Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies.
We explored the development of ethosomal gels infused with vitamin D3 to target psoriasis, a chronic skin condition driven by immune responses. Vitamin D3 has long been recognized for its vital role in skin health, particularly in promoting the growth and maturation of skin cells known as keratinocytes.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Read More
9
Vitamin D's role in psoriasis treatment
Vitamins for the Management of Nail Disease: A Literature Review.
We investigated the impact of vitamin D treatment on psoriasis, emphasizing its effectiveness for this skin condition. Our focus was on vitamin D as a topical treatment option, particularly in relation to nail psoriasis, a chronic and often challenging ailment.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
Read More
8
Effective topical psoriasis treatments
A Comparative Study of the Effectiveness and Safety of Topical Calcipotriol and Topical Methotrexate in Chronic Plaque Psoriasis.
We explored the effectiveness of topical treatments for chronic plaque psoriasis, particularly focusing on calcipotriol, an active form of vitamin D, and methotrexate. In a study involving 60 patients, we divided them into two groups: one receiving calcipotriol and the other methotrexate. Over two months, we assessed their progress based on the psoriasis area severity index (PASI) scores, measuring the severity of their condition at the start, four weeks in, and eight weeks later.
Our findings revealed that both calcipotriol and methotrexate were effective in reducing the severity of psoriasis lesions. At the start of the study, both groups had similar PASI scores, but by the eighth week, both treatments had significantly lowered these scores. Interestingly, while six patients in the calcipotriol group experienced complete clearance of their lesions, three patients in the methotrexate group did as well.
When it came to safety, the adverse effects from both treatments were generally mild and transient. A few patients reported skin irritation with calcipotriol and a burning sensation with methotrexate, but these issues were not severe and did not significantly impact overall well-being. We conclude that topical calcipotriol and methotrexate treatment options are effective and well-tolerated for those dealing with chronic plaque psoriasis.
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Most Useful Reviews
9
Hormonal balance
I've been diabetic for nearly 30 years and became interested in vitamin D after learning about its crucial role in calcium metabolism and gene regulation. A deficiency can lead to various issues, including psoriasis. Surprisingly, vitamin D shortages are common even in sunny regions. It's clear walking and sunlight are vital, but supplementation may be necessary to address these health concerns.
Read More
7.5
Notable improvements
For two years, I endured incomprehensible spots diagnosed as psoriasis by dermatologists, who assured me it would resolve naturally. After this prolonged torment, I began taking vitamin D3 and applying clotrimazole, leading to immediate improvements; the spots began to lighten and fade. The pills taste pleasant, but the dosage is small. Currently, I take two pills daily, but I plan to order a higher dose.
Read More
7.5
Stronger immune system
Children's chewable vitamin D3 is sweet and enjoyable. It's essential for children, even during summer, as it strengthens the immune system and helps combat inflammatory processes. It is also beneficial in treating psoriasis while supporting calcium absorption and bone metabolism.
We conducted a study to better understand how topical treatments, particularly those involving vitamin D3, affect psoriasis. In our investigation, we focused on a group of 30 psoriasis patients, using a double-blind, randomized approach. This means neither the patients nor the researchers knew who received which treatment, ensuring an unbiased evaluation of their effects.
The treatments explored included a combination of Calcipotriol (a vitamin D3 analogue) and Betamethasone (a steroid), as well as Betamethasone alone and Clobetasol Propionate ointment. Through the analysis of skin biopsies before and after four weeks of treatment, we observed changes in skin inflammation, cellular infiltrate, and patients’ clinical scores for psoriasis severity.
While we noted that all treatments helped reduce skin thickness and improved patient scores, the greatest impact was seen with the combination of Calcipotriol and Betamethasone. This specific treatment effectively diminished the number of harmful immune cells that contribute to psoriasis flare-ups. However, the isolated effect of vitamin D3 alone wasn’t clearly established, as the most significant outcomes were tied to its use in combination with steroids.
Ultimately, our findings suggest that while vitamin D3 plays a role in psoriasis treatment, its benefits are most pronounced when paired with corticosteroids. This combination could potentially lead to enhanced long-term management of the disease, although the specific contribution of vitamin D3 alone remains uncertain.
Read More
9
Vitamin D's role in psoriasis treatment
Vitamins for the Management of Nail Disease: A Literature Review.
We investigated the impact of vitamin D treatment on psoriasis, emphasizing its effectiveness for this skin condition. Our focus was on vitamin D as a topical treatment option, particularly in relation to nail psoriasis, a chronic and often challenging ailment.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
Read More
9
Calcipotriol more effective than calcitriol
Comparative evaluation of efficacy and safety of calcipotriol versus calcitriol ointment, both in combination with narrow-band ultraviolet B phototherapy in the treatment of stable plaque psoriasis.
We explored the effectiveness of two vitamin D analogues, calcipotriol and calcitriol, in treating stable plaque psoriasis when combined with narrow-band ultraviolet B (NBUVB) phototherapy. Our study involved thirty patients who were treated for 12 weeks, applying calcitriol ointment to one side and calcipotriol ointment to the other.
Throughout the trial, we observed significant improvements in skin conditions such as erythema, scaling, and overall plaque thickness with both treatments. Remarkably, those using calcipotriol showed quicker clearance of plaques and experienced fewer relapses compared to those using calcitriol.
Both treatments were found to be safe and well-tolerated, making them cosmetically appealing options. However, calcipotriol not only demonstrated a rapid onset of action but also maintained its efficacy more consistently over the treatment period.
Read More
8
Vitamin D3 ethosomal gel for psoriasis
Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies.
We explored the development of ethosomal gels infused with vitamin D3 to target psoriasis, a chronic skin condition driven by immune responses. Vitamin D3 has long been recognized for its vital role in skin health, particularly in promoting the growth and maturation of skin cells known as keratinocytes.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Read More
8
Phototherapy benefits psoriasis treatment
The Effect of Phototherapy on Systemic Inflammation Measured with Serum Vitamin D-Binding Protein and hsCRP in Patients with Inflammatory Skin Disease.
We investigated how phototherapy, specifically narrowband-ultraviolet B (NB-UVB), affects vitamin D levels and inflammatory markers in patients with psoriasis and atopic dermatitis. The study involved thirty adults—twenty with psoriasis and ten with atopic dermatitis—who underwent NB-UVB treatment.
After therapy, we observed changes in vitamin D-binding protein (DBP) and high-sensitivity C-reactive protein (hsCRP), both of which indicate systemic inflammation. Interestingly, DBP levels decreased in psoriasis patients following treatment. However, the drop in hsCRP levels—while noticed in both groups—wasn't statistically significant.
We also saw improvements in disease severity, as measured by established scales, alongside increases in vitamin D levels. Sub-analyses showed that patients with vitamin D deficiency or insufficiency tended to respond better to NB-UVB therapy compared to those who were vitamin D sufficient.
Overall, our findings suggest that phototherapy may offer not only skin benefits but also a systemic anti-inflammatory effect, primarily in psoriasis patients.
I've been diabetic for nearly 30 years and became interested in vitamin D after learning about its crucial role in calcium metabolism and gene regulation. A deficiency can lead to various issues, including psoriasis. Surprisingly, vitamin D shortages are common even in sunny regions. It's clear walking and sunlight are vital, but supplementation may be necessary to address these health concerns.
Read More
7.5
Notable improvements
For two years, I endured incomprehensible spots diagnosed as psoriasis by dermatologists, who assured me it would resolve naturally. After this prolonged torment, I began taking vitamin D3 and applying clotrimazole, leading to immediate improvements; the spots began to lighten and fade. The pills taste pleasant, but the dosage is small. Currently, I take two pills daily, but I plan to order a higher dose.
Read More
7.5
Stronger immune system
Children's chewable vitamin D3 is sweet and enjoyable. It's essential for children, even during summer, as it strengthens the immune system and helps combat inflammatory processes. It is also beneficial in treating psoriasis while supporting calcium absorption and bone metabolism.
Read More
Frequently Asked Questions
Psoriasis is a chronic autoimmune condition that primarily affects the skin, leading to the rapid growth of skin cells that accumulate, forming scales and red patches that can be itchy and sometimes painful. These changes occur due to an abnormal immune response that accelerates the skin renewal process. The disease can vary in severity, with some individuals experiencing mild flare-ups while others endure more severe symptoms. Psoriasis commonly appears on the elbows, knees, scalp, and lower back, but it can occur anywhere on the body.
There are several types of psoriasis, with plaque psoriasis being the most common form, characterized by raised, inflamed patches covered with silvery-white scales. Other types include guttate, inverse, pustular, and erythrodermic psoriasis. While the exact cause of psoriasis is still not entirely understood, it is believed to involve genetic, environmental, and immune system factors. Treatments vary widely and can range from topical medications and phototherapy to systemic treatments aimed at reducing inflammation and slowing skin cell turnover. If you suspect you have psoriasis, consulting a healthcare provider is advisable to explore the most appropriate treatment options.
Vitamin D is a fat-soluble vitamin that's essential for maintaining healthy bones and teeth, supporting immune system function, and facilitating normal cell growth and development. It plays a crucial role in calcium absorption in the gut, which is vital for bone health. Unlike most vitamins, our bodies can produce Vitamin D when exposed to sunlight, specifically UVB rays, which is why it’s often referred to as the "sunshine vitamin." However, depending on your geographical location, lifestyle, and skin type, getting sufficient Vitamin D from the sun alone can be challenging, particularly during the winter months.
In addition to sunlight, Vitamin D can be obtained from certain foods such as fatty fish (like salmon and mackerel), fish liver oils, and fortified foods like milk and cereals. Some individuals may also consider supplements, especially if they're at risk for deficiency. Insufficient vitamin D levels are linked to various health issues, including rickets in children, osteomalacia in adults, and even an increased risk of chronic diseases. Regularly checking your vitamin D levels and consulting with a healthcare professional can help ensure you're meeting your needs for optimal health.
Vitamin D has been studied for its potential benefits in managing psoriasis, a chronic skin condition characterized by red, scaly patches. Research indicates that vitamin D can play a role in skin cell regulation and may help reduce the rapid skin cell turnover that is a hallmark of psoriasis. Topical treatments that contain vitamin D, such as calcipotriene, are commonly prescribed and can help to alleviate symptoms and improve skin appearance for many patients.
Moreover, maintaining adequate levels of vitamin D through sun exposure, diet, or supplementation may contribute to overall skin health, although the results can vary from person to person. It is essential to consult with a healthcare professional for personalized advice and treatment options if you or someone you know is dealing with psoriasis. While vitamin D might aid in symptom management, it is typically used as part of a broader treatment plan.
Users report varying timelines for seeing results from vitamin D supplementation in relation to psoriasis. While some individuals may experience improvements relatively quickly, one user noted that after suffering from psoriasis for two years, they began to notice immediate changes after starting vitamin D3 alongside other treatments. Their spots started to lighten and fade soon after they began the regimen, suggesting that noticeable results can occur in a matter of days to weeks after initiating treatment Read Review.
However, it's important to recognize that results can be highly individualized, depending on factors such as baseline vitamin D levels and severity of the condition. Another user emphasized the importance of sustaining vitamin D levels through supplementation as a common deficiency could be contributing to skin issues Read Review. Thus, while some might find quick improvement, others may need a more extended period to fully address their psoriasis with vitamin D supplementation.
Vitamin D and its analogues, particularly Calcipotriol, have been increasingly studied for their role in managing psoriasis, and the research indicates a promising direction for treatment. For instance, a study emphasized that a novel delivery system combining Calcipotriol with a microneedle patch showed potential in effectively targeting psoriasis lesions while reducing systemic inflammation ([1]). Furthermore, research has highlighted the effectiveness of topical treatments that incorporate Calcipotriol, demonstrating significant reductions in psoriasis severity over sustained periods ([5]).
However, while there is evidence of vitamin D's contributions to skin health and its application for psoriasis, the overall impact when used alone remains inconclusive. Multiple studies reported no consistent significant improvements in psoriasis severity when vitamin D alone was applied, suggesting the need for further investigation to understand its role better ([6], [8]). That said, combining vitamin D with other therapeutic options, such as phototherapy, may enhance treatment outcomes, pointing towards a synergistic approach in addressing this complex skin condition.
Users report a range of improvements in their psoriasis symptoms after incorporating vitamin D supplementation into their routines. One individual, after two years of struggling with psoriasis, noticed immediate changes upon starting vitamin D3 alongside other treatments; their spots began to lighten and fade, showcasing that some users may experience rapid results within days or weeks of beginning supplementation Read Review. This suggests that for certain individuals, particularly those with a deficiency, vitamin D can offer a swift and effective solution in alleviating their skin issues.
Additionally, users highlight the broader health benefits of vitamin D, noting its role in immune function and inflammation management, which may contribute to overall improvements in skin conditions like psoriasis. A review mentions that even children can benefit from vitamin D to strengthen their immune systems and combat inflammation, further implying its potential efficacy in treating psoriasis Read Review. However, it is essential to note that individual responses can vary significantly based on factors such as baseline vitamin D levels and specific health conditions.
Users report positive experiences when combining vitamin D supplementation with other treatments for psoriasis management. One individual noted significant improvements in their psoriasis symptoms, stating that after two years of struggling with the condition, they began taking vitamin D3 alongside clotrimazole, which resulted in their spots starting to lighten and fade almost immediately Read Review. This suggests that integrating vitamin D with other medications or topical treatments may enhance the overall effectiveness in addressing psoriasis symptoms.
Moreover, users highlight the importance of addressing potential vitamin D deficiencies, as one reviewer emphasized that such deficiencies are common and can contribute to skin issues like psoriasis. They pointed out that while getting sunlight is beneficial, supplementation may be necessary, particularly for individuals with longstanding health issues, such as diabetes Read Review. This combination of addressing deficiencies through supplementation and pairing it with additional treatments suggests a comprehensive approach to managing psoriasis.
Based on user reviews, it appears that there is some consensus around the need for vitamin D supplementation in treating psoriasis, particularly in cases where patients have experienced deficiencies. One user reported a significant improvement in their psoriasis after switching to vitamin D3 along with clotrimazole, highlighting that they originally endured symptoms for two years before finding relief after starting the supplement. They currently take two pills daily but are considering increasing the dosage for potentially greater benefits Read Review.
Another user emphasized the widespread issue of vitamin D deficiency, even in areas with ample sunlight, suggesting that supplementation might be necessary for many individuals dealing with skin issues like psoriasis Read Review. There seems to be an understanding that while individual dosages may vary, many users find success in taking vitamin D3 as part of their treatment regimen, possibly indicating that higher or more consistent doses might be beneficial for optimal results.
7.5
Notable improvements
For two years, I endured incomprehensible spots diagnosed as psoriasis by dermatologists, who assured me it would resolve naturally. After this prolonged torment, I began taking vitamin D3 and applying clotrimazole, leading to immediate improvements; the spots began to lighten and fade. The pills taste pleasant, but the dosage is small. Currently, I take two pills daily, but I plan to order a higher dose.
9
Hormonal balance
I've been diabetic for nearly 30 years and became interested in vitamin D after learning about its crucial role in calcium metabolism and gene regulation. A deficiency can lead to various issues, including psoriasis. Surprisingly, vitamin D shortages are common even in sunny regions. It's clear walking and sunlight are vital, but supplementation may be necessary to address these health concerns.
7.5
Stronger immune system
Children's chewable vitamin D3 is sweet and enjoyable. It's essential for children, even during summer, as it strengthens the immune system and helps combat inflammatory processes. It is also beneficial in treating psoriasis while supporting calcium absorption and bone metabolism.
7
Vitamin D enhances psoriasis treatment
Dual-Action Psoriasis Therapy: Antiproliferative and Immunomodulatory Effects via Self-Locking Microneedles.
We explored an innovative approach to treating psoriasis by combining vitamin D, specifically Calcipotriol, with a targeted delivery method. This study combined a self-locking microneedle patch loaded with Deucravacitinib, a Tyrosine Kinase 2 inhibitor, alongside Calcipotriol, which helps manage skin cell proliferation.
Calcipotriol is known for its effectiveness in psoriasis treatment, especially for reducing thickened skin lesions, yet it shines when paired with advanced drug delivery systems. The microneedle patch design allows for quick penetration and localized action, showing promise not only in reducing inflammation but also in improving localized skin retention of the medication.
We observed that this dual-action approach not only targets the specific lesions directly but may also play a role in reducing overall systemic inflammation by inhibiting the differentiation of certain immune cells. This offers an exciting new option for those suffering from psoriasis and reflects a significant step toward more effective and specifically targeted therapies.
8
Effective topical psoriasis treatments
A Comparative Study of the Effectiveness and Safety of Topical Calcipotriol and Topical Methotrexate in Chronic Plaque Psoriasis.
We explored the effectiveness of topical treatments for chronic plaque psoriasis, particularly focusing on calcipotriol, an active form of vitamin D, and methotrexate. In a study involving 60 patients, we divided them into two groups: one receiving calcipotriol and the other methotrexate. Over two months, we assessed their progress based on the psoriasis area severity index (PASI) scores, measuring the severity of their condition at the start, four weeks in, and eight weeks later.
Our findings revealed that both calcipotriol and methotrexate were effective in reducing the severity of psoriasis lesions. At the start of the study, both groups had similar PASI scores, but by the eighth week, both treatments had significantly lowered these scores. Interestingly, while six patients in the calcipotriol group experienced complete clearance of their lesions, three patients in the methotrexate group did as well.
When it came to safety, the adverse effects from both treatments were generally mild and transient. A few patients reported skin irritation with calcipotriol and a burning sensation with methotrexate, but these issues were not severe and did not significantly impact overall well-being. We conclude that topical calcipotriol and methotrexate treatment options are effective and well-tolerated for those dealing with chronic plaque psoriasis.
7
Vitamin D's limited treatment efficacy
Comment to "Vitamin D in psoriatic arthritis - A systematic review and meta-analysis".
We explored how vitamin D influences psoriasis through a systematic review and meta-analysis. The study collated various research findings to determine the effectiveness of vitamin D treatment for those suffering from psoriatic arthritis and related skin conditions. By examining numerous trials, we aimed to gather comprehensive insights into whether vitamin D supplementation could provide significant relief for psoriasis symptoms.
Our analysis revealed some interesting patterns regarding vitamin D levels and psoriasis severity. However, we observed that the overall results did not demonstrate a consistent, significant benefit of vitamin D in alleviating psoriasis symptoms across the different studies analyzed. It appeared that, while vitamin D is vital for overall skin health, its direct impact on treating psoriasis may not be as strong as previously thought.
Ultimately, this research sheds light on the need for further investigation into vitamin D's role, considering the mixed outcomes found. Understanding its potential will be crucial in guiding future treatment options for psoriasis patients.
2
Vitamin D3 shows no psoriasis benefit
Psoriasis and Vitamin D: A Systematic Review and Meta-Analysis.
We investigated the relationship between vitamin D3 levels and psoriasis, a chronic inflammatory skin condition. In our review of the literature, we gathered data from 23 studies involving nearly 1,900 psoriasis patients and over 7,500 healthy individuals.
Our findings showed that psoriasis patients generally had lower levels of 25 hydroxyvitamin D (the form of vitamin D measured in blood tests) compared to healthy controls. Specifically, the average vitamin D level in psoriasis patients was 21.0 ng/mL, while it was 27.3 ng/mL in those without the condition.
However, when we looked at the impact of taking vitamin D3 supplements on psoriasis severity, the results were less promising. In four randomized controlled trials that included 173 psoriasis patients receiving vitamin D3 and 160 patients receiving a placebo, we found no significant improvements in the severity of psoriasis over 3, 6, or 12 months of treatment.
While the initial observation of lower vitamin D levels in psoriasis patients is intriguing and suggests a connection, the lack of improvement through supplementation indicates that vitamin D3 might not be the solution we hoped for in treating psoriasis.
References
Wang ZY, Zhao ZQ, Sheng YJ, Chen KJ, Chen BZ, et al. Dual-Action Psoriasis Therapy: Antiproliferative and Immunomodulatory Effects via Self-Locking Microneedles. Adv Sci (Weinh). 2024;11:e2409359. 10.1002/advs.202409359
Zanghaneh AJ, Elmelid A, Gillstedt M, Ahmic O, Andersson B, et al. The Expression of Vitamin D Receptor on Peripheral Blood Mononuclear Cells in Patients with Psoriasis. Int J Mol Sci. 2024;25. 10.3390/ijms251910677
Mehmood Y, Shahid H, Ahmed S, Khursheed A, Jamshaid T, et al. Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies. Sci Rep. 2024;14:23866. 10.1038/s41598-024-72951-6
Elmelid A, Vandikas MS, Gillstedt M, Alsterholm M, Osmancevic A. The Effect of Phototherapy on Systemic Inflammation Measured with Serum Vitamin D-Binding Protein and hsCRP in Patients with Inflammatory Skin Disease. Int J Mol Sci. 2024;25. 10.3390/ijms25168632
Das K, Ranjan R, Kumar P, Chandra S. A Comparative Study of the Effectiveness and Safety of Topical Calcipotriol and Topical Methotrexate in Chronic Plaque Psoriasis. Cureus. 2024;16:e59878. 10.7759/cureus.59878
Formisano E, Proietti E, Borgarelli C, Pisciotta L. Comment to "Vitamin D in psoriatic arthritis - A systematic review and meta-analysis". Semin Arthritis Rheum. 2024;67:152457. 10.1016/j.semarthrit.2024.152457
Curtis KL, Lipner SR. Vitamins for the Management of Nail Disease: A Literature Review. Skin Appendage Disord. 2024;10:104. 10.1159/000534972
Formisano E, Proietti E, Borgarelli C, Pisciotta L. Psoriasis and Vitamin D: A Systematic Review and Meta-Analysis. Nutrients. 2023;15. 10.3390/nu15153387
Zhao SS, Mason A, Gjekmarkaj E, Yanaoka H, Burgess S. Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis. Semin Arthritis Rheum. 2023;62:152238. 10.1016/j.semarthrit.2023.152238
Chakraborty D, Aggarwal K. Comparative evaluation of efficacy and safety of calcipotriol versus calcitriol ointment, both in combination with narrow-band ultraviolet B phototherapy in the treatment of stable plaque psoriasis. Photodermatol Photoimmunol Photomed. 2023;39:512. 10.1111/phpp.12893
Holmback J, Carlsson A, Rinwa P. Efficacy and Safety of Water-Free Lipid Formulation System Containing Calcipotriol Against Psoriasis Vulgaris. J Drugs Dermatol. 2023;22:197. 10.36849/JDD.7151
Mazur A, Koziorowska K, Dynarowicz K, Aebisher D, Bartusik-Aebisher D. Vitamin D and Vitamin D3 Supplementation during Photodynamic Therapy: A Review. Nutrients. 2022;14. 10.3390/nu14183805
Heim M, Irondelle M, Duteil L, Cardot-Leccia N, Rocchi S, et al. Impact of topical emollient, steroids alone or combined with calcipotriol, on the immune infiltrate and clinical outcome in psoriasis. Exp Dermatol. 2022;31:1764. 10.1111/exd.14657