Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.9
USERS' SCORE
Good
Based on 10 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Thiamin (Vitamin B-1) (from Thiamin HCl)
50 mg
4167%
Riboflavin (Vitamin B-2)
50 mg
3846%
Niacin (Vitamin B-3) (as Niacinamide)
50 mg
313%
Vitamin B-6 (from Pyridoxine HCl)
50 mg
2941%
Folate
680 mcg DFE (400 mcg folic acid)
170%
Vitamin B-12 (as Cyanocobalamin)
50 mcg
2083%
Biotin
50 mcg
167%
Pantothenic Acid (from Calcium Pantothenate)
50 mg
1000%
Choline (from Choline Bitartrate)
25 mg
5%
PABA (Para-Aminobenzoic Acid)
25 mg
†
Inositol
25 mg
†
Top Medical Research Studies
8
Vitamin B12 improves vision recovery
We explored the effects of vitamin B12 on a 33-year-old woman living with HIV, who faced severe vision loss due to optic neuritis, a rare outcome of vitamin B12 deficiency. Prior to this, she had battled significant peripheral neuropathy treated with vitamin B12 tablets. After starting vitamin B12 injections following her vision loss, she experienced gradual improvement and regained her sight. This case highlights the importance of recognizing vitamin B12 deficiency, particularly since its signs can easily go unnoticed.
Read More
9
We aimed to investigate how paclitaxel-induced peripheral neuropathy affects salivary glands in rats and whether using a vitamin B/ATP complex could help. After inducing neuropathy with paclitaxel, we treated the animals with vitamin B for nine days.
We found that while the neuropathy did lead to significant changes in the salivary glands, treatment with the vitamin combination effectively restored their function. Notably, this treatment helped reduce oxidative stress and balance protein synthesis in the glands.
We found that while the neuropathy did lead to significant changes in the salivary glands, treatment with the vitamin combination effectively restored their function. Notably, this treatment helped reduce oxidative stress and balance protein synthesis in the glands.
Read More
We explored the effects of daily oral thiamine (vitamin B1) treatment on patients with Charcot-Marie-Tooth (CMT) neuropathy, a condition without an effective cure. Our pilot study focused on measuring hand grip strength before and after administering 100 mg of thiamine.
Interestingly, we observed that thiamine did improve hand grip strength; however, there were no significant differences in thiamine-related enzyme levels between CMT patients and healthy controls. We noted that while thiamine seemed beneficial, its exact impact can vary based on individual thiamine metabolism in patients.
Interestingly, we observed that thiamine did improve hand grip strength; however, there were no significant differences in thiamine-related enzyme levels between CMT patients and healthy controls. We noted that while thiamine seemed beneficial, its exact impact can vary based on individual thiamine metabolism in patients.
Read More
Most Useful Reviews
9
Nerve support
I am very impressed with B-50. I've noticed significant support for my nervous system, especially an improvement in the neuropathy in my feet. The quality from NOW is exceptional, and I felt the effects of B-50 entering my system quickly.
Read More
9
Effective combination
This particular combination of B vitamins is excellent for neuropathy. European brands offer similar combos for triple the price, specifically aimed at nerve regeneration and pain relief. I will buy again.
Read More
9
Best for neuropathy
I find this product to be the best for neuropathy. I take it in the evening with magnesium; it’s an effective preparation. Highly recommend.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.9
- All Researches
9
We aimed to investigate how paclitaxel-induced peripheral neuropathy affects salivary glands in rats and whether using a vitamin B/ATP complex could help. After inducing neuropathy with paclitaxel, we treated the animals with vitamin B for nine days.
We found that while the neuropathy did lead to significant changes in the salivary glands, treatment with the vitamin combination effectively restored their function. Notably, this treatment helped reduce oxidative stress and balance protein synthesis in the glands.
We found that while the neuropathy did lead to significant changes in the salivary glands, treatment with the vitamin combination effectively restored their function. Notably, this treatment helped reduce oxidative stress and balance protein synthesis in the glands.
Read More
8
We examined how a combination of vitamins B1, B6, and B12 may improve recovery in peripheral neuropathy. Our research showed that using all three vitamins together led to better healing and nerve connectivity than vitamin B12 on its own.
This combination encourages cell maturation and counters oxidative stress, which are key for recovering damaged nerves. The findings point to the potential benefits of taking all three vitamins for those suffering from nerve-related issues.
This combination encourages cell maturation and counters oxidative stress, which are key for recovering damaged nerves. The findings point to the potential benefits of taking all three vitamins for those suffering from nerve-related issues.
Read More
8
This case presents an Iranian woman, 40, who struggled for a decade with unexplained symptoms such as fatigue and cognitive issues. Initially misdiagnosed with various conditions, her critical vitamin B12 deficiency was finally revealed after persistent symptoms led to further testing.
Treatment with vitamin B12 injections significantly improved her neurological symptoms, illustrating the critical role of recognizing vitamin B12 deficiency—even when traditional blood tests do not show anemia. This case reminds us to consider deficiency diagnoses in complex symptom profiles.
Treatment with vitamin B12 injections significantly improved her neurological symptoms, illustrating the critical role of recognizing vitamin B12 deficiency—even when traditional blood tests do not show anemia. This case reminds us to consider deficiency diagnoses in complex symptom profiles.
Read More
8
Combination treatment improves neuropathy symptoms
We investigated how a combination of vitamins, minerals, and other compounds affects pain and overall nerve function in people with diabetic neuropathy. The study included 73 individuals with type 2 diabetes, who were randomly assigned to receive either the treatment or a placebo for six months.
Results showed a significant improvement in pain levels, vibration perception, and vitamin B12 levels for those taking the supplement. Overall, our findings suggest that combining these elements can beneficially impact the symptoms of diabetic neuropathy.
Results showed a significant improvement in pain levels, vibration perception, and vitamin B12 levels for those taking the supplement. Overall, our findings suggest that combining these elements can beneficially impact the symptoms of diabetic neuropathy.
Read More
We explored the effects of daily oral thiamine (vitamin B1) treatment on patients with Charcot-Marie-Tooth (CMT) neuropathy, a condition without an effective cure. Our pilot study focused on measuring hand grip strength before and after administering 100 mg of thiamine.
Interestingly, we observed that thiamine did improve hand grip strength; however, there were no significant differences in thiamine-related enzyme levels between CMT patients and healthy controls. We noted that while thiamine seemed beneficial, its exact impact can vary based on individual thiamine metabolism in patients.
Interestingly, we observed that thiamine did improve hand grip strength; however, there were no significant differences in thiamine-related enzyme levels between CMT patients and healthy controls. We noted that while thiamine seemed beneficial, its exact impact can vary based on individual thiamine metabolism in patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Nerve support
I am very impressed with B-50. I've noticed significant support for my nervous system, especially an improvement in the neuropathy in my feet. The quality from NOW is exceptional, and I felt the effects of B-50 entering my system quickly.
Read More
9
Effective combination
This particular combination of B vitamins is excellent for neuropathy. European brands offer similar combos for triple the price, specifically aimed at nerve regeneration and pain relief. I will buy again.
Read More
9
Best for neuropathy
I find this product to be the best for neuropathy. I take it in the evening with magnesium; it’s an effective preparation. Highly recommend.
Read More
9
Excellent treatment
An excellent medication for treating polyneuropathy in patients with diabetes mellitus!
Read More
8.5
Maintains neuropathy control
B-50 taken twice a day helps manage my foot neuropathy effectively. It has worked well for me for over 15 years. I also appreciate iHerb; not only are the prices good, but my shipments typically arrive within a day or two here in California.
Read More
Frequently Asked Questions
7.5
Increased energy
I tried this for the first time and absolutely love it. After several weeks, I’ve noticed an increase in energy, and my neuropathy seems to be improving.
8.5
Maintains neuropathy control
B-50 taken twice a day helps manage my foot neuropathy effectively. It has worked well for me for over 15 years. I also appreciate iHerb; not only are the prices good, but my shipments typically arrive within a day or two here in California.
9
Best for neuropathy
I find this product to be the best for neuropathy. I take it in the evening with magnesium; it’s an effective preparation. Highly recommend.
7.5
Neuropathy improvement
8 people found this helpful
B vitamins must be replenished daily, which is not always easy to manage with meals. Dietary supplements can help. My intake coincides with Alpha lipoic acid, essential for diabetics, and my endocrinologist recommended taking this B-50 complex alongside it. I take it four times a year for 30 days, with a 60-day break. I noticed no pain or heartburn. For two years, I've followed a low-carb diet requiring supplements, and my sugar levels are normal. My hypertension has receded, and my neuropathy, a diabetes complication, is gradually improving too!
9
Nerve support
I am very impressed with B-50. I've noticed significant support for my nervous system, especially an improvement in the neuropathy in my feet. The quality from NOW is exceptional, and I felt the effects of B-50 entering my system quickly.
8
We examined how a combination of vitamins B1, B6, and B12 may improve recovery in peripheral neuropathy. Our research showed that using all three vitamins together led to better healing and nerve connectivity than vitamin B12 on its own.
This combination encourages cell maturation and counters oxidative stress, which are key for recovering damaged nerves. The findings point to the potential benefits of taking all three vitamins for those suffering from nerve-related issues.
This combination encourages cell maturation and counters oxidative stress, which are key for recovering damaged nerves. The findings point to the potential benefits of taking all three vitamins for those suffering from nerve-related issues.
8
Combination treatment improves neuropathy symptoms
We investigated how a combination of vitamins, minerals, and other compounds affects pain and overall nerve function in people with diabetic neuropathy. The study included 73 individuals with type 2 diabetes, who were randomly assigned to receive either the treatment or a placebo for six months.
Results showed a significant improvement in pain levels, vibration perception, and vitamin B12 levels for those taking the supplement. Overall, our findings suggest that combining these elements can beneficially impact the symptoms of diabetic neuropathy.
Results showed a significant improvement in pain levels, vibration perception, and vitamin B12 levels for those taking the supplement. Overall, our findings suggest that combining these elements can beneficially impact the symptoms of diabetic neuropathy.
8
We explored a case study involving two elderly patients suffering from vitamin B12 deficiency. Both presented with significant neurological symptoms, such as cognitive decline and impaired mobility.
Despite one patient having normal B12 levels due to treatment, and the other exhibiting low levels with elevated homocysteine and methylmalonic acid, vitamin B12 injections led to notable improvements in their cognitive, emotional, and motor functions.
This highlights the importance of recognizing B12 deficiency, even in patients with normal blood levels, particularly if there are risk factors present.
Despite one patient having normal B12 levels due to treatment, and the other exhibiting low levels with elevated homocysteine and methylmalonic acid, vitamin B12 injections led to notable improvements in their cognitive, emotional, and motor functions.
This highlights the importance of recognizing B12 deficiency, even in patients with normal blood levels, particularly if there are risk factors present.
8
This case presents an Iranian woman, 40, who struggled for a decade with unexplained symptoms such as fatigue and cognitive issues. Initially misdiagnosed with various conditions, her critical vitamin B12 deficiency was finally revealed after persistent symptoms led to further testing.
Treatment with vitamin B12 injections significantly improved her neurological symptoms, illustrating the critical role of recognizing vitamin B12 deficiency—even when traditional blood tests do not show anemia. This case reminds us to consider deficiency diagnoses in complex symptom profiles.
Treatment with vitamin B12 injections significantly improved her neurological symptoms, illustrating the critical role of recognizing vitamin B12 deficiency—even when traditional blood tests do not show anemia. This case reminds us to consider deficiency diagnoses in complex symptom profiles.
8
Vitamin B12 improves vision recovery
We explored the effects of vitamin B12 on a 33-year-old woman living with HIV, who faced severe vision loss due to optic neuritis, a rare outcome of vitamin B12 deficiency. Prior to this, she had battled significant peripheral neuropathy treated with vitamin B12 tablets. After starting vitamin B12 injections following her vision loss, she experienced gradual improvement and regained her sight. This case highlights the importance of recognizing vitamin B12 deficiency, particularly since its signs can easily go unnoticed.
References
- Cuyubamba O, Braga CP, Swift D, Stickney JT, Viel C. The Combination of Neurotropic Vitamins B1, B6, and B12 Enhances Neural Cell Maturation and Connectivity Superior to Single B Vitamins. Cells. 2025;14. 10.3390/cells14070477
- Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. 10.1186/s13256-025-05149-7
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. 10.3390/nu16183045
- Artiukhov AV, Solovjeva ON, Balashova NV, Sidorova OP, Graf AV, et al. Pharmacological Doses of Thiamine Benefit Patients with the Charcot-Marie-Tooth Neuropathy by Changing Thiamine Diphosphate Levels and Affecting Regulation of Thiamine-Dependent Enzymes. Biochemistry (Mosc). 2024;89:1161. 10.1134/S0006297924070010
- Lubega G, Lutaakome J, Kibirige M, Opoka D, Atukunda I, et al. Vitamin B12 deficiency presenting as progressive blindness in a 33-year-old HIV-positive female patient on Efavirenz-based regimen: case report. Pan Afr Med J. 2024;47:164. 10.11604/pamj.2024.47.164.43048
- Dekker MJHJ, Heerdink GC, Plattel CHM. Vitamin B12 Deficiency-Induced Neuropathy and Cognitive and Motor Impairment in the Elderly: A Case Study. Food Nutr Bull. 2024;45:S53. 10.1177/03795721241226886
- Gautam S, Mittal C, Ranjan A, Singh G. Association of Diabetic Peripheral Neuropathy with Micronutrients. J Assoc Physicians India. 2024;72:65. 10.59556/japi.72.0493
- Tykhonovych K, Kryvoruchko T, Nikitina N, Berehovyi S, Neporada K. CORRECTION OF PATHOLOGICAL CHANGES IN SALIVARY GLANDS OF ANIMALS WITH PACLITAXEL-INDUCED NEUROPATHY. Exp Oncol. 2024;46:38. 10.15407/exp-oncology.2024.01.038
- Park KJ, Choi E, Jung IY, Kim ST. Pharmacologic management of trigeminal nerve injury after endodontic treatment: A retrospective analysis. J Oral Rehabil. 2024;51:1737. 10.1111/joor.13765
