral density and biomechanical properties. It also enhanced new bone formation by 55.2% and reduced marrow fat better than DHA-TG. We observed that DHA-PC promoted the differentiation of bone-forming cells while inhibiting fat cell formation, which are both crucial for bone health.
Mechanically, this beneficial effect is linked to the up-regulation of the Wnt/β-catenin signaling pathway in bone marrow stem cells. This pathway plays a vital role in ensuring that these cells become bone-forming cells rather than fat cells. Overall, we see compelling evidence that DHA-PC offers superior effects in combating obesity-related osteoporosis compared to its triglyceride counterpart.
Our findings revealed that DHA-PC significantly improved bone mineral density and biomechanical properties. It also enhanced new bone formation by 55.2% and reduced marrow fat better than DHA-TG. We observed that DHA-PC promoted the differentiation of bone-forming cells while inhibiting fat cell formation, which are both crucial for bone health.
Mechanically, this beneficial effect is linked to the up-regulation of the Wnt/β-catenin signaling pathway in bone marrow stem cells. This pathway plays a vital role in ensuring that these cells become bone-forming cells rather than fat cells. Overall, we see compelling evidence that DHA-PC offers superior effects in combating obesity-related osteoporosis compared to its triglyceride counterpart.
Read More
Most Useful Reviews
7.5
Reduced inflammation benefits
97 people found this helpful
Omega-3s support joint health and osteoporosis prevention. They combat inflammation, mitigate bone loss, and relieve joint pain. Moreover, they help lessen rheumatoid arthritis symptoms and slow the degeneration of articular cartilage in cases of arthrosis.
Read More
7.5
Joint health improvement
Omega-3 fatty acids are beneficial in preventing osteoporosis and maintaining healthy joints. They alleviate pain during flare-ups, combat bone loss, and reduce inflammation. These acids help ease rheumatoid arthritis symptoms and slow the deterioration of articular cartilage in arthrosis.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.7
- All Researches
9
DHA-PC benefits osteoporosis treatment
We explored how different forms of docosahexaenoic acid (DHA), particularly DHA-enriched phosphatidylcholine (DHA-PC) and traditional DHA in triglyceride form (DHA-TG), affect obesity-induced osteoporosis. In an experiment with mice that had been induced with osteoporosis, we provided them with DHA-TG and DHA-PC supplements over a 120-day period.
Our findings revealed that DHA-PC significantly improved bone mineral density and biomechanical properties. It also enhanced new bone formation by 55.2% and reduced marrow fat better than DHA-TG. We observed that DHA-PC promoted the differentiation of bone-forming cells while inhibiting fat cell formation, which are both crucial for bone health.
Mechanically, this beneficial effect is linked to the up-regulation of the Wnt/β-catenin signaling pathway in bone marrow stem cells. This pathway plays a vital role in ensuring that these cells become bone-forming cells rather than fat cells. Overall, we see compelling evidence that DHA-PC offers superior effects in combating obesity-related osteoporosis compared to its triglyceride counterpart.
Our findings revealed that DHA-PC significantly improved bone mineral density and biomechanical properties. It also enhanced new bone formation by 55.2% and reduced marrow fat better than DHA-TG. We observed that DHA-PC promoted the differentiation of bone-forming cells while inhibiting fat cell formation, which are both crucial for bone health.
Mechanically, this beneficial effect is linked to the up-regulation of the Wnt/β-catenin signaling pathway in bone marrow stem cells. This pathway plays a vital role in ensuring that these cells become bone-forming cells rather than fat cells. Overall, we see compelling evidence that DHA-PC offers superior effects in combating obesity-related osteoporosis compared to its triglyceride counterpart.
Read More
9
DHA enhances bone health effectively
We conducted a study investigating the effects of docosahexaenoic acid (DHA) on osteoporosis, specifically looking at how different molecular forms of DHA could affect bone health. Using ovariectomized mice, which are a common model for studying osteoporosis, we analyzed the potential of DHA in promoting the transformation of chondrocytes—cells found in cartilage—into bone-forming cells called osteoblasts.
Over 13 weeks, the mice were given oral doses of DHA in three different forms: triglycerides, phosphatidylcholine, and ethyl esters. Our findings revealed that both the DHA-triglyceride (DHA-TG) and DHA-phosphatidylcholine (DHA-PC) significantly improved bone mineral density and increased the growth plate height by boosting the number of hypertrophic chondrocytes. In contrast, DHA-ethyl esters showed little to no effect.
Further investigation showed that DHA-PC and DHA-TG facilitated the transformation of chondrocytes to osteoblasts even better than our initial expectations, with DHA-PC performing notably well. Additionally, we observed that these forms of DHA helped prevent chondrocyte apoptosis, meaning they supported cell survival rather than triggering cell death. This points to a dual role of DHA in not just enhancing bone formation but also in protecting the cells responsible for that formation.
To sum it up, our research indicates that the benefits of DHA for bone health significantly depend on its molecular structure. This work opens the door for further studies into how fish oil, rich in DHA, could be a valuable nutritional intervention for improving bone density and combating osteoporosis.
Over 13 weeks, the mice were given oral doses of DHA in three different forms: triglycerides, phosphatidylcholine, and ethyl esters. Our findings revealed that both the DHA-triglyceride (DHA-TG) and DHA-phosphatidylcholine (DHA-PC) significantly improved bone mineral density and increased the growth plate height by boosting the number of hypertrophic chondrocytes. In contrast, DHA-ethyl esters showed little to no effect.
Further investigation showed that DHA-PC and DHA-TG facilitated the transformation of chondrocytes to osteoblasts even better than our initial expectations, with DHA-PC performing notably well. Additionally, we observed that these forms of DHA helped prevent chondrocyte apoptosis, meaning they supported cell survival rather than triggering cell death. This points to a dual role of DHA in not just enhancing bone formation but also in protecting the cells responsible for that formation.
To sum it up, our research indicates that the benefits of DHA for bone health significantly depend on its molecular structure. This work opens the door for further studies into how fish oil, rich in DHA, could be a valuable nutritional intervention for improving bone density and combating osteoporosis.
Read More
9
DHA's role in osteoporosis treatment
We recently looked into how docosahexaenoic acid (DHA), through its enriched phosphatidylcholine form (DHA-PC), affects osteoporosis. Using a model that simulates the condition in women after ovariectomy, we compared the impact of DHA-PC with eicosapentaenoic acid (EPA) enriched phosphatidylcholine (EPA-PC). Our findings revealed that both DHA-PC and EPA-PC significantly improved the structural quality of trabecular bone, boosted the rate of new bone formation, and elevated bone mineral density, which are crucial factors in combating osteoporosis.
We also discovered that both compounds worked to regulate bone formation by down-regulating the overactive Wnt/β-catenin signaling pathway, which is key to osteogenesis. This means that rather than allowing excessive bone growth, DHA-PC and EPA-PC help bring osteogenesis back to normal levels. Thus, our results suggest that incorporating DHA and EPA phosphatidylcholine could potentially serve as a beneficial strategy in osteoporosis management, highlighting their promising role in health and nutrition.
Overall, this study offers valuable insights into the anti-osteoporotic effects of DHA-PC and EPA-PC and supports their further exploration as functional foods in our diets.
We also discovered that both compounds worked to regulate bone formation by down-regulating the overactive Wnt/β-catenin signaling pathway, which is key to osteogenesis. This means that rather than allowing excessive bone growth, DHA-PC and EPA-PC help bring osteogenesis back to normal levels. Thus, our results suggest that incorporating DHA and EPA phosphatidylcholine could potentially serve as a beneficial strategy in osteoporosis management, highlighting their promising role in health and nutrition.
Overall, this study offers valuable insights into the anti-osteoporotic effects of DHA-PC and EPA-PC and supports their further exploration as functional foods in our diets.
Read More
9
Docosahexaenoic acid benefits bone health
We set out to understand how docosahexaenoic acid (DHA), a type of omega-3 unsaturated fatty acid, influences bone health, particularly in the context of osteoporosis. Research indicates that DHA interacts with a receptor called FFAR4, which is present in bone cells and may help regulate the balance between bone resorption and formation.
Our findings showed that DHA effectively inhibits the differentiation of osteoclasts, which are the cells responsible for bone resorption. This action appears to require the FFAR4/β-arrestin 2 signaling pathway. Additionally, we observed that DHA, along with other unsaturated fatty acids, promotes the activity of osteoblasts, the cells that help build bone.
Overall, our study suggests that DHA is beneficial for bone health, potentially offering protective effects against conditions like osteoporosis by regulating both osteoclasts and osteoblasts.
Our findings showed that DHA effectively inhibits the differentiation of osteoclasts, which are the cells responsible for bone resorption. This action appears to require the FFAR4/β-arrestin 2 signaling pathway. Additionally, we observed that DHA, along with other unsaturated fatty acids, promotes the activity of osteoblasts, the cells that help build bone.
Overall, our study suggests that DHA is beneficial for bone health, potentially offering protective effects against conditions like osteoporosis by regulating both osteoclasts and osteoblasts.
Read More
9
We began our exploration by examining how docosahexaenoic acid (DHA), commonly found in fish oil, influences osteoporosis, particularly in ovariectomised (OVX) rats. This study revealed that DHA plays a crucial role in maintaining bone health by inhibiting the formation of osteoclasts, which are the cells responsible for bone loss. We noted significant interaction effects when DHA was combined with soy isoflavones, further enhancing its beneficial impact on bone integrity.
Our investigation did not stop at cell models; we extended our research by including animal studies, specifically using OVX rats and various mouse models. After feeding these subjects green kiwifruit for several weeks, we observed a reduction in the rate of bone loss. Notably, we discovered that kiwifruit consumption lowered levels of important markers linked to bone degradation, such as C-telopeptide of Type 1 collagen and RANKL expression. In addition, our human studies indicated promising effects, with menopausal women experiencing improved blood lipids and positive changes in bone health markers after consuming kiwifruit.
Overall, our findings suggest that DHA, particularly in combination with other natural components like those found in kiwifruit, can play a significant role in supporting bone health. This research highlights the potential benefits of incorporating these nutrients into our diets to combat osteoporosis effectively.
Our investigation did not stop at cell models; we extended our research by including animal studies, specifically using OVX rats and various mouse models. After feeding these subjects green kiwifruit for several weeks, we observed a reduction in the rate of bone loss. Notably, we discovered that kiwifruit consumption lowered levels of important markers linked to bone degradation, such as C-telopeptide of Type 1 collagen and RANKL expression. In addition, our human studies indicated promising effects, with menopausal women experiencing improved blood lipids and positive changes in bone health markers after consuming kiwifruit.
Overall, our findings suggest that DHA, particularly in combination with other natural components like those found in kiwifruit, can play a significant role in supporting bone health. This research highlights the potential benefits of incorporating these nutrients into our diets to combat osteoporosis effectively.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Reduced inflammation benefits
97 people found this helpful
Omega-3s support joint health and osteoporosis prevention. They combat inflammation, mitigate bone loss, and relieve joint pain. Moreover, they help lessen rheumatoid arthritis symptoms and slow the degeneration of articular cartilage in cases of arthrosis.
Read More
7.5
Joint health improvement
Omega-3 fatty acids are beneficial in preventing osteoporosis and maintaining healthy joints. They alleviate pain during flare-ups, combat bone loss, and reduce inflammation. These acids help ease rheumatoid arthritis symptoms and slow the deterioration of articular cartilage in arthrosis.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Li L, Wen Y, Liu D, Lan JP, Yang B. Causal link between docosahexaenoic acid and osteoporosis: A 2-sample Mendelian randomization study. Medicine (Baltimore). 2024;103:e38893. 10.1097/MD.0000000000038893
- Yue H, Bo Y, Tian Y, Mao L, Xue C, et al. Docosahexaenoic Acid-Enriched Phosphatidylcholine Exerted Superior Effects to Triglyceride in Ameliorating Obesity-Induced Osteoporosis through Up-Regulating the Wnt/β-Catenin Pathway. J Agric Food Chem. 2022;70:13904. 10.1021/acs.jafc.2c06081
- Cifuentes-Mendiola SE, Moreno-Fierros L, González-Alva P, García-Hernández AL. Docosahexaenoic acid improves altered mineralization proteins, the decreased quality of hydroxyapatite crystals and suppresses oxidative stress induced by high glucose. Exp Ther Med. 2022;23:235. 10.3892/etm.2022.11160
- Dou Y, Wang Y, Chen Z, Yu X, Ma D. Effect of n-3 polyunsaturated fatty acid on bone health: A systematic review and meta-analysis of randomized controlled trials. Food Sci Nutr. 2022;10:145. 10.1002/fsn3.2655
- Zhang T, Tian Y, Wang Q, Fu M, Xue C, et al. Comparative Study of DHA with Different Molecular Forms for Ameliorating Osteoporosis by Promoting Chondrocyte-to-Osteoblast Transdifferentiation in the Growth Plate of Ovariectomized Mice. J Agric Food Chem. 2021;69:10562. 10.1021/acs.jafc.1c03228
- Fang-Jie W, Ting W, Fang-Mei L, Chuan-Xiang Z, Shao L. [Study on anti-osteoporosis effect of Eucommiae Cortex based on GC-MS metabonomics]. Zhongguo Zhong Yao Za Zhi. 2020;45:5555. 10.19540/j.cnki.cjcmm.20200624.202
- Fu M, Tian Y, Zhang T, Zhan Q, Zhang L, et al. Comparative study of DHA-enriched phosphatidylcholine and EPA-enriched phosphatidylcholine on ameliorating high bone turnover regulation of the osteogenesis-related Wnt/β-catenin pathway in ovariectomized mice. Food Funct. 2020;11:10094. 10.1039/d0fo01563f
- Abou-Saleh H, Ouhtit A, Halade GV, Rahman MM. Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content. Nutrients. 2019;11. 10.3390/nu11112701
- Kasonga AE, Kruger MC, Coetzee M. Free fatty acid receptor 4-β-arrestin 2 pathway mediates the effects of different classes of unsaturated fatty acids in osteoclasts and osteoblasts. Biochim Biophys Acta Mol Cell Biol Lipids. 2019;1864:281. 10.1016/j.bbalip.2018.12.009
- Lavado-García J, Roncero-Martin R, Moran JM, Pedrera-Canal M, Aliaga I, et al. Long-chain omega-3 polyunsaturated fatty acid dietary intake is positively associated with bone mineral density in normal and osteopenic Spanish women. PLoS One. 2018;13:e0190539. 10.1371/journal.pone.0190539
- Kim HJ, Ohk B, Yoon HJ, Kang WY, Seong SJ, et al. Docosahexaenoic acid signaling attenuates the proliferation and differentiation of bone marrow-derived osteoclast precursors and promotes apoptosis in mature osteoclasts. Cell Signal. 2017;29:226. 10.1016/j.cellsig.2016.11.007
- Kruger MC, Tousen Y, Katsumata S, Tadaishi M, Kasonga AE, et al. Effects of Soy Phytoestrogens and New Zealand Functional Foods on Bone Health. J Nutr Sci Vitaminol (Tokyo). 2015;61 Suppl:S142. 10.3177/jnsv.61.S142
- Dong H, Hutchins-Wiese H, Kleppinger A, Annis K, Liva E, et al. Effects of Omega-3 Polyunsaturated Fatty Acid Supplementation on Bone Turnover in Older Women. Int J Vitam Nutr Res. 2014;84:124. 10.1024/0300-9831/a000199
- Erfanian A, Mirhosseini H, Rasti B, Hair-Bejo M, Bin Mustafa S, et al. Absorption and Bioavailability of Nano-Size Reduced Calcium Citrate Fortified Milk Powder in Ovariectomized and Ovariectomized-Osteoporosis Rats. J Agric Food Chem. 2015;63:5795. 10.1021/acs.jafc.5b01468
- Akiyama M, Nakahama K, Morita I. Impact of docosahexaenoic acid on gene expression during osteoclastogenesis in vitro--a comprehensive analysis. Nutrients. 2013;5:3151. 10.3390/nu5083151
- Das UN. Is there a role for essential fatty acids in osteoporosis?. Eur J Clin Nutr. 2024;78:659. 10.1038/s41430-024-01456-2
- Wang Z, Wu J, Li L, Wang K, Wu X, et al. Eicosapentaenoic acid supplementation modulates the osteoblast/osteoclast balance in inflammatory environments and protects against estrogen deficiency-induced bone loss in mice. Clin Nutr. 2023;42:1715. 10.1016/j.clnu.2023.07.022
- Longo AB, Ward WE. Providing Flaxseed Oil but Not Menhaden Oil Protects against OVX Induced Bone Loss in the Mandible of Sprague-Dawley Rats. Nutrients. 2016;8. 10.3390/nu8100597
- Jørgensen HS, Eide IA, Hartmann A, Åsberg A, Christensen JH, et al. Plasma n-3 Polyunsaturated Fatty Acids and Bone Mineral Density in Renal Transplant Recipients. J Ren Nutr. 2016;26:196. 10.1053/j.jrn.2015.11.007
- Mirás A, Bóveda MD, Leis MR, Mera A, Aldámiz-Echevarría L, et al. Risk factors for developing mineral bone disease in phenylketonuric patients. Mol Genet Metab. 2013;108:149. 10.1016/j.ymgme.2012.12.008
- Moon HJ, Kim TH, Byun DW, Park Y. Positive correlation between erythrocyte levels of n-3 polyunsaturated fatty acids and bone mass in postmenopausal Korean women with osteoporosis. Ann Nutr Metab. 2012;60:146. 10.1159/000337302
- Lappe J, Kunz I, Bendik I, Prudence K, Weber P, et al. Effect of a combination of genistein, polyunsaturated fatty acids and vitamins D3 and K1 on bone mineral density in postmenopausal women: a randomized, placebo-controlled, double-blind pilot study. Eur J Nutr. 2013;52:203.
- Farina EK, Kiel DP, Roubenoff R, Schaefer EJ, Cupples LA, et al. Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study. Am J Clin Nutr. 2011;93:1142. 10.3945/ajcn.110.005926
- Bonnet N, Ferrari SL. Effects of long-term supplementation with omega-3 fatty acids on longitudinal changes in bone mass and microstructure in mice. J Nutr Biochem. 2011;22:665. 10.1016/j.jnutbio.2010.05.006
- Sun L, Tamaki H, Ishimaru T, Teruya T, Ohta Y, et al. Inhibition of osteoporosis due to restricted food intake by the fish oils DHA and EPA and perilla oil in the rat. Biosci Biotechnol Biochem. 2004;68:2613.
