Effect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: Protocol for an 8-week, parallel group, double-blind randomized controlled trial.
We conducted a study to see how vitamin D3 might help improve iron levels in women of childbearing age who had marginally low iron stores. Our approach involved a carefully designed 8-week randomized controlled trial, where 120 women aged between 19 and 40 were divided into two groups. One group received fruit juice fortified with 4000 IU of vitamin D3 daily, while the other had a placebo juice.
Throughout the study, we collected blood samples and monitored various health indicators every four weeks. We aimed to find out if the vitamin D3 supplementation could positively influence the iron status of the participants compared to the placebo.
Given the promising role of vitamin D in enhancing iron absorption, we hoped to uncover new insights into dietary strategies for managing iron deficiency. By observing the interaction over time between vitamin D levels and iron status, we aimed to provide valuable information on whether this fortification could serve as a practical alternative to traditional iron supplements.
As we gathered data, we explored the potential of vitamin D3 beyond its usual role, assessing if it could indeed help improve the anemia indicators in our target group.
Read More
9
Vitamin D may reduce anemia risk
Serum Vitamin D Levels and Risk of Iron Deficiency Anemia in Adults: A Cross-Sectional Study and Mendelian Randomization Analysis.
Our investigation centered on whether vitamin D levels play a significant role in iron deficiency anemia (IDA). We examined data from the National Health and Nutrition Examination Survey, which included over 3,700 participants, to explore the relationship between vitamin D and IDA.
Our findings indicated that higher levels of serum vitamin D are linked to a lower risk of developing IDA. Specifically, those in the highest quartile of vitamin D levels had a significantly reduced risk compared to those in the lowest quartile. Interestingly, this protective effect appeared to be more pronounced in women.
We also found a non-linear relationship, suggesting that the effects of vitamin D on anemia become more complex at different levels. This was further supported by a Mendelian randomization analysis, which provided genetic evidence for a causal connection between vitamin D and IDA.
Overall, our results suggest that adequate vitamin D levels could be important for preventing anemia, especially among women. However, further research is certainly needed to confirm these findings and to investigate the potential for vitamin D treatment in managing IDA directly.
Read More
9
Vitamin D3 improves iron status
An 8-Week Vitamin D3-Fortified Fruit Drink Supplementation Increases Serum Ferritin Concentration: A Randomized Controlled Trial in Malaysian Women With Low Iron Stores.
We conducted an 8-week, double-blind randomized controlled trial to see how vitamin D3-fortified fruit drinks affect iron levels in women with low iron stores. Our subjects, a group of 45 healthy women aged between 18 and 40, received either the vitamin D3 drink or a placebo, helping us assess the impact of this nutrient on their health.
Throughout the study, we measured key biomarkers such as serum ferritin, which indicates iron stores, and 25-hydroxyvitamin D, the active form of vitamin D in the body. After the 8 weeks, we noted a significant increase in both vitamin D levels and serum ferritin among those who participated in the vitamin D3-fortified drink regimen. This suggests that supplementing with vitamin D3 can indeed help improve iron stores in women who are iron deficient.
Given these findings, it becomes clear that there is potential for vitamin D to play a role in managing anemia. However, we also recognize the need for further research to confirm these effects and explore the safety and practicality of such fortifications across different populations.
Read More
Most Useful Reviews
9
Significant vitamin increase
1 people found this helpful
My vitamin D rose from 14.2 to 45.3 ng/ml in 8 months, after I started taking 5000 IU alongside Omega-3. I noticed improvements in bone pain, hair loss, and energy levels after starting the supplement. Following my endocrinologist's advice, I adjusted the timing of my intake for better absorption. Vitamin D likely aided my recovery from coronavirus, and I aim to increase my levels further to enhance my health alongside managing my anaemia.
Read More
7.5
Improved tissue nourishment
235 people found this helpful
Vitamin D3 is crucial for those with anemia. It enhances tissue nourishment, but one must be cautious about dosage. For example, if there's anaemia alongside vitamin D3 deficiency, start with small doses. Elderly individuals or those post-gastrointestinal surgery should opt for sublingual forms for better absorption. Co-factors like vitamin K2, magnesium, and vitamin A are vital, as their levels impact proper absorption and distribution. This supplement has effectively raised my vitamin D3 levels, which I consider beneficial for overall health.
Read More
9
Essential for wellbeing
These are excellent vitamins for preventing deficiencies. Vitamin D3 is essential for healthy functioning and aids iron absorption, which is vital for anaemia. The capsules are conveniently sized, and my doctor has approved their dosage. I recommend them for anyone dealing with anaemia or aiming for preventative health.
Our investigation centered on whether vitamin D levels play a significant role in iron deficiency anemia (IDA). We examined data from the National Health and Nutrition Examination Survey, which included over 3,700 participants, to explore the relationship between vitamin D and IDA.
Our findings indicated that higher levels of serum vitamin D are linked to a lower risk of developing IDA. Specifically, those in the highest quartile of vitamin D levels had a significantly reduced risk compared to those in the lowest quartile. Interestingly, this protective effect appeared to be more pronounced in women.
We also found a non-linear relationship, suggesting that the effects of vitamin D on anemia become more complex at different levels. This was further supported by a Mendelian randomization analysis, which provided genetic evidence for a causal connection between vitamin D and IDA.
Overall, our results suggest that adequate vitamin D levels could be important for preventing anemia, especially among women. However, further research is certainly needed to confirm these findings and to investigate the potential for vitamin D treatment in managing IDA directly.
Read More
9
Vitamin D3 improves iron status
An 8-Week Vitamin D3-Fortified Fruit Drink Supplementation Increases Serum Ferritin Concentration: A Randomized Controlled Trial in Malaysian Women With Low Iron Stores.
We conducted an 8-week, double-blind randomized controlled trial to see how vitamin D3-fortified fruit drinks affect iron levels in women with low iron stores. Our subjects, a group of 45 healthy women aged between 18 and 40, received either the vitamin D3 drink or a placebo, helping us assess the impact of this nutrient on their health.
Throughout the study, we measured key biomarkers such as serum ferritin, which indicates iron stores, and 25-hydroxyvitamin D, the active form of vitamin D in the body. After the 8 weeks, we noted a significant increase in both vitamin D levels and serum ferritin among those who participated in the vitamin D3-fortified drink regimen. This suggests that supplementing with vitamin D3 can indeed help improve iron stores in women who are iron deficient.
Given these findings, it becomes clear that there is potential for vitamin D to play a role in managing anemia. However, we also recognize the need for further research to confirm these effects and explore the safety and practicality of such fortifications across different populations.
Read More
8
Vitamin D improves anemia management
[Cholecalciferol supplementation improves secondary hyperparathyroidism control in hemodialysis patients].
We examined the impact of cholecalciferol (vitamin D3) supplementation on anemia in hemodialysis patients suffering from vitamin D deficiency and secondary hyperparathyroidism. Our study included 122 patients who had low vitamin D levels and high parathyroid hormone (PTH) levels. We divided the participants into two groups: one received cholecalciferol supplements, while the other served as a control group.
In the group that received cholecalciferol, we observed significant improvements. PTH levels decreased notably, from an average of 476 to 296 pg/mL, indicating better regulation of calcium balance in the body. Alongside this, the 25-hydroxyvitamin D levels rose from 10.3 to 33.5 ng/mL, demonstrating a successful increase in vitamin D status.
More encouragingly, we noticed that hemoglobin levels, which reflect anemia status, increased from 11.6 to 12.2 g/dL in the supplemented group. This rise illustrates a potential benefit of vitamin D3 supplementation in managing anemia among hemodialysis patients. Additionally, the patients needed less paricalcitol, another medication used for managing PTH levels, revealing a positive overall impact on their treatment regimen.
Read More
7
Vitamin D3's role in anemia
Effect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: Protocol for an 8-week, parallel group, double-blind randomized controlled trial.
We conducted a study to see how vitamin D3 might help improve iron levels in women of childbearing age who had marginally low iron stores. Our approach involved a carefully designed 8-week randomized controlled trial, where 120 women aged between 19 and 40 were divided into two groups. One group received fruit juice fortified with 4000 IU of vitamin D3 daily, while the other had a placebo juice.
Throughout the study, we collected blood samples and monitored various health indicators every four weeks. We aimed to find out if the vitamin D3 supplementation could positively influence the iron status of the participants compared to the placebo.
Given the promising role of vitamin D in enhancing iron absorption, we hoped to uncover new insights into dietary strategies for managing iron deficiency. By observing the interaction over time between vitamin D levels and iron status, we aimed to provide valuable information on whether this fortification could serve as a practical alternative to traditional iron supplements.
As we gathered data, we explored the potential of vitamin D3 beyond its usual role, assessing if it could indeed help improve the anemia indicators in our target group.
Read More
7
Vitamin D epimers and anemia effects
Vitamin D epimers are associated with circulating haemoglobin levels independently of C-reactive protein.
We explored the connection between vitamin D, particularly its epimer known as 3'-epi-25(OH)D, and anemia. The study analyzed data from 1,655 participants, examining how different forms of vitamin D relate to hemoglobin levels—a key indicator for anemia—while also considering other factors like age, sex, and body mass index (BMI).
Interestingly, we found that the total serum level of vitamin D didn't directly correlate with hemoglobin levels. However, when we focused on the 3'-epimeric form of vitamin D, we saw a significant association with hemoglobin levels, even when we accounted for age, sex, BMI, and high-sensitivity C-reactive protein (hsCRP). This suggests that 3'-epi-25(OH)D may have a unique role in improving hemoglobin levels, supporting its importance in red blood cell and iron metabolism.
On the other hand, the non-3'-epimeric form of vitamin D did not show a significant impact on hemoglobin levels. Overall, our findings highlight the potential benefits of vitamin D epimers in managing anemia and reinforce the need to look at vitamin D in its various forms when considering treatment options.
My vitamin D rose from 14.2 to 45.3 ng/ml in 8 months, after I started taking 5000 IU alongside Omega-3. I noticed improvements in bone pain, hair loss, and energy levels after starting the supplement. Following my endocrinologist's advice, I adjusted the timing of my intake for better absorption. Vitamin D likely aided my recovery from coronavirus, and I aim to increase my levels further to enhance my health alongside managing my anaemia.
Read More
7.5
Improved tissue nourishment
235 people found this helpful
Vitamin D3 is crucial for those with anemia. It enhances tissue nourishment, but one must be cautious about dosage. For example, if there's anaemia alongside vitamin D3 deficiency, start with small doses. Elderly individuals or those post-gastrointestinal surgery should opt for sublingual forms for better absorption. Co-factors like vitamin K2, magnesium, and vitamin A are vital, as their levels impact proper absorption and distribution. This supplement has effectively raised my vitamin D3 levels, which I consider beneficial for overall health.
Read More
9
Essential for wellbeing
These are excellent vitamins for preventing deficiencies. Vitamin D3 is essential for healthy functioning and aids iron absorption, which is vital for anaemia. The capsules are conveniently sized, and my doctor has approved their dosage. I recommend them for anyone dealing with anaemia or aiming for preventative health.
Read More
9
Boosts immune health
I've been taking 5000 IU of vitamin D3 for my anaemia for several months on my doctor's advice. It supports my immune system, especially during these times. I take one capsule daily with breakfast, and my experience has been very positive, enhancing my overall health.
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7.5
Supports immune system
I recommend these small, convenient capsules for everyone, particularly during the pandemic. They are odourless and tasteless, taken with food for better absorption. Vitamin D supports lung function and is crucial for individuals with anaemia, pregnant women, children, and the elderly. However, it's vital to consult a healthcare professional for proper dosage based on individual needs.
Anemia is a medical condition characterized by a deficiency of red blood cells or hemoglobin in the blood, which can result in reduced oxygen flow to the body's organs. The most common type of anemia is iron-deficiency anemia, which occurs when the body does not have enough iron to produce adequate hemoglobin. Other types can arise from chronic diseases, genetic conditions, or a lack of certain vitamins such as B12 or folate. Symptoms often include fatigue, weakness, pale skin, and shortness of breath, particularly during physical activity.
Diagnosing anemia typically involves blood tests to measure levels of red blood cells, hemoglobin concentration, and other related factors. Treatment varies depending on the underlying cause but may include dietary changes, supplements, or medications. In some cases, more serious interventions may be necessary, such as blood transfusions or treatments for associated conditions. If you suspect you have anemia, it's essential to consult a healthcare professional for appropriate evaluation and management.
Vitamin D is a fat-soluble vitamin that's essential for maintaining healthy bones and teeth, supporting immune system function, and facilitating normal cell growth and development. It plays a crucial role in calcium absorption in the gut, which is vital for bone health. Unlike most vitamins, our bodies can produce Vitamin D when exposed to sunlight, specifically UVB rays, which is why it’s often referred to as the "sunshine vitamin." However, depending on your geographical location, lifestyle, and skin type, getting sufficient Vitamin D from the sun alone can be challenging, particularly during the winter months.
In addition to sunlight, Vitamin D can be obtained from certain foods such as fatty fish (like salmon and mackerel), fish liver oils, and fortified foods like milk and cereals. Some individuals may also consider supplements, especially if they're at risk for deficiency. Insufficient vitamin D levels are linked to various health issues, including rickets in children, osteomalacia in adults, and even an increased risk of chronic diseases. Regularly checking your vitamin D levels and consulting with a healthcare professional can help ensure you're meeting your needs for optimal health.
Vitamin D plays a crucial role in many bodily functions, particularly in maintaining bone health and supporting the immune system. However, its relationship with anemia is not straightforward. Anemia can arise from various factors, including iron deficiency, vitamin B12 deficiency, or chronic diseases, and while there is growing evidence linking vitamin D deficiency with some forms of anemia, particularly anemia of chronic disease or inflammation, vitamin D itself does not directly treat anemia.
Research has suggested that sufficient levels of vitamin D might be associated with improved erythropoiesis (the production of red blood cells), particularly in individuals with chronic kidney disease or certain inflammatory conditions. However, supplementation with vitamin D alone is generally not recommended as a treatment for anemia without addressing the underlying causes. If you're experiencing symptoms of anemia or have concerns about your vitamin D levels, it's best to consult with a healthcare professional for a proper diagnosis and treatment plan tailored to your specific needs.
Based on user reviews, it appears that individuals typically begin to see improvements in their anemia symptoms after several weeks to several months of consistent vitamin D supplementation. For instance, one user reported significant improvements in their anemia symptoms after a few months of taking the supplement daily Read Review. Another reviewer noted that after following their doctor's advice and taking vitamin D for two years, they experienced better overall health and decreased fatigue Read Review.
Moreover, some users mentioned the importance of combining vitamin D with other nutrients to facilitate better absorption and effectiveness, such as vitamin K2 and Omega-3. This indicates that results can vary based on individual health conditions and supplement combinations, but a general timeframe of several weeks to months seems common for noticeable effects on anemia Read Review. Engaging with a healthcare professional for personalized advice on dosage and duration is also recommended for optimal results.
Supplementation with vitamin D has garnered attention in the context of anemia, and emerging research suggests a potential link between vitamin D levels and improved anemia management. Notably, a study involving a large participant pool indicated that higher serum vitamin D levels are associated with a reduced risk of iron deficiency anemia (IDA), particularly in women [1]. Furthermore, randomized controlled trials have shown that vitamin D3 supplementation can enhance iron levels in populations with low iron stores, suggesting it may play a role in addressing anemia [3].
While the findings are encouraging, there are caveats. Some studies, such as those conducted with patients suffering from chronic kidney disease or undergoing dialysis, revealed mixed results regarding the effectiveness of high doses of vitamin D on anemia markers [4], [9]. Despite some improvements in hemoglobin levels observed in specific groups, the overall impact can vary based on individual health conditions and existing vitamin D levels. Thus, while there is scientific backing to suggest that vitamin D supplementation could be beneficial for anemia, further research is necessary to confirm these benefits universally and understand the nuances involved in its application across different populations.
Users have reported a variety of improvements in their symptoms related to anemia after incorporating vitamin D into their supplement regimen. Many individuals noted enhancements in energy levels, with one user sharing that their vitamin D levels increased significantly over eight months, resulting in reduced bone pain, improved hair health, and boosted energy (Read Review). Another reviewer emphasized that vitamin D aids iron absorption—crucial for those dealing with anemia—and has positively impacted their overall health since starting their regimen (Read Review).
Moreover, users highlighted the importance of combining vitamin D with other nutrients, such as omega-3 and vitamin K2, for better absorption and effectiveness in managing anemia. For example, one individual reported noticeable improvements in nutrient absorption and energy storage after starting vitamin D as part of their treatment for a weak intestine related to anemia (Read Review). Another user experienced long-term benefits, like less fatigue and stronger hair and nails, after two years of consistent use (Read Review). These experiences underscore that while results can vary based on personal health circumstances, many users experience significant symptom relief with appropriate supplementation.
Users have reported that combining vitamin D with other supplements can be beneficial for managing anemia. Specifically, many reviewers emphasize the importance of pairing vitamin D with omega-3, vitamin K2, magnesium, and vitamin A for optimal absorption and efficacy. One user noted significant improvements in energy levels and overall health after taking vitamin D alongside omega-3, suggesting that this combination may enhance its effectiveness in addressing anemia symptoms (Read Review). Another reviewer pointed out that proper dosage and co-factors are crucial, advising that those with anemia should be particularly mindful of their nutrient combinations to ensure they effectively support iron absorption and distribution in the body (Read Review).
Additionally, multiple users highlighted the role of vitamin D in aiding iron absorption, making it a key component of anemia management. For instance, one reviewer specifically mentioned how vitamin D3 can enhance the nutritional support needed in treating anemia while correctly adjusting iron intake timing is equally important for maximizing benefits (Read Review). Overall, these insights suggest that while vitamin D can play a significant role in managing anemia, combining it with other supplements may lead to more pronounced improvements in health.
Users have reported varying doses of Vitamin D for treating anemia, with many finding that higher amounts, such as 5000 IU daily, can be effective. One user noted an increase in their Vitamin D level from 14.2 to 45.3 ng/ml over eight months while using this dosage, and they experienced improvements in overall health, including energy levels and symptoms of anemia Read Review. Another review suggested that for those with anemia and Vitamin D3 deficiency, it's wise to begin with small doses, especially for elderly individuals or those recovering from gastrointestinal surgery Read Review.
Moreover, users have emphasized the importance of consulting healthcare professionals to tailor the dosage to individual needs, as they highlight the interactions between Vitamin D and other nutrients such as Vitamin K2 and magnesium Read Review. It is also pointed out that while Vitamin D is crucial for overall health and aiding iron absorption, it should be monitored alongside iron levels to enhance its effectiveness in managing anemia Read Review.
7.5
Improved overall condition
These capsules are easy to swallow and have a good composition. After taking them, my anaemia symptoms improved significantly. The entire family takes them without allergic reactions. I feel my overall health has improved, particularly the darkening in my eyes associated with anaemia.
6
Enhances physical energy
Two years ago, I started taking vitamin D under my doctor's advice for anaemia and found it extremely effective. Unlike previous options, this product offers an adequate dosage that lasts long. I've noticed better skin, stronger hair and nails, and less fatigue. It's essential to maintain balanced iron levels to properly absorb vitamin D. I will continue using and recommending it.
6
Essential for calcium exchange
I took vitamin D alongside my anaemia treatment, as it plays a role in calcium and magnesium exchange. It's crucial to take it with Omega-3 and vitamin K2 while keeping iron intake separate. After following my doctor's recommendations, I reached the lower limits of the norm for vitamin D levels. It's essential to monitor all microelements for effective anaemia management.
9
Significant vitamin increase
1 people found this helpful
My vitamin D rose from 14.2 to 45.3 ng/ml in 8 months, after I started taking 5000 IU alongside Omega-3. I noticed improvements in bone pain, hair loss, and energy levels after starting the supplement. Following my endocrinologist's advice, I adjusted the timing of my intake for better absorption. Vitamin D likely aided my recovery from coronavirus, and I aim to increase my levels further to enhance my health alongside managing my anaemia.
9
Essential for wellbeing
These are excellent vitamins for preventing deficiencies. Vitamin D3 is essential for healthy functioning and aids iron absorption, which is vital for anaemia. The capsules are conveniently sized, and my doctor has approved their dosage. I recommend them for anyone dealing with anaemia or aiming for preventative health.
6
Improves energy levels
I have a weak intestine and, as part of my anaemia treatment, was advised to take vitamin D to enhance my gut health. I've noticed improved energy storage and nutrient absorption since starting this supplement. It's small, easy to swallow, and well-recommended by my doctor, helping me manage my anaemia effectively.
7.5
Improved tissue nourishment
235 people found this helpful
Vitamin D3 is crucial for those with anemia. It enhances tissue nourishment, but one must be cautious about dosage. For example, if there's anaemia alongside vitamin D3 deficiency, start with small doses. Elderly individuals or those post-gastrointestinal surgery should opt for sublingual forms for better absorption. Co-factors like vitamin K2, magnesium, and vitamin A are vital, as their levels impact proper absorption and distribution. This supplement has effectively raised my vitamin D3 levels, which I consider beneficial for overall health.
7.5
Supports immune system
I recommend these small, convenient capsules for everyone, particularly during the pandemic. They are odourless and tasteless, taken with food for better absorption. Vitamin D supports lung function and is crucial for individuals with anaemia, pregnant women, children, and the elderly. However, it's vital to consult a healthcare professional for proper dosage based on individual needs.
9
Vitamin D may reduce anemia risk
Serum Vitamin D Levels and Risk of Iron Deficiency Anemia in Adults: A Cross-Sectional Study and Mendelian Randomization Analysis.
Our investigation centered on whether vitamin D levels play a significant role in iron deficiency anemia (IDA). We examined data from the National Health and Nutrition Examination Survey, which included over 3,700 participants, to explore the relationship between vitamin D and IDA.
Our findings indicated that higher levels of serum vitamin D are linked to a lower risk of developing IDA. Specifically, those in the highest quartile of vitamin D levels had a significantly reduced risk compared to those in the lowest quartile. Interestingly, this protective effect appeared to be more pronounced in women.
We also found a non-linear relationship, suggesting that the effects of vitamin D on anemia become more complex at different levels. This was further supported by a Mendelian randomization analysis, which provided genetic evidence for a causal connection between vitamin D and IDA.
Overall, our results suggest that adequate vitamin D levels could be important for preventing anemia, especially among women. However, further research is certainly needed to confirm these findings and to investigate the potential for vitamin D treatment in managing IDA directly.
9
Vitamin D3 improves iron status
An 8-Week Vitamin D3-Fortified Fruit Drink Supplementation Increases Serum Ferritin Concentration: A Randomized Controlled Trial in Malaysian Women With Low Iron Stores.
We conducted an 8-week, double-blind randomized controlled trial to see how vitamin D3-fortified fruit drinks affect iron levels in women with low iron stores. Our subjects, a group of 45 healthy women aged between 18 and 40, received either the vitamin D3 drink or a placebo, helping us assess the impact of this nutrient on their health.
Throughout the study, we measured key biomarkers such as serum ferritin, which indicates iron stores, and 25-hydroxyvitamin D, the active form of vitamin D in the body. After the 8 weeks, we noted a significant increase in both vitamin D levels and serum ferritin among those who participated in the vitamin D3-fortified drink regimen. This suggests that supplementing with vitamin D3 can indeed help improve iron stores in women who are iron deficient.
Given these findings, it becomes clear that there is potential for vitamin D to play a role in managing anemia. However, we also recognize the need for further research to confirm these effects and explore the safety and practicality of such fortifications across different populations.
4
Vitamin D3's variable effects on anemia
The effect of high-dose vitamin D supplementation on hepcidin-25 and erythropoiesis in patients with chronic kidney disease.
We conducted a study to investigate how high doses of vitamin D3 affect anemia in patients with chronic kidney disease (CKD). In this randomized controlled trial, patients with CKD stages G3-G4 received either 8000 international units of vitamin D daily or a placebo for 12 weeks. We measured key markers related to hepcidin—an important hormone in iron metabolism—and erythropoiesis, which is the process of producing red blood cells.
Interestingly, our findings indicated that high-dose vitamin D supplementation did not show a significant impact on hepcidin levels or markers of anemia overall. However, we found that in patients who started with low levels of vitamin D, the supplementation appeared to improve both erythropoiesis and iron availability. On the other hand, those who had high baseline vitamin D levels seemed to experience a decrease in hepcidin, potentially due to a deterioration in their iron status.
In summary, while high-dose vitamin D3 might not be a universal fix for anemia in CKD patients, it could offer benefits for those with low initial vitamin D levels. This suggests the importance of checking vitamin D status before treatment to tailor approaches that may work best for individuals.
7
Vitamin D3's complex effects noted
Effect of cholecalciferol on serum hepcidin and parameters of anaemia and CKD-MBD among haemodialysis patients: a randomized clinical trial.
We conducted a multicenter, double-blind randomized clinical trial to explore the effects of oral cholecalciferol, a form of vitamin D3, on anemia among patients undergoing haemodialysis. Participants were divided into different groups, receiving varying doses of cholecalciferol or a placebo to compare results.
Over the course of the study, we observed that while serum hepcidin levels increased shortly after vitamin D3 supplementation, they later decreased at the six-month mark, which correlated with increased resistance to erythropoietin—a hormone that helps produce red blood cells.
Importantly, vitamin D3 supplementation also elevated levels of active vitamin D in patients, leading many to reduce their dependency on active vitamin D drugs. However, it’s worth noting that in the long term, the increased erythropoietin resistance may pose challenges for managing anemia.
Overall, our findings illustrate that while cholecalciferol can influence certain biological markers related to anemia, its long-term implications might not be entirely beneficial for patients facing the complexities of dialysis treatment.
References
Chen L, Gu N, Qiu K, Chen H, Tian F, et al. Serum Vitamin D Levels and Risk of Iron Deficiency Anemia in Adults: A Cross-Sectional Study and Mendelian Randomization Analysis. Food Sci Nutr. 2025;13:e4746. doi:10.1002/fsn3.4746
Ahamed F, Jaiswal A, Sahoo S, Ghosh T, Kaur A, et al. Impact of supplementation with iron-folic acid (IFA) and vitamin D compared with IFA alone on haemoglobin levels in elderly people with mild-to-moderate anaemia: protocol for the double-blind, randomised, placebo-controlled Iron and vitamin D trial in Elderly Anemia (IDEA). BMJ Open. 2024;14:e080303. doi:10.1136/bmjopen-2023-080303
Suhaimi NA, Loh SP, Ab Manan N, Zalbahar N, Mohamad Alwi MN, et al. An 8-Week Vitamin D3-Fortified Fruit Drink Supplementation Increases Serum Ferritin Concentration: A Randomized Controlled Trial in Malaysian Women With Low Iron Stores. J Acad Nutr Diet. 2024;124:1440. doi:10.1016/j.jand.2024.02.013
Pistis KD, Westerberg PA, Qureshi AR, Beshara S, Sterner G, et al. The effect of high-dose vitamin D supplementation on hepcidin-25 and erythropoiesis in patients with chronic kidney disease. BMC Nephrol. 2023;24:20. doi:10.1186/s12882-022-03014-z
Ahmad Fuzi SF, Su Peng L, Zabaha Zalbahar N, Ab Manan N, Mohamad Alwi MN. Effect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: Protocol for an 8-week, parallel group, double-blind randomized controlled trial. PLoS One. 2022;17:e0265772. doi:10.1371/journal.pone.0265772
Chailurkit LO, Sritara P, Vathesatogkit P, Yamwong S, Thongmung N, et al. Vitamin D epimers are associated with circulating haemoglobin levels independently of C-reactive protein. Sci Rep. 2021;11:20747. doi:10.1038/s41598-021-00086-z
Li M, Xu J, Wan Q, He Q, Ma Y, et al. Relationship between serum vitamin D3 concentration and anaemia in patients with chronic kidney disease in China. J Int Med Res. 2021;49:3000605211012231. doi:10.1177/03000605211012231
Obi Y, Ichimaru N, Sakaguchi Y, Iwadoh K, Ishii D, et al. Correcting anemia and native vitamin D supplementation in kidney transplant recipients: a multicenter, 2 × 2 factorial, open-label, randomized clinical trial. Transpl Int. 2021;34:1212. doi:10.1111/tri.13885
Obi Y, Yamaguchi S, Hamano T, Sakaguchi Y, Shimomura A, et al. Effect of cholecalciferol on serum hepcidin and parameters of anaemia and CKD-MBD among haemodialysis patients: a randomized clinical trial. Sci Rep. 2020;10:15500. doi:10.1038/s41598-020-72385-w
Massimetti C, Bellasi A, Feriozzi S. [Cholecalciferol supplementation improves secondary hyperparathyroidism control in hemodialysis patients]. G Ital Nefrol. 2020;37.