Last update
5/30/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.1
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Thiamin (from Thiamin HCl) (Vitamin B-1)
100 mg
8333%
Riboflavin (Vitamin B-2)
100 mg
7692%
Niacin (Vitamin B-3) (as Niacinamide)
100 mg
625%
Vitamin B-6 (from Pyridoxine HCl)
100 mg
5882%
Folate
680 mcg DFE (400 mcg folic acid)
170%
Vitamin B-12 (as Cyanocobalamin)
100 mcg
4167%
Biotin
100 mcg
333%
Pantothenic Acid (from Calcium Pantothenate)
100 mg
2000%
Choline (from Choline Bitartrate)
10 mg
2%
Inositol
10 mg
†
PABA (Para-Aminobenzoic Acid)
10 mg
†
Top Medical Research Studies
8
Vitamin B12 deficiency diagnosed and treated
We examined a case of a 40-year-old woman who struggled for a decade with vague symptoms like fatigue and numbness, initially diagnosed with various other conditions. It wasn't until further investigation that she was found to have critically low vitamin B12 levels due to pernicious anemia.
After starting parenteral B12 therapy, we saw significant neurologic improvement, highlighting the vital role vitamin B12 plays in treating neuropathy. This case serves as a reminder to consider vitamin deficiencies in similar patients, even when traditional blood tests don't reveal anemia.
After starting parenteral B12 therapy, we saw significant neurologic improvement, highlighting the vital role vitamin B12 plays in treating neuropathy. This case serves as a reminder to consider vitamin deficiencies in similar patients, even when traditional blood tests don't reveal anemia.
Read More
8
We explored how folic acid (FA) supports the healing of nerve injuries, specifically in the context of peripheral nerve damage. Utilizing a rat model of sciatic nerve crush injury, we assessed various effects, including cell growth, survival, and motor function improvement.
Our results showed that FA effectively balanced methionine metabolism, enhanced neuron survival, and improved motor abilities following injury. Additionally, FA seemed to regulate gene expression linked to nerve repair by modulating DNA and histone modifications.
However, it’s vital to note that while the findings are promising, further research is needed to fully understand FA's capabilities in nerve repair.
Our results showed that FA effectively balanced methionine metabolism, enhanced neuron survival, and improved motor abilities following injury. Additionally, FA seemed to regulate gene expression linked to nerve repair by modulating DNA and histone modifications.
However, it’s vital to note that while the findings are promising, further research is needed to fully understand FA's capabilities in nerve repair.
Read More
9
Vitamin B12 improves vision loss
We examined a case of optic neuritis in a 33-year-old woman with HIV, who experienced sudden vision loss. Interestingly, she had a history of severe peripheral neuropathy treated with vitamin B12 tablets years earlier. As her treatment progressed, vitamin B12 injections were administered daily for 10 days, followed by monthly doses. Encouragingly, after five months of this treatment, she regained her sight.
This case highlights the importance of recognizing vitamin B12 deficiency, especially in patients with other health challenges, to prevent potentially serious complications.
This case highlights the importance of recognizing vitamin B12 deficiency, especially in patients with other health challenges, to prevent potentially serious complications.
Read More
Most Useful Reviews
6
Effective daily support
45 people found this helpful
I take B-100 caps daily, which help with my eyesight and also alleviate neuropathy in my feet caused by diabetes. I usually take two capsules at once, though I find the effects last for three to four hours. Capsules seem to work more effectively than pills. While I prefer the Twin Labs brand, Now Foods is often more affordable and equally effective. The 250-capsule size is a good value for money.
Read More
7.5
Top-notch supplement
2 people found this helpful
My favourite supplement for neuropathy.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.9
- All Researches
9
Vitamin B12 improves vision loss
We examined a case of optic neuritis in a 33-year-old woman with HIV, who experienced sudden vision loss. Interestingly, she had a history of severe peripheral neuropathy treated with vitamin B12 tablets years earlier. As her treatment progressed, vitamin B12 injections were administered daily for 10 days, followed by monthly doses. Encouragingly, after five months of this treatment, she regained her sight.
This case highlights the importance of recognizing vitamin B12 deficiency, especially in patients with other health challenges, to prevent potentially serious complications.
This case highlights the importance of recognizing vitamin B12 deficiency, especially in patients with other health challenges, to prevent potentially serious complications.
Read More
8
Vitamin B12 deficiency diagnosed and treated
We examined a case of a 40-year-old woman who struggled for a decade with vague symptoms like fatigue and numbness, initially diagnosed with various other conditions. It wasn't until further investigation that she was found to have critically low vitamin B12 levels due to pernicious anemia.
After starting parenteral B12 therapy, we saw significant neurologic improvement, highlighting the vital role vitamin B12 plays in treating neuropathy. This case serves as a reminder to consider vitamin deficiencies in similar patients, even when traditional blood tests don't reveal anemia.
After starting parenteral B12 therapy, we saw significant neurologic improvement, highlighting the vital role vitamin B12 plays in treating neuropathy. This case serves as a reminder to consider vitamin deficiencies in similar patients, even when traditional blood tests don't reveal anemia.
Read More
8
We explored how folic acid (FA) supports the healing of nerve injuries, specifically in the context of peripheral nerve damage. Utilizing a rat model of sciatic nerve crush injury, we assessed various effects, including cell growth, survival, and motor function improvement.
Our results showed that FA effectively balanced methionine metabolism, enhanced neuron survival, and improved motor abilities following injury. Additionally, FA seemed to regulate gene expression linked to nerve repair by modulating DNA and histone modifications.
However, it’s vital to note that while the findings are promising, further research is needed to fully understand FA's capabilities in nerve repair.
Our results showed that FA effectively balanced methionine metabolism, enhanced neuron survival, and improved motor abilities following injury. Additionally, FA seemed to regulate gene expression linked to nerve repair by modulating DNA and histone modifications.
However, it’s vital to note that while the findings are promising, further research is needed to fully understand FA's capabilities in nerve repair.
Read More
8
We evaluated the effectiveness of the Tangbi Formula alongside conventional medication in treating diabetic distal symmetric polyneuropathy. In our multicenter study, 188 participants were randomly assigned to either receive this herbal blend or a placebo, both combined with methylcobalamin, over 24 weeks.
The results showed that those on the Tangbi Formula experienced significantly greater improvements in clinical symptoms compared to the control group. However, nerve conduction velocities did not change notably for either group. Overall, we found that this herbal treatment may offer a safer and more effective option for managing symptoms of diabetic neuropathy.
The results showed that those on the Tangbi Formula experienced significantly greater improvements in clinical symptoms compared to the control group. However, nerve conduction velocities did not change notably for either group. Overall, we found that this herbal treatment may offer a safer and more effective option for managing symptoms of diabetic neuropathy.
Read More
8
Nicotinamide shows no clear benefits
We evaluated the effects of nicotinamide (NAm) and N-GABA on nerve damage caused by type 1 diabetes in rats. After six weeks of diabetes, the rats received two weeks of treatment with either substance.
While NAm didn't show benefits in blood glucose or body weight, N-GABA reduced glucose levels and enhanced the expression of myelin basic protein, which is crucial for nerve health.
Our findings suggest that N-GABA, in particular, may protect nerves and improve myelination, hinting at its potential as a therapeutic option against diabetes-related nerve issues.
While NAm didn't show benefits in blood glucose or body weight, N-GABA reduced glucose levels and enhanced the expression of myelin basic protein, which is crucial for nerve health.
Our findings suggest that N-GABA, in particular, may protect nerves and improve myelination, hinting at its potential as a therapeutic option against diabetes-related nerve issues.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
6
Effective daily support
45 people found this helpful
I take B-100 caps daily, which help with my eyesight and also alleviate neuropathy in my feet caused by diabetes. I usually take two capsules at once, though I find the effects last for three to four hours. Capsules seem to work more effectively than pills. While I prefer the Twin Labs brand, Now Foods is often more affordable and equally effective. The 250-capsule size is a good value for money.
Read More
7.5
Top-notch supplement
2 people found this helpful
My favourite supplement for neuropathy.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. 10.1186/s13256-025-05149-7
- Kang W, Zhang Y, Cui W, Meng H, Zhang D. Folic Acid Promotes Peripheral Nerve Injury Repair via Regulating DNM3-AKT Pathway Through Mediating Methionine Cycle Metabolism. Neuromolecular Med. 2025;27:23. 10.1007/s12017-025-08845-1
- Zhao X, An X, Cui Y, Dong L, Fang Z, et al. TangBi Formula for Painful Diabetic Distal Symmetric Polyneuropathy: A Multicenter, Randomized, Double-Blind, Placebo-Controlled and Parallel-Group Trial. J Diabetes. 2025;17:e70045. 10.1111/1753-0407.70045
- Brunt TM, van den Brink W, van Amsterdam J. Rare but relevant: Nitrous oxide and peripheral neurotoxicity, what do we know?. Addiction. 2025;120:1046. 10.1111/add.16753
- Kuchmerovska T, Tykhonenko T, Yanitska L, Savosko S, Pryvrotska I. Nicotinamide and Nicotinoyl-Gamma-Aminobutyric Acid as Neuroprotective Agents Against Type 1 Diabetes-Induced Nervous System Impairments in Rats. Neurochem Res. 2024;50:1. 10.1007/s11064-024-04257-y
- Bandara P, Wijenayake W, Fernando S, Padeniya P, Mettananda S. Vitamin B12 responsive developmental and epileptic encephalopathy due to a novel mutation in the FUT2 gene: a case report. BMC Pediatr. 2024;24:622. 10.1186/s12887-024-05106-1
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. 10.3390/nu16183045
- Artiukhov AV, Solovjeva ON, Balashova NV, Sidorova OP, Graf AV, et al. Pharmacological Doses of Thiamine Benefit Patients with the Charcot-Marie-Tooth Neuropathy by Changing Thiamine Diphosphate Levels and Affecting Regulation of Thiamine-Dependent Enzymes. Biochemistry (Mosc). 2024;89:1161. 10.1134/S0006297924070010
- Scharf K, Tang J, Jamall S, Baker N. Atypical presentation of Wernicke encephalopathy due to thiamine deficiency in a patient post sleeve gastrectomy. BMJ Case Rep. 2024;17. 10.1136/bcr-2024-261292
- Lubega G, Lutaakome J, Kibirige M, Opoka D, Atukunda I, et al. Vitamin B12 deficiency presenting as progressive blindness in a 33-year-old HIV-positive female patient on Efavirenz-based regimen: case report. Pan Afr Med J. 2024;47:164. 10.11604/pamj.2024.47.164.43048
