Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8
USERS' SCORE
Good
Based on 10 Reviews
8.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Rutin Powder (non-citrus source)(Sophora japonica) (Flower Bud)
450 mg
*
Top Medical Research Studies
9
We examined the various health benefits of leaf extract, particularly its potential against cancer. The research revealed that the ethanol extract is rich in beneficial compounds like rutin and demonstrated significant antioxidant activities.
Notably, it selectively inhibited the growth of specific cancer cells while sparing normal cells. Additionally, treatment led to improved survival in tumor-bearing mice, showcasing its possible life-prolonging properties.
Overall, our findings suggest that this leaf extract could be a promising natural source for antioxidant and anticancer support.
Notably, it selectively inhibited the growth of specific cancer cells while sparing normal cells. Additionally, treatment led to improved survival in tumor-bearing mice, showcasing its possible life-prolonging properties.
Overall, our findings suggest that this leaf extract could be a promising natural source for antioxidant and anticancer support.
Read More
9
We prepared and evaluated rutin-loaded solid-lipid nanoparticles (Ru-SLNs) aimed at targeting melanoma cells. The nanoparticles were made using an ultrasonication technique and underwent a thorough evaluation for characteristics such as size, stability, and drug release.
Our results showed that the optimized Ru-SLNs had a high effectiveness against melanoma cells, proving to be 15 times more effective than standard treatments. Furthermore, the gel formulation demonstrated better skin retention, allowing a sustained release of rutin. Overall, Ru-SLNs gel appears to be a promising approach in targeting melanoma effectively.
Our results showed that the optimized Ru-SLNs had a high effectiveness against melanoma cells, proving to be 15 times more effective than standard treatments. Furthermore, the gel formulation demonstrated better skin retention, allowing a sustained release of rutin. Overall, Ru-SLNs gel appears to be a promising approach in targeting melanoma effectively.
Read More
8
We delved into how Troxerutin influences lung adenocarcinoma (LUAD) by targeting a specific gene, EGLN3, linked to cancer cell behavior. By examining several datasets and employing advanced data analysis techniques, we identified 26 sialylation-related genes tied to patient outcomes.
Our findings revealed that Troxerutin significantly inhibits EGLN3 expression, which is crucial for reducing LUAD cell growth, migration, and invasion. This study suggests that Troxerutin may offer a promising strategy for LUAD treatment, enhancing patient survival and immune response.
Our findings revealed that Troxerutin significantly inhibits EGLN3 expression, which is crucial for reducing LUAD cell growth, migration, and invasion. This study suggests that Troxerutin may offer a promising strategy for LUAD treatment, enhancing patient survival and immune response.
Read More
Most Useful Reviews
9
Cat cancer improvement
150 people found this helpful
Absolutely helped my cat! He has liver cancer and developed severe ascites. Despite being on Lasix, he wasn't improving. After three weeks on Rutin, his fluid levels started to diminish. Recent X-rays showed no fluid in his lungs and minimal in his abdomen. This has saved his life, at least for now, making him more comfortable.
Read More
9
Pain relief without side effects
11 people found this helpful
As an arthritis sufferer, I needed a source of pain relief without unacceptable side effects due to a cancer medication I’m taking. I found that Rutin combined with Bromelain provided excellent relief from arthritic pain with no side effects. I take one capsule of each, and within twenty minutes, my pain disappears. This combination works far better than either one alone, so I keep both in my medicine cabinet.
Read More
9
Reduces cancer risk
The element reduces the risk of developing cancer cells, particularly effective against blood and breast cancer. It also alleviates eye pressure. Rutin is a powerful ingredient that guarantees a reduction in intraocular pressure to a safe level.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8
- All Researches
9
We examined the various health benefits of leaf extract, particularly its potential against cancer. The research revealed that the ethanol extract is rich in beneficial compounds like rutin and demonstrated significant antioxidant activities.
Notably, it selectively inhibited the growth of specific cancer cells while sparing normal cells. Additionally, treatment led to improved survival in tumor-bearing mice, showcasing its possible life-prolonging properties.
Overall, our findings suggest that this leaf extract could be a promising natural source for antioxidant and anticancer support.
Notably, it selectively inhibited the growth of specific cancer cells while sparing normal cells. Additionally, treatment led to improved survival in tumor-bearing mice, showcasing its possible life-prolonging properties.
Overall, our findings suggest that this leaf extract could be a promising natural source for antioxidant and anticancer support.
Read More
9
We prepared and evaluated rutin-loaded solid-lipid nanoparticles (Ru-SLNs) aimed at targeting melanoma cells. The nanoparticles were made using an ultrasonication technique and underwent a thorough evaluation for characteristics such as size, stability, and drug release.
Our results showed that the optimized Ru-SLNs had a high effectiveness against melanoma cells, proving to be 15 times more effective than standard treatments. Furthermore, the gel formulation demonstrated better skin retention, allowing a sustained release of rutin. Overall, Ru-SLNs gel appears to be a promising approach in targeting melanoma effectively.
Our results showed that the optimized Ru-SLNs had a high effectiveness against melanoma cells, proving to be 15 times more effective than standard treatments. Furthermore, the gel formulation demonstrated better skin retention, allowing a sustained release of rutin. Overall, Ru-SLNs gel appears to be a promising approach in targeting melanoma effectively.
Read More
8
Rutin may protect against toxicity
We aimed to explore how rutin, a natural flavonoid, could protect against the harmful effects of the cancer treatment paclitaxel in mice. Our research showed that while paclitaxel increased damaging substances in the body, rutin significantly lowered these levels and helped reverse some of the toxic effects.
By activating certain protective pathways, rutin reduced cell death in vital organs. The results suggest that rutin might be a helpful addition to chemotherapy, potentially reducing the negative side effects of treatments like paclitaxel.
By activating certain protective pathways, rutin reduced cell death in vital organs. The results suggest that rutin might be a helpful addition to chemotherapy, potentially reducing the negative side effects of treatments like paclitaxel.
Read More
8
We examined how flavonoids, particularly rutin, could help in treating cancer by understanding their mechanisms. Using advanced techniques like network pharmacology and molecular simulations, we identified important cancer-related proteins and pathways affected by these compounds.
Notably, rutin showed strong binding to specific proteins, hinting at its promising anticancer effects. Although these findings are encouraging, we must undertake more experimental studies to establish their true potential in clinical settings, especially in line with Traditional Chinese Medicine practices.
Notably, rutin showed strong binding to specific proteins, hinting at its promising anticancer effects. Although these findings are encouraging, we must undertake more experimental studies to establish their true potential in clinical settings, especially in line with Traditional Chinese Medicine practices.
Read More
8
We delved into how Troxerutin influences lung adenocarcinoma (LUAD) by targeting a specific gene, EGLN3, linked to cancer cell behavior. By examining several datasets and employing advanced data analysis techniques, we identified 26 sialylation-related genes tied to patient outcomes.
Our findings revealed that Troxerutin significantly inhibits EGLN3 expression, which is crucial for reducing LUAD cell growth, migration, and invasion. This study suggests that Troxerutin may offer a promising strategy for LUAD treatment, enhancing patient survival and immune response.
Our findings revealed that Troxerutin significantly inhibits EGLN3 expression, which is crucial for reducing LUAD cell growth, migration, and invasion. This study suggests that Troxerutin may offer a promising strategy for LUAD treatment, enhancing patient survival and immune response.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cat cancer improvement
150 people found this helpful
Absolutely helped my cat! He has liver cancer and developed severe ascites. Despite being on Lasix, he wasn't improving. After three weeks on Rutin, his fluid levels started to diminish. Recent X-rays showed no fluid in his lungs and minimal in his abdomen. This has saved his life, at least for now, making him more comfortable.
Read More
9
Pain relief without side effects
11 people found this helpful
As an arthritis sufferer, I needed a source of pain relief without unacceptable side effects due to a cancer medication I’m taking. I found that Rutin combined with Bromelain provided excellent relief from arthritic pain with no side effects. I take one capsule of each, and within twenty minutes, my pain disappears. This combination works far better than either one alone, so I keep both in my medicine cabinet.
Read More
9
Reduces cancer risk
The element reduces the risk of developing cancer cells, particularly effective against blood and breast cancer. It also alleviates eye pressure. Rutin is a powerful ingredient that guarantees a reduction in intraocular pressure to a safe level.
Read More
9
Prevents multiple cancers
Sulforaphane is effective against stomach, bladder, and breast cancer, and possesses antibacterial properties. It induces self-destruction of tumours and lowers estrogen levels, making it beneficial for women, especially during the latter part of their cycle. For maximum sulforaphane content, broccoli should be prepared by chopping and resting before cooking.
Read More
6
Supports cancer treatment
7 people found this helpful
Rutin, or vitamin P, is a bioflavonoid found in buckwheat bran, citrus fruits, figs, tea, and apple peel. It helps lower cholesterol, reduce blood pressure, and maintain capillary strength. Additionally, it promotes collagen production and aids vitamin C absorption. Known to combat cancer, it also alleviates arthritis.
Read More
Frequently Asked Questions
6
Supports cancer treatment
7 people found this helpful
Rutin, or vitamin P, is a bioflavonoid found in buckwheat bran, citrus fruits, figs, tea, and apple peel. It helps lower cholesterol, reduce blood pressure, and maintain capillary strength. Additionally, it promotes collagen production and aids vitamin C absorption. Known to combat cancer, it also alleviates arthritis.
9
Reduces cancer risk
The element reduces the risk of developing cancer cells, particularly effective against blood and breast cancer. It also alleviates eye pressure. Rutin is a powerful ingredient that guarantees a reduction in intraocular pressure to a safe level.
9
Prevents multiple cancers
Sulforaphane is effective against stomach, bladder, and breast cancer, and possesses antibacterial properties. It induces self-destruction of tumours and lowers estrogen levels, making it beneficial for women, especially during the latter part of their cycle. For maximum sulforaphane content, broccoli should be prepared by chopping and resting before cooking.
7.5
Improves cancer outlook
4 people found this helpful
Rutin enhances kidney function and heart health, prevents cancer, combats senility, boosts endurance, and treats osteoporosis. I take the prescribed dosage of 450 mg once a week with apples, preferably with pectin, without any side effects.
7.5
Anti-cancer properties noted
I take rutin combined with vitamin C to support my blood vessels and veins. It acts as an antioxidant, protecting cells and demonstrating anti-inflammatory and anti-cancer properties!
8
We examined how flavonoids, particularly rutin, could help in treating cancer by understanding their mechanisms. Using advanced techniques like network pharmacology and molecular simulations, we identified important cancer-related proteins and pathways affected by these compounds.
Notably, rutin showed strong binding to specific proteins, hinting at its promising anticancer effects. Although these findings are encouraging, we must undertake more experimental studies to establish their true potential in clinical settings, especially in line with Traditional Chinese Medicine practices.
Notably, rutin showed strong binding to specific proteins, hinting at its promising anticancer effects. Although these findings are encouraging, we must undertake more experimental studies to establish their true potential in clinical settings, especially in line with Traditional Chinese Medicine practices.
8
Rutin may protect against toxicity
We aimed to explore how rutin, a natural flavonoid, could protect against the harmful effects of the cancer treatment paclitaxel in mice. Our research showed that while paclitaxel increased damaging substances in the body, rutin significantly lowered these levels and helped reverse some of the toxic effects.
By activating certain protective pathways, rutin reduced cell death in vital organs. The results suggest that rutin might be a helpful addition to chemotherapy, potentially reducing the negative side effects of treatments like paclitaxel.
By activating certain protective pathways, rutin reduced cell death in vital organs. The results suggest that rutin might be a helpful addition to chemotherapy, potentially reducing the negative side effects of treatments like paclitaxel.
8
We evaluated how rutin, a plant-based flavonoid, and sodium butyrate, a fatty acid, work together against metastatic castration-resistant prostate cancer (mCRPC) cells. Our study involved treating PC-3 cells with varying doses of both compounds.
The results showed that the combination significantly lowered cell viability and boosted apoptosis compared to when each was used alone. We saw an increase in reactive oxygen species and observed notable changes in cell and nuclear shape.
This synergy emphasizes the potential of combining natural and conventional treatments, suggesting a promising direction for future cancer therapies.
The results showed that the combination significantly lowered cell viability and boosted apoptosis compared to when each was used alone. We saw an increase in reactive oxygen species and observed notable changes in cell and nuclear shape.
This synergy emphasizes the potential of combining natural and conventional treatments, suggesting a promising direction for future cancer therapies.
8
We set out to understand how rutin might help treat triple-negative breast cancer (TNBC) using a combination of network pharmacology and lab experiments.
By predicting potential targets for rutin and analyzing them with various databases, we created a visual network to describe its interaction with cancer-related targets.
Our experiments showed that rutin significantly inhibited the growth of TNBC cells, triggering cell death and lowering important growth factor expressions.
While our findings are promising, they serve as a theoretical foundation rather than definitive proof of rutin's effectiveness in cancer treatment.
By predicting potential targets for rutin and analyzing them with various databases, we created a visual network to describe its interaction with cancer-related targets.
Our experiments showed that rutin significantly inhibited the growth of TNBC cells, triggering cell death and lowering important growth factor expressions.
While our findings are promising, they serve as a theoretical foundation rather than definitive proof of rutin's effectiveness in cancer treatment.
9
We prepared and evaluated rutin-loaded solid-lipid nanoparticles (Ru-SLNs) aimed at targeting melanoma cells. The nanoparticles were made using an ultrasonication technique and underwent a thorough evaluation for characteristics such as size, stability, and drug release.
Our results showed that the optimized Ru-SLNs had a high effectiveness against melanoma cells, proving to be 15 times more effective than standard treatments. Furthermore, the gel formulation demonstrated better skin retention, allowing a sustained release of rutin. Overall, Ru-SLNs gel appears to be a promising approach in targeting melanoma effectively.
Our results showed that the optimized Ru-SLNs had a high effectiveness against melanoma cells, proving to be 15 times more effective than standard treatments. Furthermore, the gel formulation demonstrated better skin retention, allowing a sustained release of rutin. Overall, Ru-SLNs gel appears to be a promising approach in targeting melanoma effectively.
References
- Sut S, Dall'Acqua S, Flores GA, Cusumano G, Koyuncu İ, et al. and as Health Promoting Nutraceuticals: Assessing Their Role Combining In Vitro In Silico and Chemical Approaches. Food Sci Nutr. 2025;13:e70053. doi:10.1002/fsn3.70053
- Biswas S, Mondal M, Pakhira S, Ghosh R, Samanta P, et al. Attenuation of paclitaxel-induced toxicities by polyphenolic natural compound rutin through inhibition of apoptosis and activation of NRF2/ARE signaling pathways. Food Chem Toxicol. 2025;200:115408. doi:10.1016/j.fct.2025.115408
- Guo Z, Dong G, Liu X, Chen L, Yang H, et al. Unraveling the mechanisms of antitumor action of flavonoids via network pharmacology and molecular simulation. In Silico Pharmacol. 2025;13:48. doi:10.1007/s40203-025-00338-0
- Wu Y, Ge Y, Gan J, Jin Y, Cui Y, et al. Mechanism of action for Troxerutin targeting the sialylation-related gene EGLN3 for the treatment of LUAD. Sci Rep. 2025;15:9298. doi:10.1038/s41598-025-92028-2
- El-Gendi H, Albrahim JS, Alenezi H, El-Fakharany EM, El-Maradny YA, et al. Bioactive bacterial cellulose/chitosan/sodium alginate composite film functionalized with Moringa oleifera seed extract: Antimicrobial, anticancer, and molecular docking studies. Int J Biol Macromol. 2025;307:141958. doi:10.1016/j.ijbiomac.2025.141958
- Alimudin J, Betts Z, Ozkan AD. Natural Compounds and Histone Deacetylase Inhibitors: A Combined Approach Against mCRPC Cells. Biomedicines. 2025;13. doi:10.3390/biomedicines13020296
- Loarca-Piña G, Manríquez-Núñez J, Ramos-Gómez M, Recio I, Sánchez-Quezada V. Oral-gastric digestion effect of emulsion-type ingredient of avocado seed and cytotoxic potential in gastric cancer cell. Food Res Int. 2025;202:115705. doi:10.1016/j.foodres.2025.115705
- Gamal NK, El-Naga RN, Ayoub IM, George MY. Neuromodulatory effect of troxerutin against doxorubicin and cyclophosphamide-induced cognitive impairment in rats: Potential crosstalk between gut-brain and NLRP3 inflammasome axes. Int Immunopharmacol. 2025;149:114216. doi:10.1016/j.intimp.2025.114216
- Saeed S, Hassan AF, Suliman A, Moustafa AA, Alali F. Methanolic Leaves Extract of Inhibits Cell Proliferation and Migration of HER2-Positive Breast Cancer via p38 MAPK Signaling Pathway. Int J Mol Sci. 2025;26. doi:10.3390/ijms26020654
- Al-Samydai A, Al Qaraleh M, Al-Halaseh LK, Abu Hajleh MN, Carradori S, et al. Optimized Rutin-incorporating PEGylated Nanoliposomes as a Model with Remarkable Selectivity Against PANC1 and MCF7 Cell Lines. Anticancer Agents Med Chem. 2025. doi:10.2174/0118715206231749241209073759
- Chang C, Jia R, Fang B, Miao Y, Zhang L. Network pharmacological analysis and testing of the rutin effects on triple-negative breast cancer. Open Med (Wars). 2025;20:20241079. doi:10.1515/med-2024-1079
- Yoon WJ, Min HJ, Cho HD, Kim HG, Park WL, et al. Bioactivity Evaluation and Phytochemical Characterization of (Thunb.) Siebold Leaf Extract. Biomedicines. 2024;12. doi:10.3390/biomedicines12122928
- Dabaghkar Y, Eghlima G, Behboudi H, Ebrahimi M, Ghorbanpour M. Agro-morphological characterization and assessment of metabolic profiling and anticancer activities in various tribulus (Tribulus terrestris L.) populations. BMC Plant Biol. 2025;25:20. doi:10.1186/s12870-024-06021-4
- Modanwal S, Mishra A, Mishra N. Exploration of rutin derivatives as potential inhibitors of prostate cancer signaling pathways: A comprehensive in-silico study. Biochem Biophys Res Commun. 2025;746:151279. doi:10.1016/j.bbrc.2024.151279
- Dewangan HK, Shah K, Vadaga AK, Veer M, Alam P. Optimisation and evaluation of long circulating Ru-SLNs carrier for targeting melanoma cells. J Microencapsul. 2025;42:107. doi:10.1080/02652048.2024.2443436
- Tikent A, Laaraj S, Bouddine T, Chebaibi M, Bouhrim M, et al. Antioxidant potential, antimicrobial activity, polyphenol profile analysis, and cytotoxicity against breast cancer cell lines of hydro-ethanolic extracts of leaves of ( L.) from Eastern Morocco. Front Chem. 2024;12:1505473. doi:10.3389/fchem.2024.1505473
