Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Thiamin (from Thiamin HCl) (Vitamin B-1)
100 mg
8333%
Riboflavin (Vitamin B-2)
100 mg
7692%
Niacin (Vitamin B-3) (as Niacinamide)
100 mg
625%
Vitamin B-6 (from Pyridoxine HCl)
100 mg
5882%
Folate
680 mcg DFE(400 mcg folic acid)
170%
Vitamin B-12 (as Cyanocobalamin)
100 mcg
4167%
Biotin
100 mcg
333%
Pantothenic Acid (from Calcium Pantothenate)
100 mg
2000%
Choline (from Choline Bitartrate)
35 mg
6%
Inositol
100 mg
â€
PABA (Para-Aminobenzoic Acid)
10 mg
â€
Top Medical Research Studies
8
Vitamin B12 improves vision recovery
We explored the effects of vitamin B12 on a 33-year-old woman living with HIV, who faced severe vision loss due to optic neuritis, a rare outcome of vitamin B12 deficiency. Prior to this, she had battled significant peripheral neuropathy treated with vitamin B12 tablets. After starting vitamin B12 injections following her vision loss, she experienced gradual improvement and regained her sight. This case highlights the importance of recognizing vitamin B12 deficiency, particularly since its signs can easily go unnoticed.
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9
We aimed to investigate how paclitaxel-induced peripheral neuropathy affects salivary glands in rats and whether using a vitamin B/ATP complex could help. After inducing neuropathy with paclitaxel, we treated the animals with vitamin B for nine days.
We found that while the neuropathy did lead to significant changes in the salivary glands, treatment with the vitamin combination effectively restored their function. Notably, this treatment helped reduce oxidative stress and balance protein synthesis in the glands.
We found that while the neuropathy did lead to significant changes in the salivary glands, treatment with the vitamin combination effectively restored their function. Notably, this treatment helped reduce oxidative stress and balance protein synthesis in the glands.
Read More
We explored the effects of daily oral thiamine (vitamin B1) treatment on patients with Charcot-Marie-Tooth (CMT) neuropathy, a condition without an effective cure. Our pilot study focused on measuring hand grip strength before and after administering 100 mg of thiamine.
Interestingly, we observed that thiamine did improve hand grip strength; however, there were no significant differences in thiamine-related enzyme levels between CMT patients and healthy controls. We noted that while thiamine seemed beneficial, its exact impact can vary based on individual thiamine metabolism in patients.
Interestingly, we observed that thiamine did improve hand grip strength; however, there were no significant differences in thiamine-related enzyme levels between CMT patients and healthy controls. We noted that while thiamine seemed beneficial, its exact impact can vary based on individual thiamine metabolism in patients.
Read More
Most Useful Reviews
7.5
Cost-effective aid
23 people found this helpful
Helps with neuropathy. I use this for my peripheral neuropathy and have tried several brands over the last few years; this one is the most cost-effective and effective I’ve found. If you’re after a reputable oral vitamin B source, I highly recommend this one.
Read More
6
Prevents worsening symptoms
12 people found this helpful
Excellent quality vitamins! My husband takes this B-complex to prevent worsening his peripheral neuropathy due to chemotherapy. Although mild symptoms persist, they have not worsened, and he copes well. Just a note: these vitamins have a strong odour.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.9
- All Researches
9
We aimed to investigate how paclitaxel-induced peripheral neuropathy affects salivary glands in rats and whether using a vitamin B/ATP complex could help. After inducing neuropathy with paclitaxel, we treated the animals with vitamin B for nine days.
We found that while the neuropathy did lead to significant changes in the salivary glands, treatment with the vitamin combination effectively restored their function. Notably, this treatment helped reduce oxidative stress and balance protein synthesis in the glands.
We found that while the neuropathy did lead to significant changes in the salivary glands, treatment with the vitamin combination effectively restored their function. Notably, this treatment helped reduce oxidative stress and balance protein synthesis in the glands.
Read More
8
We examined how a combination of vitamins B1, B6, and B12 may improve recovery in peripheral neuropathy. Our research showed that using all three vitamins together led to better healing and nerve connectivity than vitamin B12 on its own.
This combination encourages cell maturation and counters oxidative stress, which are key for recovering damaged nerves. The findings point to the potential benefits of taking all three vitamins for those suffering from nerve-related issues.
This combination encourages cell maturation and counters oxidative stress, which are key for recovering damaged nerves. The findings point to the potential benefits of taking all three vitamins for those suffering from nerve-related issues.
Read More
8
This case presents an Iranian woman, 40, who struggled for a decade with unexplained symptoms such as fatigue and cognitive issues. Initially misdiagnosed with various conditions, her critical vitamin B12 deficiency was finally revealed after persistent symptoms led to further testing.
Treatment with vitamin B12 injections significantly improved her neurological symptoms, illustrating the critical role of recognizing vitamin B12 deficiency—even when traditional blood tests do not show anemia. This case reminds us to consider deficiency diagnoses in complex symptom profiles.
Treatment with vitamin B12 injections significantly improved her neurological symptoms, illustrating the critical role of recognizing vitamin B12 deficiency—even when traditional blood tests do not show anemia. This case reminds us to consider deficiency diagnoses in complex symptom profiles.
Read More
8
Combination treatment improves neuropathy symptoms
We investigated how a combination of vitamins, minerals, and other compounds affects pain and overall nerve function in people with diabetic neuropathy. The study included 73 individuals with type 2 diabetes, who were randomly assigned to receive either the treatment or a placebo for six months.
Results showed a significant improvement in pain levels, vibration perception, and vitamin B12 levels for those taking the supplement. Overall, our findings suggest that combining these elements can beneficially impact the symptoms of diabetic neuropathy.
Results showed a significant improvement in pain levels, vibration perception, and vitamin B12 levels for those taking the supplement. Overall, our findings suggest that combining these elements can beneficially impact the symptoms of diabetic neuropathy.
Read More
We explored the effects of daily oral thiamine (vitamin B1) treatment on patients with Charcot-Marie-Tooth (CMT) neuropathy, a condition without an effective cure. Our pilot study focused on measuring hand grip strength before and after administering 100 mg of thiamine.
Interestingly, we observed that thiamine did improve hand grip strength; however, there were no significant differences in thiamine-related enzyme levels between CMT patients and healthy controls. We noted that while thiamine seemed beneficial, its exact impact can vary based on individual thiamine metabolism in patients.
Interestingly, we observed that thiamine did improve hand grip strength; however, there were no significant differences in thiamine-related enzyme levels between CMT patients and healthy controls. We noted that while thiamine seemed beneficial, its exact impact can vary based on individual thiamine metabolism in patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Cost-effective aid
23 people found this helpful
Helps with neuropathy. I use this for my peripheral neuropathy and have tried several brands over the last few years; this one is the most cost-effective and effective I’ve found. If you’re after a reputable oral vitamin B source, I highly recommend this one.
Read More
6
Prevents worsening symptoms
12 people found this helpful
Excellent quality vitamins! My husband takes this B-complex to prevent worsening his peripheral neuropathy due to chemotherapy. Although mild symptoms persist, they have not worsened, and he copes well. Just a note: these vitamins have a strong odour.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Cuyubamba O, Braga CP, Swift D, Stickney JT, Viel C. The Combination of Neurotropic Vitamins B1, B6, and B12 Enhances Neural Cell Maturation and Connectivity Superior to Single B Vitamins. Cells. 2025;14. doi:10.3390/cells14070477
- Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. doi:10.1186/s13256-025-05149-7
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. doi:10.3390/nu16183045
- Artiukhov AV, Solovjeva ON, Balashova NV, Sidorova OP, Graf AV, et al. Pharmacological Doses of Thiamine Benefit Patients with the Charcot-Marie-Tooth Neuropathy by Changing Thiamine Diphosphate Levels and Affecting Regulation of Thiamine-Dependent Enzymes. Biochemistry (Mosc). 2024;89:1161. doi:10.1134/S0006297924070010
- Lubega G, Lutaakome J, Kibirige M, Opoka D, Atukunda I, et al. Vitamin B12 deficiency presenting as progressive blindness in a 33-year-old HIV-positive female patient on Efavirenz-based regimen: case report. Pan Afr Med J. 2024;47:164. doi:10.11604/pamj.2024.47.164.43048
- Dekker MJHJ, Heerdink GC, Plattel CHM. Vitamin B12 Deficiency-Induced Neuropathy and Cognitive and Motor Impairment in the Elderly: A Case Study. Food Nutr Bull. 2024;45:S53. doi:10.1177/03795721241226886
- Gautam S, Mittal C, Ranjan A, Singh G. Association of Diabetic Peripheral Neuropathy with Micronutrients. J Assoc Physicians India. 2024;72:65. doi:10.59556/japi.72.0493
- Tykhonovych K, Kryvoruchko T, Nikitina N, Berehovyi S, Neporada K. CORRECTION OF PATHOLOGICAL CHANGES IN SALIVARY GLANDS OF ANIMALS WITH PACLITAXEL-INDUCED NEUROPATHY. Exp Oncol. 2024;46:38. doi:10.15407/exp-oncology.2024.01.038
- Park KJ, Choi E, Jung IY, Kim ST. Pharmacologic management of trigeminal nerve injury after endodontic treatment: A retrospective analysis. J Oral Rehabil. 2024;51:1737. doi:10.1111/joor.13765
