Medical Researches
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Based on 9 Researches
Vitamin D3 improves iron statusAn 8-Week Vitamin D3-Fortified Fruit Drink Supplementation Increases Serum Ferritin Concentration: A Randomized Controlled Trial in Malaysian Women With Low Iron Stores.
Direct evaluation of vitamin D3
We conducted an 8-week, double-blind randomized controlled trial to see how vitamin D3-fortified fruit drinks affect iron levels in women with low iron stores. Our subjects, a group of 45 healthy women aged between 18 and 40, received either the vitamin D3 drink or a placebo, helping us assess the impact of this nutrient on their health.
Throughout the study, we measured key biomarkers such as serum ferritin, which indicates iron stores, and 25-hydroxyvitamin D, the active form of vitamin D in the body. After the 8 weeks, we noted a significant increase in both vitamin D levels and serum ferritin among those who participated in the vitamin D3-fortified drink regimen. This suggests that supplementing with vitamin D3 can indeed help improve iron stores in women who are iron deficient.
Given these findings, it becomes clear that there is potential for vitamin D to play a role in managing anemia. However, we also recognize the need for further research to confirm these effects and explore the safety and practicality of such fortifications across different populations.
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We examined the impact of cholecalciferol (vitamin D3) supplementation on anemia in hemodialysis patients suffering from vitamin D deficiency and secondary hyperparathyroidism. Our study included 122 patients who had low vitamin D levels and high parathyroid hormone (PTH) levels. We divided the participants into two groups: one received cholecalciferol supplements, while the other served as a control group.
In the group that received cholecalciferol, we observed significant improvements. PTH levels decreased notably, from an average of 476 to 296 pg/mL, indicating better regulation of calcium balance in the body. Alongside this, the 25-hydroxyvitamin D levels rose from 10.3 to 33.5 ng/mL, demonstrating a successful increase in vitamin D status.
More encouragingly, we noticed that hemoglobin levels, which reflect anemia status, increased from 11.6 to 12.2 g/dL in the supplemented group. This rise illustrates a potential benefit of vitamin D3 supplementation in managing anemia among hemodialysis patients. Additionally, the patients needed less paricalcitol, another medication used for managing PTH levels, revealing a positive overall impact on their treatment regimen.
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Vitamin D3's role in anemiaEffect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: Protocol for an 8-week, parallel group, double-blind randomized controlled trial.
Directly studies vitamin D3 and anemia
We conducted a study to see how vitamin D3 might help improve iron levels in women of childbearing age who had marginally low iron stores. Our approach involved a carefully designed 8-week randomized controlled trial, where 120 women aged between 19 and 40 were divided into two groups. One group received fruit juice fortified with 4000 IU of vitamin D3 daily, while the other had a placebo juice.
Throughout the study, we collected blood samples and monitored various health indicators every four weeks. We aimed to find out if the vitamin D3 supplementation could positively influence the iron status of the participants compared to the placebo.
Given the promising role of vitamin D in enhancing iron absorption, we hoped to uncover new insights into dietary strategies for managing iron deficiency. By observing the interaction over time between vitamin D levels and iron status, we aimed to provide valuable information on whether this fortification could serve as a practical alternative to traditional iron supplements.
As we gathered data, we explored the potential of vitamin D3 beyond its usual role, assessing if it could indeed help improve the anemia indicators in our target group.
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We explored the connection between vitamin D, particularly its epimer known as 3'-epi-25(OH)D, and anemia. The study analyzed data from 1,655 participants, examining how different forms of vitamin D relate to hemoglobin levels—a key indicator for anemia—while also considering other factors like age, sex, and body mass index (BMI).
Interestingly, we found that the total serum level of vitamin D didn't directly correlate with hemoglobin levels. However, when we focused on the 3'-epimeric form of vitamin D, we saw a significant association with hemoglobin levels, even when we accounted for age, sex, BMI, and high-sensitivity C-reactive protein (hsCRP). This suggests that 3'-epi-25(OH)D may have a unique role in improving hemoglobin levels, supporting its importance in red blood cell and iron metabolism.
On the other hand, the non-3'-epimeric form of vitamin D did not show a significant impact on hemoglobin levels. Overall, our findings highlight the potential benefits of vitamin D epimers in managing anemia and reinforce the need to look at vitamin D in its various forms when considering treatment options.
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Vitamin D3 impacts CKD anemia riskRelationship between serum vitamin D3 concentration and anaemia in patients with chronic kidney disease in China.
Direct link between vitamin D3 and anemia
We explored how vitamin D3 levels relate to anemia in patients with chronic kidney disease (CKD) in China. In our study, 225 CKD patients were assigned to three groups based on their serum vitamin D3 levels: severe deficiency, deficiency, and sufficiency. Through our analysis, we measured the prevalence of anemia within these groups to identify any potential links.
The results were quite telling. Among the participants, 79.5% of those in the severe deficiency group had anemia, compared to 63.5% in the deficiency group, and 48.0% in the sufficiency group. This shows a clear trend—the more deficient the vitamin D3 levels, the higher the likelihood of experiencing anemia. We also noted that as the stages of CKD progressed, from 1 to 5, the prevalence of anemia increased significantly, peaking at almost 95% in the most advanced stage.
Our findings suggest that vitamin D3 deficiency may indeed elevate the risk of anemia in individuals suffering from CKD. Addressing vitamin D3 levels in these patients could be an essential factor in managing their anemia effectively.
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User Reviews
I give vitamin D to my children from birth, and they rarely fall ill. I provide both my eldest, who is 5 years old, and the youngest, who is 2.5 years old, with one tablet after breakfast. Vitamin D3 fortifies the immune system and aids in the development of a newborn's nervous system. It also enhances iron absorption, as rickets and anemia in children are often linked.
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I began taking this supplement with ease as I don't often go outside, and surprisingly, my haemoglobin level was recorded at 12 in my blood test. I was shocked to find no signs of anaemia despite an increase in menstrual flow, although I had not taken any iron supplements. Interestingly, I discovered that vitamin D aids in the production of blood. I took two pills daily and recommend it for those suffering from anaemia.
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The quality is excellent, with superb ingredients and the perfect size. The minerals are effective, and the packaging is intact. The benefits are assured and the composition is great. This supplement has alleviated my symptoms of anaemia, and I enjoy the pleasant taste.