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SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
USERS' SCORE
Good
Based on 77 Reviews
8.9
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
Vitamin D3 offers anti-cancer benefits
Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth.
Study emphasizes isolated effects
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
Read More
9
Vitamin D3 derivatives improve cancer treatment
Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities.
Highly relevant to cancer treatment
We focused on how modified forms of vitamin D3 can positively affect cancer treatment. The study revealed that a specific derivative, known as MART-10, demonstrated significant anti-tumor effects in mouse models. When administered at low doses, this compound showed robust anti-cancer activity against BxpC-3 cancer cells.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Read More
8
Vitamin D's potential in CRC
Exploration and Identification of Vitamin D and Related Genes as Potential Biomarkers for Colorectal Tumors.
High relevance to cancer treatment
We delved into the intriguing relationship between vitamin D and colorectal cancer (CRC) to uncover how this nutrient might influence cancer development and treatment. The study involved measuring the serum levels of active vitamin D (1,25(OH)D) in different groups, including those with normal conditions, colorectal adenomas (CRA), and colorectal cancer (CRC).
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Read More
Most Useful Reviews
8.8
Supports cancer treatment
Vitamine D is crucial for bone health and has anti-cancer benefits. If your 25 (OH) D level is 20 or less, it's advisable to start with 5000 IU daily. For levels 21-30, take 2,000 IU, and if it's 31-40, take 1000 IU daily. After three months, retest. The optimal level is 50-70. Vitamin D supplementation raises levels effectively without odour. Sunlight aids production, but sunscreen can hinder it. This supplement has improved my health significantly. Happy shopping!
Read More
8.3
Cancer prevention
The composition of lanolin is good. Current research suggests vitamin D is crucial in preventing SARS and infections. Studies show that higher blood levels of vitamin D correlate with a reduced risk of various types of cancer.
Read More
9.5
Improves sperm health
I believe my input will assist you. This medicine offers significant benefits: improving sperm health, increasing sexual desire, enhancing sperm production, achieving optimal penis erection, and preventing cancer. My experience shows that recognising these benefits is fortunate, and I hope you find my comment useful.
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
9
Vitamin D3 derivatives improve cancer treatment
Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities.
Highly relevant to cancer treatment
We focused on how modified forms of vitamin D3 can positively affect cancer treatment. The study revealed that a specific derivative, known as MART-10, demonstrated significant anti-tumor effects in mouse models. When administered at low doses, this compound showed robust anti-cancer activity against BxpC-3 cancer cells.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Read More
8
Vitamin D3 offers anti-cancer benefits
Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth.
Study emphasizes isolated effects
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
Read More
8
Vitamin D's potential in CRC
Exploration and Identification of Vitamin D and Related Genes as Potential Biomarkers for Colorectal Tumors.
High relevance to cancer treatment
We delved into the intriguing relationship between vitamin D and colorectal cancer (CRC) to uncover how this nutrient might influence cancer development and treatment. The study involved measuring the serum levels of active vitamin D (1,25(OH)D) in different groups, including those with normal conditions, colorectal adenomas (CRA), and colorectal cancer (CRC).
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Read More
8
Vitamin D3 enhances glioma treatment
Enhanced Antiglioma Effect by a Vitamin D3-Inserted Lipid Hybrid Neutrophil Membrane Biomimetic Multimodal Nanoplatform.
Significant relevance to cancer treatment
We developed an innovative treatment approach using a special type of nanoplatform that combines vitamin D3 with neutrophil membranes and chemotherapy medication doxorubicin. This platform was specifically designed to target glioblastoma, which is known as one of the most aggressive and challenging brain cancers.
Not only did we find that this treatment method was effective in delivering chemotherapy and promoting cell death in tumor cells, but we also observed that it significantly boosted the immune response against cancer. The combination activated a specific immune pathway, leading to increased production of important signaling molecules that can help fight tumors. This resulted in a shift from an immune-resistant environment to one more responsive to treatment, encouraging immune cells to attack the cancer more effectively.
Overall, the use of vitamin D3 in this multimodal strategy shows great promise for enhancing cancer therapy, opening the door for further exploration into its potential for improving glioma treatment outcomes and possibly developing more effective immune therapies.
Not only did we find that this treatment method was effective in delivering chemotherapy and promoting cell death in tumor cells, but we also observed that it significantly boosted the immune response against cancer. The combination activated a specific immune pathway, leading to increased production of important signaling molecules that can help fight tumors. This resulted in a shift from an immune-resistant environment to one more responsive to treatment, encouraging immune cells to attack the cancer more effectively.
Overall, the use of vitamin D3 in this multimodal strategy shows great promise for enhancing cancer therapy, opening the door for further exploration into its potential for improving glioma treatment outcomes and possibly developing more effective immune therapies.
Read More
8
Vitamin D3 improves nutritional status
The Effects of Omega-3 Fatty Acids and Vitamin D Supplementation on the Nutritional Status of Women with Breast Cancer in Palestine: An Open-Label Randomized Controlled Trial.
Supplementation combination affects outcomes
We assessed the effects of vitamin D3 supplementation in women newly diagnosed with breast cancer, focusing on how it can enhance nutritional health. In a randomized controlled trial, 88 women were split into four groups to receive either omega-3 fatty acids, vitamin D3, both, or none at all.
Over nine weeks, we noticed that those who took daily omega-3s and weekly vitamin D3 showed notable improvements in their nutritional status. We used various tools—including self-assessments and blood tests—to gauge changes. The results indicated better dietary intake, higher blood albumin levels, and improved subjective assessments of their overall nutrition in those who received supplementation.
Although vitamin D3 was part of the combination therapy with omega-3, it contributed positively to the participants' health during active cancer treatment. Thus, supplementing with vitamin D3 appears to be a beneficial strategy in managing the nutritional challenges faced by women undergoing treatment for breast cancer.
Over nine weeks, we noticed that those who took daily omega-3s and weekly vitamin D3 showed notable improvements in their nutritional status. We used various tools—including self-assessments and blood tests—to gauge changes. The results indicated better dietary intake, higher blood albumin levels, and improved subjective assessments of their overall nutrition in those who received supplementation.
Although vitamin D3 was part of the combination therapy with omega-3, it contributed positively to the participants' health during active cancer treatment. Thus, supplementing with vitamin D3 appears to be a beneficial strategy in managing the nutritional challenges faced by women undergoing treatment for breast cancer.
Read More
User Reviews
USERS' SCORE
Good
Based on 77 Reviews
8.9
10
Supports immune function
Vitamin D3 is essential, especially for those with autoimmune diseases, who struggle with its natural production. It aids calcium absorption and bone formation, and studies confirm its role in cancer cell suppression. Regular monitoring of vitamin D3 levels is critical.
9.5
Protects against cancer
Vitamin D3 5000 IU capsules support numerous bodily processes, including calcium absorption and immunity. They enhance fertility in men and improve mood. However, testing for vitamin D levels is advisable before starting. Low levels are linked to a weakened immune system and increased cancer risk. Women with higher levels experience significantly lower breast cancer risk. Consult a doctor for correct dosages based on health and weight.
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9.5
Anti-cancer properties
Vitamin D, a key prohormone, plays a crucial role in maintaining health and youth. It's recognised as the main anti-cancer and anti-depressant vitamin, influencing numerous body functions and activating many genes. For overall health and vitality, I recommend NOW Foods Vitamin D-3 5000 IU.
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9.5
Important for cancer
Vitamin D is essential for maintaining youth and health, with proven effects against cancer and depression. It influences all organs and activates over two thousand genes, making it vital for well-being. I recommend NOW Foods Vitamin D-3 5000 IU, but always consult a doctor before use.
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9.5
Lowers cancer chances
Vitamin D can significantly prolong life by stimulating autophagy, increasing telomere length, and reducing the risk of age-related diseases, including cancer. The recommended daily intake is crucial to inhibit ageing effectively. Adequate vitamin D levels can restore immune function against various ailments associated with ageing.
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