' 
![]()
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.2
USERS' SCORE
Good
Based on 10 Reviews
8.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin E (as d-alpha Tocopheryl Acetate)
268 mg
1787%
Top Medical Research Studies
8
Gamma-tocopherol in cancer research
Gamma-Tocopherol: A Comprehensive Review of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties.
Strong focus on cancer effects
We examined the effects of gamma-tocopherol, a major form of vitamin E, on cancer treatment and prevention. This powerful antioxidant is noted for its ability to combat oxidative stress, which plays a significant role in the development and progression of various cancers.
In several studies, we observed that gamma-tocopherol not only neutralizes harmful reactive oxygen species but also exhibits anti-inflammatory properties. These characteristics help reduce chronic inflammation tied to cancer risks. Furthermore, it has shown the potential to inhibit tumor growth, induce cancer cell death, and restrict blood vessel formation that tumors require to grow.
Specifically, findings indicated that gamma-tocopherol is particularly effective in cancers such as prostate, lung, and colon. With promising results from both preclinical and clinical trials, there is a growing interest in how this natural compound can be beneficial in cancer management.
While we noted excellent tolerance at normal doses, it’s essential to consider careful monitoring at higher levels to avoid any adverse effects. Hence, we believe that ongoing research and advancements in drug delivery methods could further enhance its effectiveness.
In several studies, we observed that gamma-tocopherol not only neutralizes harmful reactive oxygen species but also exhibits anti-inflammatory properties. These characteristics help reduce chronic inflammation tied to cancer risks. Furthermore, it has shown the potential to inhibit tumor growth, induce cancer cell death, and restrict blood vessel formation that tumors require to grow.
Specifically, findings indicated that gamma-tocopherol is particularly effective in cancers such as prostate, lung, and colon. With promising results from both preclinical and clinical trials, there is a growing interest in how this natural compound can be beneficial in cancer management.
While we noted excellent tolerance at normal doses, it’s essential to consider careful monitoring at higher levels to avoid any adverse effects. Hence, we believe that ongoing research and advancements in drug delivery methods could further enhance its effectiveness.
Read More
9
Vitamin E reprograms immune cells
Reprogramming tumor-associated macrophages with lipid nanosystems reduces PDAC tumor burden and liver metastasis.
High relevance to cancer treatment
Our study delves into the innovative use of vitamin E as part of a lipid nanosystem to change the behavior of tumor-associated macrophages (TAMs). These immune cells typically foster a pro-cancer environment, and we aimed to see if reprogramming them could impact pancreatic cancer's progression and metastasis, particularly in the liver.
We found that treating M2-polarized macrophages with a nanoemulsion of vitamin E and sphingomyelin made them shift from a pro-tumor state to a more neutral or anti-tumor state. The treatment decreased markers associated with the M2 phenotype, which promotes cancer growth, and increased markers of the M1 phenotype that fight cancer. Notably, when we coupled this treatment with a drug that inhibits TGF-βR1, it led to reduced tumor growth and liver metastasis in models of pancreatic cancer.
This work underscores vitamin E's potential as a part of a broader therapeutic strategy aimed at reprogramming immune cells to better combat cancer. By targeting TAMs, we are opening new avenues for treatments that not only manage the primary tumors but also curb the spread of cancer to other organs, like the liver, which is vital for improving outcomes for patients dealing with aggressive forms of the disease.
We found that treating M2-polarized macrophages with a nanoemulsion of vitamin E and sphingomyelin made them shift from a pro-tumor state to a more neutral or anti-tumor state. The treatment decreased markers associated with the M2 phenotype, which promotes cancer growth, and increased markers of the M1 phenotype that fight cancer. Notably, when we coupled this treatment with a drug that inhibits TGF-βR1, it led to reduced tumor growth and liver metastasis in models of pancreatic cancer.
This work underscores vitamin E's potential as a part of a broader therapeutic strategy aimed at reprogramming immune cells to better combat cancer. By targeting TAMs, we are opening new avenues for treatments that not only manage the primary tumors but also curb the spread of cancer to other organs, like the liver, which is vital for improving outcomes for patients dealing with aggressive forms of the disease.
Read More
9
Vitamin E impacts cancer growth
Targeting DTX2/UFD1-mediated FTO degradation to regulate antitumor immunity.
High relevance to cancer treatment
We observed that vitamin E succinate (VES) has the potential to serve as a tool for fighting cancer, particularly by targeting a protein called fat mass and obesity-associated protein (FTO), which plays a role in tumor growth. This study highlights how VES can act as a degrader of FTO, leading to its suppression, thereby hindering tumor progression and enhancing the effectiveness of immunotherapy.
When VES binds to both FTO and an associated protein called DTX2, it boosts the interaction between them. This ultimately promotes the process that marks FTO for degradation. In animal models, treatment with VES resulted in reduced tumor size and a significant improvement in the immune response against tumors, suggesting a promising avenue for enhancing cancer treatment strategies.
Furthermore, reducing FTO levels increased the methylation of a specific gene, LIF, involved in regulating immune responses, which allowed melanoma cells to become more susceptible to T cell attacks. Overall, these findings shed light on how VES not only degrades FTO but also holds the potential to improve outcomes for patients undergoing cancer therapies.
When VES binds to both FTO and an associated protein called DTX2, it boosts the interaction between them. This ultimately promotes the process that marks FTO for degradation. In animal models, treatment with VES resulted in reduced tumor size and a significant improvement in the immune response against tumors, suggesting a promising avenue for enhancing cancer treatment strategies.
Furthermore, reducing FTO levels increased the methylation of a specific gene, LIF, involved in regulating immune responses, which allowed melanoma cells to become more susceptible to T cell attacks. Overall, these findings shed light on how VES not only degrades FTO but also holds the potential to improve outcomes for patients undergoing cancer therapies.
Read More
Most Useful Reviews
7.8
Synergistic effects
Vitamin E is vital for those practising Fujikawa's theory. High in antioxidants, it is expected to offer anti-aging benefits and cancer prevention. It enhances the effects of vitamins B and C when taken separately.
Read More
8
Cancer prevention benefits
Excellent! My wife and I take a NOW Foods E-400 softgel with mixed tocopherols each morning. We chose Vitamin E for its antioxidant properties, immune support, and vascular health. Consuming avocados, a natural source of Vitamin E, may also help reduce the likelihood of developing cancer. Good value.
Read More
8.8
Women's health support
I take Vitamin E regularly for my thyroid health. Known for its positive effects on women's health, it normalises cycles and improves hair, nail, and skin condition. It inhibits oxidative processes linked to cancer.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.2
9
Nanoparticles improve cancer therapies
Computer-Aided Design of Self-Assembled Nanoparticles to Enhance Cancer Chemoimmunotherapy via Dual-Modulation Strategy.
Combination treatments complicate isolation
This study focuses on the innovative use of self-assembled nanoparticles to improve cancer treatment, particularly for triple-negative breast cancer. By leveraging computer-aided strategies, researchers identified key properties that guide the creation of these nanoparticles.
We observed that vitamin E, when combined with hydroxychloroquine and bortezomib, resulted in a unique nanoparticle formulation. This formulation not only helps reduce harmful M2-type tumor-associated macrophages but also induces a process known as immunogenic cell death in tumor cells.
In experiments conducted on mouse models, the nanoparticles displayed promising results. They effectively decreased levels of regulatory T cells and transforming growth factor-β while enhancing the presence of cytotoxic T lymphocytes. Moreover, they inhibited the secretion of a pro-inflammatory factor known as Interleukin-6, which can contribute to tumor growth and poor immune response.
The combination of vitamin E and other compounds showcases a dual modulation approach, potentially reprogramming the tumor microenvironment to enhance chemotherapy combined with immunotherapy.
However, while the study highlights potential benefits, it also suggests that isolating vitamin E's effect in cancer treatment is challenging due to its application alongside other treatments.
We observed that vitamin E, when combined with hydroxychloroquine and bortezomib, resulted in a unique nanoparticle formulation. This formulation not only helps reduce harmful M2-type tumor-associated macrophages but also induces a process known as immunogenic cell death in tumor cells.
In experiments conducted on mouse models, the nanoparticles displayed promising results. They effectively decreased levels of regulatory T cells and transforming growth factor-β while enhancing the presence of cytotoxic T lymphocytes. Moreover, they inhibited the secretion of a pro-inflammatory factor known as Interleukin-6, which can contribute to tumor growth and poor immune response.
The combination of vitamin E and other compounds showcases a dual modulation approach, potentially reprogramming the tumor microenvironment to enhance chemotherapy combined with immunotherapy.
However, while the study highlights potential benefits, it also suggests that isolating vitamin E's effect in cancer treatment is challenging due to its application alongside other treatments.
Read More
9
Vitamin E reprograms immune cells
Reprogramming tumor-associated macrophages with lipid nanosystems reduces PDAC tumor burden and liver metastasis.
High relevance to cancer treatment
Our study delves into the innovative use of vitamin E as part of a lipid nanosystem to change the behavior of tumor-associated macrophages (TAMs). These immune cells typically foster a pro-cancer environment, and we aimed to see if reprogramming them could impact pancreatic cancer's progression and metastasis, particularly in the liver.
We found that treating M2-polarized macrophages with a nanoemulsion of vitamin E and sphingomyelin made them shift from a pro-tumor state to a more neutral or anti-tumor state. The treatment decreased markers associated with the M2 phenotype, which promotes cancer growth, and increased markers of the M1 phenotype that fight cancer. Notably, when we coupled this treatment with a drug that inhibits TGF-βR1, it led to reduced tumor growth and liver metastasis in models of pancreatic cancer.
This work underscores vitamin E's potential as a part of a broader therapeutic strategy aimed at reprogramming immune cells to better combat cancer. By targeting TAMs, we are opening new avenues for treatments that not only manage the primary tumors but also curb the spread of cancer to other organs, like the liver, which is vital for improving outcomes for patients dealing with aggressive forms of the disease.
We found that treating M2-polarized macrophages with a nanoemulsion of vitamin E and sphingomyelin made them shift from a pro-tumor state to a more neutral or anti-tumor state. The treatment decreased markers associated with the M2 phenotype, which promotes cancer growth, and increased markers of the M1 phenotype that fight cancer. Notably, when we coupled this treatment with a drug that inhibits TGF-βR1, it led to reduced tumor growth and liver metastasis in models of pancreatic cancer.
This work underscores vitamin E's potential as a part of a broader therapeutic strategy aimed at reprogramming immune cells to better combat cancer. By targeting TAMs, we are opening new avenues for treatments that not only manage the primary tumors but also curb the spread of cancer to other organs, like the liver, which is vital for improving outcomes for patients dealing with aggressive forms of the disease.
Read More
9
Vitamin E impacts cancer growth
Targeting DTX2/UFD1-mediated FTO degradation to regulate antitumor immunity.
High relevance to cancer treatment
We observed that vitamin E succinate (VES) has the potential to serve as a tool for fighting cancer, particularly by targeting a protein called fat mass and obesity-associated protein (FTO), which plays a role in tumor growth. This study highlights how VES can act as a degrader of FTO, leading to its suppression, thereby hindering tumor progression and enhancing the effectiveness of immunotherapy.
When VES binds to both FTO and an associated protein called DTX2, it boosts the interaction between them. This ultimately promotes the process that marks FTO for degradation. In animal models, treatment with VES resulted in reduced tumor size and a significant improvement in the immune response against tumors, suggesting a promising avenue for enhancing cancer treatment strategies.
Furthermore, reducing FTO levels increased the methylation of a specific gene, LIF, involved in regulating immune responses, which allowed melanoma cells to become more susceptible to T cell attacks. Overall, these findings shed light on how VES not only degrades FTO but also holds the potential to improve outcomes for patients undergoing cancer therapies.
When VES binds to both FTO and an associated protein called DTX2, it boosts the interaction between them. This ultimately promotes the process that marks FTO for degradation. In animal models, treatment with VES resulted in reduced tumor size and a significant improvement in the immune response against tumors, suggesting a promising avenue for enhancing cancer treatment strategies.
Furthermore, reducing FTO levels increased the methylation of a specific gene, LIF, involved in regulating immune responses, which allowed melanoma cells to become more susceptible to T cell attacks. Overall, these findings shed light on how VES not only degrades FTO but also holds the potential to improve outcomes for patients undergoing cancer therapies.
Read More
9
Vitamin E enhances cancer treatment
Combination therapy of Lapatinib/Letrozole-based protein-vitamin nanoparticles to enhance the therapeutic effectiveness in drug-resistant breast cancer.
Evaluates combination therapy effectiveness
In our exploration of breast cancer treatments, we investigated how nanoparticles infused with vitamin E could effectively deliver cancer medications. Our study specifically focused on drug-resistant HER2-positive breast cancer, which is challenging to treat due to its tendency to develop resistance to standard therapies.
We developed nanoparticles from human serum albumin linked with vitamin E, designed to encapsulate and deliver targeted cancer drugs. Through sophisticated methods, including infrared spectroscopy and cell viability assays, we confirmed that the nanoparticles efficiently bound the drugs and released them over time.
Our results revealed that combining these vitamin E-laden nanoparticles—specifically Lapatinib and Letrozole—in a carefully designed ratio led to a substantial reduction in tumor growth. This combination not only outperformed individual treatments but also proved effective in drug-resistant cell lines, showcasing the potential of vitamin E as a vehicle for enhancing cancer therapy.
Overall, while the study highlighted the promising role of vitamin E in this innovative drug delivery approach, it primarily emphasized the combined effects of the therapies rather than isolating vitamin E's impact alone.
We developed nanoparticles from human serum albumin linked with vitamin E, designed to encapsulate and deliver targeted cancer drugs. Through sophisticated methods, including infrared spectroscopy and cell viability assays, we confirmed that the nanoparticles efficiently bound the drugs and released them over time.
Our results revealed that combining these vitamin E-laden nanoparticles—specifically Lapatinib and Letrozole—in a carefully designed ratio led to a substantial reduction in tumor growth. This combination not only outperformed individual treatments but also proved effective in drug-resistant cell lines, showcasing the potential of vitamin E as a vehicle for enhancing cancer therapy.
Overall, while the study highlighted the promising role of vitamin E in this innovative drug delivery approach, it primarily emphasized the combined effects of the therapies rather than isolating vitamin E's impact alone.
Read More
8
Gamma-tocopherol in cancer research
Gamma-Tocopherol: A Comprehensive Review of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties.
Strong focus on cancer effects
We examined the effects of gamma-tocopherol, a major form of vitamin E, on cancer treatment and prevention. This powerful antioxidant is noted for its ability to combat oxidative stress, which plays a significant role in the development and progression of various cancers.
In several studies, we observed that gamma-tocopherol not only neutralizes harmful reactive oxygen species but also exhibits anti-inflammatory properties. These characteristics help reduce chronic inflammation tied to cancer risks. Furthermore, it has shown the potential to inhibit tumor growth, induce cancer cell death, and restrict blood vessel formation that tumors require to grow.
Specifically, findings indicated that gamma-tocopherol is particularly effective in cancers such as prostate, lung, and colon. With promising results from both preclinical and clinical trials, there is a growing interest in how this natural compound can be beneficial in cancer management.
While we noted excellent tolerance at normal doses, it’s essential to consider careful monitoring at higher levels to avoid any adverse effects. Hence, we believe that ongoing research and advancements in drug delivery methods could further enhance its effectiveness.
In several studies, we observed that gamma-tocopherol not only neutralizes harmful reactive oxygen species but also exhibits anti-inflammatory properties. These characteristics help reduce chronic inflammation tied to cancer risks. Furthermore, it has shown the potential to inhibit tumor growth, induce cancer cell death, and restrict blood vessel formation that tumors require to grow.
Specifically, findings indicated that gamma-tocopherol is particularly effective in cancers such as prostate, lung, and colon. With promising results from both preclinical and clinical trials, there is a growing interest in how this natural compound can be beneficial in cancer management.
While we noted excellent tolerance at normal doses, it’s essential to consider careful monitoring at higher levels to avoid any adverse effects. Hence, we believe that ongoing research and advancements in drug delivery methods could further enhance its effectiveness.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.3
9.5
Cancer risk reduction
A good natural Vitamin E helps with various health issues. Its deficiency can increase the risk of cancer and other diseases, while proper intake may enhance immunity and reduce cardiovascular issues.
8.8
Women's health support
I take Vitamin E regularly for my thyroid health. Known for its positive effects on women's health, it normalises cycles and improves hair, nail, and skin condition. It inhibits oxidative processes linked to cancer.
8.8
Brain function preservation
An excellent natural vitamin, E helps preserve brain function and reduces cancer risk. Highly recommend it.
8.8
Skin improvement noted
I tolerate this well and my skin looks better. I started taking Vitamin E after a cancer diagnosis – the cancer is nothing to worry about since it is extraordinarily curable. Vitamin E is a great antioxidant and I noticed my skin improved a couple of weeks later. I didn't realise it needed improvement until it got better.
Read More
8.5
Glowing appearance
This supplement gives me a glowing appearance. I take it daily for its antioxidant properties, which help fight free radicals linked to cancer.
