We aimed to explore the effectiveness of vitamin D supplementation in alleviating the symptoms of fibromyalgia—a condition marked by chronic pain, fatigue, and cognitive challenges. Our research included a group of 180 women, aged 18 to 65, who met the criteria for fibromyalgia. We administered a high-dose vitamin D3 supplement of 50,000 IU over a span of 12 weeks and assessed the impact on their quality of life through the Fibromyalgia Impact Questionnaire (FIQ) and the Visual Analog Scale (VAS).
After the treatment, we observed significant improvements in both FIQ and VAS scores, indicating a notable positive effect of vitamin D on the quality of life and pain reduction in these patients. Particularly, the results suggested that many of the participants had a pre-existing vitamin D deficiency, which is more common among individuals with fibromyalgia.
Overall, this study highlights the potential benefits of vitamin D supplementation for those suffering from fibromyalgia and encourages further investigation into its role in managing this challenging condition.
Read More
9
Vitamin D aids fibromyalgia treatment
Efficacy of Vitamin D Supplementation in the Improvement of Clinical Status in Patients Diagnosed with Fibromyalgia Syndrome: A Systematic Review.
We explored the potential benefits of vitamin D supplementation for individuals suffering from fibromyalgia, a condition known for causing widespread pain and fatigue. Our review involved examining various studies, including randomized controlled trials and observational studies, focusing on those published between early 2011 and May 2021.
After a thorough search, we found a total of 2,651 studies, narrowing it down to 12 high-quality studies that met our criteria. Remarkably, 11 of these studies presented clear evidence of improvement in clinical status and various related outcomes after participants received vitamin D supplements. This suggests that vitamin D could play a key role in alleviating fibromyalgia symptoms.
Our findings highlight a promising link between vitamin D supplementation and the enhancement of health in fibromyalgia patients. As we move forward, we recognize the need for continued research to further standardize how we detect and treat this complex condition, potentially offering cost-effective solutions that incorporate vitamin D.
Read More
9
Vitamin D3 may alleviate fibromyalgia
Efficacy of Vitamin D Supplementation in the Improvement of Clinical Status in Patients Diagnosed with Fibromyalgia Syndrome: A Systematic Review.
We conducted a thorough review of the existing literature to understand how vitamin D3 supplementation affects those suffering from fibromyalgia. This condition is often marked by widespread pain and fatigue, and we wanted to see if vitamin D3 could help alleviate these troubling symptoms.
In our search, we scoured various databases for studies published between January 2011 and May 2021. This included randomized controlled trials, observational studies, and other well-documented research focused explicitly on fibromyalgia. Out of the 2,651 studies retrieved, 12 met our strict criteria for inclusion, of which 11 were of high quality, showing minimal bias.
The results were promising, as 11 of those high-quality studies indicated a significant positive impact on the clinical status of fibromyalgia patients who received vitamin D3. This suggests that vitamin D3 might play an important role in managing fibromyalgia symptoms.
While our findings point towards the benefits of vitamin D3 supplementation, they also highlight the need for further research. As we continue to explore effective treatments for fibromyalgia, vitamin D3 stands out as a potentially beneficial option worth considering for patients seeking relief.
Read More
Most Useful Reviews
8.8
Strong bones benefit
Great! Vitamin D3 is essential. It's a high-quality product with great ingredients, easy to take with water. Since we often lack sunlight, this vitamin D3 quickly boosts my immunity. I recommend getting an exam to check for deficiency and repeating it after three months to observe improvements in bone strength and pain relief. I've been using this brand for two years, and I'm very satisfied, especially with my fibromyalgia.
Read More
8.8
Improved recovery process
Important, good quality, non-GMO, and reasonably priced. This vitamin is crucial for life. I take a high amount due to my fibromyalgia, needing elevated levels for recovery. Thank you, iHerb.
Read More
8.8
Increased immunity
Vitamin D in high dosage! As a fibromyalgia sufferer, I follow the Coimbra protocol, and this dosage is excellent for improving my immunity, especially in Brazil’s low-sun months.
We aimed to explore the effectiveness of vitamin D supplementation in alleviating the symptoms of fibromyalgia—a condition marked by chronic pain, fatigue, and cognitive challenges. Our research included a group of 180 women, aged 18 to 65, who met the criteria for fibromyalgia. We administered a high-dose vitamin D3 supplement of 50,000 IU over a span of 12 weeks and assessed the impact on their quality of life through the Fibromyalgia Impact Questionnaire (FIQ) and the Visual Analog Scale (VAS).
After the treatment, we observed significant improvements in both FIQ and VAS scores, indicating a notable positive effect of vitamin D on the quality of life and pain reduction in these patients. Particularly, the results suggested that many of the participants had a pre-existing vitamin D deficiency, which is more common among individuals with fibromyalgia.
Overall, this study highlights the potential benefits of vitamin D supplementation for those suffering from fibromyalgia and encourages further investigation into its role in managing this challenging condition.
Read More
9
Vitamin D aids fibromyalgia treatment
Efficacy of Vitamin D Supplementation in the Improvement of Clinical Status in Patients Diagnosed with Fibromyalgia Syndrome: A Systematic Review.
We explored the potential benefits of vitamin D supplementation for individuals suffering from fibromyalgia, a condition known for causing widespread pain and fatigue. Our review involved examining various studies, including randomized controlled trials and observational studies, focusing on those published between early 2011 and May 2021.
After a thorough search, we found a total of 2,651 studies, narrowing it down to 12 high-quality studies that met our criteria. Remarkably, 11 of these studies presented clear evidence of improvement in clinical status and various related outcomes after participants received vitamin D supplements. This suggests that vitamin D could play a key role in alleviating fibromyalgia symptoms.
Our findings highlight a promising link between vitamin D supplementation and the enhancement of health in fibromyalgia patients. As we move forward, we recognize the need for continued research to further standardize how we detect and treat this complex condition, potentially offering cost-effective solutions that incorporate vitamin D.
Read More
9
Fibromyalgia treatment approach explored
Fibromyalgia associated with Chagas' disease treated with nutraceuticals.
We examined a unique case involving a 61-year-old woman with Chagas' disease who was also diagnosed with fibromyalgia. This patient had been suffering from severe gastrointestinal issues for years, alongside diffuse body pain and sleep difficulties. She was treated with a combination of psychotherapy, vitamin D supplementation, and physical exercise, specifically Pilates and walking.
Remarkably, after six months of this treatment regimen, the patient showed significant improvement. Her pain was greatly reduced, anxiety levels were controlled, and her vitamin D levels became normal. This raises an interesting point about the role of vitamin D in treating fibromyalgia, although we must note that the positive effects could not be attributed solely to vitamin D, as other treatments were also involved.
Our exploration of related literature revealed various connections between infections and fibromyalgia; however, there was no specific mention of Trypanosoma cruzi, the parasite responsible for Chagas' disease, being linked to fibromyalgia symptoms. This suggests that while infectious agents might play a role in fibromyalgia, the relationship with T. cruzi in this context remains uncertain.
Overall, this case highlights a promising alternative treatment approach for fibromyalgia using vitamin D, alongside other supportive measures but also cautions us to consider the multifaceted nature of the condition.
Read More
9
Vitamin D3 may alleviate fibromyalgia
Efficacy of Vitamin D Supplementation in the Improvement of Clinical Status in Patients Diagnosed with Fibromyalgia Syndrome: A Systematic Review.
We conducted a thorough review of the existing literature to understand how vitamin D3 supplementation affects those suffering from fibromyalgia. This condition is often marked by widespread pain and fatigue, and we wanted to see if vitamin D3 could help alleviate these troubling symptoms.
In our search, we scoured various databases for studies published between January 2011 and May 2021. This included randomized controlled trials, observational studies, and other well-documented research focused explicitly on fibromyalgia. Out of the 2,651 studies retrieved, 12 met our strict criteria for inclusion, of which 11 were of high quality, showing minimal bias.
The results were promising, as 11 of those high-quality studies indicated a significant positive impact on the clinical status of fibromyalgia patients who received vitamin D3. This suggests that vitamin D3 might play an important role in managing fibromyalgia symptoms.
While our findings point towards the benefits of vitamin D3 supplementation, they also highlight the need for further research. As we continue to explore effective treatments for fibromyalgia, vitamin D3 stands out as a potentially beneficial option worth considering for patients seeking relief.
Read More
9
Vitamin D3 improves fibromyalgia symptoms
Efficacy of vitamin D replacement therapy on patients with chronic nonspecific widespread musculoskeletal pain with vitamin D deficiency.
We aimed to understand how vitamin D3 replacement therapy could help alleviate symptoms for those suffering from chronic widespread musculoskeletal pain (CWP) and fibromyalgia (FM). Our research included patients who had low levels of vitamin D and experienced significant musculoskeletal discomfort.
To see if vitamin D3 could make a difference, we administered a treatment of 50,000 IU of oral vitamin D3 weekly for three months. Before and after this treatment, we assessed various health markers, like pain severity, fatigue levels, depression, and quality of life.
The results were quite promising. Patients showed a significant increase in vitamin D levels post-treatment, rising from an average of 10.6 ng/mL to 46.5 ng/mL. Alongside this improvement, there was a marked reduction in pain, fatigue, and depressive symptoms, along with enhanced overall quality of life. A notable number of patients reported satisfaction with the treatment, and the percentage of those meeting the criteria for fibromyalgia decreased after vitamin D3 therapy.
Overall, this study suggests that vitamin D3 replacement can lead to meaningful improvements for individuals with fibromyalgia and chronic pain, emphasizing the need to check for vitamin D deficiency in these patients.
Great! Vitamin D3 is essential. It's a high-quality product with great ingredients, easy to take with water. Since we often lack sunlight, this vitamin D3 quickly boosts my immunity. I recommend getting an exam to check for deficiency and repeating it after three months to observe improvements in bone strength and pain relief. I've been using this brand for two years, and I'm very satisfied, especially with my fibromyalgia.
Read More
8.8
Improved recovery process
Important, good quality, non-GMO, and reasonably priced. This vitamin is crucial for life. I take a high amount due to my fibromyalgia, needing elevated levels for recovery. Thank you, iHerb.
Read More
8.8
Increased immunity
Vitamin D in high dosage! As a fibromyalgia sufferer, I follow the Coimbra protocol, and this dosage is excellent for improving my immunity, especially in Brazil’s low-sun months.
Read More
9.5
Managed sleep apnea
Vitamin D is essential. After taking this high dose with magnesium, zinc, and K2 for six weeks, my levels improved significantly. I plan to reduce my dose now. I noticed my sleep apnea returned when I stopped it, but it resolved quickly when I resumed. This quality product is critical for my fibromyalgia recovery. Thank you, iHerb.
Read More
9.5
Enhanced energy levels
Great choice! I take two capsules monthly, keeping my levels at around 70 ng/mL. It aids in energy, muscle regeneration, and restful sleep. Doctors often overlook that fibromyalgia symptoms can stem from low vitamin D levels.
Fibromyalgia is a chronic condition characterized by widespread musculoskeletal pain, fatigue, and tenderness in localized areas. Individuals with fibromyalgia often experience a variety of symptoms, including sleep disturbances, cognitive difficulties (often referred to as "fibro fog"), and heightened sensitivity to pain. This condition affects the way the brain processes pain signals, leading to an increased perception of pain from stimuli that would normally be considered mild. Though the exact cause of fibromyalgia is still not fully understood, it may be linked to genetics, infections, physical or emotional trauma, and changes in how the brain and nervous system process pain signals.
Diagnosis of fibromyalgia typically relies on the presence of specific symptoms and the exclusion of other conditions that may cause similar symptoms. There is no definitive laboratory test for the condition, which can make it challenging to diagnose. Treatment often involves a combination of medication, physical therapy, lifestyle changes, and stress management techniques. Patients may benefit from medications aimed at reducing pain and improving sleep, alongside engaging in regular physical activity and practicing mindfulness techniques. While fibromyalgia is a lifelong condition, effective management can significantly improve quality of life for those affected.
Vitamin D is a fat-soluble vitamin that's essential for maintaining healthy bones and teeth, supporting immune system function, and facilitating normal cell growth and development. It plays a crucial role in calcium absorption in the gut, which is vital for bone health. Unlike most vitamins, our bodies can produce Vitamin D when exposed to sunlight, specifically UVB rays, which is why it’s often referred to as the "sunshine vitamin." However, depending on your geographical location, lifestyle, and skin type, getting sufficient Vitamin D from the sun alone can be challenging, particularly during the winter months.
In addition to sunlight, Vitamin D can be obtained from certain foods such as fatty fish (like salmon and mackerel), fish liver oils, and fortified foods like milk and cereals. Some individuals may also consider supplements, especially if they're at risk for deficiency. Insufficient vitamin D levels are linked to various health issues, including rickets in children, osteomalacia in adults, and even an increased risk of chronic diseases. Regularly checking your vitamin D levels and consulting with a healthcare professional can help ensure you're meeting your needs for optimal health.
While there is no definitive cure for fibromyalgia, some studies suggest that vitamin D may play a role in managing symptoms associated with the condition. Vitamin D is essential for various bodily functions, including bone health and immune system regulation. Since individuals with fibromyalgia often report pain sensitivity and fatigue, maintaining adequate levels of vitamin D could potentially help alleviate some of these symptoms. Research indicates that many fibromyalgia patients have lower levels of vitamin D, which has led some healthcare professionals to recommend supplementation.
That said, it’s important to approach vitamin D supplementation cautiously. The effectiveness of vitamin D in treating fibromyalgia may vary from person to person, and not all patients will experience relief. If you suspect you have a vitamin D deficiency or are considering supplementation, it’s crucial to speak with a healthcare provider. They can recommend appropriate testing and the right dosage based on your individual needs. Overall, while vitamin D may provide some benefits for fibromyalgia sufferers, it should be viewed as a potential adjunct to a comprehensive treatment plan rather than a standalone solution.
Based on user reviews, many individuals taking Vitamin D3 for fibromyalgia report seeing results after about six weeks of consistent use. One user highlights significant improvement in their levels after this duration, noting that the quality product played a critical role in their fibromyalgia recovery ((Read Review)). Others suggest that it is beneficial to check for vitamin D deficiency and retest after around three months to observe improvements, particularly in bone strength and pain levels ((Read Review); (Read Review)).
Users have reported that maintaining high levels of vitamin D, especially while following certain protocols or during low-sun months, can significantly alleviate symptoms associated with fibromyalgia such as muscle and joint pain, and even improve sleep quality ((Read Review); (Read Review)). However, individual experiences may vary, and regular monitoring of vitamin D levels through testing is recommended for optimal results.
The role of vitamin D supplementation in managing fibromyalgia has garnered attention from researchers, and the existing studies present a mixed but generally promising picture. Several studies suggest that vitamin D deficiency is prevalent among fibromyalgia patients, and supplementation might lead to improvements in symptoms such as pain and overall quality of life. For instance, a study involving 180 women found significant improvements in quality of life after 12 weeks of high-dose vitamin D3 supplementation [5]. Furthermore, a meta-analysis indicated positive effects of vitamin D on physical and emotional health among fibromyalgia sufferers, although it did not significantly reduce pain levels [7].
On the other hand, not all studies have confirmed these benefits, with some failing to demonstrate significant differences in pain relief compared to placebo groups [19]. The complexities surrounding individual patient responses and the need for further targeted research make things unclear [13]. Despite the varied conclusions drawn, the evidence does support a potential role for vitamin D as part of a broader treatment strategy for managing fibromyalgia symptoms, particularly for those identified as deficient in the nutrient. Overall, while vitamin D might not be a standalone solution, it could contribute positively when integrated into a comprehensive management plan for fibromyalgia [7].
Based on user reviews, many individuals using Vitamin D3 report notable improvements in their fibromyalgia symptoms. Users have indicated that after consistent use, particularly at higher dosages, they experience relief from muscle, joint, and bone pain, along with enhancements in energy levels and sleep quality ((Read Review), (Read Review)). One reviewer mentioned that after six weeks of supplementation, they noticed significant improvements in their vitamin D levels, which they found crucial for managing their fibromyalgia symptoms ((Read Review)).
Moreover, several users emphasized the importance of monitoring vitamin D levels, suggesting a retest after three months to evaluate improvements in bone strength and overall pain reduction ((Read Review), (Read Review)). While these anecdotal experiences are encouraging, it is important to note that individual results can vary, and what works for one person may not have the same effect on another.
Based on user reviews, many individuals find success in combining Vitamin D3 with other supplements for managing fibromyalgia. One user highlighted the effectiveness of pairing Vitamin D3 with magnesium, zinc, and K2, reporting significant improvements in their levels and overall health after six weeks of consistent use ((Read Review)). This combination appears to aid in recovery from fibromyalgia symptoms, particularly when high doses are utilized. Moreover, users have stressed the importance of maintaining elevated vitamin D levels, especially while adhering to specific protocols like the Coimbra protocol, which seems to be beneficial in enhancing immunity during low-sun months ((Read Review)).
Users recommend ongoing monitoring of vitamin D levels, suggesting retesting after three months to ensure the effectiveness of the combination supplements. Several reviews indicate that this approach can lead to significant relief from muscle, joint, and bone pain associated with fibromyalgia ((Read Review); (Read Review)). While these experiences are encouraging, it is essential to recognize that responses to supplement combinations can vary between individuals.
The optimal dose for Vitamin D in treating fibromyalgia appears to be around 50,000 IU weekly, based on several studies. For instance, research involving 80 fibromyalgia patients indicated significant improvements in pain and quality of life after three months on this dosage alongside rehabilitation [17]. Similarly, another clinical trial noted that participants showed meaningful reductions in symptoms and enhanced overall quality of life after receiving this high-dose treatment over a span of 12 weeks [5].
Despite these encouraging results, it’s important to recognize that individual responses can vary, and not all studies found a direct correlation between Vitamin D supplementation and pain relief [19]. While Vitamin D supplementation has shown potential to improve some symptoms, the relationship between serum levels and symptom severity remains complex, warranting further investigation [18]. Ultimately, optimizing vitamin D levels might be a crucial part of a comprehensive approach to managing fibromyalgia symptoms but should be monitored closely under medical guidance.
9.5
Managed sleep apnea
Vitamin D is essential. After taking this high dose with magnesium, zinc, and K2 for six weeks, my levels improved significantly. I plan to reduce my dose now. I noticed my sleep apnea returned when I stopped it, but it resolved quickly when I resumed. This quality product is critical for my fibromyalgia recovery. Thank you, iHerb.
8.8
Strong bones benefit
Great! Vitamin D3 is essential. It's a high-quality product with great ingredients, easy to take with water. Since we often lack sunlight, this vitamin D3 quickly boosts my immunity. I recommend getting an exam to check for deficiency and repeating it after three months to observe improvements in bone strength and pain relief. I've been using this brand for two years, and I'm very satisfied, especially with my fibromyalgia.
8.8
Strengthened bones
This is a high-quality product with excellent ingredients. The small softgels are easy to take. Since we often lack sun exposure, this Vitamin D3 boosts my immunity effectively. I'd advise checking for deficiency and retesting after three months to see improvements in bone strength and pain levels. I highly recommend it, especially as a fibromyalgia sufferer.
8.8
Increased immunity
Vitamin D in high dosage! As a fibromyalgia sufferer, I follow the Coimbra protocol, and this dosage is excellent for improving my immunity, especially in Brazil’s low-sun months.
8.8
Reduced pain
This product has quality ingredients, and the size is perfect. It is vital for my fibromyalgia, alleviating muscle, joint, and bone pain, improving my sleep and immunity. Thank you.
9.5
Enhanced energy levels
Great choice! I take two capsules monthly, keeping my levels at around 70 ng/mL. It aids in energy, muscle regeneration, and restful sleep. Doctors often overlook that fibromyalgia symptoms can stem from low vitamin D levels.
9
Vitamin D improves fibromyalgia symptoms
The effect of vitamin D treatment on quality of life in patients with fibromyalgia.
We aimed to explore the effectiveness of vitamin D supplementation in alleviating the symptoms of fibromyalgia—a condition marked by chronic pain, fatigue, and cognitive challenges. Our research included a group of 180 women, aged 18 to 65, who met the criteria for fibromyalgia. We administered a high-dose vitamin D3 supplement of 50,000 IU over a span of 12 weeks and assessed the impact on their quality of life through the Fibromyalgia Impact Questionnaire (FIQ) and the Visual Analog Scale (VAS).
After the treatment, we observed significant improvements in both FIQ and VAS scores, indicating a notable positive effect of vitamin D on the quality of life and pain reduction in these patients. Particularly, the results suggested that many of the participants had a pre-existing vitamin D deficiency, which is more common among individuals with fibromyalgia.
Overall, this study highlights the potential benefits of vitamin D supplementation for those suffering from fibromyalgia and encourages further investigation into its role in managing this challenging condition.
7
Vitamin D may boost wellness in fibromyalgia
Psychological Outcomes and Quality of Life of Fibromyalgia Patients with Vitamin D Supplementation-A Meta-Analysis.
We aimed to understand how vitamin D supplementation might influence fibromyalgia patients, particularly focusing on psychological outcomes and overall quality of life. Our evaluation included a thorough meta-analysis of 8 randomized controlled trials, encompassing a total of 694 participants.
We found that vitamin D showed positive effects on several areas, such as physical function and emotional health. Notably, improvements were seen in role limitations due to emotional health and social function, indicating that vitamin D could play a role in enhancing these aspects of health.
However, while we noted a slight improvement in overall wellness measured by the Fibromyalgia Impact Questionnaire, there were no significant changes observed in pain levels or depressive symptoms. Therefore, while vitamin D supplements may be beneficial for certain psychological facets and quality of life in fibromyalgia patients, they are not a cure-all solution for pain management or depression.
0
Vitamin D shows no benefit for FM
Efficacy and safety of weekly vitamin D in patients with fibromyalgia: 12-week, double-blind, randomized, controlled placebo trial.
We conducted a rigorous clinical trial to explore whether vitamin D supplementation could help alleviate symptoms in patients with fibromyalgia (FM). Over 12 weeks, female participants aged 18 and older, who met established criteria for FM, were randomly assigned to receive either a weekly dose of 50,000 IU of vitamin D or a placebo.
This study was designed to be double-blind, ensuring that neither the participants nor the researchers knew who received the vitamin D or placebo to eliminate bias in the results. At the beginning of the study, we measured pain levels and quality of life using validated tools, specifically focusing on the Visual Analog Scale (VAS) and the Fibromyalgia Impact Questionnaire (FIQ).
However, our findings indicated that there was no significant difference between the vitamin D group and the placebo group in terms of pain relief or overall improvement in FM symptoms. Despite confirming that vitamin D levels increased in those receiving the supplement, this did not translate into better outcomes for the patients involved.
Overall, the study clearly suggests that vitamin D supplementation may not be effective in improving symptoms for fibromyalgia patients, challenging the existing beliefs around vitamin D’s role in treating this condition.
4
Vitamin D and fibromyalgia insight
The Role of Vitamin D in the Management of Chronic Pain in Fibromyalgia: A Narrative Review.
We evaluated the role of vitamin D in managing fibromyalgia (FM), a condition known for causing widespread chronic pain. Considering the limited success of conventional medications approved by the FDA, our exploration aimed to assess how vitamin D supplementation might offer relief. We found that low levels of vitamin D have been associated with various chronic pain conditions, including FM.
Although several studies suggest that vitamin D supplementation can lead to reduced pain and improved quality of life for FM patients, the limitations of the research cannot be overlooked. Many of these studies lack the necessary strength in design to provide definitive conclusions.
Overall, while the initial findings are encouraging, we recognize that more rigorous studies are essential to establish the extent of vitamin D's efficacy in pain management for fibromyalgia. Notably, vitamin D is cost-effective and has minimal side effects, making it a worthwhile consideration for patients, regardless of its impact on pain relief.
8
Vitamin D improves fibromyalgia treatment
Can the Combination of Rehabilitation and Vitamin D Supplementation Improve Fibromyalgia Symptoms at All Ages?
We conducted a study to explore the effects of vitamin D3 supplementation coupled with rehabilitation on fibromyalgia symptoms among different age groups. The research involved 80 patients, split into two age groups: those aged 50 and younger, and those over 50. Each group received a high dose of vitamin D (50,000 IU) weekly for three months, alongside a structured rehabilitation protocol.
Through regular assessments over six months, we noted distinct improvements based on age. For younger patients, high-dose vitamin D led to impressive short-term relief from musculoskeletal pain and enhanced long-term functional capacity. On the other hand, older patients experienced significant improvements in their overall quality of life and management of musculoskeletal pain over time.
These findings suggest that vitamin D can play a beneficial role in managing fibromyalgia symptoms, emphasizing the importance of considering age in treatment approaches. Essentially, while the young benefited in terms of functionality, the elderly saw improvements in their quality of life and pain management after vitamin D supplementation.
9
Vitamin D3 may alleviate fibromyalgia
Efficacy of Vitamin D Supplementation in the Improvement of Clinical Status in Patients Diagnosed with Fibromyalgia Syndrome: A Systematic Review.
We conducted a thorough review of the existing literature to understand how vitamin D3 supplementation affects those suffering from fibromyalgia. This condition is often marked by widespread pain and fatigue, and we wanted to see if vitamin D3 could help alleviate these troubling symptoms.
In our search, we scoured various databases for studies published between January 2011 and May 2021. This included randomized controlled trials, observational studies, and other well-documented research focused explicitly on fibromyalgia. Out of the 2,651 studies retrieved, 12 met our strict criteria for inclusion, of which 11 were of high quality, showing minimal bias.
The results were promising, as 11 of those high-quality studies indicated a significant positive impact on the clinical status of fibromyalgia patients who received vitamin D3. This suggests that vitamin D3 might play an important role in managing fibromyalgia symptoms.
While our findings point towards the benefits of vitamin D3 supplementation, they also highlight the need for further research. As we continue to explore effective treatments for fibromyalgia, vitamin D3 stands out as a potentially beneficial option worth considering for patients seeking relief.
References
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Ismail O, Albdour K, Albdour Z, Jaber K. Differences in Ferritin, Vitamin D, and Vitamin B12 Between Fibromyalgia Patients and Healthy Individuals: A Systematic Review and Meta-Analysis. Musculoskeletal Care. 2025;23:e70057. doi:10.1002/msc.70057
Tarsitano MG, Dolcini G, Pandozzi C, Greco F, Iannuncelli C, et al. Role of micronutrients in the symptoms of fibromyalgia: a review of the literature and analysis of an Italian female sample. Eur Rev Med Pharmacol Sci. 2024;28:4038. doi:10.26355/eurrev_202407_36579
Badaeva A, Danilov A, Kosareva A, Lepshina M, Novikov V, et al. Neuronutritional Approach to Fibromyalgia Management: A Narrative Review. Pain Ther. 2024;13:1047. doi:10.1007/s40122-024-00641-2
Ersoy S, Kesiktas FN, Sirin B, Bugdayci D, Paker N. The effect of vitamin D treatment on quality of life in patients with fibromyalgia. Ir J Med Sci. 2024;193:1111. doi:10.1007/s11845-023-03521-4
Zabihiyeganeh M, Amini Kadijani A, Akbari A, Yahyazadeh H, Mirzaei A. Association of serum vitamin D status with serum pro-inflammatory cytokine levels and clinical severity of fibromyalgia patients. Clin Nutr ESPEN. 2023;55:71. doi:10.1016/j.clnesp.2023.03.006
Yang CC, Tsai ST, Ting B, Cheng YC, Wang CK, et al. Psychological Outcomes and Quality of Life of Fibromyalgia Patients with Vitamin D Supplementation-A Meta-Analysis. J Clin Med. 2023;12. doi:10.3390/jcm12072750
Erkilic B, Dalgic GS. The preventive role of vitamin D in the prevention and management of Fibromyalgia syndrome. Nutr Health. 2023;29:223. doi:10.1177/02601060221144801
Lombardo M, Feraco A, Ottaviani M, Rizzo G, Camajani E, et al. The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musculoskeletal Pain. Nutrients. 2022;14. doi:10.3390/nu14153010
Scaturro D, Vitagliani F, Tomasello S, Filippetti M, Picelli A, et al. Can the Combination of Rehabilitation and Vitamin D Supplementation Improve Fibromyalgia Symptoms at All Ages?. J Funct Morphol Kinesiol. 2022;7. doi:10.3390/jfmk7020051
Qu K, Li MX, Zhou YL, Yu P, Dong M. The efficacy of vitamin D in treatment of fibromyalgia: a meta-analysis of randomized controlled studies and systematic review. Expert Rev Clin Pharmacol. 2022;15:433. doi:10.1080/17512433.2022.2081151
Venkatesan N, Gyawali M, Botleroo RA, Ahmed R, Kareem R, et al. Efficacy of Vitamin D Supplementation in the Improvement of Clinical Status in Patients Diagnosed with Fibromyalgia Syndrome: A Systematic Review. Curr Rheumatol Rev. 2022;18:317. doi:10.2174/1573397118666220307122152
Haddad HW, Jumonville AC, Stark KJ, Temple SN, Dike CC, et al. The Role of Vitamin D in the Management of Chronic Pain in Fibromyalgia: A Narrative Review. Health Psychol Res. 2021;9:25208. doi:10.52965/001c.25208
Ali OME. Prevalence of Vitamin D Deficiency and Its Relationship with Clinical Outcomes in Patients with Fibromyalgia: a Systematic Review of the Literature. SN Compr Clin Med. 2022;4:38. doi:10.1007/s42399-021-01105-w
Kucuk A, Baykara RA, Tuzcu A, Omma A, Cure MC, et al. Could ferritin, vitamin B, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?. Rom J Intern Med. 2021;59:384. doi:10.2478/rjim-2021-0022
de Carvalho JF, Lerner A. Fibromyalgia associated with Chagas' disease treated with nutraceuticals. Clin Nutr ESPEN. 2021;42:212. doi:10.1016/j.clnesp.2021.01.037
Scaturro D, Vitagliani F, Tomasello S, Filippetti M, Picelli A, et al. Can the Combination of Rehabilitation and Vitamin D Supplementation Improve Fibromyalgia Symptoms at All Ages?. J Funct Morphol Kinesiol. 2022;7. doi:10.3390/jfmk7020051
Venkatesan N, Gyawali M, Botleroo RA, Ahmed R, Kareem R, et al. Efficacy of Vitamin D Supplementation in the Improvement of Clinical Status in Patients Diagnosed with Fibromyalgia Syndrome: A Systematic Review. Curr Rheumatol Rev. 2022;18:317. doi:10.2174/1573397118666220307122152
Lozano-Plata LI, Vega-Morales D, Esquivel-Valerio JA, Garza-Elizondo MA, Galarza-Delgado DA, et al. Efficacy and safety of weekly vitamin D in patients with fibromyalgia: 12-week, double-blind, randomized, controlled placebo trial. Clin Rheumatol. 2021;40:3257. doi:10.1007/s10067-021-05640-8
Yong WC, Sanguankeo A, Upala S. Effect of vitamin D supplementation in chronic widespread pain: a systematic review and meta-analysis. Clin Rheumatol. 2017;36:2825. doi:10.1007/s10067-017-3754-y
Yilmaz R, Salli A, Cingoz HT, Kucuksen S, Ugurlu H. Efficacy of vitamin D replacement therapy on patients with chronic nonspecific widespread musculoskeletal pain with vitamin D deficiency. Int J Rheum Dis. 2016;19:1255. doi:10.1111/1756-185X.12960
Wepner F, Scheuer R, Schuetz-Wieser B, Machacek P, Pieler-Bruha E, et al. Effects of vitamin D on patients with fibromyalgia syndrome: a randomized placebo-controlled trial. Pain. 2014;155:261. doi:10.1016/j.pain.2013.10.002
Chaudhari SA, Sacerdote A, Bahtiyar G. 1-α hydroxylation defect in postural orthostatic tachycardia syndrome: remission with calcitriol supplementation. BMJ Case Rep. 2012;2012. doi:10.1136/bcr.02.2012.5730
Harari M, Dramsdahl E, Shany S, Baumfeld Y, Ingber A, et al. Increased vitamin D serum levels correlate with clinical improvement of rheumatic diseases after Dead Sea climatotherapy. Isr Med Assoc J. 2011;13:212.
Arvold DS, Odean MJ, Dornfeld MP, Regal RR, Arvold JG, et al. Correlation of symptoms with vitamin D deficiency and symptom response to cholecalciferol treatment: a randomized controlled trial. Endocr Pract. 2009;15:203.