Last update
3/21/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Iron (elemental) (from 180 mg Ferrous Bisglycinate)(Ferrochel™)
36 mg
200%
Top Medical Research Studies
9
We investigated the role of dietary iron in recovery from colitis, specifically focusing on its effects in weaned mice. The study involved two groups of mice fed different diets: one with a regular amount of iron and another enriched with significantly more iron. After two weeks on their respective diets, both groups were subjected to dextran sodium sulfate (DSS) treatment to induce colitis.
Throughout the recovery phase, we observed that the iron-enriched diet proved especially beneficial for the weaned mice. By day three of recovery, those on the iron diet showed less weight loss, shorter colon lengths, and less damage to intestinal structure compared to their counterparts. Iron not only promoted the vitality of intestinal stem cells but also helped maintain the integrity of the intestinal lining.
Furthermore, analyses of organoids revealed that the iron diet stimulated the expression of certain genes involved in differentiation and metabolism, which suggests a deeper mechanism at play. Overall, this study indicates that dietary iron may significantly enhance the repair of intestinal injuries and support the regeneration of healthy tissue following inflammation.
Throughout the recovery phase, we observed that the iron-enriched diet proved especially beneficial for the weaned mice. By day three of recovery, those on the iron diet showed less weight loss, shorter colon lengths, and less damage to intestinal structure compared to their counterparts. Iron not only promoted the vitality of intestinal stem cells but also helped maintain the integrity of the intestinal lining.
Furthermore, analyses of organoids revealed that the iron diet stimulated the expression of certain genes involved in differentiation and metabolism, which suggests a deeper mechanism at play. Overall, this study indicates that dietary iron may significantly enhance the repair of intestinal injuries and support the regeneration of healthy tissue following inflammation.
Read More
7
We aimed to investigate how iron depletion influences the development and recovery phases of experimental colitis, a condition closely tied to inflammation in the intestine. By using a compound called deferoxamine to deplete iron at various stages of colitis induced by dextran sulfate sodium, we were able to observe the effects on colon health and the behavior of intestinal stem cells.
Our findings revealed that the timing of iron depletion is crucial. When applied at different phases of colitis, it significantly affected the health outcomes. For instance, we noted changes in the intestinal barrier, stem cell function, and overall inflammation levels, indicating that iron plays a complex role in both the worsening and healing processes of colitis.
This study points to iron metabolism as a potential therapeutic target for treating inflammatory bowel disease (IBD) in clinical settings, emphasizing the need for a balanced approach to iron management during treatment.
Our findings revealed that the timing of iron depletion is crucial. When applied at different phases of colitis, it significantly affected the health outcomes. For instance, we noted changes in the intestinal barrier, stem cell function, and overall inflammation levels, indicating that iron plays a complex role in both the worsening and healing processes of colitis.
This study points to iron metabolism as a potential therapeutic target for treating inflammatory bowel disease (IBD) in clinical settings, emphasizing the need for a balanced approach to iron management during treatment.
Read More
Most Useful Reviews
0
Damaging colitis effects
2 people found this helpful
If you have active colitis, I advise you to avoid this product completely. It absolutely destroyed my gut.
Read More
9
Free from anaemia
Thank you for taking a large amount of iron. I have ulcerative colitis and experience melena daily, but my doctor doesn’t prescribe iron supplements, so I take three capsules each night. As a result, the previously white eyelids under my eyes are now bright red, and I am free from anaemia. Compared to commercially available heme iron supplements, this allows for a larger intake of iron, is easy to consume, and doesn’t cause stomach pain. I feel that it suits me very well.
Read More
7.5
Relieves constipation
I’m very happy with my purchase. I love NOW products for their quality ingredients and good size. I have heavy periods that sometimes make me anaemic, but iron tablets usually constipate me, and I also suffer from ulcerative colitis. However, this supplement provides the necessary minerals without causing constipation or gastritis. Occasionally, I feel dizzy from blood loss, but after two days, I notice the benefits.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
- All Researches
9
We investigated the role of dietary iron in recovery from colitis, specifically focusing on its effects in weaned mice. The study involved two groups of mice fed different diets: one with a regular amount of iron and another enriched with significantly more iron. After two weeks on their respective diets, both groups were subjected to dextran sodium sulfate (DSS) treatment to induce colitis.
Throughout the recovery phase, we observed that the iron-enriched diet proved especially beneficial for the weaned mice. By day three of recovery, those on the iron diet showed less weight loss, shorter colon lengths, and less damage to intestinal structure compared to their counterparts. Iron not only promoted the vitality of intestinal stem cells but also helped maintain the integrity of the intestinal lining.
Furthermore, analyses of organoids revealed that the iron diet stimulated the expression of certain genes involved in differentiation and metabolism, which suggests a deeper mechanism at play. Overall, this study indicates that dietary iron may significantly enhance the repair of intestinal injuries and support the regeneration of healthy tissue following inflammation.
Throughout the recovery phase, we observed that the iron-enriched diet proved especially beneficial for the weaned mice. By day three of recovery, those on the iron diet showed less weight loss, shorter colon lengths, and less damage to intestinal structure compared to their counterparts. Iron not only promoted the vitality of intestinal stem cells but also helped maintain the integrity of the intestinal lining.
Furthermore, analyses of organoids revealed that the iron diet stimulated the expression of certain genes involved in differentiation and metabolism, which suggests a deeper mechanism at play. Overall, this study indicates that dietary iron may significantly enhance the repair of intestinal injuries and support the regeneration of healthy tissue following inflammation.
Read More
7
We aimed to investigate how iron depletion influences the development and recovery phases of experimental colitis, a condition closely tied to inflammation in the intestine. By using a compound called deferoxamine to deplete iron at various stages of colitis induced by dextran sulfate sodium, we were able to observe the effects on colon health and the behavior of intestinal stem cells.
Our findings revealed that the timing of iron depletion is crucial. When applied at different phases of colitis, it significantly affected the health outcomes. For instance, we noted changes in the intestinal barrier, stem cell function, and overall inflammation levels, indicating that iron plays a complex role in both the worsening and healing processes of colitis.
This study points to iron metabolism as a potential therapeutic target for treating inflammatory bowel disease (IBD) in clinical settings, emphasizing the need for a balanced approach to iron management during treatment.
Our findings revealed that the timing of iron depletion is crucial. When applied at different phases of colitis, it significantly affected the health outcomes. For instance, we noted changes in the intestinal barrier, stem cell function, and overall inflammation levels, indicating that iron plays a complex role in both the worsening and healing processes of colitis.
This study points to iron metabolism as a potential therapeutic target for treating inflammatory bowel disease (IBD) in clinical settings, emphasizing the need for a balanced approach to iron management during treatment.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
0
Damaging colitis effects
2 people found this helpful
If you have active colitis, I advise you to avoid this product completely. It absolutely destroyed my gut.
Read More
9
Free from anaemia
Thank you for taking a large amount of iron. I have ulcerative colitis and experience melena daily, but my doctor doesn’t prescribe iron supplements, so I take three capsules each night. As a result, the previously white eyelids under my eyes are now bright red, and I am free from anaemia. Compared to commercially available heme iron supplements, this allows for a larger intake of iron, is easy to consume, and doesn’t cause stomach pain. I feel that it suits me very well.
Read More
7.5
Relieves constipation
I’m very happy with my purchase. I love NOW products for their quality ingredients and good size. I have heavy periods that sometimes make me anaemic, but iron tablets usually constipate me, and I also suffer from ulcerative colitis. However, this supplement provides the necessary minerals without causing constipation or gastritis. Occasionally, I feel dizzy from blood loss, but after two days, I notice the benefits.
Read More
Frequently Asked Questions
7.5
Relieves constipation
I’m very happy with my purchase. I love NOW products for their quality ingredients and good size. I have heavy periods that sometimes make me anaemic, but iron tablets usually constipate me, and I also suffer from ulcerative colitis. However, this supplement provides the necessary minerals without causing constipation or gastritis. Occasionally, I feel dizzy from blood loss, but after two days, I notice the benefits.
9
Free from anaemia
Thank you for taking a large amount of iron. I have ulcerative colitis and experience melena daily, but my doctor doesn’t prescribe iron supplements, so I take three capsules each night. As a result, the previously white eyelids under my eyes are now bright red, and I am free from anaemia. Compared to commercially available heme iron supplements, this allows for a larger intake of iron, is easy to consume, and doesn’t cause stomach pain. I feel that it suits me very well.
9
We investigated the role of dietary iron in recovery from colitis, specifically focusing on its effects in weaned mice. The study involved two groups of mice fed different diets: one with a regular amount of iron and another enriched with significantly more iron. After two weeks on their respective diets, both groups were subjected to dextran sodium sulfate (DSS) treatment to induce colitis.
Throughout the recovery phase, we observed that the iron-enriched diet proved especially beneficial for the weaned mice. By day three of recovery, those on the iron diet showed less weight loss, shorter colon lengths, and less damage to intestinal structure compared to their counterparts. Iron not only promoted the vitality of intestinal stem cells but also helped maintain the integrity of the intestinal lining.
Furthermore, analyses of organoids revealed that the iron diet stimulated the expression of certain genes involved in differentiation and metabolism, which suggests a deeper mechanism at play. Overall, this study indicates that dietary iron may significantly enhance the repair of intestinal injuries and support the regeneration of healthy tissue following inflammation.
Throughout the recovery phase, we observed that the iron-enriched diet proved especially beneficial for the weaned mice. By day three of recovery, those on the iron diet showed less weight loss, shorter colon lengths, and less damage to intestinal structure compared to their counterparts. Iron not only promoted the vitality of intestinal stem cells but also helped maintain the integrity of the intestinal lining.
Furthermore, analyses of organoids revealed that the iron diet stimulated the expression of certain genes involved in differentiation and metabolism, which suggests a deeper mechanism at play. Overall, this study indicates that dietary iron may significantly enhance the repair of intestinal injuries and support the regeneration of healthy tissue following inflammation.
7
We aimed to investigate how iron depletion influences the development and recovery phases of experimental colitis, a condition closely tied to inflammation in the intestine. By using a compound called deferoxamine to deplete iron at various stages of colitis induced by dextran sulfate sodium, we were able to observe the effects on colon health and the behavior of intestinal stem cells.
Our findings revealed that the timing of iron depletion is crucial. When applied at different phases of colitis, it significantly affected the health outcomes. For instance, we noted changes in the intestinal barrier, stem cell function, and overall inflammation levels, indicating that iron plays a complex role in both the worsening and healing processes of colitis.
This study points to iron metabolism as a potential therapeutic target for treating inflammatory bowel disease (IBD) in clinical settings, emphasizing the need for a balanced approach to iron management during treatment.
Our findings revealed that the timing of iron depletion is crucial. When applied at different phases of colitis, it significantly affected the health outcomes. For instance, we noted changes in the intestinal barrier, stem cell function, and overall inflammation levels, indicating that iron plays a complex role in both the worsening and healing processes of colitis.
This study points to iron metabolism as a potential therapeutic target for treating inflammatory bowel disease (IBD) in clinical settings, emphasizing the need for a balanced approach to iron management during treatment.
References
- Zeng X, Yin L, Zhang Y, Wang Q, Li J, et al. Dietary Iron Alleviates Dextran Sodium Sulfate-Induced Intestinal Injury by Regulating Regeneration of Intestinal Stem Cells in Weaned Mice. Biol Trace Elem Res. 2025. 10.1007/s12011-025-04546-9
- Wang S, Liu X, Xu L, Lang J, Liu D. Phase-dependent iron depletion differentially regulates the niche of intestinal stem cells in experimental colitis via ERK/STAT3 signaling pathway. Front Immunol. 2025;16:1537651. 10.3389/fimmu.2025.1537651
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