Overview
SCIENTIFIC SCORE
Questionable
Based on 23 Researches
6.2
USERS' SCORE
Good
Based on 9 Reviews
8.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (From Lanolin)
1,250 mcg (50,000 IU)
6250%
Top Medical Research Studies
9
We aimed to explore the effectiveness of vitamin D supplementation in alleviating the symptoms of fibromyalgia—a condition marked by chronic pain, fatigue, and cognitive challenges. Our research included a group of 180 women, aged 18 to 65, who met the criteria for fibromyalgia. We administered a high-dose vitamin D3 supplement of 50,000 IU over a span of 12 weeks and assessed the impact on their quality of life through the Fibromyalgia Impact Questionnaire (FIQ) and the Visual Analog Scale (VAS).
After the treatment, we observed significant improvements in both FIQ and VAS scores, indicating a notable positive effect of vitamin D on the quality of life and pain reduction in these patients. Particularly, the results suggested that many of the participants had a pre-existing vitamin D deficiency, which is more common among individuals with fibromyalgia.
Overall, this study highlights the potential benefits of vitamin D supplementation for those suffering from fibromyalgia and encourages further investigation into its role in managing this challenging condition.
After the treatment, we observed significant improvements in both FIQ and VAS scores, indicating a notable positive effect of vitamin D on the quality of life and pain reduction in these patients. Particularly, the results suggested that many of the participants had a pre-existing vitamin D deficiency, which is more common among individuals with fibromyalgia.
Overall, this study highlights the potential benefits of vitamin D supplementation for those suffering from fibromyalgia and encourages further investigation into its role in managing this challenging condition.
Read More
9
Vitamin D aids fibromyalgia treatment
We explored the potential benefits of vitamin D supplementation for individuals suffering from fibromyalgia, a condition known for causing widespread pain and fatigue. Our review involved examining various studies, including randomized controlled trials and observational studies, focusing on those published between early 2011 and May 2021.
After a thorough search, we found a total of 2,651 studies, narrowing it down to 12 high-quality studies that met our criteria. Remarkably, 11 of these studies presented clear evidence of improvement in clinical status and various related outcomes after participants received vitamin D supplements. This suggests that vitamin D could play a key role in alleviating fibromyalgia symptoms.
Our findings highlight a promising link between vitamin D supplementation and the enhancement of health in fibromyalgia patients. As we move forward, we recognize the need for continued research to further standardize how we detect and treat this complex condition, potentially offering cost-effective solutions that incorporate vitamin D.
After a thorough search, we found a total of 2,651 studies, narrowing it down to 12 high-quality studies that met our criteria. Remarkably, 11 of these studies presented clear evidence of improvement in clinical status and various related outcomes after participants received vitamin D supplements. This suggests that vitamin D could play a key role in alleviating fibromyalgia symptoms.
Our findings highlight a promising link between vitamin D supplementation and the enhancement of health in fibromyalgia patients. As we move forward, we recognize the need for continued research to further standardize how we detect and treat this complex condition, potentially offering cost-effective solutions that incorporate vitamin D.
Read More
0
Vitamin D shows no benefit for FM
We conducted a rigorous clinical trial to explore whether vitamin D supplementation could help alleviate symptoms in patients with fibromyalgia (FM). Over 12 weeks, female participants aged 18 and older, who met established criteria for FM, were randomly assigned to receive either a weekly dose of 50,000 IU of vitamin D or a placebo.
This study was designed to be double-blind, ensuring that neither the participants nor the researchers knew who received the vitamin D or placebo to eliminate bias in the results. At the beginning of the study, we measured pain levels and quality of life using validated tools, specifically focusing on the Visual Analog Scale (VAS) and the Fibromyalgia Impact Questionnaire (FIQ).
However, our findings indicated that there was no significant difference between the vitamin D group and the placebo group in terms of pain relief or overall improvement in FM symptoms. Despite confirming that vitamin D levels increased in those receiving the supplement, this did not translate into better outcomes for the patients involved.
Overall, the study clearly suggests that vitamin D supplementation may not be effective in improving symptoms for fibromyalgia patients, challenging the existing beliefs around vitamin D’s role in treating this condition.
This study was designed to be double-blind, ensuring that neither the participants nor the researchers knew who received the vitamin D or placebo to eliminate bias in the results. At the beginning of the study, we measured pain levels and quality of life using validated tools, specifically focusing on the Visual Analog Scale (VAS) and the Fibromyalgia Impact Questionnaire (FIQ).
However, our findings indicated that there was no significant difference between the vitamin D group and the placebo group in terms of pain relief or overall improvement in FM symptoms. Despite confirming that vitamin D levels increased in those receiving the supplement, this did not translate into better outcomes for the patients involved.
Overall, the study clearly suggests that vitamin D supplementation may not be effective in improving symptoms for fibromyalgia patients, challenging the existing beliefs around vitamin D’s role in treating this condition.
Read More
Most Useful Reviews
7.5
Strong bones benefit
10 people found this helpful
Great! Vitamin D3 is essential. It's a high-quality product with great ingredients, easy to take with water. Since we often lack sunlight, this vitamin D3 quickly boosts my immunity. I recommend getting an exam to check for deficiency and repeating it after three months to observe improvements in bone strength and pain relief. I've been using this brand for two years, and I'm very satisfied, especially with my fibromyalgia.
Read More
7.5
Improved recovery process
5 people found this helpful
Important, good quality, non-GMO, and reasonably priced. This vitamin is crucial for life. I take a high amount due to my fibromyalgia, needing elevated levels for recovery. Thank you, iHerb.
Read More
7.5
Increased immunity
1 people found this helpful
Vitamin D in high dosage! As a fibromyalgia sufferer, I follow the Coimbra protocol, and this dosage is excellent for improving my immunity, especially in Brazil’s low-sun months.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 23 Researches
6.2
- All Researches
9
We aimed to explore the effectiveness of vitamin D supplementation in alleviating the symptoms of fibromyalgia—a condition marked by chronic pain, fatigue, and cognitive challenges. Our research included a group of 180 women, aged 18 to 65, who met the criteria for fibromyalgia. We administered a high-dose vitamin D3 supplement of 50,000 IU over a span of 12 weeks and assessed the impact on their quality of life through the Fibromyalgia Impact Questionnaire (FIQ) and the Visual Analog Scale (VAS).
After the treatment, we observed significant improvements in both FIQ and VAS scores, indicating a notable positive effect of vitamin D on the quality of life and pain reduction in these patients. Particularly, the results suggested that many of the participants had a pre-existing vitamin D deficiency, which is more common among individuals with fibromyalgia.
Overall, this study highlights the potential benefits of vitamin D supplementation for those suffering from fibromyalgia and encourages further investigation into its role in managing this challenging condition.
After the treatment, we observed significant improvements in both FIQ and VAS scores, indicating a notable positive effect of vitamin D on the quality of life and pain reduction in these patients. Particularly, the results suggested that many of the participants had a pre-existing vitamin D deficiency, which is more common among individuals with fibromyalgia.
Overall, this study highlights the potential benefits of vitamin D supplementation for those suffering from fibromyalgia and encourages further investigation into its role in managing this challenging condition.
Read More
9
Vitamin D aids fibromyalgia treatment
We explored the potential benefits of vitamin D supplementation for individuals suffering from fibromyalgia, a condition known for causing widespread pain and fatigue. Our review involved examining various studies, including randomized controlled trials and observational studies, focusing on those published between early 2011 and May 2021.
After a thorough search, we found a total of 2,651 studies, narrowing it down to 12 high-quality studies that met our criteria. Remarkably, 11 of these studies presented clear evidence of improvement in clinical status and various related outcomes after participants received vitamin D supplements. This suggests that vitamin D could play a key role in alleviating fibromyalgia symptoms.
Our findings highlight a promising link between vitamin D supplementation and the enhancement of health in fibromyalgia patients. As we move forward, we recognize the need for continued research to further standardize how we detect and treat this complex condition, potentially offering cost-effective solutions that incorporate vitamin D.
After a thorough search, we found a total of 2,651 studies, narrowing it down to 12 high-quality studies that met our criteria. Remarkably, 11 of these studies presented clear evidence of improvement in clinical status and various related outcomes after participants received vitamin D supplements. This suggests that vitamin D could play a key role in alleviating fibromyalgia symptoms.
Our findings highlight a promising link between vitamin D supplementation and the enhancement of health in fibromyalgia patients. As we move forward, we recognize the need for continued research to further standardize how we detect and treat this complex condition, potentially offering cost-effective solutions that incorporate vitamin D.
Read More
9
Fibromyalgia treatment approach explored
We examined a unique case involving a 61-year-old woman with Chagas' disease who was also diagnosed with fibromyalgia. This patient had been suffering from severe gastrointestinal issues for years, alongside diffuse body pain and sleep difficulties. She was treated with a combination of psychotherapy, vitamin D supplementation, and physical exercise, specifically Pilates and walking.
Remarkably, after six months of this treatment regimen, the patient showed significant improvement. Her pain was greatly reduced, anxiety levels were controlled, and her vitamin D levels became normal. This raises an interesting point about the role of vitamin D in treating fibromyalgia, although we must note that the positive effects could not be attributed solely to vitamin D, as other treatments were also involved.
Our exploration of related literature revealed various connections between infections and fibromyalgia; however, there was no specific mention of Trypanosoma cruzi, the parasite responsible for Chagas' disease, being linked to fibromyalgia symptoms. This suggests that while infectious agents might play a role in fibromyalgia, the relationship with T. cruzi in this context remains uncertain.
Overall, this case highlights a promising alternative treatment approach for fibromyalgia using vitamin D, alongside other supportive measures but also cautions us to consider the multifaceted nature of the condition.
Remarkably, after six months of this treatment regimen, the patient showed significant improvement. Her pain was greatly reduced, anxiety levels were controlled, and her vitamin D levels became normal. This raises an interesting point about the role of vitamin D in treating fibromyalgia, although we must note that the positive effects could not be attributed solely to vitamin D, as other treatments were also involved.
Our exploration of related literature revealed various connections between infections and fibromyalgia; however, there was no specific mention of Trypanosoma cruzi, the parasite responsible for Chagas' disease, being linked to fibromyalgia symptoms. This suggests that while infectious agents might play a role in fibromyalgia, the relationship with T. cruzi in this context remains uncertain.
Overall, this case highlights a promising alternative treatment approach for fibromyalgia using vitamin D, alongside other supportive measures but also cautions us to consider the multifaceted nature of the condition.
Read More
9
We aimed to understand how vitamin D3 replacement therapy could help alleviate symptoms for those suffering from chronic widespread musculoskeletal pain (CWP) and fibromyalgia (FM). Our research included patients who had low levels of vitamin D and experienced significant musculoskeletal discomfort.
To see if vitamin D3 could make a difference, we administered a treatment of 50,000 IU of oral vitamin D3 weekly for three months. Before and after this treatment, we assessed various health markers, like pain severity, fatigue levels, depression, and quality of life.
The results were quite promising. Patients showed a significant increase in vitamin D levels post-treatment, rising from an average of 10.6 ng/mL to 46.5 ng/mL. Alongside this improvement, there was a marked reduction in pain, fatigue, and depressive symptoms, along with enhanced overall quality of life. A notable number of patients reported satisfaction with the treatment, and the percentage of those meeting the criteria for fibromyalgia decreased after vitamin D3 therapy.
Overall, this study suggests that vitamin D3 replacement can lead to meaningful improvements for individuals with fibromyalgia and chronic pain, emphasizing the need to check for vitamin D deficiency in these patients.
To see if vitamin D3 could make a difference, we administered a treatment of 50,000 IU of oral vitamin D3 weekly for three months. Before and after this treatment, we assessed various health markers, like pain severity, fatigue levels, depression, and quality of life.
The results were quite promising. Patients showed a significant increase in vitamin D levels post-treatment, rising from an average of 10.6 ng/mL to 46.5 ng/mL. Alongside this improvement, there was a marked reduction in pain, fatigue, and depressive symptoms, along with enhanced overall quality of life. A notable number of patients reported satisfaction with the treatment, and the percentage of those meeting the criteria for fibromyalgia decreased after vitamin D3 therapy.
Overall, this study suggests that vitamin D3 replacement can lead to meaningful improvements for individuals with fibromyalgia and chronic pain, emphasizing the need to check for vitamin D deficiency in these patients.
Read More
8
We explored the potential of vitamin D in relieving pain associated with fibromyalgia syndrome (FMS) and chronic musculoskeletal pain (CMP). Our systematic review of randomized controlled trials provided clear insights into the relationship between vitamin D deficiency and these pain syndromes.
Our analysis included 14 studies that met our criteria, revealing a notable correlation between low levels of vitamin D and the experience of widespread muscle pain. The evidence suggests that some individuals suffering from these conditions may indeed have significant vitamin D deficiency.
We found that vitamin D supplementation can lead to positive outcomes for patients who are deficient, with several studies showcasing a reduction in pain levels following appropriate treatment. It appears that for those with established deficiencies, vitamin D may play a beneficial role in managing pain, hinting at a pathway for relief for those who deal with these challenging conditions.
Overall, the findings indicate that vitamin D supplementation may help alleviate pain for individuals with FMS and CMP, particularly if they are found to be deficient in this important nutrient.
Our analysis included 14 studies that met our criteria, revealing a notable correlation between low levels of vitamin D and the experience of widespread muscle pain. The evidence suggests that some individuals suffering from these conditions may indeed have significant vitamin D deficiency.
We found that vitamin D supplementation can lead to positive outcomes for patients who are deficient, with several studies showcasing a reduction in pain levels following appropriate treatment. It appears that for those with established deficiencies, vitamin D may play a beneficial role in managing pain, hinting at a pathway for relief for those who deal with these challenging conditions.
Overall, the findings indicate that vitamin D supplementation may help alleviate pain for individuals with FMS and CMP, particularly if they are found to be deficient in this important nutrient.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Strong bones benefit
10 people found this helpful
Great! Vitamin D3 is essential. It's a high-quality product with great ingredients, easy to take with water. Since we often lack sunlight, this vitamin D3 quickly boosts my immunity. I recommend getting an exam to check for deficiency and repeating it after three months to observe improvements in bone strength and pain relief. I've been using this brand for two years, and I'm very satisfied, especially with my fibromyalgia.
Read More
7.5
Improved recovery process
5 people found this helpful
Important, good quality, non-GMO, and reasonably priced. This vitamin is crucial for life. I take a high amount due to my fibromyalgia, needing elevated levels for recovery. Thank you, iHerb.
Read More
7.5
Increased immunity
1 people found this helpful
Vitamin D in high dosage! As a fibromyalgia sufferer, I follow the Coimbra protocol, and this dosage is excellent for improving my immunity, especially in Brazil’s low-sun months.
Read More
9
Managed sleep apnea
Vitamin D is essential. After taking this high dose with magnesium, zinc, and K2 for six weeks, my levels improved significantly. I plan to reduce my dose now. I noticed my sleep apnea returned when I stopped it, but it resolved quickly when I resumed. This quality product is critical for my fibromyalgia recovery. Thank you, iHerb.
Read More
9
Enhanced energy levels
Great choice! I take two capsules monthly, keeping my levels at around 70 ng/mL. It aids in energy, muscle regeneration, and restful sleep. Doctors often overlook that fibromyalgia symptoms can stem from low vitamin D levels.
Read More
Frequently Asked Questions
9
Managed sleep apnea
Vitamin D is essential. After taking this high dose with magnesium, zinc, and K2 for six weeks, my levels improved significantly. I plan to reduce my dose now. I noticed my sleep apnea returned when I stopped it, but it resolved quickly when I resumed. This quality product is critical for my fibromyalgia recovery. Thank you, iHerb.
7.5
Strong bones benefit
10 people found this helpful
Great! Vitamin D3 is essential. It's a high-quality product with great ingredients, easy to take with water. Since we often lack sunlight, this vitamin D3 quickly boosts my immunity. I recommend getting an exam to check for deficiency and repeating it after three months to observe improvements in bone strength and pain relief. I've been using this brand for two years, and I'm very satisfied, especially with my fibromyalgia.
7.5
Strengthened bones
This is a high-quality product with excellent ingredients. The small softgels are easy to take. Since we often lack sun exposure, this Vitamin D3 boosts my immunity effectively. I'd advise checking for deficiency and retesting after three months to see improvements in bone strength and pain levels. I highly recommend it, especially as a fibromyalgia sufferer.
7.5
Increased immunity
1 people found this helpful
Vitamin D in high dosage! As a fibromyalgia sufferer, I follow the Coimbra protocol, and this dosage is excellent for improving my immunity, especially in Brazil’s low-sun months.
7.5
Reduced pain
This product has quality ingredients, and the size is perfect. It is vital for my fibromyalgia, alleviating muscle, joint, and bone pain, improving my sleep and immunity. Thank you.
9
Enhanced energy levels
Great choice! I take two capsules monthly, keeping my levels at around 70 ng/mL. It aids in energy, muscle regeneration, and restful sleep. Doctors often overlook that fibromyalgia symptoms can stem from low vitamin D levels.
9
We aimed to explore the effectiveness of vitamin D supplementation in alleviating the symptoms of fibromyalgia—a condition marked by chronic pain, fatigue, and cognitive challenges. Our research included a group of 180 women, aged 18 to 65, who met the criteria for fibromyalgia. We administered a high-dose vitamin D3 supplement of 50,000 IU over a span of 12 weeks and assessed the impact on their quality of life through the Fibromyalgia Impact Questionnaire (FIQ) and the Visual Analog Scale (VAS).
After the treatment, we observed significant improvements in both FIQ and VAS scores, indicating a notable positive effect of vitamin D on the quality of life and pain reduction in these patients. Particularly, the results suggested that many of the participants had a pre-existing vitamin D deficiency, which is more common among individuals with fibromyalgia.
Overall, this study highlights the potential benefits of vitamin D supplementation for those suffering from fibromyalgia and encourages further investigation into its role in managing this challenging condition.
After the treatment, we observed significant improvements in both FIQ and VAS scores, indicating a notable positive effect of vitamin D on the quality of life and pain reduction in these patients. Particularly, the results suggested that many of the participants had a pre-existing vitamin D deficiency, which is more common among individuals with fibromyalgia.
Overall, this study highlights the potential benefits of vitamin D supplementation for those suffering from fibromyalgia and encourages further investigation into its role in managing this challenging condition.
7
We aimed to understand how vitamin D supplementation might influence fibromyalgia patients, particularly focusing on psychological outcomes and overall quality of life. Our evaluation included a thorough meta-analysis of 8 randomized controlled trials, encompassing a total of 694 participants.
We found that vitamin D showed positive effects on several areas, such as physical function and emotional health. Notably, improvements were seen in role limitations due to emotional health and social function, indicating that vitamin D could play a role in enhancing these aspects of health.
However, while we noted a slight improvement in overall wellness measured by the Fibromyalgia Impact Questionnaire, there were no significant changes observed in pain levels or depressive symptoms. Therefore, while vitamin D supplements may be beneficial for certain psychological facets and quality of life in fibromyalgia patients, they are not a cure-all solution for pain management or depression.
We found that vitamin D showed positive effects on several areas, such as physical function and emotional health. Notably, improvements were seen in role limitations due to emotional health and social function, indicating that vitamin D could play a role in enhancing these aspects of health.
However, while we noted a slight improvement in overall wellness measured by the Fibromyalgia Impact Questionnaire, there were no significant changes observed in pain levels or depressive symptoms. Therefore, while vitamin D supplements may be beneficial for certain psychological facets and quality of life in fibromyalgia patients, they are not a cure-all solution for pain management or depression.
0
Vitamin D shows no benefit for FM
We conducted a rigorous clinical trial to explore whether vitamin D supplementation could help alleviate symptoms in patients with fibromyalgia (FM). Over 12 weeks, female participants aged 18 and older, who met established criteria for FM, were randomly assigned to receive either a weekly dose of 50,000 IU of vitamin D or a placebo.
This study was designed to be double-blind, ensuring that neither the participants nor the researchers knew who received the vitamin D or placebo to eliminate bias in the results. At the beginning of the study, we measured pain levels and quality of life using validated tools, specifically focusing on the Visual Analog Scale (VAS) and the Fibromyalgia Impact Questionnaire (FIQ).
However, our findings indicated that there was no significant difference between the vitamin D group and the placebo group in terms of pain relief or overall improvement in FM symptoms. Despite confirming that vitamin D levels increased in those receiving the supplement, this did not translate into better outcomes for the patients involved.
Overall, the study clearly suggests that vitamin D supplementation may not be effective in improving symptoms for fibromyalgia patients, challenging the existing beliefs around vitamin D’s role in treating this condition.
This study was designed to be double-blind, ensuring that neither the participants nor the researchers knew who received the vitamin D or placebo to eliminate bias in the results. At the beginning of the study, we measured pain levels and quality of life using validated tools, specifically focusing on the Visual Analog Scale (VAS) and the Fibromyalgia Impact Questionnaire (FIQ).
However, our findings indicated that there was no significant difference between the vitamin D group and the placebo group in terms of pain relief or overall improvement in FM symptoms. Despite confirming that vitamin D levels increased in those receiving the supplement, this did not translate into better outcomes for the patients involved.
Overall, the study clearly suggests that vitamin D supplementation may not be effective in improving symptoms for fibromyalgia patients, challenging the existing beliefs around vitamin D’s role in treating this condition.
4
We evaluated the role of vitamin D in managing fibromyalgia (FM), a condition known for causing widespread chronic pain. Considering the limited success of conventional medications approved by the FDA, our exploration aimed to assess how vitamin D supplementation might offer relief. We found that low levels of vitamin D have been associated with various chronic pain conditions, including FM.
Although several studies suggest that vitamin D supplementation can lead to reduced pain and improved quality of life for FM patients, the limitations of the research cannot be overlooked. Many of these studies lack the necessary strength in design to provide definitive conclusions.
Overall, while the initial findings are encouraging, we recognize that more rigorous studies are essential to establish the extent of vitamin D's efficacy in pain management for fibromyalgia. Notably, vitamin D is cost-effective and has minimal side effects, making it a worthwhile consideration for patients, regardless of its impact on pain relief.
Although several studies suggest that vitamin D supplementation can lead to reduced pain and improved quality of life for FM patients, the limitations of the research cannot be overlooked. Many of these studies lack the necessary strength in design to provide definitive conclusions.
Overall, while the initial findings are encouraging, we recognize that more rigorous studies are essential to establish the extent of vitamin D's efficacy in pain management for fibromyalgia. Notably, vitamin D is cost-effective and has minimal side effects, making it a worthwhile consideration for patients, regardless of its impact on pain relief.
7
We conducted a study to see how vitamin D might improve fibromyalgia symptoms, particularly when paired with physical rehabilitation. In this research, we evaluated 80 patients with fibromyalgia, dividing them into two groups based on their age. Group A consisted of individuals aged 50 and younger, while Group B included those older than 50. Each group received weekly vitamin D supplements of 50,000 IU for three months alongside a rehabilitation program.
After assessing the patients at the beginning of the study, then at three and six months, we focused on pain levels, functional capacity, and quality of life. What we found was quite interesting. For younger patients, high doses of vitamin D significantly improved short-term musculoskeletal pain and contributed positively to their overall functioning in the long run. In contrast, the elderly saw improvements in their musculoskeletal pain and quality of life over time.
Overall, this suggests that vitamin D supplementation can indeed help relieve pain and enhance quality of life and functionality in fibromyalgia patients, albeit in slightly different ways depending on age. The results indicate that incorporating vitamin D into the treatment plan could be beneficial for both younger and older adults suffering from fibromyalgia symptoms.
After assessing the patients at the beginning of the study, then at three and six months, we focused on pain levels, functional capacity, and quality of life. What we found was quite interesting. For younger patients, high doses of vitamin D significantly improved short-term musculoskeletal pain and contributed positively to their overall functioning in the long run. In contrast, the elderly saw improvements in their musculoskeletal pain and quality of life over time.
Overall, this suggests that vitamin D supplementation can indeed help relieve pain and enhance quality of life and functionality in fibromyalgia patients, albeit in slightly different ways depending on age. The results indicate that incorporating vitamin D into the treatment plan could be beneficial for both younger and older adults suffering from fibromyalgia symptoms.
9
Vitamin D aids fibromyalgia treatment
We explored the potential benefits of vitamin D supplementation for individuals suffering from fibromyalgia, a condition known for causing widespread pain and fatigue. Our review involved examining various studies, including randomized controlled trials and observational studies, focusing on those published between early 2011 and May 2021.
After a thorough search, we found a total of 2,651 studies, narrowing it down to 12 high-quality studies that met our criteria. Remarkably, 11 of these studies presented clear evidence of improvement in clinical status and various related outcomes after participants received vitamin D supplements. This suggests that vitamin D could play a key role in alleviating fibromyalgia symptoms.
Our findings highlight a promising link between vitamin D supplementation and the enhancement of health in fibromyalgia patients. As we move forward, we recognize the need for continued research to further standardize how we detect and treat this complex condition, potentially offering cost-effective solutions that incorporate vitamin D.
After a thorough search, we found a total of 2,651 studies, narrowing it down to 12 high-quality studies that met our criteria. Remarkably, 11 of these studies presented clear evidence of improvement in clinical status and various related outcomes after participants received vitamin D supplements. This suggests that vitamin D could play a key role in alleviating fibromyalgia symptoms.
Our findings highlight a promising link between vitamin D supplementation and the enhancement of health in fibromyalgia patients. As we move forward, we recognize the need for continued research to further standardize how we detect and treat this complex condition, potentially offering cost-effective solutions that incorporate vitamin D.
References
- Saija C, Bertuccio MP, Scoglio A, Macaione V, Cacciola F, et al. Role of Vitamin D Status and Alterations in Gut Microbiota Metabolism in Fibromyalgia-Associated Chronic Inflammatory Pain. Biomedicines. 2025;13. 10.3390/biomedicines13010139
- Ismail O, Albdour K, Albdour Z, Jaber K. Differences in Ferritin, Vitamin D, and Vitamin B12 Between Fibromyalgia Patients and Healthy Individuals: A Systematic Review and Meta-Analysis. Musculoskeletal Care. 2025;23:e70057. 10.1002/msc.70057
- Tarsitano MG, Dolcini G, Pandozzi C, Greco F, Iannuncelli C, et al. Role of micronutrients in the symptoms of fibromyalgia: a review of the literature and analysis of an Italian female sample. Eur Rev Med Pharmacol Sci. 2024;28:4038. 10.26355/eurrev_202407_36579
- Badaeva A, Danilov A, Kosareva A, Lepshina M, Novikov V, et al. Neuronutritional Approach to Fibromyalgia Management: A Narrative Review. Pain Ther. 2024;13:1047. 10.1007/s40122-024-00641-2
- Ersoy S, Kesiktas FN, Sirin B, Bugdayci D, Paker N. The effect of vitamin D treatment on quality of life in patients with fibromyalgia. Ir J Med Sci. 2024;193:1111. 10.1007/s11845-023-03521-4
- Zabihiyeganeh M, Amini Kadijani A, Akbari A, Yahyazadeh H, Mirzaei A. Association of serum vitamin D status with serum pro-inflammatory cytokine levels and clinical severity of fibromyalgia patients. Clin Nutr ESPEN. 2023;55:71. 10.1016/j.clnesp.2023.03.006
- Yang CC, Tsai ST, Ting B, Cheng YC, Wang CK, et al. Psychological Outcomes and Quality of Life of Fibromyalgia Patients with Vitamin D Supplementation-A Meta-Analysis. J Clin Med. 2023;12. 10.3390/jcm12072750
- Erkilic B, Dalgic GS. The preventive role of vitamin D in the prevention and management of Fibromyalgia syndrome. Nutr Health. 2023;29:223. 10.1177/02601060221144801
- Lombardo M, Feraco A, Ottaviani M, Rizzo G, Camajani E, et al. The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musculoskeletal Pain. Nutrients. 2022;14. 10.3390/nu14153010
- Scaturro D, Vitagliani F, Tomasello S, Filippetti M, Picelli A, et al. Can the Combination of Rehabilitation and Vitamin D Supplementation Improve Fibromyalgia Symptoms at All Ages?. J Funct Morphol Kinesiol. 2022;7. 10.3390/jfmk7020051
- Qu K, Li MX, Zhou YL, Yu P, Dong M. The efficacy of vitamin D in treatment of fibromyalgia: a meta-analysis of randomized controlled studies and systematic review. Expert Rev Clin Pharmacol. 2022;15:433. 10.1080/17512433.2022.2081151
- Venkatesan N, Gyawali M, Botleroo RA, Ahmed R, Kareem R, et al. Efficacy of Vitamin D Supplementation in the Improvement of Clinical Status in Patients Diagnosed with Fibromyalgia Syndrome: A Systematic Review. Curr Rheumatol Rev. 2022;18:317. 10.2174/1573397118666220307122152
- Haddad HW, Jumonville AC, Stark KJ, Temple SN, Dike CC, et al. The Role of Vitamin D in the Management of Chronic Pain in Fibromyalgia: A Narrative Review. Health Psychol Res. 2021;9:25208. 10.52965/001c.25208
- Ali OME. Prevalence of Vitamin D Deficiency and Its Relationship with Clinical Outcomes in Patients with Fibromyalgia: a Systematic Review of the Literature. SN Compr Clin Med. 2022;4:38. 10.1007/s42399-021-01105-w
- Kucuk A, Baykara RA, Tuzcu A, Omma A, Cure MC, et al. Could ferritin, vitamin B, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?. Rom J Intern Med. 2021;59:384. 10.2478/rjim-2021-0022
- de Carvalho JF, Lerner A. Fibromyalgia associated with Chagas' disease treated with nutraceuticals. Clin Nutr ESPEN. 2021;42:212. 10.1016/j.clnesp.2021.01.037
- Lozano-Plata LI, Vega-Morales D, Esquivel-Valerio JA, Garza-Elizondo MA, Galarza-Delgado DA, et al. Efficacy and safety of weekly vitamin D in patients with fibromyalgia: 12-week, double-blind, randomized, controlled placebo trial. Clin Rheumatol. 2021;40:3257. 10.1007/s10067-021-05640-8
- Yong WC, Sanguankeo A, Upala S. Effect of vitamin D supplementation in chronic widespread pain: a systematic review and meta-analysis. Clin Rheumatol. 2017;36:2825. 10.1007/s10067-017-3754-y
- Yilmaz R, Salli A, Cingoz HT, Kucuksen S, Ugurlu H. Efficacy of vitamin D replacement therapy on patients with chronic nonspecific widespread musculoskeletal pain with vitamin D deficiency. Int J Rheum Dis. 2016;19:1255. 10.1111/1756-185X.12960
- Wepner F, Scheuer R, Schuetz-Wieser B, Machacek P, Pieler-Bruha E, et al. Effects of vitamin D on patients with fibromyalgia syndrome: a randomized placebo-controlled trial. Pain. 2014;155:261. 10.1016/j.pain.2013.10.002
- Chaudhari SA, Sacerdote A, Bahtiyar G. 1-α hydroxylation defect in postural orthostatic tachycardia syndrome: remission with calcitriol supplementation. BMJ Case Rep. 2012;2012. 10.1136/bcr.02.2012.5730
- Harari M, Dramsdahl E, Shany S, Baumfeld Y, Ingber A, et al. Increased vitamin D serum levels correlate with clinical improvement of rheumatic diseases after Dead Sea climatotherapy. Isr Med Assoc J. 2011;13:212.
- Arvold DS, Odean MJ, Dornfeld MP, Regal RR, Arvold JG, et al. Correlation of symptoms with vitamin D deficiency and symptom response to cholecalciferol treatment: a randomized controlled trial. Endocr Pract. 2009;15:203.
