Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.6
USERS' SCORE
Good
Based on 292 Reviews
8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Iron (elemental) (from 180 mg Ferrous Bisglycinate)(Ferrochel™)
36 mg
200%

Top Medical Research Studies

We examined how iron treatment specifically impacts anemia, particularly during pregnancy. Iron deficiency is a leading cause of anemia, and finding the right treatment is crucial for both mothers and their developing babies.

Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.

However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
Read More
8
Iron treatment and CKD anemia
We explored the critical relationship between iron treatment and anemia in chronic kidney disease (CKD). Anemia often arises in CKD patients, whether they are on dialysis or not, primarily due to erythropoietin deficiency. However, iron deficiency plays a significant role and can be categorized into absolute, caused by blood loss, or functional, which is affected by inflammation and high levels of hepcidin.

Hepcidin impedes the body’s ability to use iron effectively, trapping it where it's not accessible for red blood cell production. This disruption in iron metabolism also means that oral iron supplements may not work well, especially in advanced CKD. Therefore, we reviewed various intravenous (IV) iron formulations available for treatment and outlined the diagnostic criteria and treatment benchmarks for iron deficiency in CKD patients.

Our findings led us to consider future therapeutic directions to improve patient outcomes. With advancements in the understanding of iron’s role in this context, the hope is to enhance treatment strategies for managing anemia in CKD effectively.
Read More
8
Ferric Carboxymaltose Replaces Iron Sucrose
We aimed to find a better way to manage anemia in pediatric patients undergoing hemodialysis. Traditionally, these patients receive intravenous (IV) iron therapy using iron sucrose, which requires frequent treatments and carries a risk of allergic reactions. Moving forward with a home hemodialysis program, we investigated ferric carboxymaltose as a safer and more effective alternative.

In our study, we looked closely at how ferric carboxymaltose performed in maintaining healthy levels of hemoglobin, transferrin saturation, and reticulocyte hemoglobin content over a 12-month period. We also compared its efficacy against traditional iron sucrose treatments. The results were encouraging, showing that ferric carboxymaltose not only matched the effectiveness of iron sucrose but also required fewer hospital visits, significantly easing the treatment burden on families.

Overall, our findings suggest that ferric carboxymaltose is both clinically effective and cost-efficient. By reducing the frequency of administration, this approach can enhance the quality of life for pediatric patients with anemia due to chronic kidney disease who depend on hemodialysis. We believe this innovation presents a promising shift in anemia management for this vulnerable population.
Read More

Most Useful Reviews

9
Improved hemoglobin
618 people found this helpful
I found this iron supplement incredibly effective during my pregnancy when I suffered from anemia. None of the prescribed medications improved my condition. After researching, I discovered that diglycinate is well absorbed. Within three weeks of taking this supplement, my hemoglobin rose from 96 to 123, and my ferritin levels improved from 40 to nearly 90. Unlike earlier medications, I experienced no gastrointestinal issues. I hope my review helps you!
Read More
9
Positive dynamics
241 people found this helpful
This iron supplement was prescribed by my hematologist and has shown excellent results for my anemia. After a month of use, I noticed positive changes in my condition.
Read More
9
No side effects
161 people found this helpful
This is the optimal iron supplement for those with severe anemia. I experienced no side effects, despite having gastritis, and followed the instructions carefully.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.6
  • All Researches
We examined how iron treatment specifically impacts anemia, particularly during pregnancy. Iron deficiency is a leading cause of anemia, and finding the right treatment is crucial for both mothers and their developing babies.

Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.

However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
Read More
9.5
Identifying and treating hookworm infection
We explored the challenges of diagnosing hookworm infections, particularly in severe cases. By using both morphological and molecular methods, we successfully identified a 75-year-old woman suffering from anemia linked to the hookworm species, Necator americanus. After confirming the infection through various tests, we initiated treatment with albendazole. Following this, we observed a significant improvement in her condition, with both the hookworm and her anemia effectively resolved.
Read More
9
Iron supplementation effects on anemia
We explored the impact of iron and folic acid supplementation on children suffering from mild-to-moderate anemia in India. This study specifically aimed to assess how effective iron treatments are in improving overall hemoglobin levels and reducing anemia symptoms.

The research consisted of controlled trials where groups of children received iron supplements, while others did not. By comparing these groups, we aimed to determine if there was a significant difference in the rates of recovery from anemia.

While we hoped for positive outcomes from the supplementation, the findings showed mixed results. In some cases, we observed improvements in hemoglobin levels, but the overall effectiveness was not as pronounced as anticipated. It's essential to take these findings into account when considering future strategies for combating anemia in children.

Our analysis highlights that while iron supplementation is a crucial piece of the puzzle for treating anemia, it’s also clear that additional factors may play significant roles in achieving optimal health outcomes for affected children.
Read More
9
Serum hepcidin aids anemia diagnosis
We explored the effectiveness of serum hepcidin levels in diagnosing types of anemia in elderly patients, specifically focusing on iron deficiency anemia (IDA) and anemia of chronic disease (ACD). By studying a group of 100 elderly patients alongside 15 healthy controls, we aimed to find a less invasive way to distinguish between these two common conditions.

Through our evaluation, we observed significant differences in iron levels and hepcidin concentrations between patients with IDA and those with ACD. We discovered that serum hepcidin could effectively differentiate between the two types of anemia, boasting a remarkable sensitivity of 93.9% and a specificity of 92.2%. This points to hepcidin as a promising alternative to the traditional bone marrow iron study.

Interestingly, while hepcidin is a valuable marker, relying solely on it can lead to misdiagnoses, similar concerns arise with ferritin levels. Our findings suggest that combining hepcidin with the iron profile provides a more accurate assessment and could potentially replace more invasive diagnostic methods for anemia in the elderly. Overall, we find this combined approach to be a vital step forward in understanding and treating anemia related to iron levels.
Read More
We investigated the combination of Roxadustat, a newer treatment for anemia related to chronic kidney disease (CKD), alongside polysaccharide-iron complex (PIC) in rats. By dividing them into different groups, we observed how various doses of iron impacted hemoglobin levels and kidney function. The results showed that this combination significantly improved hemoglobin levels and kidney health. Importantly, adequate iron supply early on was crucial for effective anemia treatment. Combining these therapies appears beneficial in addressing anemia in CKD effectively.
Read More

User Reviews

USERS' SCORE
Good
Based on 292 Reviews
8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Improved hemoglobin
618 people found this helpful
I found this iron supplement incredibly effective during my pregnancy when I suffered from anemia. None of the prescribed medications improved my condition. After researching, I discovered that diglycinate is well absorbed. Within three weeks of taking this supplement, my hemoglobin rose from 96 to 123, and my ferritin levels improved from 40 to nearly 90. Unlike earlier medications, I experienced no gastrointestinal issues. I hope my review helps you!
Read More
9
Positive dynamics
241 people found this helpful
This iron supplement was prescribed by my hematologist and has shown excellent results for my anemia. After a month of use, I noticed positive changes in my condition.
Read More
9
No side effects
161 people found this helpful
This is the optimal iron supplement for those with severe anemia. I experienced no side effects, despite having gastritis, and followed the instructions carefully.
Read More
9
Ferritin increase
113 people found this helpful
I have been taking this iron for over three years, inspired by Dr. Fujikawa's programme. My ferritin levels were alarmingly low, but after taking one tablet daily with protein, they rose significantly. I plan to continue this regimen.
Read More
9
Anemia during pregnancy
97 people found this helpful
This excellent supplement helped me manage my anemia quickly, with no side effects. I continued taking it during my pregnancy and still use it while breastfeeding, following my nutritionist's guidance.
Read More

Frequently Asked Questions

9
Gentle on stomach
29 people found this helpful
I have struggled with anemia for years but avoided iron supplements due to constipation. However, I tried this one, which is gentle on the stomach and caused no side effects. The day after starting it, I felt an increase in energy, as if a weight had lifted, so I'll continue and check my blood.
9
Positive dynamics
241 people found this helpful
This iron supplement was prescribed by my hematologist and has shown excellent results for my anemia. After a month of use, I noticed positive changes in my condition.
9
Life-changing effects
28 people found this helpful
Although not diagnosed with anemia, I had persistent fatigue and dizziness for a decade. After taking this supplement for two weeks, my condition dramatically improved, restoring my energy. I now take it every two days and am extremely grateful for the change.
9
Significant improvement
20 people found this helpful
I recently discovered I was anemic. I adopted a comprehensive approach to treatment, including B12 and iron with vitamin C for better absorption. After a month of taking this iron supplement, my levels increased significantly, improving my health and energy levels. I highly recommend it.
9
Anemia treatment success
34 people found this helpful
I followed a comprehensive treatment for anemia and raised my hemoglobin by 7 points in two months with supplements. After three months, my ferritin tripled, and my anemia resolved. It's crucial to continue taking iron even after tests improve to prevent future shortages.
8
Health improved
17 people found this helpful
After eight months of using this iron for my deficiency anemia, my levels reached normal limits, allowing me to improve my health and conceive. I experienced no adverse effects from the supplement, especially after eliminating gluten from my diet.
9
Improved hemoglobin
618 people found this helpful
I found this iron supplement incredibly effective during my pregnancy when I suffered from anemia. None of the prescribed medications improved my condition. After researching, I discovered that diglycinate is well absorbed. Within three weeks of taking this supplement, my hemoglobin rose from 96 to 123, and my ferritin levels improved from 40 to nearly 90. Unlike earlier medications, I experienced no gastrointestinal issues. I hope my review helps you!
9
Increased energy
75 people found this helpful
This product saved me! After being diagnosed with anaemia during pregnancy, I struggled with iron supplements. However, since taking this iron, I have so much more energy, and my home is much cleaner. I'm genuinely grateful!
7.5
Symptoms reduced
31 people found this helpful
I experienced lightheadedness and visual disturbances due to anemia for years. Although past supplements did not help, since I began taking this one, those symptoms have subsided. I still feel dizzy occasionally, but I intend to continue the treatment.
9
Ferritin increase
113 people found this helpful
I have been taking this iron for over three years, inspired by Dr. Fujikawa's programme. My ferritin levels were alarmingly low, but after taking one tablet daily with protein, they rose significantly. I plan to continue this regimen.
0
Iron overload warning
39 people found this helpful
When my ferritin rose to 200, I struggled with sleep, indicating iron overload. I believe that while many may start taking iron supplements for anaemia, it can lead to complications in the long run. Excessive iron can be detrimental to health.
We explored the impact of ferric carboxymaltose (FCM) on iron deficiency anemia (IDA) in patients with inflammatory bowel disease (IBD) through a thorough retrospective study involving 41 individuals. We observed that hemoglobin levels significantly increased from 9.8 g/dL to 11.8 g/dL in just 16 weeks after treatment. However, the gains in hemoglobin were similar for patients regardless of inflammation levels. While some adverse effects were recorded, they were relatively rare. Overall, FCM shows promise for treating anemia in IBD with fewer applications needed.
8
Effective iron treatment for anemia
We examined how well low-dose ferric carboxymaltose (FCM) works compared to oral ferrous sulfate for treating anemia in postpartum East Asian women. In a randomized controlled trial, we found that FCM led to a bigger boost in hemoglobin levels after two weeks and improved iron stores at four weeks.

While the overall hemoglobin increase was similar at four weeks, FCM users reported fewer gastrointestinal side effects, like nausea and constipation. This suggests that low-dose FCM could be a better choice for managing postpartum anemia due to its effectiveness and better tolerance.
8
Improved anemia management with iron
We explored how iron treatment impacts functional iron-deficiency anemia (FIDA) in cancer patients undergoing chemotherapy. The study compared darbepoetin alfa alone with its combination with ferric derisomaltose.

We found that those receiving the iron and darbepoetin alfa combination had improved hemoglobin, transferrin saturation, and ferritin levels compared to the monotherapy group.

However, both treatments showed no significant impact on cell death related to chemotherapy drugs. Overall, combining iron with darbepoetin alfa yielded better anemia management for cancer patients.
4
Anaemia treatment's unclear effect
We examined the relationship between iron treatment and improvements in anemia among pregnant women and how these changes might affect the risk of postpartum depression. The study involved 438 pregnant women in Lagos, Nigeria, who were treated for anemia—defined as having a hemoglobin concentration below 11 g/dL—either through intravenous or oral iron supplements.

After four weeks of treatment, participants were reassessed for anemia and iron levels, and their mental health was evaluated using a well-known depression survey two weeks after giving birth. Despite our hopes, we found that while there was a slight non-significant trend suggesting that improvement in anemia was linked to lower risk of postpartum depression, we did not see any notable association with improvements in iron levels.

This suggests that while treating anemia in late pregnancy could potentially lessen the risk of postpartum depression, the evidence remains inconclusive, particularly due to the limitations of our sample size. Our findings highlight the complex relationship between physical health and mental well-being during pregnancy and postpartum periods.
9
Iron supplementation effects on anemia
We explored the impact of iron and folic acid supplementation on children suffering from mild-to-moderate anemia in India. This study specifically aimed to assess how effective iron treatments are in improving overall hemoglobin levels and reducing anemia symptoms.

The research consisted of controlled trials where groups of children received iron supplements, while others did not. By comparing these groups, we aimed to determine if there was a significant difference in the rates of recovery from anemia.

While we hoped for positive outcomes from the supplementation, the findings showed mixed results. In some cases, we observed improvements in hemoglobin levels, but the overall effectiveness was not as pronounced as anticipated. It's essential to take these findings into account when considering future strategies for combating anemia in children.

Our analysis highlights that while iron supplementation is a crucial piece of the puzzle for treating anemia, it’s also clear that additional factors may play significant roles in achieving optimal health outcomes for affected children.

References

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  2. Upadhyay RP, Chowdhury R, Mundra S, Taneja S, Jacob M, et al. Comparative effectiveness of daily therapeutic supplementation with multiple micronutrients and iron-folic acid versus iron-folic acid alone in children with mild-to-moderate anaemia in rural India: an open-label, randomised controlled trial. Lancet Glob Health. 2025;13:e497. doi:10.1016/S2214-109X(24)00559-X
  3. Thomas T, Kurpad A. Childhood iron-folic acid supplementation in India for mild-to-moderate anaemia. Lancet Glob Health. 2025;13:e383. doi:10.1016/S2214-109X(25)00053-1
  4. Babah OA, Beňová L, Larsson EC, Hanson C, Afolabi BB. Is an improvement in anaemia and iron levels associated with the risk of early postpartum depression? A cohort study from Lagos, Nigeria. BMC Public Health. 2025;25:808. doi:10.1186/s12889-025-21942-x
  5. Crispell EH, Cassianni CE, Burt JM, Gonzalez JA, Petsch JL, et al. Design and Staged Implementation of a Multidisciplinary Preoperative Anemia Clinic at a Tertiary Care Medical Center. Anesth Analg. 2025. doi:10.1213/ANE.0000000000007435
  6. Akpan IJ, Narang M, Zampaglione E, Marshall S, Stefanik D. Iron deficiency anemia in patients with heavy menstrual bleeding: The patients' perspective from diagnosis to treatment. Womens Health (Lond). 2025;21:17455057251321221. doi:10.1177/17455057251321221
  7. Khalaf K, Fujiyoshi Y, Bechara R. Endoscopic and clinical characteristics of autoimmune atrophic gastritis: Retrospective study. Endosc Int Open. 2025;13:a24774666. doi:10.1055/a-2477-4666
  8. White F, Polakowski N, Merlington E, Leimanis M, Dudick B, et al. Intravenous Sodium Ferric Gluconate Complex for Hospitalized Pediatric Patients with Iron Deficiency Anemia. Children (Basel). 2025;12. doi:10.3390/children12020189
  9. Maidana D, Arroyo-Álvarez A, Barreres-Martín G, Arenas-Loriente A, Cepas-Guillen P, et al. Targeting Inflammation and Iron Deficiency in Heart Failure: A Focus on Older Adults. Biomedicines. 2025;13. doi:10.3390/biomedicines13020462
  10. McDonnell T, Kalra PA. Iron in Chronic Kidney Disease and End-Stage Kidney Disease-Current Trends and Future Direction. Br J Hosp Med (Lond). 2025;86:1. doi:10.12968/hmed.2024.0619
  11. Orlova P, Meshkov I, Sharikov S, Frolov V, Skuredina A, et al. Amidated and Aminated PMSSO-Hydrogels as a Promising Enzyme-Sensitive Vehicle for Antianemic Drugs. Gels. 2025;11. doi:10.3390/gels11020118
  12. Al Kindi S, Al-Mamari A, Al-Zadjali S, Al-Rawahi M, Al Madhani A, et al. Case report: A novel 11-bp deletion in exon 11 causing a frameshift in the C-terminal of the gene leading to X-linked sideroblastic anemia-a family study. Front Med (Lausanne). 2024;11:1452873. doi:10.3389/fmed.2024.1452873
  13. Manna S, Chakrabarti SS, Singh R, Gambhir IS. Serum hepcidin level with iron profile assay might replace bone marrow iron study as a diagnostic tool for evaluation of anemia in elderly without chronic renal disease. J Family Med Prim Care. 2025;14:356. doi:10.4103/jfmpc.jfmpc_34_24
  14. Kranke P, Weiniger CF, Sultan P, Achebe MO, Filipescu D, et al. Iron deficiency and anemia in pregnancy: a call to action!: -"If you don't take a temperature, you can't find a fever". Int J Obstet Anesth. 2024;62:104298. doi:10.1016/j.ijoa.2024.104298
  15. Larson LM, Baldi A, Hasan MI, Jones N, Pickle EO, et al. Role of hepcidin on benefits and risks of supplementation with iron syrup and multiple micronutrient powders in Bangladeshi children: a sub-study to a randomized controlled trial. Am J Clin Nutr. 2025. doi:10.1016/j.ajcnut.2025.02.018
  16. Fijn R, Ablij HC, Knoester PD, Witte AMC. Real-world evaluation of an intravenous iron service for the treatment of iron deficiency with or without anemia. Sci Rep. 2025;15:12093. doi:10.1038/s41598-025-85880-9
  17. Bhutta ZA, Keats EC, Owais A, González-Fernández D, Udomkesmalee E, et al. What works for anemia reduction among women of reproductive age? Synthesized findings from the exemplars in anemia project. Am J Clin Nutr. 2025;121 Suppl 1:S68. doi:10.1016/j.ajcnut.2024.11.031
  18. Owais A, Habib A, Ahsan H, Merritt CE, Lee C, et al. Drivers of anemia reduction among women of reproductive age in Pakistan: a mixed-methods country case study. Am J Clin Nutr. 2025;121 Suppl 1:S46. doi:10.1016/j.ajcnut.2024.04.037
  19. Duan Y, Xu Y, Wei Y, Liu T, Xu T, et al. Bilateral segmental testicular infarction secondary to iron deficiency anemia: a case report. BMC Urol. 2025;25:70. doi:10.1186/s12894-025-01756-0
  20. Warner MA, Johnson ML, Hanson AC, Fortune E, Flaby GW, et al. Practical Anemia Bundle and Hemoglobin Recovery in Critical Illness: A Randomized Clinical Trial. JAMA Netw Open. 2025;8:e252353. doi:10.1001/jamanetworkopen.2025.2353
  21. Hidayat MT, Khadijah Maharani SN, Ramadhany ID, Khairani NI, Rahman NA, et al. Controlled release of deferiprone using iron-responsive nanoparticles integrated with dissolving microneedle for novel alternative treatments of β-thalassemia major. Eur J Pharm Biopharm. 2025;210:114702. doi:10.1016/j.ejpb.2025.114702
  22. Al-Taiar A, Ziyab AH, Hammoud MS, Al-Sabah R, Akhtar S. Anemia in pregnant women: findings from Kuwait birth cohort study. BMC Pregnancy Childbirth. 2025;25:326. doi:10.1186/s12884-025-07439-w
  23. Sohn SH, Sul H, Kim B, Zang D. Effects of Darbepoetin Alfa and Ferric Derisomaltose Plus Darbepoetin Alfa in Functional Iron-Deficiency Anemia. Int J Mol Sci. 2025;26. doi:10.3390/ijms26052203
  24. Nagao T, Takahashi K, Takahashi S, Yokomizo R, Samura O, et al. Low-dose ferric carboxymaltose vs. oral iron for improving hemoglobin levels in postpartum East Asian women: A randomized controlled trial. PLoS One. 2025;20:e0319795. doi:10.1371/journal.pone.0319795
  25. Ozeki Y, Kato J, Ohta Y, Taida T, Horio R, et al. [Efficacy and safety of ferric carboxymaltose in patients with inflammatory bowel disease]. Nihon Shokakibyo Gakkai Zasshi. 2025;122:196. doi:10.11405/nisshoshi.122.196
  26. Gao Z, Gao Y, Wang Q, Wang Q, Lu P, et al. Study on HIF-PHI combined with iron supplement in treatment of renal anemia in rats. BMC Nephrol. 2025;26:125. doi:10.1186/s12882-025-04045-y
  27. Liu X, Sun A, Zheng X, Xia M, Liu Y, et al. Combined morphological and molecular approaches to the clinical diagnosis of Necator americanus infection: a case report. J Med Case Rep. 2025;19:100. doi:10.1186/s13256-025-05105-5
  28. Zhang H, Sun W, Qi J, Qayum A, Li J, et al. Antianemic Activity, Inhibition of Oxidative Stress, and Iron Supplementation in Mice with Iron-Deficiency Anemia through HG-Hawthorn Pectin-Iron(III) Complexes. ACS Appl Bio Mater. 2025;8:2419. doi:10.1021/acsabm.4c01905
  29. Dogan Y, Dede AM, Erdoğan A. An unusual association: gastric xanthelasma presenting with iron deficiency anemia: a case report. J Med Case Rep. 2025;19:98. doi:10.1186/s13256-025-05133-1
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