5/19/2025
Last update
5/19/2025
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A(60% as Beta-Carotene and 40% from Fish Liver Oil)
7,500 mcg
833%
Vitamin D3(as Cholecalciferol) (from Lanolin)
25 mcg (1,000 IU)
125%
Top Medical Research Studies
9.5
Vitamin D3 ethosomes for psoriasis
We aimed to explore the effectiveness of a special gel infused with vitamin D3, known as an ethosome, in managing psoriasis. This inflammatory skin condition is driven by an overactive immune response, and vitamin D3 plays a crucial role in the growth and development of skin cells called keratinocytes, making it a promising treatment option.
In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
Read More
8
We explored how vitamin D influences psoriasis, a persistent skin condition marked by red, flaky patches. Our study analyzed data from a significant number of participants in the UK Biobank, including those diagnosed with various autoimmune diseases, with a focus on individuals suffering from psoriasis.
Through a unique approach known as Mendelian randomization, we looked into the causal relationship between vitamin D levels and psoriasis risk. This method allowed us to consider genetic variations linked to vitamin D metabolism, helping us predict how these levels could affect the likelihood of developing psoriasis.
The results we observed were quite promising. We found that higher genetically-predicted vitamin D levels were associated with a lower risk of developing psoriasis. Specifically, for every 10 ng/ml increase in vitamin D, the risk of psoriasis decreased significantly, suggesting a beneficial influence of vitamin D in this context.
While we also examined other autoimmune diseases, evidence supporting a similar protective effect for conditions like systemic lupus erythematosus was not as strong. However, our findings highlight the potential of vitamin D in managing psoriasis, paving the way for future prevention and treatment strategies.
Through a unique approach known as Mendelian randomization, we looked into the causal relationship between vitamin D levels and psoriasis risk. This method allowed us to consider genetic variations linked to vitamin D metabolism, helping us predict how these levels could affect the likelihood of developing psoriasis.
The results we observed were quite promising. We found that higher genetically-predicted vitamin D levels were associated with a lower risk of developing psoriasis. Specifically, for every 10 ng/ml increase in vitamin D, the risk of psoriasis decreased significantly, suggesting a beneficial influence of vitamin D in this context.
While we also examined other autoimmune diseases, evidence supporting a similar protective effect for conditions like systemic lupus erythematosus was not as strong. However, our findings highlight the potential of vitamin D in managing psoriasis, paving the way for future prevention and treatment strategies.
Read More
8
We evaluated the effectiveness of a new treatment involving calcipotriol, a vitamin D3 analogue, specifically designed to combat psoriasis vulgaris. This clinical trial included 24 participants, who underwent treatment with a water-free lipid-based formulation once daily for 12 days, allowing us to see how this innovative delivery system could enhance the medication's effects.
Our findings were promising, showing a significant reduction in psoriatic infiltrates—about 34% to 37%—after treatment with calcipotriol compared to a minimal change with the vehicle formulations. This suggests that the lipid-based formulations can effectively tackle the symptoms of psoriasis. However, it was essential to note that the improvement wasn't superior to the effects seen with marketed calcipotriol solutions and creams.
Participants reported some mild and non-serious side effects, but overall, the treatment was well-tolerated. In conclusion, the new lipid-based calcipotriol formulations showed efficacy and displayed an acceptable safety profile, making them a viable option for patients seeking relief from psoriasis symptoms.
Our findings were promising, showing a significant reduction in psoriatic infiltrates—about 34% to 37%—after treatment with calcipotriol compared to a minimal change with the vehicle formulations. This suggests that the lipid-based formulations can effectively tackle the symptoms of psoriasis. However, it was essential to note that the improvement wasn't superior to the effects seen with marketed calcipotriol solutions and creams.
Participants reported some mild and non-serious side effects, but overall, the treatment was well-tolerated. In conclusion, the new lipid-based calcipotriol formulations showed efficacy and displayed an acceptable safety profile, making them a viable option for patients seeking relief from psoriasis symptoms.
Read More
Most Useful Reviews
9
Effective for psoriasis
2 people found this helpful
Good afternoon. I have very dry skin, so I purchased this dietary supplement with fat-soluble vitamins. It helped with my psoriasis without needing creams or hormones. I also recommend it for eye and bone health. The dosage is appropriate, and vitamin D supports immunity. The packaging is compact, and the taste is reminiscent of Aevit.
Read More
7.5
Skin improvement
3 people found this helpful
I aimed to improve my skin issues, including psoriasis. The dermatological ointments I was prescribed contained vitamins A and D, which I believe are key for enhancing skin conditions. I began taking supplements, which are affordable and seem potent enough to help with skin problems. I feel that my skin has become somewhat stronger.
Read More
7.5
Rapid skin healing
This is a great combination of two vitamins with a good dosage that I take in the morning. It's particularly suitable for those experiencing skin issues, like psoriasis, and promotes rapid healing.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
- All Researches
9.5
Vitamin D3 ethosomes for psoriasis
We aimed to explore the effectiveness of a special gel infused with vitamin D3, known as an ethosome, in managing psoriasis. This inflammatory skin condition is driven by an overactive immune response, and vitamin D3 plays a crucial role in the growth and development of skin cells called keratinocytes, making it a promising treatment option.
In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
Read More
9.5
We conducted a study to better understand how topical treatments, particularly those involving vitamin D3, affect psoriasis. In our investigation, we focused on a group of 30 psoriasis patients, using a double-blind, randomized approach. This means neither the patients nor the researchers knew who received which treatment, ensuring an unbiased evaluation of their effects.
The treatments explored included a combination of Calcipotriol (a vitamin D3 analogue) and Betamethasone (a steroid), as well as Betamethasone alone and Clobetasol Propionate ointment. Through the analysis of skin biopsies before and after four weeks of treatment, we observed changes in skin inflammation, cellular infiltrate, and patients’ clinical scores for psoriasis severity.
While we noted that all treatments helped reduce skin thickness and improved patient scores, the greatest impact was seen with the combination of Calcipotriol and Betamethasone. This specific treatment effectively diminished the number of harmful immune cells that contribute to psoriasis flare-ups. However, the isolated effect of vitamin D3 alone wasn’t clearly established, as the most significant outcomes were tied to its use in combination with steroids.
Ultimately, our findings suggest that while vitamin D3 plays a role in psoriasis treatment, its benefits are most pronounced when paired with corticosteroids. This combination could potentially lead to enhanced long-term management of the disease, although the specific contribution of vitamin D3 alone remains uncertain.
The treatments explored included a combination of Calcipotriol (a vitamin D3 analogue) and Betamethasone (a steroid), as well as Betamethasone alone and Clobetasol Propionate ointment. Through the analysis of skin biopsies before and after four weeks of treatment, we observed changes in skin inflammation, cellular infiltrate, and patients’ clinical scores for psoriasis severity.
While we noted that all treatments helped reduce skin thickness and improved patient scores, the greatest impact was seen with the combination of Calcipotriol and Betamethasone. This specific treatment effectively diminished the number of harmful immune cells that contribute to psoriasis flare-ups. However, the isolated effect of vitamin D3 alone wasn’t clearly established, as the most significant outcomes were tied to its use in combination with steroids.
Ultimately, our findings suggest that while vitamin D3 plays a role in psoriasis treatment, its benefits are most pronounced when paired with corticosteroids. This combination could potentially lead to enhanced long-term management of the disease, although the specific contribution of vitamin D3 alone remains uncertain.
Read More
9
Calcipotriol more effective than calcitriol
We explored the effectiveness of two vitamin D analogues, calcipotriol and calcitriol, in treating stable plaque psoriasis when combined with narrow-band ultraviolet B (NBUVB) phototherapy. Our study involved thirty patients who were treated for 12 weeks, applying calcitriol ointment to one side and calcipotriol ointment to the other.
Throughout the trial, we observed significant improvements in skin conditions such as erythema, scaling, and overall plaque thickness with both treatments. Remarkably, those using calcipotriol showed quicker clearance of plaques and experienced fewer relapses compared to those using calcitriol.
Both treatments were found to be safe and well-tolerated, making them cosmetically appealing options. However, calcipotriol not only demonstrated a rapid onset of action but also maintained its efficacy more consistently over the treatment period.
Throughout the trial, we observed significant improvements in skin conditions such as erythema, scaling, and overall plaque thickness with both treatments. Remarkably, those using calcipotriol showed quicker clearance of plaques and experienced fewer relapses compared to those using calcitriol.
Both treatments were found to be safe and well-tolerated, making them cosmetically appealing options. However, calcipotriol not only demonstrated a rapid onset of action but also maintained its efficacy more consistently over the treatment period.
Read More
8
We explored how vitamin D influences psoriasis, a persistent skin condition marked by red, flaky patches. Our study analyzed data from a significant number of participants in the UK Biobank, including those diagnosed with various autoimmune diseases, with a focus on individuals suffering from psoriasis.
Through a unique approach known as Mendelian randomization, we looked into the causal relationship between vitamin D levels and psoriasis risk. This method allowed us to consider genetic variations linked to vitamin D metabolism, helping us predict how these levels could affect the likelihood of developing psoriasis.
The results we observed were quite promising. We found that higher genetically-predicted vitamin D levels were associated with a lower risk of developing psoriasis. Specifically, for every 10 ng/ml increase in vitamin D, the risk of psoriasis decreased significantly, suggesting a beneficial influence of vitamin D in this context.
While we also examined other autoimmune diseases, evidence supporting a similar protective effect for conditions like systemic lupus erythematosus was not as strong. However, our findings highlight the potential of vitamin D in managing psoriasis, paving the way for future prevention and treatment strategies.
Through a unique approach known as Mendelian randomization, we looked into the causal relationship between vitamin D levels and psoriasis risk. This method allowed us to consider genetic variations linked to vitamin D metabolism, helping us predict how these levels could affect the likelihood of developing psoriasis.
The results we observed were quite promising. We found that higher genetically-predicted vitamin D levels were associated with a lower risk of developing psoriasis. Specifically, for every 10 ng/ml increase in vitamin D, the risk of psoriasis decreased significantly, suggesting a beneficial influence of vitamin D in this context.
While we also examined other autoimmune diseases, evidence supporting a similar protective effect for conditions like systemic lupus erythematosus was not as strong. However, our findings highlight the potential of vitamin D in managing psoriasis, paving the way for future prevention and treatment strategies.
Read More
8
We evaluated the effectiveness of a new treatment involving calcipotriol, a vitamin D3 analogue, specifically designed to combat psoriasis vulgaris. This clinical trial included 24 participants, who underwent treatment with a water-free lipid-based formulation once daily for 12 days, allowing us to see how this innovative delivery system could enhance the medication's effects.
Our findings were promising, showing a significant reduction in psoriatic infiltrates—about 34% to 37%—after treatment with calcipotriol compared to a minimal change with the vehicle formulations. This suggests that the lipid-based formulations can effectively tackle the symptoms of psoriasis. However, it was essential to note that the improvement wasn't superior to the effects seen with marketed calcipotriol solutions and creams.
Participants reported some mild and non-serious side effects, but overall, the treatment was well-tolerated. In conclusion, the new lipid-based calcipotriol formulations showed efficacy and displayed an acceptable safety profile, making them a viable option for patients seeking relief from psoriasis symptoms.
Our findings were promising, showing a significant reduction in psoriatic infiltrates—about 34% to 37%—after treatment with calcipotriol compared to a minimal change with the vehicle formulations. This suggests that the lipid-based formulations can effectively tackle the symptoms of psoriasis. However, it was essential to note that the improvement wasn't superior to the effects seen with marketed calcipotriol solutions and creams.
Participants reported some mild and non-serious side effects, but overall, the treatment was well-tolerated. In conclusion, the new lipid-based calcipotriol formulations showed efficacy and displayed an acceptable safety profile, making them a viable option for patients seeking relief from psoriasis symptoms.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective for psoriasis
2 people found this helpful
Good afternoon. I have very dry skin, so I purchased this dietary supplement with fat-soluble vitamins. It helped with my psoriasis without needing creams or hormones. I also recommend it for eye and bone health. The dosage is appropriate, and vitamin D supports immunity. The packaging is compact, and the taste is reminiscent of Aevit.
Read More
7.5
Skin improvement
3 people found this helpful
I aimed to improve my skin issues, including psoriasis. The dermatological ointments I was prescribed contained vitamins A and D, which I believe are key for enhancing skin conditions. I began taking supplements, which are affordable and seem potent enough to help with skin problems. I feel that my skin has become somewhat stronger.
Read More
7.5
Rapid skin healing
This is a great combination of two vitamins with a good dosage that I take in the morning. It's particularly suitable for those experiencing skin issues, like psoriasis, and promotes rapid healing.
Read More
Frequently Asked Questions
7.5
Skin improvement
3 people found this helpful
I aimed to improve my skin issues, including psoriasis. The dermatological ointments I was prescribed contained vitamins A and D, which I believe are key for enhancing skin conditions. I began taking supplements, which are affordable and seem potent enough to help with skin problems. I feel that my skin has become somewhat stronger.
7.5
Rapid skin healing
This is a great combination of two vitamins with a good dosage that I take in the morning. It's particularly suitable for those experiencing skin issues, like psoriasis, and promotes rapid healing.
9
Effective for psoriasis
2 people found this helpful
Good afternoon. I have very dry skin, so I purchased this dietary supplement with fat-soluble vitamins. It helped with my psoriasis without needing creams or hormones. I also recommend it for eye and bone health. The dosage is appropriate, and vitamin D supports immunity. The packaging is compact, and the taste is reminiscent of Aevit.
9.5
Vitamin D3 ethosomes for psoriasis
We aimed to explore the effectiveness of a special gel infused with vitamin D3, known as an ethosome, in managing psoriasis. This inflammatory skin condition is driven by an overactive immune response, and vitamin D3 plays a crucial role in the growth and development of skin cells called keratinocytes, making it a promising treatment option.
In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
8
We explored how vitamin D influences psoriasis, a persistent skin condition marked by red, flaky patches. Our study analyzed data from a significant number of participants in the UK Biobank, including those diagnosed with various autoimmune diseases, with a focus on individuals suffering from psoriasis.
Through a unique approach known as Mendelian randomization, we looked into the causal relationship between vitamin D levels and psoriasis risk. This method allowed us to consider genetic variations linked to vitamin D metabolism, helping us predict how these levels could affect the likelihood of developing psoriasis.
The results we observed were quite promising. We found that higher genetically-predicted vitamin D levels were associated with a lower risk of developing psoriasis. Specifically, for every 10 ng/ml increase in vitamin D, the risk of psoriasis decreased significantly, suggesting a beneficial influence of vitamin D in this context.
While we also examined other autoimmune diseases, evidence supporting a similar protective effect for conditions like systemic lupus erythematosus was not as strong. However, our findings highlight the potential of vitamin D in managing psoriasis, paving the way for future prevention and treatment strategies.
Through a unique approach known as Mendelian randomization, we looked into the causal relationship between vitamin D levels and psoriasis risk. This method allowed us to consider genetic variations linked to vitamin D metabolism, helping us predict how these levels could affect the likelihood of developing psoriasis.
The results we observed were quite promising. We found that higher genetically-predicted vitamin D levels were associated with a lower risk of developing psoriasis. Specifically, for every 10 ng/ml increase in vitamin D, the risk of psoriasis decreased significantly, suggesting a beneficial influence of vitamin D in this context.
While we also examined other autoimmune diseases, evidence supporting a similar protective effect for conditions like systemic lupus erythematosus was not as strong. However, our findings highlight the potential of vitamin D in managing psoriasis, paving the way for future prevention and treatment strategies.
2
We investigated the relationship between vitamin D3 levels and psoriasis, a chronic inflammatory skin condition. In our review of the literature, we gathered data from 23 studies involving nearly 1,900 psoriasis patients and over 7,500 healthy individuals.
Our findings showed that psoriasis patients generally had lower levels of 25 hydroxyvitamin D (the form of vitamin D measured in blood tests) compared to healthy controls. Specifically, the average vitamin D level in psoriasis patients was 21.0 ng/mL, while it was 27.3 ng/mL in those without the condition.
However, when we looked at the impact of taking vitamin D3 supplements on psoriasis severity, the results were less promising. In four randomized controlled trials that included 173 psoriasis patients receiving vitamin D3 and 160 patients receiving a placebo, we found no significant improvements in the severity of psoriasis over 3, 6, or 12 months of treatment.
While the initial observation of lower vitamin D levels in psoriasis patients is intriguing and suggests a connection, the lack of improvement through supplementation indicates that vitamin D3 might not be the solution we hoped for in treating psoriasis.
Our findings showed that psoriasis patients generally had lower levels of 25 hydroxyvitamin D (the form of vitamin D measured in blood tests) compared to healthy controls. Specifically, the average vitamin D level in psoriasis patients was 21.0 ng/mL, while it was 27.3 ng/mL in those without the condition.
However, when we looked at the impact of taking vitamin D3 supplements on psoriasis severity, the results were less promising. In four randomized controlled trials that included 173 psoriasis patients receiving vitamin D3 and 160 patients receiving a placebo, we found no significant improvements in the severity of psoriasis over 3, 6, or 12 months of treatment.
While the initial observation of lower vitamin D levels in psoriasis patients is intriguing and suggests a connection, the lack of improvement through supplementation indicates that vitamin D3 might not be the solution we hoped for in treating psoriasis.
7
We investigated the impact of vitamin D3 supplementation in conjunction with photodynamic therapy, particularly focusing on its effects on psoriasis. Previous research has suggested a potential improvement in psoriasis symptoms when vitamin D3 is added to treatment regimens.
During our review of existing literature, we found that combining vitamin D3 with photodynamic therapy could enhance the overall effectiveness of treatment. Many studies indicate a significant improvement in psoriasis, with reported responses increasing by 6-30%, and in some cases, even up to 10 times greater than when photodynamic therapy is used alone.
It appears that vitamin D3 not only supports but potentially amplifies the effects of photodynamic therapy, which may lead to further research and clinical trials. Overall, the findings suggest a promising avenue for improving psoriasis treatment through vitamin D3 supplementation alongside traditional therapies.
During our review of existing literature, we found that combining vitamin D3 with photodynamic therapy could enhance the overall effectiveness of treatment. Many studies indicate a significant improvement in psoriasis, with reported responses increasing by 6-30%, and in some cases, even up to 10 times greater than when photodynamic therapy is used alone.
It appears that vitamin D3 not only supports but potentially amplifies the effects of photodynamic therapy, which may lead to further research and clinical trials. Overall, the findings suggest a promising avenue for improving psoriasis treatment through vitamin D3 supplementation alongside traditional therapies.
9.5
We conducted a study to better understand how topical treatments, particularly those involving vitamin D3, affect psoriasis. In our investigation, we focused on a group of 30 psoriasis patients, using a double-blind, randomized approach. This means neither the patients nor the researchers knew who received which treatment, ensuring an unbiased evaluation of their effects.
The treatments explored included a combination of Calcipotriol (a vitamin D3 analogue) and Betamethasone (a steroid), as well as Betamethasone alone and Clobetasol Propionate ointment. Through the analysis of skin biopsies before and after four weeks of treatment, we observed changes in skin inflammation, cellular infiltrate, and patients’ clinical scores for psoriasis severity.
While we noted that all treatments helped reduce skin thickness and improved patient scores, the greatest impact was seen with the combination of Calcipotriol and Betamethasone. This specific treatment effectively diminished the number of harmful immune cells that contribute to psoriasis flare-ups. However, the isolated effect of vitamin D3 alone wasn’t clearly established, as the most significant outcomes were tied to its use in combination with steroids.
Ultimately, our findings suggest that while vitamin D3 plays a role in psoriasis treatment, its benefits are most pronounced when paired with corticosteroids. This combination could potentially lead to enhanced long-term management of the disease, although the specific contribution of vitamin D3 alone remains uncertain.
The treatments explored included a combination of Calcipotriol (a vitamin D3 analogue) and Betamethasone (a steroid), as well as Betamethasone alone and Clobetasol Propionate ointment. Through the analysis of skin biopsies before and after four weeks of treatment, we observed changes in skin inflammation, cellular infiltrate, and patients’ clinical scores for psoriasis severity.
While we noted that all treatments helped reduce skin thickness and improved patient scores, the greatest impact was seen with the combination of Calcipotriol and Betamethasone. This specific treatment effectively diminished the number of harmful immune cells that contribute to psoriasis flare-ups. However, the isolated effect of vitamin D3 alone wasn’t clearly established, as the most significant outcomes were tied to its use in combination with steroids.
Ultimately, our findings suggest that while vitamin D3 plays a role in psoriasis treatment, its benefits are most pronounced when paired with corticosteroids. This combination could potentially lead to enhanced long-term management of the disease, although the specific contribution of vitamin D3 alone remains uncertain.
References
- Mehmood Y, Shahid H, Ahmed S, Khursheed A, Jamshaid T, et al. Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies. Sci Rep. 2024;14:23866. 10.1038/s41598-024-72951-6
- Formisano E, Proietti E, Borgarelli C, Pisciotta L. Psoriasis and Vitamin D: A Systematic Review and Meta-Analysis. Nutrients. 2023;15. 10.3390/nu15153387
- Zhao SS, Mason A, Gjekmarkaj E, Yanaoka H, Burgess S. Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis. Semin Arthritis Rheum. 2023;62:152238. 10.1016/j.semarthrit.2023.152238
- Chakraborty D, Aggarwal K. Comparative evaluation of efficacy and safety of calcipotriol versus calcitriol ointment, both in combination with narrow-band ultraviolet B phototherapy in the treatment of stable plaque psoriasis. Photodermatol Photoimmunol Photomed. 2023;39:512. 10.1111/phpp.12893
- Holmback J, Carlsson A, Rinwa P. Efficacy and Safety of Water-Free Lipid Formulation System Containing Calcipotriol Against Psoriasis Vulgaris. J Drugs Dermatol. 2023;22:197. 10.36849/JDD.7151
- Mazur A, Koziorowska K, Dynarowicz K, Aebisher D, Bartusik-Aebisher D. Vitamin D and Vitamin D3 Supplementation during Photodynamic Therapy: A Review. Nutrients. 2022;14. 10.3390/nu14183805
- Heim M, Irondelle M, Duteil L, Cardot-Leccia N, Rocchi S, et al. Impact of topical emollient, steroids alone or combined with calcipotriol, on the immune infiltrate and clinical outcome in psoriasis. Exp Dermatol. 2022;31:1764. 10.1111/exd.14657
