We explored the case of a 23-month-old boy diagnosed with Imerslund-Gräsbeck syndrome (IGS), a rare disorder causing severe anemia. This child showed significant blood cell reduction and poor growth, which led to investigations identifying two genetic variants linked to his condition.
Remarkably, vitamin B12 replacement therapy resulted in a strong recovery. This case highlights how vital it is to diagnose IGS early in cases of severe anemia, ensuring timely treatment to avoid long-term complications, including potential neurological damage.
Read More
9
Rare genetic defect in B12 transport
Transcobalamin deficiency - a rare genetic defect in transportation of cobalamin; case report.
We examined a rare genetic condition, Transcobalamin deficiency, which affects vitamin B12 transport in the body. This deficiency can lead to serious issues like pancytopenia and megaloblastic anemia.
A fascinating case was reported about a 2-year-old boy suffering from these issues. After using advanced genetic testing, doctors found a new variant in the TCN2 gene and treated him with high doses of methylcobalamin.
As a result, significant health improvements were noted, highlighting the importance of early diagnosis and treatment in preventing severe complications.
Read More
8
WIFAS improving folate and hemoglobin
Effect of School-Based Weekly Iron and Folic Acid Supplementation Program on the Serum Folate Status of Adolescent Girls in Sidama Region, Southern Ethiopia: Comparative Cross-Sectional Study.
We explored how a school-based weekly iron and folic acid supplementation program (WIFAS) impacts serum folate levels among adolescent girls in the Sidama Region of Ethiopia.
Using a cross-sectional study design, we compared serum folate levels between girls at schools with WIFAS and those without. Our findings showed that girls participating in the program had significantly higher serum folate and hemoglobin levels.
This suggests that WIFAS could be an effective approach to combat anemia and improve folate status, advocating for its expansion in areas facing similar deficiencies.
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Most Useful Reviews
9
Safe dosage
16 people found this helpful
An excellent B-vitamin complex! Many supplements contain high dosages, which may be harmful. I suggest taking one capsule daily. B vitamins are vital for the nervous system and help with energy metabolism, reducing stress, and combating anemia. Highly recommend this complex!
Read More
9
Anemia problem solved
2 people found this helpful
I have been taking vitamin B complexes to tackle my low ferritin levels. This product is effective, making me feel vibrant throughout the day, and my anaemia problem has significantly improved.
Read More
9
Synergistic effect
I take iron supplements daily to combat anemia, and B-50 for its synergistic effects. It aids blood formation and helps recover from fatigue. My water turns yellow the next morning, indicating absorption. I will repurchase it once I run out!
We assessed the impact of nutrition education paired with iron-folic acid supplementation on anemia levels in pregnant women in Ethiopia.
Over three months, we provided community-based education alongside supplementation to women, comparing their outcomes to a control group.
Remarkably, the anemia rate in our intervention group dropped significantly from 27.8% to 7.2%.
Notably, those who received education were over two times more likely to adhere to supplementation, highlighting the importance of such interventions in improving health outcomes during pregnancy.
Read More
9.5
Thiamine resolves rare anemia effectively
Thiamine-responsive megaloblastic anaemia in a young adult with acute pancytopenia.
In our examination, we focused on thiamine-responsive megaloblastic anemia (TRMA), a rare genetic disorder affecting young individuals. We learned about a young man with diabetes who faced pancytopenia, initially linked to a COVID-19 infection.
Genetic testing revealed pathogenic variants indicating TRMA, and following treatment with oral thiamine supplementation, we observed a complete resolution of his symptoms. This case underscores the importance of considering genetic factors in anemia, emphasizing that early diagnosis and treatment can significantly improve health outcomes.
Read More
9.5
Case study: Vitamin B12 efficacy
Severe pancytopenia at the presentation of Imerslund-Gräsbeck syndrome in a 23-month-old Italian boy.
We explored the case of a 23-month-old boy diagnosed with Imerslund-Gräsbeck syndrome (IGS), a rare disorder causing severe anemia. This child showed significant blood cell reduction and poor growth, which led to investigations identifying two genetic variants linked to his condition.
Remarkably, vitamin B12 replacement therapy resulted in a strong recovery. This case highlights how vital it is to diagnose IGS early in cases of severe anemia, ensuring timely treatment to avoid long-term complications, including potential neurological damage.
Read More
9
Health education improves anemia outcomes
Family-centered Health Education Intervention for Improving Iron-folic Acid Adherence and Anemia Reduction among Antenatal Mothers in Rural Jodhpur: A Quasi-experimental Study.
We explored the effectiveness of a family-centered health education intervention aimed at boosting the adherence to iron-folic acid supplements and improving anemia in rural pregnant women.
In our quasi-experimental study involving women with mild to moderate anemia, we utilized a multi-stage sampling method to separate intervention and control groups.
The results were promising; the intervention group showed a significant reduction in anemia prevalence and an increase in hemoglobin levels, demonstrating the positive impact of education on health behaviors and outcomes.
Read More
9
Rare genetic defect in B12 transport
Transcobalamin deficiency - a rare genetic defect in transportation of cobalamin; case report.
We examined a rare genetic condition, Transcobalamin deficiency, which affects vitamin B12 transport in the body. This deficiency can lead to serious issues like pancytopenia and megaloblastic anemia.
A fascinating case was reported about a 2-year-old boy suffering from these issues. After using advanced genetic testing, doctors found a new variant in the TCN2 gene and treated him with high doses of methylcobalamin.
As a result, significant health improvements were noted, highlighting the importance of early diagnosis and treatment in preventing severe complications.
An excellent B-vitamin complex! Many supplements contain high dosages, which may be harmful. I suggest taking one capsule daily. B vitamins are vital for the nervous system and help with energy metabolism, reducing stress, and combating anemia. Highly recommend this complex!
Read More
9
Anemia problem solved
2 people found this helpful
I have been taking vitamin B complexes to tackle my low ferritin levels. This product is effective, making me feel vibrant throughout the day, and my anaemia problem has significantly improved.
Read More
9
Synergistic effect
I take iron supplements daily to combat anemia, and B-50 for its synergistic effects. It aids blood formation and helps recover from fatigue. My water turns yellow the next morning, indicating absorption. I will repurchase it once I run out!
Read More
9
Noticeable results
This complex has an impressive formulation; I noticed results within a week. B vitamins are vital for cellular metabolism and nervous system function. They are essential for maintaining health and helping with issues related to anaemia.
Read More
9
Improved metabolism
The vitamin complex is crucial for the body, particularly for those suffering from anemia. I've learned that B vitamins are essential for metabolism and nerve cell function. The pleasant taste and quality of these natural ingredients are commendable. I rate it 5 stars.
Anemia is a medical condition characterized by a deficiency of red blood cells or hemoglobin in the blood, which can result in reduced oxygen flow to the body's organs. The most common type of anemia is iron-deficiency anemia, which occurs when the body does not have enough iron to produce adequate hemoglobin. Other types can arise from chronic diseases, genetic conditions, or a lack of certain vitamins such as B12 or folate. Symptoms often include fatigue, weakness, pale skin, and shortness of breath, particularly during physical activity.
Diagnosing anemia typically involves blood tests to measure levels of red blood cells, hemoglobin concentration, and other related factors. Treatment varies depending on the underlying cause but may include dietary changes, supplements, or medications. In some cases, more serious interventions may be necessary, such as blood transfusions or treatments for associated conditions. If you suspect you have anemia, it's essential to consult a healthcare professional for appropriate evaluation and management.
Vitamin B Complex refers to a group of water-soluble vitamins that play important roles in cell metabolism and overall health. This group typically includes eight essential vitamins: B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin). Each of these vitamins contributes uniquely to various bodily functions, such as energy production, red blood cell formation, and nervous system function. For instance, B12 and folate are crucial in preventing anemia, while B6 is vital for brain development and function.
Many people can obtain their daily requirements of B vitamins through a balanced diet that includes whole grains, meats, eggs, nuts, leafy greens, and dairy products. However, certain groups—like vegetarians, pregnant women, and older adults—may benefit from supplementation to meet their nutritional needs. It's important to consult with a healthcare professional before starting any supplement regimen, as excessive intake of certain B vitamins can lead to adverse effects. Overall, ensuring adequate intake of Vitamin B Complex is vital for maintaining energy levels and supporting overall health.
Vitamin B Complex can play a significant role in managing certain types of anemia, particularly those related to deficiencies in specific B vitamins, such as B12 and folate. Vitamin B12 is essential for the production of red blood cells and effective functioning of the nervous system. A deficiency in B12 can lead to pernicious anemia, characterized by the production of large, ineffective red blood cells, which can result in fatigue and weakness. Similarly, folate (B9) is crucial for DNA synthesis and cell division, and its deficiency can lead to megaloblastic anemia, where the bone marrow produces oversized and dysfunctional red blood cells.
However, it's important to note that not all types of anemia are related to B vitamin deficiencies. For instance, iron deficiency anemia is the most common form and would require iron supplementation instead. If you're considering taking a B Complex vitamin to address symptoms of anemia, it’s advisable to consult a healthcare provider first. They can recommend appropriate testing and determine whether a B vitamin deficiency is contributing to your anemia and help you identify the right treatment plan tailored to your needs.
Based on user reviews, many individuals report experiencing noticeable improvements in their anemia symptoms within a relatively short period, often around one week of regular supplementation. For instance, one user mentioned that they noticed significant results in just a week after starting the B vitamin complex, highlighting its importance for cellular metabolism and overall health Read Review. Additionally, another user experienced a surge of energy after only a few days of taking the vitamins, which they found especially beneficial for combating anemia Read Review.
However, the timeline for experiencing results can vary depending on individual health conditions and dietary factors. Some users noted that while they felt improvements in their energy levels with continued use, indicators of anemia dropped again when they stopped the supplement Read Review. Therefore, consistency is key, and it is recommended to maintain regular supplementation to sustain the benefits, particularly for those facing significant deficiencies.
The supplement in question shows substantial support from scientific research, specifically regarding its efficacy in treating different types of anemia. For instance, a study on pernicious anemia demonstrated that methylcobalamin therapy significantly improved health outcomes, indicating the crucial role of vitamin B12 in addressing anemia caused by deficiencies [1]. In another study, the efficacy of iron and folic acid supplementation was highlighted, as it led to a marked reduction in anemia rates among pregnant women, suggesting that this combination can be a powerful intervention for improving anemia-related health outcomes [2].
Based on user reviews, many individuals report substantial improvements in their symptoms of anemia after incorporating a B-vitamin complex into their daily routine. Users have emphasized an increase in energy and vitality, with one user noting a significant enhancement in their well-being just days after starting the supplement. Specifically, they remarked feeling a surge of energy after a brief period of use, which they found particularly beneficial in managing anemia-related fatigue Read Review. Another reviewer stated that this blend not only addressed their anemia but also improved their overall mood and resilience throughout the day, leading to a noticeable reduction in signs of anemia Read Review.
Moreover, some users highlighted quicker recovery times from fatigue associated with anemia and improvements in their overall health as they maintained a consistent supplementation schedule. For example, one individual reported a remarkable improvement in their well-being and stamina post-coronavirus, attributing their recovery to the B vitamins Read Review. While experiences vary, it appears that regular intake of these vitamins can provide significant benefits for those dealing with anemia, particularly when combined with a comprehensive health regimen.
Based on user reviews, many individuals have reported positive experiences when combining B vitamin complexes with other supplements to address anemia. For instance, one user noted the effectiveness of pairing iron supplements with a B-50 complex, citing its synergistic effects in aiding blood formation and improving energy recovery. They emphasized that this combination is beneficial for combating fatigue associated with anemia Read Review. Additionally, another review highlighted a user who incorporated chelated iron and buffered vitamin C alongside the B complex, resulting in what they described as a vibrant energy boost for managing their anemia Read Review.
Moreover, several users have pointed out the importance of B vitamins in alleviating symptoms of anemia and enhancing overall well-being. Feedback indicates that these vitamins not only help with fatigue but also improve resilience and mood. One reviewer specifically mentioned that they felt their anemia symptoms were diminishing after consistent supplementation of the B vitamins, underscoring the vital role these nutrients play in their energy levels and health management Read Review. This suggests that combining B vitamins with other supportive supplements might provide a more comprehensive approach to managing anemia.
Based on user reviews, many individuals report positive experiences with a daily intake of Vitamin B Complex for managing anemia. A common recommendation among users is to take one capsule daily as part of a balanced regimen to support energy metabolism and overall vitality, especially in conjunction with iron supplements. For instance, one user stated, "I suggest taking one capsule daily" as it plays a vital role in combating anemia and enhancing well-being Read Review. Others express that their symptoms of anemia have significantly improved by regularly including B vitamins in their daily routine, particularly reporting enhanced energy levels and reduced fatigue Read Review.
Moreover, certain users highlight the importance of the synergistic effect of B vitamins alongside iron, noting that the combination has led to a marked decrease in fatigue and improvement in overall health Read Review. Keeping in mind that each person's needs may differ, it's emphasized that regular supplementation of B vitamins, particularly B12 and folic acid, is essential for preventing fatigue and further managing symptoms of anemia Read Review. Overall, the consensus is that a daily dose of Vitamin B Complex serves as an effective component of an anemia treatment plan.
9
Noticeable results
This complex has an impressive formulation; I noticed results within a week. B vitamins are vital for cellular metabolism and nervous system function. They are essential for maintaining health and helping with issues related to anaemia.
7.5
Increased energy
32 people found this helpful
Great vitamins! After a few days of taking them, I felt a surge of energy. I take one capsule after breakfast for a month, followed by a break. This complex is particularly beneficial for those under constant stress or suffering from anemia. Be healthy!
4
Essential for women
While taking this complex, I noticed a positive impact on my levels. Once I stopped, however, my indicators dropped again. Women require iron, B vitamins, especially B12, and folic acid regularly to prevent fatigue and anaemia.
9
Enhanced vitality
This balanced complex has improved my external beauty and vitality. Since taking it, signs of anaemia have diminished, and I feel more resilient and energetic throughout the day.
7.5
Mood improved
After suffering severe fatigue and anaemia post-coronavirus, my mother found relief with these vitamins, claiming her strength and mood have significantly improved.
9
Synergistic effect
I take iron supplements daily to combat anemia, and B-50 for its synergistic effects. It aids blood formation and helps recover from fatigue. My water turns yellow the next morning, indicating absorption. I will repurchase it once I run out!
9
Excellent energy drink
I adore this B vitamin complex, which I take alongside chelated iron and buffered vitamin C, creating a fabulous energy drink for my anaemia.
9
Safe dosage
16 people found this helpful
An excellent B-vitamin complex! Many supplements contain high dosages, which may be harmful. I suggest taking one capsule daily. B vitamins are vital for the nervous system and help with energy metabolism, reducing stress, and combating anemia. Highly recommend this complex!
9
Anemia problem solved
2 people found this helpful
I have been taking vitamin B complexes to tackle my low ferritin levels. This product is effective, making me feel vibrant throughout the day, and my anaemia problem has significantly improved.
8
Pernicious anemia case highlights treatment
Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.
We explored a compelling case of pernicious anemia in a 51-year-old Ugandan man presenting with lower limb weakness. Initially treated for vitamin B12 deficiency years earlier, he experienced similar symptoms once again.
Through careful testing, he was diagnosed with pernicious anemia, confirming that a lack of vitamin B12 affects many aspects of health. The patient showed improvement after receiving parenteral methylcobalamin therapy, indicating that vitamin B complex can be beneficial in treating anemia caused by deficiencies.
This case underlines the need for awareness and early diagnosis of vitamin B12 deficiency, especially in resource-limited settings.
9.5
Nutrition education reduces anemia prevalence
Effect of nutrition education and iron-folic acid supplementation on anemia among pregnant women in Ethiopia: a quasi-experimental study.
We assessed the impact of nutrition education paired with iron-folic acid supplementation on anemia levels in pregnant women in Ethiopia.
Over three months, we provided community-based education alongside supplementation to women, comparing their outcomes to a control group.
Remarkably, the anemia rate in our intervention group dropped significantly from 27.8% to 7.2%.
Notably, those who received education were over two times more likely to adhere to supplementation, highlighting the importance of such interventions in improving health outcomes during pregnancy.
References
Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. 10.1186/s13256-025-05095-4
Anato A, Reshid M. Effect of nutrition education and iron-folic acid supplementation on anemia among pregnant women in Ethiopia: a quasi-experimental study. Sci Rep. 2025;15:3556. 10.1038/s41598-025-87957-x
Aziz Ali S, Genkinger J, Kahe K, Valeri L, Khowaja N, et al. Role of preconception nutrition supplements in maternal anemia and intrauterine growth: a systematic review and meta-analysis of randomized controlled trials. Syst Rev. 2025;14:11. 10.1186/s13643-024-02726-7
Bolka A, Bosha T, Gebremedhin S. Effect of School-Based Weekly Iron and Folic Acid Supplementation Program on the Serum Folate Status of Adolescent Girls in Sidama Region, Southern Ethiopia: Comparative Cross-Sectional Study. Food Nutr Bull. 2025. 10.1177/03795721241304475
Singh G, Ranjitha R, Baskaran P, Goel AD, Gupta MK, et al. Family-centered Health Education Intervention for Improving Iron-folic Acid Adherence and Anemia Reduction among Antenatal Mothers in Rural Jodhpur: A Quasi-experimental Study. Indian J Public Health. 2024;68:495. 10.4103/ijph.ijph_844_23
Zhang C, Cha R, Long K, Liu Y, Dong Y, et al. Functionalized Iron Oxide Nanoparticles for Both Dual-Modal Imaging and Erythropoiesis. ACS Appl Mater Interfaces. 2024;16:68905. 10.1021/acsami.4c15206
Pascoe MA, Hall AM, Gray A. Thiamine-responsive megaloblastic anaemia in a young adult with acute pancytopenia. BMJ Case Rep. 2024;17. 10.1136/bcr-2024-261435
Zhang D, Liu S, Xi B, Zhu Y, Chen Y, et al. Imerslund-Gräsbeck syndrome in a child with a novel compound heterozygous mutations in the AMN gene: a case report. Ital J Pediatr. 2024;50:191. 10.1186/s13052-024-01757-z
Di Sario F, Piloni F, Gasparini F, Serpetti E, Bruschi B, et al. Severe pancytopenia at the presentation of Imerslund-Gräsbeck syndrome in a 23-month-old Italian boy. Ital J Pediatr. 2024;50:186. 10.1186/s13052-024-01759-x
Finkelstein JL, Cuthbert A, Weeks J, Venkatramanan S, Larvie DY, et al. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2024;8:CD004736. 10.1002/14651858.CD004736.pub6
Iqbal N, Meghani MA, Khalid W, Ansari AH, Ansari MUH, et al. Transcobalamin deficiency - a rare genetic defect in transportation of cobalamin; case report. Ann Hematol. 2024;103:3243. 10.1007/s00277-024-05878-7