5/28/2025
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 27 Researches
8.3
USERS' SCORE
Good
Based on 82 Reviews
8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Selenium (elemental) (from 20 mg L-Selenomethionine)
100 mcg
182%
Top Medical Research Studies
9.5
We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
8
We explored how selenium, a trace element, can play a role in preventing and treating lung cancer. This review focused on various forms of selenium, including sodium selenite, methylselenic acid, selenomethionine, and selenium nanoparticles.
We observed that these compounds could exert a cytotoxic effect on lung cancer cells, which is crucial for developing new therapies. Additionally, we discussed recent advancements in lung cancer nanomedicine that utilize selenium-based nanoparticles and nanocomposites, assessing their potential to form effective anti-cancer drugs.
Moreover, we studied selenoproteins' roles and the signaling pathways they affect in lung cancer progression or inhibition. Overall, this review provides valuable insights into how selenium and its related compounds might impact lung cancer therapy, while also highlighting the need for further research to realize their full potential in treatment and prevention strategies.
We observed that these compounds could exert a cytotoxic effect on lung cancer cells, which is crucial for developing new therapies. Additionally, we discussed recent advancements in lung cancer nanomedicine that utilize selenium-based nanoparticles and nanocomposites, assessing their potential to form effective anti-cancer drugs.
Moreover, we studied selenoproteins' roles and the signaling pathways they affect in lung cancer progression or inhibition. Overall, this review provides valuable insights into how selenium and its related compounds might impact lung cancer therapy, while also highlighting the need for further research to realize their full potential in treatment and prevention strategies.
9
We aimed to understand the impact of selenium-enriched Akkermansia muciniphila (Se-AM) on colon cancer, specifically looking at its effectiveness in treating tumors in mice. By enriching the probiotics with inorganic selenium, we prepared Se-AM and evaluated its performance against colon cancer cells using a mouse model.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
Most Useful Reviews
9
Anti-cancer properties
214 people found this helpful
Selenium is recognised for its potent anti-cancer properties and is effective in preventing various diseases. Its roles in DNA repair and enhancing immune functions, along with antioxidant benefits, imply selenium's significant role in cancer prevention. Studies indicate that a daily intake of 200 mcg can notably lower the risk of colorectal, prostate, and lung cancers while reducing overall cancer-related mortality.
10
Inhibits cancer effects
13 people found this helpful
My mother has lung adenocarcinoma. I learned that selenium supplementation can inhibit cell mutation, block nutrient supply to cancer cells, prevent cell division, and activate natural killer cells around the tumour. The dosage I have is sufficient for daily needs, but moderation is essential.
9
Reduces cancer risk
11 people found this helpful
Antioxidant selenium is essential! Who wants to get sick and age quickly? I recommend daily intake; it's excellent for health as it has anti-inflammatory, anti-atherosclerotic, and anti-tumour effects. It promotes hair growth and helps mitigate environmental damage. This element can reduce cancer incidence by 40% and cancer mortality by 50%. Cancer research confirms that selenium is a powerful immunostimulatory agent with a wide array of health benefits.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 27 Researches
8.3
- All Researches
9.5
We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
9.5
We investigated the impact of selenium nanoparticles (SeNPs) on enhancing treatment for advanced non-small-cell lung cancer (NSCLC). Our research revealed that selenium deficiency is linked to immune dysfunction in patients, contributing to cancer progression. In experiments with mice, low selenium led to weakened immunity and faster tumor growth.
Importantly, we found that SeNPs can improve the effectiveness of chemotherapy drugs by promoting the immune response. A clinical trial showed striking results with an 83.3% response rate and 100% disease control with SeNPs in combination with standard treatments. Thus, selenium is shown to significantly support cancer therapy.
Importantly, we found that SeNPs can improve the effectiveness of chemotherapy drugs by promoting the immune response. A clinical trial showed striking results with an 83.3% response rate and 100% disease control with SeNPs in combination with standard treatments. Thus, selenium is shown to significantly support cancer therapy.
9
We aimed to understand the impact of selenium-enriched Akkermansia muciniphila (Se-AM) on colon cancer, specifically looking at its effectiveness in treating tumors in mice. By enriching the probiotics with inorganic selenium, we prepared Se-AM and evaluated its performance against colon cancer cells using a mouse model.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
9
Selenium nanoparticles show cancer potential
We focused on the potential of selenium nanoparticles (SeNPs) derived from the medicinal plant Indigofera aspalathoides in treating cancer, particularly its hepatoprotective capabilities. In our exploration, we utilized an ethanolic extract of the plant to green-synthesize SeNPs and then characterized them using several analytical techniques.
The particle sizes were found to be between 50-80 nm, ensuring they are both stable and effective for biological interactions. We evaluated their antioxidant activity and cytotoxic effects, particularly on breast cancer (MCF-7) and liver cancer (HepG2) cell lines. The SeNPs exhibited impressive antioxidant properties, with a DPPH scavenging rate of 70.32% and hydroxyl radical scavenging at 73.68%.
Notably, we discovered that the SeNPs provided significant protection to liver cells at a concentration of 88 μg/mL, maintaining 100% cell viability. However, we also identified that higher selenium concentrations could lead to cytotoxicity. Our findings highlight selenium nanoparticles as promising candidates for addressing oxidative stress and liver-related disorders while offering potential benefits in cancer treatment.
The particle sizes were found to be between 50-80 nm, ensuring they are both stable and effective for biological interactions. We evaluated their antioxidant activity and cytotoxic effects, particularly on breast cancer (MCF-7) and liver cancer (HepG2) cell lines. The SeNPs exhibited impressive antioxidant properties, with a DPPH scavenging rate of 70.32% and hydroxyl radical scavenging at 73.68%.
Notably, we discovered that the SeNPs provided significant protection to liver cells at a concentration of 88 μg/mL, maintaining 100% cell viability. However, we also identified that higher selenium concentrations could lead to cytotoxicity. Our findings highlight selenium nanoparticles as promising candidates for addressing oxidative stress and liver-related disorders while offering potential benefits in cancer treatment.
9
We synthesized thirty selenium-containing coumarin derivatives and tested their effectiveness against various malignant tumor cell lines. Notably, one compound, referred to as 11i, showed remarkable potency against SK-N-SH neuroblastoma cells, with a low inhibitory concentration of just 2.5 μM.
Our experiments demonstrated that compound 11i significantly inhibited not only cell proliferation but also migration and invasion. Through several analyses, we observed an increase in the Bax/Bcl-2 protein expression ratio, which is a marker for apoptosis, alongside the release of Cytochrome C from the mitochondria. This process triggered apoptosis via the mitochondria-mediated pathway, effectively inducing cell death in neuroblastoma.
Moreover, we noted that the compound localized within the cytoplasm and interacted closely with mitochondria, suggesting it may disrupt normal mitochondrial functions. Computational docking studies supported these findings, showing that compound 11i bound strongly to Bcl-2 and mitochondrial G-quadruplexes.
In in vivo studies, using a mouse model of neuroblastoma, compound 11i exhibited impressive anti-tumor effects, achieving tumor inhibition rates of 79% and 93% at doses of 10 and 20 mg/kg, respectively. These results indicate the potential of selenium-containing coumarin derivatives as promising candidates for developing new treatments against neuroblastoma.
Our experiments demonstrated that compound 11i significantly inhibited not only cell proliferation but also migration and invasion. Through several analyses, we observed an increase in the Bax/Bcl-2 protein expression ratio, which is a marker for apoptosis, alongside the release of Cytochrome C from the mitochondria. This process triggered apoptosis via the mitochondria-mediated pathway, effectively inducing cell death in neuroblastoma.
Moreover, we noted that the compound localized within the cytoplasm and interacted closely with mitochondria, suggesting it may disrupt normal mitochondrial functions. Computational docking studies supported these findings, showing that compound 11i bound strongly to Bcl-2 and mitochondrial G-quadruplexes.
In in vivo studies, using a mouse model of neuroblastoma, compound 11i exhibited impressive anti-tumor effects, achieving tumor inhibition rates of 79% and 93% at doses of 10 and 20 mg/kg, respectively. These results indicate the potential of selenium-containing coumarin derivatives as promising candidates for developing new treatments against neuroblastoma.
User Reviews
USERS' SCORE
Good
Based on 82 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Anti-cancer properties
214 people found this helpful
Selenium is recognised for its potent anti-cancer properties and is effective in preventing various diseases. Its roles in DNA repair and enhancing immune functions, along with antioxidant benefits, imply selenium's significant role in cancer prevention. Studies indicate that a daily intake of 200 mcg can notably lower the risk of colorectal, prostate, and lung cancers while reducing overall cancer-related mortality.
10
Inhibits cancer effects
13 people found this helpful
My mother has lung adenocarcinoma. I learned that selenium supplementation can inhibit cell mutation, block nutrient supply to cancer cells, prevent cell division, and activate natural killer cells around the tumour. The dosage I have is sufficient for daily needs, but moderation is essential.
9
Reduces cancer risk
11 people found this helpful
Antioxidant selenium is essential! Who wants to get sick and age quickly? I recommend daily intake; it's excellent for health as it has anti-inflammatory, anti-atherosclerotic, and anti-tumour effects. It promotes hair growth and helps mitigate environmental damage. This element can reduce cancer incidence by 40% and cancer mortality by 50%. Cancer research confirms that selenium is a powerful immunostimulatory agent with a wide array of health benefits.
9
Cleanses body effectively
7 people found this helpful
Selenium fights cancer and detoxifies the body. Originally bought for my hair due to its beneficial properties for hair health, I read that it’s excellent for athletes and can help diminish the risk of strokes.
9
Supports cancer diet
3 people found this helpful
Great product with fast shipping. My 17-year-old Chihuahua was diagnosed with Mast Cell Cancer—Stage 1-2. This product is an integral part of her cancer diet, and the latest blood work showed significantly improved numbers. I highly recommend this product.
Frequently Asked Questions
9
Improved immunity
1 people found this helpful
This is excellent for anticancer! I have been taking it for immunity improvement against cancer for five years.
9
Aids in detoxification
10 people found this helpful
I bought selenium for liver detoxification. After starting to take it, I felt better almost immediately! I use it primarily for cancer prevention due to its strong antioxidant power. It is often taken alongside vitamin E to maximise its antioxidant effects.
9
Supports male fertility
53 people found this helpful
Excellent organic selenium! A daily intake of 70-150mcg not only helps prevent cancer but also slows aging. It has alleviated my discomfort and improved my well-being significantly. Highly recommended, especially for male reproductive health!
9
Prevents cancer growth
1 people found this helpful
Selenium, though required in small amounts, is vital. One tablet daily can help synthesize antioxidants that protect cells from free radicals and may prevent cancer cell growth. It also boosts immune responses. For those with cancer symptoms, it’s beneficial to take more frequently.
9
Cancer breakthrough
24 people found this helpful
Selenium is described as an irreplaceable trace element capable of reducing cancer incidence by almost 40% and cancer mortality by 50%. Renowned cardiologist Dr. Atkins hailed this discovery as one of medicine's greatest breakthroughs. It also strengthens the body's defence against viruses, which is especially pertinent during the cold season. My combination of selenium, vitamin E, and C promotes their antioxidant activity effectively.
10
Inhibits cancer effects
13 people found this helpful
My mother has lung adenocarcinoma. I learned that selenium supplementation can inhibit cell mutation, block nutrient supply to cancer cells, prevent cell division, and activate natural killer cells around the tumour. The dosage I have is sufficient for daily needs, but moderation is essential.
7.5
Strengthens immune system
43 people found this helpful
Selenium must be taken alongside iodine; they complement each other perfectly. It reduces cancer risk, protects against DNA damage, and boosts immune function. I take it in courses three times a year for its myriad benefits.
9
Powerful antioxidant
1 people found this helpful
Selenium is a robust antioxidant and works synergistically with vitamin E and iodine. It's effective as an anti-cancer agent and can prevent a myriad of diseases. In conjunction with coenzyme Q10, it decreases mortality in chronic heart failure patients. Selenium also helps stimulate tissue proliferation and enhances the functionality of the gonads, heart, thyroid, and immune system, proving its critical health benefits.
9
Anti-cancer properties
214 people found this helpful
Selenium is recognised for its potent anti-cancer properties and is effective in preventing various diseases. Its roles in DNA repair and enhancing immune functions, along with antioxidant benefits, imply selenium's significant role in cancer prevention. Studies indicate that a daily intake of 200 mcg can notably lower the risk of colorectal, prostate, and lung cancers while reducing overall cancer-related mortality.
9
We aimed to understand the impact of selenium-enriched Akkermansia muciniphila (Se-AM) on colon cancer, specifically looking at its effectiveness in treating tumors in mice. By enriching the probiotics with inorganic selenium, we prepared Se-AM and evaluated its performance against colon cancer cells using a mouse model.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
9
Selenium nanoparticles show cancer potential
We focused on the potential of selenium nanoparticles (SeNPs) derived from the medicinal plant Indigofera aspalathoides in treating cancer, particularly its hepatoprotective capabilities. In our exploration, we utilized an ethanolic extract of the plant to green-synthesize SeNPs and then characterized them using several analytical techniques.
The particle sizes were found to be between 50-80 nm, ensuring they are both stable and effective for biological interactions. We evaluated their antioxidant activity and cytotoxic effects, particularly on breast cancer (MCF-7) and liver cancer (HepG2) cell lines. The SeNPs exhibited impressive antioxidant properties, with a DPPH scavenging rate of 70.32% and hydroxyl radical scavenging at 73.68%.
Notably, we discovered that the SeNPs provided significant protection to liver cells at a concentration of 88 μg/mL, maintaining 100% cell viability. However, we also identified that higher selenium concentrations could lead to cytotoxicity. Our findings highlight selenium nanoparticles as promising candidates for addressing oxidative stress and liver-related disorders while offering potential benefits in cancer treatment.
The particle sizes were found to be between 50-80 nm, ensuring they are both stable and effective for biological interactions. We evaluated their antioxidant activity and cytotoxic effects, particularly on breast cancer (MCF-7) and liver cancer (HepG2) cell lines. The SeNPs exhibited impressive antioxidant properties, with a DPPH scavenging rate of 70.32% and hydroxyl radical scavenging at 73.68%.
Notably, we discovered that the SeNPs provided significant protection to liver cells at a concentration of 88 μg/mL, maintaining 100% cell viability. However, we also identified that higher selenium concentrations could lead to cytotoxicity. Our findings highlight selenium nanoparticles as promising candidates for addressing oxidative stress and liver-related disorders while offering potential benefits in cancer treatment.
7
We investigated the potential of selenium nanoparticles, specifically those derived from Spirulina platensis, as a treatment for cancer. The study focused on understanding how these nanoparticles might impact cancer cells, which is an important area of research given selenium's reputation for health benefits.
Through our evaluation, we discovered that these selenium nanoparticles were effective in reducing the viability of certain cancer cell lines, including breast adenocarcinoma (MCF-7) and ovarian cancer (SKOV-3). At a concentration of 100 µg/ml, we saw a decrease in cell viability by 17.6% and 14.9%, respectively. This suggests that Spirulina-derived selenium could offer a pathway for developing new cancer treatments, although more research is needed to understand the full scope of its effects.
Besides their cancer-fighting potential, these selenium nanoparticles demonstrated a range of additional beneficial properties, such as antibacterial, antioxidant, and anti-inflammatory effects. This multifaceted effectiveness could make them valuable in various therapeutic contexts, not just for cancer.
Through our evaluation, we discovered that these selenium nanoparticles were effective in reducing the viability of certain cancer cell lines, including breast adenocarcinoma (MCF-7) and ovarian cancer (SKOV-3). At a concentration of 100 µg/ml, we saw a decrease in cell viability by 17.6% and 14.9%, respectively. This suggests that Spirulina-derived selenium could offer a pathway for developing new cancer treatments, although more research is needed to understand the full scope of its effects.
Besides their cancer-fighting potential, these selenium nanoparticles demonstrated a range of additional beneficial properties, such as antibacterial, antioxidant, and anti-inflammatory effects. This multifaceted effectiveness could make them valuable in various therapeutic contexts, not just for cancer.
8
We explored the effects of selenium, specifically in the form of methylselenocysteine (MSC), on two human anaplastic thyroid carcinoma (ATC) cell lines. Our primary focus was to see how MSC impacts cell viability, migration, and the critical energy process known as glycolysis. By treating the cancer cells with MSC, we assessed changes using various tests that measure cell health and movement, as well as key biochemical markers associated with energy production.
What we found was quite promising; MSC significantly inhibited the growth and mobility of these cancer cells. Notably, it appeared to do so through a mechanism involving the ERK1/2 signaling pathway. This means that as we increased the concentration of MSC, we noticed a decrease in an active form of the ERK1/2 protein, which is linked to cell proliferation and movement. Interestingly, the levels of related proteins in other pathways (JNK and p38) did not show changes, indicating a more specific action of MSC in this context.
Moreover, we observed that when the cells were stimulated with epidermal growth factor, which typically promotes growth and migration, it compromised the beneficial effects of MSC. This highlights the complexity of interactions within cancer biology. Overall, our study suggests that selenium, through MSC, may offer a new approach in the treatment of anaplastic thyroid carcinoma, potentially paving the way for novel therapies.
What we found was quite promising; MSC significantly inhibited the growth and mobility of these cancer cells. Notably, it appeared to do so through a mechanism involving the ERK1/2 signaling pathway. This means that as we increased the concentration of MSC, we noticed a decrease in an active form of the ERK1/2 protein, which is linked to cell proliferation and movement. Interestingly, the levels of related proteins in other pathways (JNK and p38) did not show changes, indicating a more specific action of MSC in this context.
Moreover, we observed that when the cells were stimulated with epidermal growth factor, which typically promotes growth and migration, it compromised the beneficial effects of MSC. This highlights the complexity of interactions within cancer biology. Overall, our study suggests that selenium, through MSC, may offer a new approach in the treatment of anaplastic thyroid carcinoma, potentially paving the way for novel therapies.
9
Exploring selenium's cancer treatment potential
We explored a fascinating approach to improve cancer treatment through a unique combination of selenium and probiotics. The study focused on a special type of probiotic called Bifidobacterium longum, which was combined with selenium nanoparticles to create a powerful tool for fighting tumors.
The resulting product, BL@SeNPs, has been shown to selectively target the hypoxic areas of tumors—regions often tough for treatments to penetrate. Once attached to tumor cells, these selenium nanoparticles help stop their growth while boosting the generation of reactive oxygen species. This increased activity damages the cancer cells’ DNA, leading to enhanced effects of radiotherapy and potentially kicking off the body’s immune response against the tumor.
Moreover, recombinant selenium not only helps with the direct attack on cancer but also plays a role in reactivating immune cells, such as dendritic cells. This process further strengthens the body’s defenses by reducing the number of immunosuppressive cells within tumor environments, allowing for a more effective overall treatment.
Overall, this innovative study sheds light on the potential of using selenium alongside probiotics to improve the outcomes of cancer therapies. Its findings suggest that there is a promising role for these combined therapies in clinical settings, advancing our ability to tackle cancer effectively.
The resulting product, BL@SeNPs, has been shown to selectively target the hypoxic areas of tumors—regions often tough for treatments to penetrate. Once attached to tumor cells, these selenium nanoparticles help stop their growth while boosting the generation of reactive oxygen species. This increased activity damages the cancer cells’ DNA, leading to enhanced effects of radiotherapy and potentially kicking off the body’s immune response against the tumor.
Moreover, recombinant selenium not only helps with the direct attack on cancer but also plays a role in reactivating immune cells, such as dendritic cells. This process further strengthens the body’s defenses by reducing the number of immunosuppressive cells within tumor environments, allowing for a more effective overall treatment.
Overall, this innovative study sheds light on the potential of using selenium alongside probiotics to improve the outcomes of cancer therapies. Its findings suggest that there is a promising role for these combined therapies in clinical settings, advancing our ability to tackle cancer effectively.
References
- Li X, Rui W, Shu P, Sun Y, Yang J. Efficacy Evaluation of Selenium-enriched Akkermansia muciniphila in the Treatment of Colon Tumor Mice. Probiotics Antimicrob Proteins. 2025. 10.1007/s12602-025-10500-x
- Raman S, Kasirajan S, Chinnapandi B, Karthikeyan K, Pandian A, et al. Luminescent Biogenic Selenium Nanoparticles From Indigofera aspalathoides Vahl ex DC: A Novel Hepatoprotective Strategy for Enhancing Live Health. Luminescence. 2025;40:e70101. 10.1002/bio.70101
- Janakiram NB, Mohammed A, Ravillah D, Choi CI, Zhang Y, et al. [Corrigendum] Chemopreventive effects of PBI‑Se, a selenium‑containing analog of PBIT, on AOM‑induced aberrant crypt foci in F344 rats. Oncol Rep. 2025;53. 10.3892/or.2025.8877
- Varlamova EG. Selenium-containing compounds, selenium nanoparticles and selenoproteins in the prevention and treatment of lung cancer. J Trace Elem Med Biol. 2025;88:127620. 10.1016/j.jtemb.2025.127620
- Qin X, Guo J, Li H, He H, Cai F, et al. Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy. Adv Sci (Weinh). 2025. 10.1002/advs.202412062
- Yu YH, Kouame KJE, Liu X, Yu X, Jin MY, et al. Preparation, characterization, and induced human colon cancer HCT-116 and HT-29 cell apoptosis performance of selenium nanoparticles stabilized by longan polysaccharides. Int J Biol Macromol. 2025. 10.1016/j.ijbiomac.2025.140719
- Yassein AS, Elamary RB, Alwaleed EA. Biogenesis, characterization, and applications of Spirulina selenium nanoparticles. Microb Cell Fact. 2025;24:39. 10.1186/s12934-025-02656-6
- Guo K, Yang X, Wang J, Chang W, Liu S, et al. Synthesis and Bioactivity of Selenium Nanoparticles From Tussilago farfara L. Polysaccharides: Antioxidant Properties and MCF-7 Cell Inhibition. Chem Biodivers. 2025. 10.1002/cbdv.202402677
- Wang M, Xu H, Xiong X, Chang L, Zhang K, et al. Antiproliferative activity of selenium-enriched coumarin derivatives on the SK-N-SH neuroblastoma cell line: Mechanistic insights. Eur J Med Chem. 2025;286:117322. 10.1016/j.ejmech.2025.117322
- Zakharia Y, Reis RJ, Kroll MR, Rataan AO, Manchkanti S, et al. Phase I Clinical Trial of High Doses of Seleno-L-methionine in Combination with Axitinib in Patients with Previously Treated Metastatic Clear Cell Renal Cell Carcinoma. Clin Cancer Res. 2025. 10.1158/1078-0432.CCR-24-3234
- Yu Y, Wang Y, Zhang J, Bu Q, Jiang D, et al. Anaerobic probiotics-in situ Se nanoradiosensitizers selectively anchor to tumor with immuno-regulations for robust cancer radio-immunotherapy. Biomaterials. 2025;318:123117. 10.1016/j.biomaterials.2025.123117
- Ban B, Yang H, Liu Y, Luo Z. Se-methylselenocysteine Inhibits Migration and Glycolysis in Anaplastic Thyroid Carcinoma Cells via the ERK1/2 Signaling Pathway . Ann Clin Lab Sci. 2024;54:810.
- He L, Zhang L, Peng Y, He Z. Selenium in cancer management: exploring the therapeutic potential. Front Oncol. 2024;14:1490740. 10.3389/fonc.2024.1490740
- Rataan AO, Xu Y, Geary SM, Zakharia Y, Kamel ES, et al. Targeting transforming growth factor-β1 by methylseleninic acid/seleno-L-methionine in clear cell renal cell carcinoma: Mechanisms and therapeutic potential. Cancer Treat Res Commun. 2024;42:100864. 10.1016/j.ctarc.2025.100864
- Ashraf R, Khalid Z, Qin QP, Iqbal MA, Taskin-Tok T, et al. Synthesis of N-heterocyclic carbene‑selenium complexes modulating apoptosis and autophagy in cancer cells: Probing the interactions with biomolecules and enzymes. Bioorg Chem. 2025;160:108435. 10.1016/j.bioorg.2025.108435
- Wei K, Yin X, Chen F, Wang X, Ding W, et al. Synthesis, characterization, and bioactivity of selenium nanoparticles stabilized by regenerated chitin nanofibers. Int J Biol Macromol. 2025. 10.1016/j.ijbiomac.2025.142791
- Hosseinzadeh Ranjbar M, Einafshar E, Javid H, Jafari N, Sajjadi SS, et al. Enhancing the anticancer effects of rosmarinic acid in PC3 and LNCaP prostate cancer cells using titanium oxide and selenium-doped graphene oxide nanoparticles. Sci Rep. 2025;15:11568. 10.1038/s41598-025-96707-y
- Doostan M, Rahmani Azar A, Maleki H. Selenium nanoparticles and paclitaxel co-delivery by a PCL based nanofibrous scaffold to enhance melanoma therapy. J Biomater Appl. 2025. 10.1177/08853282251330724
- Çiğ B. Selenium reduces oxaliplatin induced neuropathic pain: focus on TRPV1. Front Pharmacol. 2025;16:1549190. 10.3389/fphar.2025.1549190
- Xie F, Liu N, Liu X, Feng X, Yang Z, et al. Insights into folic acid functionalization of self-assembled octenyl succinic anhydride starch micelles towards targeted delivery of selenium nanoparticles. Int J Biol Macromol. 2025;308:142352. 10.1016/j.ijbiomac.2025.142352
- Fu G, Tong J. Synthesis of Epimedium extract selenium nanoparticles and evaluation their efficacy against lung cancer. Gen Physiol Biophys. 2025;44:123. 10.4149/gpb_2024046
- Yu Y, Xie B, Wang J, Luo W, Yang M, et al. Translational Selenium Nanoparticles Promotes Clinical Non-small-cell Lung Cancer Chemotherapy via Activating Selenoprotein-driven Immune Manipulation. Adv Mater. 2025. 10.1002/adma.202415818
- Wang Y, Du Z, Du H, Zhao J, Duan Y, et al. Associations between dietary intake of zinc and selenium and breast cancer: findings from a NHANES cross-sectional study. Chin Clin Oncol. 2025;14:2. 10.21037/cco-24-83
- Szwiec M, Tomiczek-Szwiec J, Marciniak W, Derkacz R, Huzarski T, et al. The Effect of Blood Selenium Level on the pCR Rate in Breast Cancer Patient Receiving Neoadjuvant Chemotherapy. Cancers (Basel). 2025;17. 10.3390/cancers17050839
- Wen X, Zhou Q, Lin S, Mai H, Zhang L. Selenium-modified hydroxyapatite titanium coating: enhancing osteogenesis and inhibiting cancer in bone invasion by head and neck squamous cell carcinoma. Front Bioeng Biotechnol. 2025;13:1552661. 10.3389/fbioe.2025.1552661
- Jin X, Tong W, Sun L, Lu S, Sun P, et al. Association of composite dietary antioxidant index with high risk of prostate cancer in middle-aged and elderly men: insights from NHANES. Front Immunol. 2025;16:1530174. 10.3389/fimmu.2025.1530174
- Sun K, Ma L, Hou J, Li Y, Jiang H, et al. Physalis peruviana heteropolysaccharide-conjugated selenium nanoparticles: Preparation, characterization, and promising applications in cancer therapy. Int J Biol Macromol. 2025;306:141639. 10.1016/j.ijbiomac.2025.141639
