Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
USERS' SCORE
Good
Based on 7 Reviews
8.5
Supplement Facts
Serving Size: 1 Fish Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Cholesterol
<5 mg
1%
Vitamin D3 (as Cholecalciferol) (from Lanolin)
25 mcg (1,000 IU)
125%
Fish Oil Concentrate
1.2 g (1,200 mg)
†
Omega-3 Fatty Acids:
Eicosapentaenoic Acid (EPA)
600 mg
†
Docosahexaenoic Acid (DHA)
300 mg
†
Top Medical Research Studies
9
We examined how eicosapentaenoic acid (EPA), an omega-3 fatty acid, influences bone health, particularly in conditions like osteoporosis caused by inflammation and estrogen deficiency. Through tests on mouse stem cells and a specific inflammatory environment, we discovered that EPA can enhance the formation of bone-building cells while reducing the activity of bone-resorbing cells.
Additionally, in an ovariectomized mouse model, EPA effectively prevented bone loss, showing promise for tackling postmenopausal osteoporosis. This suggests that dietary supplementation with EPA could be beneficial in managing bone health, although further research is essential to confirm these effects in humans.
Additionally, in an ovariectomized mouse model, EPA effectively prevented bone loss, showing promise for tackling postmenopausal osteoporosis. This suggests that dietary supplementation with EPA could be beneficial in managing bone health, although further research is essential to confirm these effects in humans.
Read More
9
We explored how different types of polyunsaturated fatty acids (PUFAs) affect bone health. Mice with postmenopausal osteoporosis were treated with Antarctic krill oil (rich in omega-3 PUFAs) or arachidonic acid-rich oil (rich in omega-6 PUFAs) over a 120-day period.
Our findings revealed that Antarctic krill oil improved bone density and strength, while arachidonic acid-rich oil worsened these conditions. This study highlights the potential benefits of omega-3 fatty acids for osteoporosis, suggesting that diet can play a crucial role in bone health.
Our findings revealed that Antarctic krill oil improved bone density and strength, while arachidonic acid-rich oil worsened these conditions. This study highlights the potential benefits of omega-3 fatty acids for osteoporosis, suggesting that diet can play a crucial role in bone health.
Read More
9
We delved into how omega-3 fatty acids, particularly from fish oil, impact bone health in aging mice suffering from osteoporosis. Through a study involving several dietary groups, we found that those on a fish oil diet had significant improvements in bone mass and lower levels of marrow adipose tissue compared to controls.
While we noted positive changes in bone density, the hematopoietic bone marrow remained stable across all groups. This suggests that omega-3 fatty acids may help counteract some age-related bone loss by reducing harmful fat tissue in the marrow.
While we noted positive changes in bone density, the hematopoietic bone marrow remained stable across all groups. This suggests that omega-3 fatty acids may help counteract some age-related bone loss by reducing harmful fat tissue in the marrow.
Read More
Most Useful Reviews
9
Joint pain relief
Excellent! Omega-3 fatty acids prevent the development of Osteoporosis, maintain healthy joints, and alleviate pain during exacerbations. They combat bone loss, reduce inflammation, and help mitigate symptoms of rheumatoid arthritis while slowing the destruction of articular cartilage in arthrosis.
Read More
9
Pain reduction
Omega-3 fatty acids help prevent Osteoporosis, maintain healthy joints, and relieve pain during exacerbations. They combat bone loss, reduce inflammation, and alleviate symptoms of rheumatoid arthritis, slowing the destruction of articular cartilage in arthrosis.
Read More
9
Inflammation reduction
It has been proven that fish oil prevents the development of Osteoporosis. EPA and DHA in fish oil block cellular processes associated with bone loss and reduce inflammation. Daily Omega-3 intake alleviates joint pain and serves as a vital source of vitamin D, essential for treating Osteoporosis.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
- All Researches
9
We examined how eicosapentaenoic acid (EPA), an omega-3 fatty acid, influences bone health, particularly in conditions like osteoporosis caused by inflammation and estrogen deficiency. Through tests on mouse stem cells and a specific inflammatory environment, we discovered that EPA can enhance the formation of bone-building cells while reducing the activity of bone-resorbing cells.
Additionally, in an ovariectomized mouse model, EPA effectively prevented bone loss, showing promise for tackling postmenopausal osteoporosis. This suggests that dietary supplementation with EPA could be beneficial in managing bone health, although further research is essential to confirm these effects in humans.
Additionally, in an ovariectomized mouse model, EPA effectively prevented bone loss, showing promise for tackling postmenopausal osteoporosis. This suggests that dietary supplementation with EPA could be beneficial in managing bone health, although further research is essential to confirm these effects in humans.
Read More
9
Omega-3 benefits in osteoporosis treatment
We explored the effects of different forms of omega-3 fish oil on obesity-induced osteoporosis in mice. The study showed that DHA-enriched phosphatidylcholine (DHA-PC) had superior benefits compared to traditional DHA triglyceride (DHA-TG).
Over 120 days, DHA-PC significantly improved bone mineral density and increased new bone formation while reducing bone marrow fat more effectively than DHA-TG. This indicates that DHA-PC not only supports bone health but also encourages beneficial cell differentiation in the treatment of osteoporosis.
Over 120 days, DHA-PC significantly improved bone mineral density and increased new bone formation while reducing bone marrow fat more effectively than DHA-TG. This indicates that DHA-PC not only supports bone health but also encourages beneficial cell differentiation in the treatment of osteoporosis.
Read More
9
We explored how different types of polyunsaturated fatty acids (PUFAs) affect bone health. Mice with postmenopausal osteoporosis were treated with Antarctic krill oil (rich in omega-3 PUFAs) or arachidonic acid-rich oil (rich in omega-6 PUFAs) over a 120-day period.
Our findings revealed that Antarctic krill oil improved bone density and strength, while arachidonic acid-rich oil worsened these conditions. This study highlights the potential benefits of omega-3 fatty acids for osteoporosis, suggesting that diet can play a crucial role in bone health.
Our findings revealed that Antarctic krill oil improved bone density and strength, while arachidonic acid-rich oil worsened these conditions. This study highlights the potential benefits of omega-3 fatty acids for osteoporosis, suggesting that diet can play a crucial role in bone health.
Read More
9
We delved into how omega-3 fatty acids, particularly from fish oil, impact bone health in aging mice suffering from osteoporosis. Through a study involving several dietary groups, we found that those on a fish oil diet had significant improvements in bone mass and lower levels of marrow adipose tissue compared to controls.
While we noted positive changes in bone density, the hematopoietic bone marrow remained stable across all groups. This suggests that omega-3 fatty acids may help counteract some age-related bone loss by reducing harmful fat tissue in the marrow.
While we noted positive changes in bone density, the hematopoietic bone marrow remained stable across all groups. This suggests that omega-3 fatty acids may help counteract some age-related bone loss by reducing harmful fat tissue in the marrow.
Read More
8
We examined how omega-3 polyunsaturated fatty acids (PUFA) could counteract bone loss caused by stress and depression in a study involving rats.
The research showed that providing omega-3 PUFA throughout an animal's life improved bone mass and structure while reducing stress hormones linked to bone loss.
Interestingly, while omega-3 PUFA helped the brain's response to stress, it had limited effects during the early developmental stages. Overall, these results suggest that a consistent supply of omega-3 can offer significant benefits for bone health in the context of chronic stress.
The research showed that providing omega-3 PUFA throughout an animal's life improved bone mass and structure while reducing stress hormones linked to bone loss.
Interestingly, while omega-3 PUFA helped the brain's response to stress, it had limited effects during the early developmental stages. Overall, these results suggest that a consistent supply of omega-3 can offer significant benefits for bone health in the context of chronic stress.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Joint pain relief
Excellent! Omega-3 fatty acids prevent the development of Osteoporosis, maintain healthy joints, and alleviate pain during exacerbations. They combat bone loss, reduce inflammation, and help mitigate symptoms of rheumatoid arthritis while slowing the destruction of articular cartilage in arthrosis.
Read More
9
Pain reduction
Omega-3 fatty acids help prevent Osteoporosis, maintain healthy joints, and relieve pain during exacerbations. They combat bone loss, reduce inflammation, and alleviate symptoms of rheumatoid arthritis, slowing the destruction of articular cartilage in arthrosis.
Read More
9
Inflammation reduction
It has been proven that fish oil prevents the development of Osteoporosis. EPA and DHA in fish oil block cellular processes associated with bone loss and reduce inflammation. Daily Omega-3 intake alleviates joint pain and serves as a vital source of vitamin D, essential for treating Osteoporosis.
Read More
9
Joint mobility improvement
Fish oil has been shown to prevent Osteoporosis. The EPA and DHA in it block processes that lead to bone loss and inflammation. Daily intake of Omega-3 fatty acids alleviates joint pain and maintains vitamin D levels, crucial for calcium metabolism and the development and prevention of Osteoporosis.
Read More
9
Prevents rickets
Omega-3 acids help remove excess "bad" cholesterol from blood vessels, preventing cholesterol plaques. Vitamin D, included in this formulation, aids calcium and phosphorus absorption, important for preventing Osteoporosis. In children, it prevents rickets, while in adults, it protects against Osteoporosis and aids fracture healing.
Read More
Frequently Asked Questions
7.5
Strengthens bones
The NOW Foods Ultra Omega 3-D formula maintains bone health and enhances heart function. Omega-3 fatty acids provide essential benefits, including reducing the risk of Osteoporosis by improving calcium absorption. They relieve joint pain, improve mobility, and support overall health.
7.5
Family health boost
Omega-3s support joint health and prevent Osteoporosis while fatty acids reduce inflammation and bone loss. They alleviate joint pain, help with rheumatoid arthritis symptoms, and slow the deterioration of articular cartilage. My family takes one capsule daily, and it’s been great!
9
Inflammation reduction
It has been proven that fish oil prevents the development of Osteoporosis. EPA and DHA in fish oil block cellular processes associated with bone loss and reduce inflammation. Daily Omega-3 intake alleviates joint pain and serves as a vital source of vitamin D, essential for treating Osteoporosis.
9
Joint mobility improvement
Fish oil has been shown to prevent Osteoporosis. The EPA and DHA in it block processes that lead to bone loss and inflammation. Daily intake of Omega-3 fatty acids alleviates joint pain and maintains vitamin D levels, crucial for calcium metabolism and the development and prevention of Osteoporosis.
9
Joint pain relief
Excellent! Omega-3 fatty acids prevent the development of Osteoporosis, maintain healthy joints, and alleviate pain during exacerbations. They combat bone loss, reduce inflammation, and help mitigate symptoms of rheumatoid arthritis while slowing the destruction of articular cartilage in arthrosis.
9
Pain reduction
Omega-3 fatty acids help prevent Osteoporosis, maintain healthy joints, and relieve pain during exacerbations. They combat bone loss, reduce inflammation, and alleviate symptoms of rheumatoid arthritis, slowing the destruction of articular cartilage in arthrosis.
9
Prevents rickets
Omega-3 acids help remove excess "bad" cholesterol from blood vessels, preventing cholesterol plaques. Vitamin D, included in this formulation, aids calcium and phosphorus absorption, important for preventing Osteoporosis. In children, it prevents rickets, while in adults, it protects against Osteoporosis and aids fracture healing.
9
We examined how eicosapentaenoic acid (EPA), an omega-3 fatty acid, influences bone health, particularly in conditions like osteoporosis caused by inflammation and estrogen deficiency. Through tests on mouse stem cells and a specific inflammatory environment, we discovered that EPA can enhance the formation of bone-building cells while reducing the activity of bone-resorbing cells.
Additionally, in an ovariectomized mouse model, EPA effectively prevented bone loss, showing promise for tackling postmenopausal osteoporosis. This suggests that dietary supplementation with EPA could be beneficial in managing bone health, although further research is essential to confirm these effects in humans.
Additionally, in an ovariectomized mouse model, EPA effectively prevented bone loss, showing promise for tackling postmenopausal osteoporosis. This suggests that dietary supplementation with EPA could be beneficial in managing bone health, although further research is essential to confirm these effects in humans.
8
Omega-3 effects on osteoporosis investigated
We explored how DHA and EPA, two types of omega-3 fatty acids, impact osteoporosis in mice. In our study, both DHA-enriched and EPA-enriched phosphatidylcholine improved the structure of bones and boosted bone density. These compounds also seemed to help by regulating the Wnt/β-catenin pathway, which is involved in bone formation.
While the results are promising in animal models, we note that further research is needed to fully understand their potential benefits for treating osteoporosis in humans.
While the results are promising in animal models, we note that further research is needed to fully understand their potential benefits for treating osteoporosis in humans.
8
We explored how regular fish oil supplement use might influence fracture risks in a large group of over 492,000 participants. After following individuals for about 8 years, we found that those who took fish oil regularly had a lower risk of both new and recurring fractures.
This effect was especially significant for people with a higher genetic risk for fractures. Although fish oil seems to offer some protection, we should note that not everyone experienced the same benefits.
This effect was especially significant for people with a higher genetic risk for fractures. Although fish oil seems to offer some protection, we should note that not everyone experienced the same benefits.
7
Looking into the impact of omega-3 fatty acids on osteoporosis, we found that the right balance of these healthy fats may benefit bone density in postmenopausal women.
While the overall link was not strong, women with a lower ratio of omega-6 to omega-3 showed better results in bone mineral density.
Specifically, higher levels of omega-3 fatty acids were connected to decreased bone loss, suggesting that these nutrients could play a helpful role in maintaining bone health.
While the overall link was not strong, women with a lower ratio of omega-6 to omega-3 showed better results in bone mineral density.
Specifically, higher levels of omega-3 fatty acids were connected to decreased bone loss, suggesting that these nutrients could play a helpful role in maintaining bone health.
7
We systematically reviewed the effects of omega-3 fatty acids on bone turnover markers in postmenopausal women by analyzing data from randomized controlled trials.
While we found that omega-3 supplementation led to a decrease in serum osteocalcin, which is a marker associated with bone turnover, other markers like bone-specific alkaline phosphatase and collagen type I C-telopeptide showed no significant changes.
This indicates a potential benefit, but further well-designed studies are needed to understand the effects on overall bone health and density.
While we found that omega-3 supplementation led to a decrease in serum osteocalcin, which is a marker associated with bone turnover, other markers like bone-specific alkaline phosphatase and collagen type I C-telopeptide showed no significant changes.
This indicates a potential benefit, but further well-designed studies are needed to understand the effects on overall bone health and density.
References
- Del Brutto OH, Mera RM, Rumbea DA, Arias EE, Guzmán EJ, et al. On the association between dietary oily fish intake and bone mineral density in frequent fish consumers of Amerindian ancestry. The three villages study. Arch Osteoporos. 2024;19:31. doi:10.1007/s11657-024-01391-6
- Wang Z, Wu J, Li L, Wang K, Wu X, et al. Eicosapentaenoic acid supplementation modulates the osteoblast/osteoclast balance in inflammatory environments and protects against estrogen deficiency-induced bone loss in mice. Clin Nutr. 2023;42:1715. doi:10.1016/j.clnu.2023.07.022
- Yue H, Bo Y, Tian Y, Mao L, Xue C, et al. Docosahexaenoic Acid-Enriched Phosphatidylcholine Exerted Superior Effects to Triglyceride in Ameliorating Obesity-Induced Osteoporosis through Up-Regulating the Wnt/β-Catenin Pathway. J Agric Food Chem. 2022;70:13904. doi:10.1021/acs.jafc.2c06081
- Feehan O, Magee PJ, Pourshahidi LK, Armstrong DJ, Slevin MM, et al. Associations of long chain polyunsaturated fatty acids with bone mineral density and bone turnover in postmenopausal women. Eur J Nutr. 2023;62:95. doi:10.1007/s00394-022-02933-9
- Choi JE, Hong Y, Heo J, Park Y. N-3 PUFA ameliorated bone loss induced by postmenopausal depression following exposure to chronic mild stress and maternal separation by regulating neuronal processes. J Nutr Biochem. 2022;100:108909. doi:10.1016/j.jnutbio.2021.108909
- Zhang T, Tian Y, Wang Q, Fu M, Xue C, et al. Comparative Study of DHA with Different Molecular Forms for Ameliorating Osteoporosis by Promoting Chondrocyte-to-Osteoblast Transdifferentiation in the Growth Plate of Ovariectomized Mice. J Agric Food Chem. 2021;69:10562. doi:10.1021/acs.jafc.1c03228
- Mei Z, Chen GC, Hu J, Lin C, Sun Z, et al. Habitual use of fish oil supplements, genetic predisposition, and risk of fractures: a large population-based study. Am J Clin Nutr. 2021;114:945. doi:10.1093/ajcn/nqab157
- Fu M, Tian Y, Zhang T, Zhan Q, Zhang L, et al. Comparative study of DHA-enriched phosphatidylcholine and EPA-enriched phosphatidylcholine on ameliorating high bone turnover regulation of the osteogenesis-related Wnt/β-catenin pathway in ovariectomized mice. Food Funct. 2020;11:10094. doi:10.1039/d0fo01563f
- Zhan Q, Tian Y, Han L, Wang K, Wang J, et al. The opposite effects of Antarctic krill oil and arachidonic acid-rich oil on bone resorption in ovariectomized mice. Food Funct. 2020;11:7048. doi:10.1039/d0fo00884b
- Abou-Saleh H, Ouhtit A, Halade GV, Rahman MM. Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content. Nutrients. 2019;11. doi:10.3390/nu11112701
- Bani Hassan E, Alderghaffar M, Wauquier F, Coxam V, Demontiero O, et al. The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis. Aging (Albany NY). 2019;11:7938. doi:10.18632/aging.102299
- Shen D, Zhang X, Li Z, Bai H, Chen L. Effects of omega-3 fatty acids on bone turnover markers in postmenopausal women: systematic review and meta-analysis. Climacteric. 2017;20:522. doi:10.1080/13697137.2017.1384952
- Longo AB, Ward WE. Providing Flaxseed Oil but Not Menhaden Oil Protects against OVX Induced Bone Loss in the Mandible of Sprague-Dawley Rats. Nutrients. 2016;8. doi:10.3390/nu8100597
- Jørgensen HS, Eide IA, Hartmann A, Åsberg A, Christensen JH, et al. Plasma n-3 Polyunsaturated Fatty Acids and Bone Mineral Density in Renal Transplant Recipients. J Ren Nutr. 2016;26:196. doi:10.1053/j.jrn.2015.11.007
- Chen TY, Zhang ZM, Zheng XC, Wang L, Huang MJ, et al. Endogenous n-3 polyunsaturated fatty acids (PUFAs) mitigate ovariectomy-induced bone loss by attenuating bone marrow adipogenesis in FAT1 transgenic mice. Drug Des Devel Ther. 2013;7:545. doi:10.2147/DDDT.S45263
- Casado-Díaz A, Santiago-Mora R, Dorado G, Quesada-Gómez JM. The omega-6 arachidonic fatty acid, but not the omega-3 fatty acids, inhibits osteoblastogenesis and induces adipogenesis of human mesenchymal stem cells: potential implication in osteoporosis. Osteoporos Int. 2013;24:1647. doi:10.1007/s00198-012-2138-z
