' 
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.3
USERS' SCORE
Good
Based on 7 Reviews
8.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
L-Glutamine (Free-Form)
1 g (1,000 mg)
**
Top Medical Research Studies
8
l-glutamine's role in anxiety
Gut microbiota mediate early life stress-induced social dysfunction and anxiety-like behaviors by impairing amino acid transport at the gut.
Study shows behavioral improvement
Our exploration delves into how early life stress affects anxiety and social behavior, particularly through the role of l-glutamine. We found that maternal separation in mice led to reduced levels of amino acid transporters in the gut, which in turn caused lower glutamine levels in the bloodstream. This was significant since glutamine is vital for brain functions, including the production of key neurotransmitters that influence mood and behavior.
In our findings, we noted that these low glutamine levels were linked to synaptic dysfunction in the medial prefrontal cortex, which is crucial for regulating emotional responses. Importantly, we observed that when we supplemented the mice with l-glutamine, there was noticeable improvement in their social behaviors and reduced anxiety-like symptoms. This indicates that enhancing amino acid transport through l-glutamine could be a beneficial strategy to mitigate the adverse effects of early life stress on mental health.
Overall, our research highlights a promising relationship between l-glutamine supplementation and emotional behavior improvements, pointing to a potential pathway through which gut bacteria may influence anxiety and social interactions.
In our findings, we noted that these low glutamine levels were linked to synaptic dysfunction in the medial prefrontal cortex, which is crucial for regulating emotional responses. Importantly, we observed that when we supplemented the mice with l-glutamine, there was noticeable improvement in their social behaviors and reduced anxiety-like symptoms. This indicates that enhancing amino acid transport through l-glutamine could be a beneficial strategy to mitigate the adverse effects of early life stress on mental health.
Overall, our research highlights a promising relationship between l-glutamine supplementation and emotional behavior improvements, pointing to a potential pathway through which gut bacteria may influence anxiety and social interactions.
Read More
4
Heat stress affects anxiety response
Heat-Stress Preconditioning Attenuates Behavioral Responses to Psychological Stress: The Role of HSP-70 in Modulating Stress Responses.
Examines l-glutamine's context
We explored the effects of heat stress on anxiety responses in male rats, particularly focusing on the role of l-glutamine in altering these responses. In the study, the rats were exposed to high temperatures for two hours, which resulted in noticeable physiological changes, such as weight loss and increased body temperature.
Following this exposure, the rats were subjected to a psychological stressor involving predator scent. Interestingly, those that underwent heat-stress preconditioning before facing this psychological stress exhibited notable resilience, displaying less anxiety-like behavior.
A significant factor in this protective effect was the induction of heat shock protein 70 (HSP-70), which is believed to play a role in how our bodies respond to stress. Although l-glutamine was introduced as a potential influencer on HSP-70 levels, the study suggests that the actual impact of l-glutamine on anxiety responses needs further evaluation. Overall, while there was an encouraging indication that heat-stress preconditioning might help with anxiety, the direct role of l-glutamine requires more investigation.
Following this exposure, the rats were subjected to a psychological stressor involving predator scent. Interestingly, those that underwent heat-stress preconditioning before facing this psychological stress exhibited notable resilience, displaying less anxiety-like behavior.
A significant factor in this protective effect was the induction of heat shock protein 70 (HSP-70), which is believed to play a role in how our bodies respond to stress. Although l-glutamine was introduced as a potential influencer on HSP-70 levels, the study suggests that the actual impact of l-glutamine on anxiety responses needs further evaluation. Overall, while there was an encouraging indication that heat-stress preconditioning might help with anxiety, the direct role of l-glutamine requires more investigation.
Read More
9
L-glutamine shows potential benefits
Synergistic effects of GG, glutamine, and curcumin on chronic unpredictable mild stress-induced depression in a mouse model.
Moderate relevance due to combination use.
In our study, we investigated how l-glutamine, when paired with curcumin and a probiotic, affects anxiety in a mouse model designed to mimic anxiety-depressive disorders. We put six-month-old mice through chronic unpredictable mild stress (CUMS) for three weeks to induce emotional disturbances. After this stress period, we administered curcumin, glutamine, and the probiotic—either alone or in combination—to see if they could alleviate anxiety and depressive-like behaviors.
We found that the combination of l-glutamine, curcumin, and the probiotic significantly improved the emotional state of the mice. Their responses to anxiety and depression were restored to levels comparable to those treated with clomipramine, a well-known antidepressant. This suggests that l-glutamine, particularly when used alongside other compounds, could be effective in managing anxiety symptoms, although we couldn't isolate its individual effects due to the nature of our treatment combinations.
Ultimately, our work points to the potential benefits of combining different treatments for better outcomes in anxiety and depression management.
We found that the combination of l-glutamine, curcumin, and the probiotic significantly improved the emotional state of the mice. Their responses to anxiety and depression were restored to levels comparable to those treated with clomipramine, a well-known antidepressant. This suggests that l-glutamine, particularly when used alongside other compounds, could be effective in managing anxiety symptoms, although we couldn't isolate its individual effects due to the nature of our treatment combinations.
Ultimately, our work points to the potential benefits of combining different treatments for better outcomes in anxiety and depression management.
Read More
Most Useful Reviews
9.5
Improved calmness
Who knew so much good could come from one supplement? This is a "must-have" amino acid for anyone with anxiety or stress. I've reached a new level of calm – and I mean calm, not sedated; there's a distinction. While medications like SSRIs and benzodiazepines work, they tend to numb the issue instead of addressing it. Taking Taurine at a dose of 2-3g daily has significantly improved my mood and made me feel less "alone or depressed". It takes a few days for it to fully take effect on anxiety, and a couple of weeks for depression, but it’s worth trying.
Read More
9.5
Stress relief
A great addition to GABA. This supplement has been incredibly helpful for my stress and anxiety as I recover from adrenal fatigue. I take it 2-3 times a day with 250 mg of GABA, and it makes a significant difference in reducing the adrenal rushes I used to experience.
Read More
10
Helpful for anxiety
Another winner from NOW. I love the NOW brand as they thoroughly quality test their products. This has helped my daughter with anxiety, and we use it alongside l-theanine. It’s been very beneficial!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.3
- All Researches
9
L-glutamine shows potential benefits
Synergistic effects of GG, glutamine, and curcumin on chronic unpredictable mild stress-induced depression in a mouse model.
Moderate relevance due to combination use.
In our study, we investigated how l-glutamine, when paired with curcumin and a probiotic, affects anxiety in a mouse model designed to mimic anxiety-depressive disorders. We put six-month-old mice through chronic unpredictable mild stress (CUMS) for three weeks to induce emotional disturbances. After this stress period, we administered curcumin, glutamine, and the probiotic—either alone or in combination—to see if they could alleviate anxiety and depressive-like behaviors.
We found that the combination of l-glutamine, curcumin, and the probiotic significantly improved the emotional state of the mice. Their responses to anxiety and depression were restored to levels comparable to those treated with clomipramine, a well-known antidepressant. This suggests that l-glutamine, particularly when used alongside other compounds, could be effective in managing anxiety symptoms, although we couldn't isolate its individual effects due to the nature of our treatment combinations.
Ultimately, our work points to the potential benefits of combining different treatments for better outcomes in anxiety and depression management.
We found that the combination of l-glutamine, curcumin, and the probiotic significantly improved the emotional state of the mice. Their responses to anxiety and depression were restored to levels comparable to those treated with clomipramine, a well-known antidepressant. This suggests that l-glutamine, particularly when used alongside other compounds, could be effective in managing anxiety symptoms, although we couldn't isolate its individual effects due to the nature of our treatment combinations.
Ultimately, our work points to the potential benefits of combining different treatments for better outcomes in anxiety and depression management.
Read More
8
l-glutamine's role in anxiety
Gut microbiota mediate early life stress-induced social dysfunction and anxiety-like behaviors by impairing amino acid transport at the gut.
Study shows behavioral improvement
Our exploration delves into how early life stress affects anxiety and social behavior, particularly through the role of l-glutamine. We found that maternal separation in mice led to reduced levels of amino acid transporters in the gut, which in turn caused lower glutamine levels in the bloodstream. This was significant since glutamine is vital for brain functions, including the production of key neurotransmitters that influence mood and behavior.
In our findings, we noted that these low glutamine levels were linked to synaptic dysfunction in the medial prefrontal cortex, which is crucial for regulating emotional responses. Importantly, we observed that when we supplemented the mice with l-glutamine, there was noticeable improvement in their social behaviors and reduced anxiety-like symptoms. This indicates that enhancing amino acid transport through l-glutamine could be a beneficial strategy to mitigate the adverse effects of early life stress on mental health.
Overall, our research highlights a promising relationship between l-glutamine supplementation and emotional behavior improvements, pointing to a potential pathway through which gut bacteria may influence anxiety and social interactions.
In our findings, we noted that these low glutamine levels were linked to synaptic dysfunction in the medial prefrontal cortex, which is crucial for regulating emotional responses. Importantly, we observed that when we supplemented the mice with l-glutamine, there was noticeable improvement in their social behaviors and reduced anxiety-like symptoms. This indicates that enhancing amino acid transport through l-glutamine could be a beneficial strategy to mitigate the adverse effects of early life stress on mental health.
Overall, our research highlights a promising relationship between l-glutamine supplementation and emotional behavior improvements, pointing to a potential pathway through which gut bacteria may influence anxiety and social interactions.
Read More
8
Probiotics and L-glutamine improve anxiety
Multi-strain Probiotic Formulation Reverses Maternal Separation and Chronic Unpredictable Mild Stress-Generated Anxiety- and Depression-like Phenotypes by Modulating Gut Microbiome-Brain Activity in Rats.
L-glutamine's isolated effect unclear
To delve into how l-glutamine affects anxiety, we examined a multi-strain probiotic formulation alongside l-glutamine in a study designed for animals subjected to stressors, such as maternal separation and unpredictable mild stress. These stressors created anxiety- and depression-like behaviors in the Sprague-Dawley rats used in our research.
Throughout six weeks, we administered a total of ten billion cfu of the probiotic formulation, combined with l-glutamine, via drinking water. The behavioral assessments we conducted—like tests for forced swimming, preferencing sucrose, and exploring open areas—helped us understand the impact of the treatment on rats' anxiety levels.
Remarkably, the treatment with the multi-strain probiotics and l-glutamine appeared to significantly improve the rats' behavior after they were stressed. While the probiotics were shown to play a critical role, the specific impact of l-glutamine alone in this context couldn't be fully isolated, as it was always paired with the probiotics.
Overall, we observed that the combination treatment successfully reversed certain mood-related issues linked to stress. However, the exact influence of l-glutamine on its own remains uncertain. The findings position the combined approach as a potential avenue for improving anxiety symptoms related to chronic stress.
Throughout six weeks, we administered a total of ten billion cfu of the probiotic formulation, combined with l-glutamine, via drinking water. The behavioral assessments we conducted—like tests for forced swimming, preferencing sucrose, and exploring open areas—helped us understand the impact of the treatment on rats' anxiety levels.
Remarkably, the treatment with the multi-strain probiotics and l-glutamine appeared to significantly improve the rats' behavior after they were stressed. While the probiotics were shown to play a critical role, the specific impact of l-glutamine alone in this context couldn't be fully isolated, as it was always paired with the probiotics.
Overall, we observed that the combination treatment successfully reversed certain mood-related issues linked to stress. However, the exact influence of l-glutamine on its own remains uncertain. The findings position the combined approach as a potential avenue for improving anxiety symptoms related to chronic stress.
Read More
4
Heat stress affects anxiety response
Heat-Stress Preconditioning Attenuates Behavioral Responses to Psychological Stress: The Role of HSP-70 in Modulating Stress Responses.
Examines l-glutamine's context
We explored the effects of heat stress on anxiety responses in male rats, particularly focusing on the role of l-glutamine in altering these responses. In the study, the rats were exposed to high temperatures for two hours, which resulted in noticeable physiological changes, such as weight loss and increased body temperature.
Following this exposure, the rats were subjected to a psychological stressor involving predator scent. Interestingly, those that underwent heat-stress preconditioning before facing this psychological stress exhibited notable resilience, displaying less anxiety-like behavior.
A significant factor in this protective effect was the induction of heat shock protein 70 (HSP-70), which is believed to play a role in how our bodies respond to stress. Although l-glutamine was introduced as a potential influencer on HSP-70 levels, the study suggests that the actual impact of l-glutamine on anxiety responses needs further evaluation. Overall, while there was an encouraging indication that heat-stress preconditioning might help with anxiety, the direct role of l-glutamine requires more investigation.
Following this exposure, the rats were subjected to a psychological stressor involving predator scent. Interestingly, those that underwent heat-stress preconditioning before facing this psychological stress exhibited notable resilience, displaying less anxiety-like behavior.
A significant factor in this protective effect was the induction of heat shock protein 70 (HSP-70), which is believed to play a role in how our bodies respond to stress. Although l-glutamine was introduced as a potential influencer on HSP-70 levels, the study suggests that the actual impact of l-glutamine on anxiety responses needs further evaluation. Overall, while there was an encouraging indication that heat-stress preconditioning might help with anxiety, the direct role of l-glutamine requires more investigation.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Improved calmness
Who knew so much good could come from one supplement? This is a "must-have" amino acid for anyone with anxiety or stress. I've reached a new level of calm – and I mean calm, not sedated; there's a distinction. While medications like SSRIs and benzodiazepines work, they tend to numb the issue instead of addressing it. Taking Taurine at a dose of 2-3g daily has significantly improved my mood and made me feel less "alone or depressed". It takes a few days for it to fully take effect on anxiety, and a couple of weeks for depression, but it’s worth trying.
Read More
9.5
Stress relief
A great addition to GABA. This supplement has been incredibly helpful for my stress and anxiety as I recover from adrenal fatigue. I take it 2-3 times a day with 250 mg of GABA, and it makes a significant difference in reducing the adrenal rushes I used to experience.
10
Helpful for anxiety
Another winner from NOW. I love the NOW brand as they thoroughly quality test their products. This has helped my daughter with anxiety, and we use it alongside l-theanine. It’s been very beneficial!
9.5
Greater stability
I feel much better overall – calmer and more stable. My anxiety has decreased, making me feel more balanced than before!
8.8
Reduced anxiety
This seems to help with my anxiety and depression, plus it gives me a little energy. I can cut back on Xanax and Adderall, which is a bonus. I take it in the morning and sometimes again later.
