Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.5
USERS' SCORE
Moderately Good
Based on 77 Reviews
7.7
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
Read More
9
Vitamin D3 derivatives improve cancer treatment
We focused on how modified forms of vitamin D3 can positively affect cancer treatment. The study revealed that a specific derivative, known as MART-10, demonstrated significant anti-tumor effects in mouse models. When administered at low doses, this compound showed robust anti-cancer activity against BxpC-3 cancer cells.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Read More
8
We delved into the intriguing relationship between vitamin D and colorectal cancer (CRC) to uncover how this nutrient might influence cancer development and treatment. The study involved measuring the serum levels of active vitamin D (1,25(OH)D) in different groups, including those with normal conditions, colorectal adenomas (CRA), and colorectal cancer (CRC).
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Read More
Most Useful Reviews
7.5
Supports cancer treatment
4809 people found this helpful
Vitamine D is crucial for bone health and has anti-cancer benefits. If your 25 (OH) D level is 20 or less, it's advisable to start with 5000 IU daily. For levels 21-30, take 2,000 IU, and if it's 31-40, take 1000 IU daily. After three months, retest. The optimal level is 50-70. Vitamin D supplementation raises levels effectively without odour. Sunlight aids production, but sunscreen can hinder it. This supplement has improved my health significantly. Happy shopping!
Read More
9
Cancer prevention
12 people found this helpful
The composition of lanolin is good. Current research suggests vitamin D is crucial in preventing SARS and infections. Studies show that higher blood levels of vitamin D correlate with a reduced risk of various types of cancer.
Read More
9
Improves sperm health
7 people found this helpful
I believe my input will assist you. This medicine offers significant benefits: improving sperm health, increasing sexual desire, enhancing sperm production, achieving optimal penis erection, and preventing cancer. My experience shows that recognising these benefits is fortunate, and I hope you find my comment useful.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.5
- All Researches
9
We explored the potential of vitamin D-based micelles designed to deliver paclitaxel, a key chemotherapy drug, specifically for pancreatic cancer treatment. This study focuses on developing enzyme-responsive micelles that not only carry paclitaxel but also utilize vitamin D as an integral part of the delivery system.
The micelles are made by combining vitamin D with polyethylene glycol, resulting in tiny structures that can release their drug load when interacting with enzymes typically found in pancreatic cancer cells. We observed that these micelles showed promising results in laboratory settings, enhancing the effectiveness of paclitaxel against aggressive pancreatic cancer cells compared to using paclitaxel alone.
Moreover, we noted that the vitamin D in the micelles may play a dual role: serving as both a hydrophobic core for drug delivery and a contributor to synergetic therapeutic effects. Our findings suggest that leveraging vitamin D in this way could increase the efficacy of existing treatment options for pancreatic cancer patients, which is particularly significant given the challenges currently faced in treating this disease.
The micelles are made by combining vitamin D with polyethylene glycol, resulting in tiny structures that can release their drug load when interacting with enzymes typically found in pancreatic cancer cells. We observed that these micelles showed promising results in laboratory settings, enhancing the effectiveness of paclitaxel against aggressive pancreatic cancer cells compared to using paclitaxel alone.
Moreover, we noted that the vitamin D in the micelles may play a dual role: serving as both a hydrophobic core for drug delivery and a contributor to synergetic therapeutic effects. Our findings suggest that leveraging vitamin D in this way could increase the efficacy of existing treatment options for pancreatic cancer patients, which is particularly significant given the challenges currently faced in treating this disease.
Read More
9
Vitamin D3 derivatives improve cancer treatment
We focused on how modified forms of vitamin D3 can positively affect cancer treatment. The study revealed that a specific derivative, known as MART-10, demonstrated significant anti-tumor effects in mouse models. When administered at low doses, this compound showed robust anti-cancer activity against BxpC-3 cancer cells.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Read More
8
We explored the potential benefits of a vitamin D analog in treating prostate cancer, which is a major cause of cancer-related deaths among men. Our work focused on understanding how this vitamin D form impacts cancer resistance and the tumor microenvironment. We used the Pten mouse model to observe the therapeutic effects of the vitamin D analog.
One significant finding was that combining this vitamin D analog with the chemotherapy drug docetaxel could overcome resistance seen in some prostate cancer cases. This combination showed promising results in primary cancer spheroids and xenografts from a patient whose cancer had resisted both docetaxel and androgen deprivation therapy.
These insights suggest that vitamin D analogs might offer new and effective strategies for managing advanced prostate cancer, particularly for those patients who have not responded well to standard treatments.
One significant finding was that combining this vitamin D analog with the chemotherapy drug docetaxel could overcome resistance seen in some prostate cancer cases. This combination showed promising results in primary cancer spheroids and xenografts from a patient whose cancer had resisted both docetaxel and androgen deprivation therapy.
These insights suggest that vitamin D analogs might offer new and effective strategies for managing advanced prostate cancer, particularly for those patients who have not responded well to standard treatments.
Read More
8
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
Read More
8
We delved into the intriguing relationship between vitamin D and colorectal cancer (CRC) to uncover how this nutrient might influence cancer development and treatment. The study involved measuring the serum levels of active vitamin D (1,25(OH)D) in different groups, including those with normal conditions, colorectal adenomas (CRA), and colorectal cancer (CRC).
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 77 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Supports cancer treatment
4809 people found this helpful
Vitamine D is crucial for bone health and has anti-cancer benefits. If your 25 (OH) D level is 20 or less, it's advisable to start with 5000 IU daily. For levels 21-30, take 2,000 IU, and if it's 31-40, take 1000 IU daily. After three months, retest. The optimal level is 50-70. Vitamin D supplementation raises levels effectively without odour. Sunlight aids production, but sunscreen can hinder it. This supplement has improved my health significantly. Happy shopping!
Read More
9
Cancer prevention
12 people found this helpful
The composition of lanolin is good. Current research suggests vitamin D is crucial in preventing SARS and infections. Studies show that higher blood levels of vitamin D correlate with a reduced risk of various types of cancer.
Read More
9
Improves sperm health
7 people found this helpful
I believe my input will assist you. This medicine offers significant benefits: improving sperm health, increasing sexual desire, enhancing sperm production, achieving optimal penis erection, and preventing cancer. My experience shows that recognising these benefits is fortunate, and I hope you find my comment useful.
Read More
10
Supports immune function
1 people found this helpful
Vitamin D3 is essential, especially for those with autoimmune diseases, who struggle with its natural production. It aids calcium absorption and bone formation, and studies confirm its role in cancer cell suppression. Regular monitoring of vitamin D3 levels is critical.
Read More
9
Immune system support
1 people found this helpful
Vitamin D is vital, enhancing the immune system and regulating calcium and phosphorus balance for strong bones. It can reduce the risk of several diseases, including cancer. I regularly check my vitamin D levels, and they remain optimal. This vitamin supports youth and vitality.
Read More
Frequently Asked Questions
9
Tumour reduction
1 people found this helpful
This vitamin D3 was recommended by my doctor for my immunity. I also gave some to my dad as he has cancer and needed a high potency dose, which actually shrunk his tumour slightly and improved his levels! So it definitely works.
7.5
Supports cancer treatment
4809 people found this helpful
Vitamine D is crucial for bone health and has anti-cancer benefits. If your 25 (OH) D level is 20 or less, it's advisable to start with 5000 IU daily. For levels 21-30, take 2,000 IU, and if it's 31-40, take 1000 IU daily. After three months, retest. The optimal level is 50-70. Vitamin D supplementation raises levels effectively without odour. Sunlight aids production, but sunscreen can hinder it. This supplement has improved my health significantly. Happy shopping!
7.5
Boosts immune response
90 people found this helpful
This vitamin supplement has substantially enhanced my overall well-being, providing energy and a positive mood. It strengthens my immune system, lowers cancer risks, and improves skin health. I recommend it for anyone seeking to elevate their quality of life.
9
Immunity enhancement
I've been taking vitamin D3 consistently for many years, increasing to 10,000 units in winter, achieving a level of 89. With this intake, my family and I rarely get sick, even forgetting about common colds. D3 is crucial for immunity and high doses are essential during covid.
9
Reduces cancer risks
4 people found this helpful
Vitamin D is a powerful steroid hormone with significant cancer-reducing properties. Achieving optimal levels decreases breast and colon cancer risks significantly. It's crucial to raise vitamin D levels before illness strikes.
9
Lowers cancer chances
56 people found this helpful
Vitamin D can significantly prolong life by stimulating autophagy, increasing telomere length, and reducing the risk of age-related diseases, including cancer. The recommended daily intake is crucial to inhibit ageing effectively. Adequate vitamin D levels can restore immune function against various ailments associated with ageing.
7.5
Autoimmune support
20 people found this helpful
As someone with autoimmune issues, I find vitamin D3 essential, as I struggle to produce it naturally. This nutrient is vital for calcium absorption, immunity, and regulating various bodily functions. Doctors now recommend monitoring vitamin D levels, especially in chronic illnesses.
9
Important for cancer
97 people found this helpful
Vitamin D is essential for maintaining youth and health, with proven effects against cancer and depression. It influences all organs and activates over two thousand genes, making it vital for well-being. I recommend NOW Foods Vitamin D-3 5000 IU, but always consult a doctor before use.
9
Protects against cancer
210 people found this helpful
Vitamin D3 5000 IU capsules support numerous bodily processes, including calcium absorption and immunity. They enhance fertility in men and improve mood. However, testing for vitamin D levels is advisable before starting. Low levels are linked to a weakened immune system and increased cancer risk. Women with higher levels experience significantly lower breast cancer risk. Consult a doctor for correct dosages based on health and weight.
References
- Len-Tayon K, Metzger D, Laverny G. [New insights of vitamin D-based therapy for prostate cancer]. Med Sci (Paris). 2025;41:154. doi:10.1051/medsci/2025011
- Soni D, Tiwari A, Kushwah PS, Dubey S, Khan S. Levels of Serum 25-Hydroxy Vitamin D in Benign and Malignant Breast Disease Patients: An Observational Study. Cureus. 2025;17:e78283. doi:10.7759/cureus.78283
- Peixoto D, Ravasco JM, Blanco-Fernandez B, Veiga F, Concheiro A, et al. Enzyme-responsive vitamin D-based micelles for paclitaxel-controlled delivery and synergistic pancreatic cancer therapy. Mater Today Bio. 2025;31:101555. doi:10.1016/j.mtbio.2025.101555
- Xu N, Lin H, Ding X, Wang P, Lin JM. Isotope tracing-assisted chip-based solid-phase extraction mass spectrometry for monitoring metabolic changes and vitamin D3 regulation in cells. Talanta. 2025;288:127754. doi:10.1016/j.talanta.2025.127754
- Jo Y, Kushram P, Bose S. Curcumin and vitamin D3 release from calcium phosphate enhances bone regeneration. Biomater Sci. 2025. doi:10.1039/d4bm01188k
- Ezcurra-Hualde M, Zalba S, Bella Á, Arrizabalaga L, Risson A, et al. Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth. Front Immunol. 2025;16:1529007. doi:10.3389/fimmu.2025.1529007
- Wang L, Xu R, Wang M, Wang M, Su S, et al. Exploration and Identification of Vitamin D and Related Genes as Potential Biomarkers for Colorectal Tumors. Onco Targets Ther. 2025;18:129. doi:10.2147/OTT.S495066
- Evans H, Greenhough A, Perry L, Lasanta G, Gonzalez CM, et al. Hypoxia Compromises the Differentiation of Human Osteosarcoma Cells to CAR-R, a Hydroxylated Derivative of Lithocholic Acid and Potent Agonist of the Vitamin D Receptor. Int J Mol Sci. 2025;26. doi:10.3390/ijms26010365
- Kittaka A. Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities. Chem Pharm Bull (Tokyo). 2025;73:1. doi:10.1248/cpb.c24-00598
- He W, Lv W, Liu L, Gong Y, Song K, et al. Enhanced Antiglioma Effect by a Vitamin D3-Inserted Lipid Hybrid Neutrophil Membrane Biomimetic Multimodal Nanoplatform. ACS Nano. 2024;18:35559. doi:10.1021/acsnano.4c13470
- Almassri HF, Abdul Kadir A, Srour M, Foo LH. The Effects of Omega-3 Fatty Acids and Vitamin D Supplementation on the Nutritional Status of Women with Breast Cancer in Palestine: An Open-Label Randomized Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16223960
- Maturana-Ramiìrez A, Aitken-Saavedra J, Rojas-Zúñiga G, Rojas-Alcayaga G, Espinoza-Santander I, et al. Hypovitaminosis D in patients with oral squamous cell carcinoma: Is a risk factor of developing this neoplasia?. Med Oral Patol Oral Cir Bucal. 2025;30:e24. doi:10.4317/medoral.26692
- Almassri HF, Abdul Kadir A, Srour M, Foo LH. The effects of Omega-3 fatty acids and vitamin D supplementation on the quality of life and blood inflammation markers in newly diagnosed breast cancer women: An open-labelled randomised controlled trial. Clin Nutr ESPEN. 2025;65:64. doi:10.1016/j.clnesp.2024.11.014
- García-Martínez JM, Chocarro-Calvo A, Martínez-Useros J, Regueira-Acebedo N, Fernández-Aceñero MJ, et al. SIRT1 Mediates the Antagonism of Wnt/β-Catenin Pathway by Vitamin D in Colon Carcinoma Cells. Int J Biol Sci. 2024;20:5495. doi:10.7150/ijbs.95875
