Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.3
USERS' SCORE
Good
Based on 18 Reviews
8.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
Vitamin D3 ethosomal gel for psoriasis
We explored the development of ethosomal gels infused with vitamin D3 to target psoriasis, a chronic skin condition driven by immune responses. Vitamin D3 has long been recognized for its vital role in skin health, particularly in promoting the growth and maturation of skin cells known as keratinocytes.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Read More
9
Vitamin D's role in psoriasis treatment
We investigated the impact of vitamin D treatment on psoriasis, emphasizing its effectiveness for this skin condition. Our focus was on vitamin D as a topical treatment option, particularly in relation to nail psoriasis, a chronic and often challenging ailment.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
Read More
8
We explored the effectiveness of topical treatments for chronic plaque psoriasis, particularly focusing on calcipotriol, an active form of vitamin D, and methotrexate. In a study involving 60 patients, we divided them into two groups: one receiving calcipotriol and the other methotrexate. Over two months, we assessed their progress based on the psoriasis area severity index (PASI) scores, measuring the severity of their condition at the start, four weeks in, and eight weeks later.
Our findings revealed that both calcipotriol and methotrexate were effective in reducing the severity of psoriasis lesions. At the start of the study, both groups had similar PASI scores, but by the eighth week, both treatments had significantly lowered these scores. Interestingly, while six patients in the calcipotriol group experienced complete clearance of their lesions, three patients in the methotrexate group did as well.
When it came to safety, the adverse effects from both treatments were generally mild and transient. A few patients reported skin irritation with calcipotriol and a burning sensation with methotrexate, but these issues were not severe and did not significantly impact overall well-being. We conclude that topical calcipotriol and methotrexate treatment options are effective and well-tolerated for those dealing with chronic plaque psoriasis.
Our findings revealed that both calcipotriol and methotrexate were effective in reducing the severity of psoriasis lesions. At the start of the study, both groups had similar PASI scores, but by the eighth week, both treatments had significantly lowered these scores. Interestingly, while six patients in the calcipotriol group experienced complete clearance of their lesions, three patients in the methotrexate group did as well.
When it came to safety, the adverse effects from both treatments were generally mild and transient. A few patients reported skin irritation with calcipotriol and a burning sensation with methotrexate, but these issues were not severe and did not significantly impact overall well-being. We conclude that topical calcipotriol and methotrexate treatment options are effective and well-tolerated for those dealing with chronic plaque psoriasis.
Read More
Most Useful Reviews
7.5
Reduced infections
281 people found this helpful
Adequate intake of vitamin D3 lowers the incidence of acute respiratory infections, while deficiency increases illness risk and autoimmune conditions like psoriasis. Insufficient cholecalciferol also affects insulin secretion. This supply lasts 120 days and is cost-effective.
Read More
9
Strengthens immune system
73 people found this helpful
Vitamin D3 is essential for regulating calcium and phosphorus metabolism, thereby enhancing overall health. It significantly boosts the immune system, aids in managing inflammation, and helps combat psoriasis. Regular intake has shown excellent results in my analyses, and I feel it contributes greatly to my well-being.
Read More
9
Prevents skin diseases
56 people found this helpful
Vitamin D promotes a longer life by stimulating autophagy and increasing telomere length. It also lowers the risk of age-related diseases, including various cancers. Adequate levels of vitamin D can significantly support immune health, which is vital for managing autoimmune conditions like psoriasis.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.3
- All Researches
9.5
We conducted a study to better understand how topical treatments, particularly those involving vitamin D3, affect psoriasis. In our investigation, we focused on a group of 30 psoriasis patients, using a double-blind, randomized approach. This means neither the patients nor the researchers knew who received which treatment, ensuring an unbiased evaluation of their effects.
The treatments explored included a combination of Calcipotriol (a vitamin D3 analogue) and Betamethasone (a steroid), as well as Betamethasone alone and Clobetasol Propionate ointment. Through the analysis of skin biopsies before and after four weeks of treatment, we observed changes in skin inflammation, cellular infiltrate, and patients’ clinical scores for psoriasis severity.
While we noted that all treatments helped reduce skin thickness and improved patient scores, the greatest impact was seen with the combination of Calcipotriol and Betamethasone. This specific treatment effectively diminished the number of harmful immune cells that contribute to psoriasis flare-ups. However, the isolated effect of vitamin D3 alone wasn’t clearly established, as the most significant outcomes were tied to its use in combination with steroids.
Ultimately, our findings suggest that while vitamin D3 plays a role in psoriasis treatment, its benefits are most pronounced when paired with corticosteroids. This combination could potentially lead to enhanced long-term management of the disease, although the specific contribution of vitamin D3 alone remains uncertain.
The treatments explored included a combination of Calcipotriol (a vitamin D3 analogue) and Betamethasone (a steroid), as well as Betamethasone alone and Clobetasol Propionate ointment. Through the analysis of skin biopsies before and after four weeks of treatment, we observed changes in skin inflammation, cellular infiltrate, and patients’ clinical scores for psoriasis severity.
While we noted that all treatments helped reduce skin thickness and improved patient scores, the greatest impact was seen with the combination of Calcipotriol and Betamethasone. This specific treatment effectively diminished the number of harmful immune cells that contribute to psoriasis flare-ups. However, the isolated effect of vitamin D3 alone wasn’t clearly established, as the most significant outcomes were tied to its use in combination with steroids.
Ultimately, our findings suggest that while vitamin D3 plays a role in psoriasis treatment, its benefits are most pronounced when paired with corticosteroids. This combination could potentially lead to enhanced long-term management of the disease, although the specific contribution of vitamin D3 alone remains uncertain.
Read More
9
Vitamin D's role in psoriasis treatment
We investigated the impact of vitamin D treatment on psoriasis, emphasizing its effectiveness for this skin condition. Our focus was on vitamin D as a topical treatment option, particularly in relation to nail psoriasis, a chronic and often challenging ailment.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
Read More
9
Calcipotriol more effective than calcitriol
We explored the effectiveness of two vitamin D analogues, calcipotriol and calcitriol, in treating stable plaque psoriasis when combined with narrow-band ultraviolet B (NBUVB) phototherapy. Our study involved thirty patients who were treated for 12 weeks, applying calcitriol ointment to one side and calcipotriol ointment to the other.
Throughout the trial, we observed significant improvements in skin conditions such as erythema, scaling, and overall plaque thickness with both treatments. Remarkably, those using calcipotriol showed quicker clearance of plaques and experienced fewer relapses compared to those using calcitriol.
Both treatments were found to be safe and well-tolerated, making them cosmetically appealing options. However, calcipotriol not only demonstrated a rapid onset of action but also maintained its efficacy more consistently over the treatment period.
Throughout the trial, we observed significant improvements in skin conditions such as erythema, scaling, and overall plaque thickness with both treatments. Remarkably, those using calcipotriol showed quicker clearance of plaques and experienced fewer relapses compared to those using calcitriol.
Both treatments were found to be safe and well-tolerated, making them cosmetically appealing options. However, calcipotriol not only demonstrated a rapid onset of action but also maintained its efficacy more consistently over the treatment period.
Read More
8
Vitamin D3 ethosomal gel for psoriasis
We explored the development of ethosomal gels infused with vitamin D3 to target psoriasis, a chronic skin condition driven by immune responses. Vitamin D3 has long been recognized for its vital role in skin health, particularly in promoting the growth and maturation of skin cells known as keratinocytes.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Read More
8
Phototherapy benefits psoriasis treatment
We investigated how phototherapy, specifically narrowband-ultraviolet B (NB-UVB), affects vitamin D levels and inflammatory markers in patients with psoriasis and atopic dermatitis. The study involved thirty adults—twenty with psoriasis and ten with atopic dermatitis—who underwent NB-UVB treatment.
After therapy, we observed changes in vitamin D-binding protein (DBP) and high-sensitivity C-reactive protein (hsCRP), both of which indicate systemic inflammation. Interestingly, DBP levels decreased in psoriasis patients following treatment. However, the drop in hsCRP levels—while noticed in both groups—wasn't statistically significant.
We also saw improvements in disease severity, as measured by established scales, alongside increases in vitamin D levels. Sub-analyses showed that patients with vitamin D deficiency or insufficiency tended to respond better to NB-UVB therapy compared to those who were vitamin D sufficient.
Overall, our findings suggest that phototherapy may offer not only skin benefits but also a systemic anti-inflammatory effect, primarily in psoriasis patients.
After therapy, we observed changes in vitamin D-binding protein (DBP) and high-sensitivity C-reactive protein (hsCRP), both of which indicate systemic inflammation. Interestingly, DBP levels decreased in psoriasis patients following treatment. However, the drop in hsCRP levels—while noticed in both groups—wasn't statistically significant.
We also saw improvements in disease severity, as measured by established scales, alongside increases in vitamin D levels. Sub-analyses showed that patients with vitamin D deficiency or insufficiency tended to respond better to NB-UVB therapy compared to those who were vitamin D sufficient.
Overall, our findings suggest that phototherapy may offer not only skin benefits but also a systemic anti-inflammatory effect, primarily in psoriasis patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Reduced infections
281 people found this helpful
Adequate intake of vitamin D3 lowers the incidence of acute respiratory infections, while deficiency increases illness risk and autoimmune conditions like psoriasis. Insufficient cholecalciferol also affects insulin secretion. This supply lasts 120 days and is cost-effective.
Read More
9
Strengthens immune system
73 people found this helpful
Vitamin D3 is essential for regulating calcium and phosphorus metabolism, thereby enhancing overall health. It significantly boosts the immune system, aids in managing inflammation, and helps combat psoriasis. Regular intake has shown excellent results in my analyses, and I feel it contributes greatly to my well-being.
Read More
9
Prevents skin diseases
56 people found this helpful
Vitamin D promotes a longer life by stimulating autophagy and increasing telomere length. It also lowers the risk of age-related diseases, including various cancers. Adequate levels of vitamin D can significantly support immune health, which is vital for managing autoimmune conditions like psoriasis.
Read More
7.5
Bone health focus
31 people found this helpful
Vitamin D3 is crucial for absorbing calcium and phosphorus, key for bone development and mineralization. It supports the musculoskeletal system in children and strengthens the immune response to infections. Additionally, it aids in reducing psoriasis and plays a role in overall metabolic functions.
Read More
9
Adjuvant treatment
2 people found this helpful
This vitamin D is a fantastic option during winter for skin diseases like psoriasis and eczema. I began taking it after suffering from COVID and found noticeable improvement, so now my whole family takes it regularly.
Read More
Frequently Asked Questions
2
Ineffective treatment
I have psoriasis and was advised to take vitamin D. Initially, the first ones I tried healed 75% in a month, but this one has no effect. I've just started using this brand and have two bottles for two months. I'm sharing my honest opinion.
9
Psoriasis improvement
I've been taking it during the pandemic. I haven't had a cold, and my husband's severe psoriasis improved significantly after starting vitamin K and D together, eliminating the need for hospital visits. Unfortunately, I regret that traditional medicine often fails to cure conditions.
9
Significant improvement
1 people found this helpful
It is essential for everyone! The NOW brand is excellent! I use various products from this manufacturer, and the quality and price are great. This highly active vitamin D3 is necessary due to widespread deficiency. I take it daily with my family during breakfast. My health, mood, sleep, skin, hair, and nails have improved significantly! I sometimes increase the dose to 10,000 IU for three months due to my psoriasis. My analysis showed 60, which is good. This jar lasts four months; I highly recommend it!
7.5
Effective supplementation
4 people found this helpful
I purchased this vitamin to address my chronic psoriasis symptoms, and it’s been more effective than I expected. I’m taking one tablet every two days and plan to continue.
7.5
Joint pain reduced
I tried 10,000 IU, and both my psoriasis and joint pain have improved. I will continue, but I must take it alongside vitamin K.
9
Essential vitamin
2 people found this helpful
It is now clear that vitamin D is vital, as deficiencies can lead to many issues, including psoriasis. To maintain good health, it's recommended to keep vitamin D levels optimal, which can support numerous bodily functions and mitigate deficiency symptoms.
9
Effective for psoriasis
11 people found this helpful
I find this vitamin excellent for managing psoriasis and plan to take it daily as it has shown great results for me.
7.5
Essential supplementation
Vitamin D3 is irreplaceable—low levels lead to various health issues, including psoriasis. Its importance is clear; supplementation is vital. Adults typically need 2000-5000 IU daily, with higher doses for pregnant women. It's crucial year-round, especially when sunlight is scarce.
7.5
Helpful for psoriasis
2 people found this helpful
We've been using this vitamin D brand for ages. My husband takes 10,000 IU for his psoriasis, and it’s useful in maintaining remission. I alternate my dosage throughout the year, ensuring we all get our necessary levels.
9
No side effects
The doctor recommended this vitamin for treating my psoriasis. The dosage is relatively high and economical, without any side effects, which is a bonus.
7
We explored an innovative approach to treating psoriasis by combining vitamin D, specifically Calcipotriol, with a targeted delivery method. This study combined a self-locking microneedle patch loaded with Deucravacitinib, a Tyrosine Kinase 2 inhibitor, alongside Calcipotriol, which helps manage skin cell proliferation.
Calcipotriol is known for its effectiveness in psoriasis treatment, especially for reducing thickened skin lesions, yet it shines when paired with advanced drug delivery systems. The microneedle patch design allows for quick penetration and localized action, showing promise not only in reducing inflammation but also in improving localized skin retention of the medication.
We observed that this dual-action approach not only targets the specific lesions directly but may also play a role in reducing overall systemic inflammation by inhibiting the differentiation of certain immune cells. This offers an exciting new option for those suffering from psoriasis and reflects a significant step toward more effective and specifically targeted therapies.
Calcipotriol is known for its effectiveness in psoriasis treatment, especially for reducing thickened skin lesions, yet it shines when paired with advanced drug delivery systems. The microneedle patch design allows for quick penetration and localized action, showing promise not only in reducing inflammation but also in improving localized skin retention of the medication.
We observed that this dual-action approach not only targets the specific lesions directly but may also play a role in reducing overall systemic inflammation by inhibiting the differentiation of certain immune cells. This offers an exciting new option for those suffering from psoriasis and reflects a significant step toward more effective and specifically targeted therapies.
9.5
We conducted a study to better understand how topical treatments, particularly those involving vitamin D3, affect psoriasis. In our investigation, we focused on a group of 30 psoriasis patients, using a double-blind, randomized approach. This means neither the patients nor the researchers knew who received which treatment, ensuring an unbiased evaluation of their effects.
The treatments explored included a combination of Calcipotriol (a vitamin D3 analogue) and Betamethasone (a steroid), as well as Betamethasone alone and Clobetasol Propionate ointment. Through the analysis of skin biopsies before and after four weeks of treatment, we observed changes in skin inflammation, cellular infiltrate, and patients’ clinical scores for psoriasis severity.
While we noted that all treatments helped reduce skin thickness and improved patient scores, the greatest impact was seen with the combination of Calcipotriol and Betamethasone. This specific treatment effectively diminished the number of harmful immune cells that contribute to psoriasis flare-ups. However, the isolated effect of vitamin D3 alone wasn’t clearly established, as the most significant outcomes were tied to its use in combination with steroids.
Ultimately, our findings suggest that while vitamin D3 plays a role in psoriasis treatment, its benefits are most pronounced when paired with corticosteroids. This combination could potentially lead to enhanced long-term management of the disease, although the specific contribution of vitamin D3 alone remains uncertain.
The treatments explored included a combination of Calcipotriol (a vitamin D3 analogue) and Betamethasone (a steroid), as well as Betamethasone alone and Clobetasol Propionate ointment. Through the analysis of skin biopsies before and after four weeks of treatment, we observed changes in skin inflammation, cellular infiltrate, and patients’ clinical scores for psoriasis severity.
While we noted that all treatments helped reduce skin thickness and improved patient scores, the greatest impact was seen with the combination of Calcipotriol and Betamethasone. This specific treatment effectively diminished the number of harmful immune cells that contribute to psoriasis flare-ups. However, the isolated effect of vitamin D3 alone wasn’t clearly established, as the most significant outcomes were tied to its use in combination with steroids.
Ultimately, our findings suggest that while vitamin D3 plays a role in psoriasis treatment, its benefits are most pronounced when paired with corticosteroids. This combination could potentially lead to enhanced long-term management of the disease, although the specific contribution of vitamin D3 alone remains uncertain.
7
We explored how vitamin D influences psoriasis through a systematic review and meta-analysis. The study collated various research findings to determine the effectiveness of vitamin D treatment for those suffering from psoriatic arthritis and related skin conditions. By examining numerous trials, we aimed to gather comprehensive insights into whether vitamin D supplementation could provide significant relief for psoriasis symptoms.
Our analysis revealed some interesting patterns regarding vitamin D levels and psoriasis severity. However, we observed that the overall results did not demonstrate a consistent, significant benefit of vitamin D in alleviating psoriasis symptoms across the different studies analyzed. It appeared that, while vitamin D is vital for overall skin health, its direct impact on treating psoriasis may not be as strong as previously thought.
Ultimately, this research sheds light on the need for further investigation into vitamin D's role, considering the mixed outcomes found. Understanding its potential will be crucial in guiding future treatment options for psoriasis patients.
Our analysis revealed some interesting patterns regarding vitamin D levels and psoriasis severity. However, we observed that the overall results did not demonstrate a consistent, significant benefit of vitamin D in alleviating psoriasis symptoms across the different studies analyzed. It appeared that, while vitamin D is vital for overall skin health, its direct impact on treating psoriasis may not be as strong as previously thought.
Ultimately, this research sheds light on the need for further investigation into vitamin D's role, considering the mixed outcomes found. Understanding its potential will be crucial in guiding future treatment options for psoriasis patients.
7
We investigated the impact of vitamin D3 supplementation in conjunction with photodynamic therapy, particularly focusing on its effects on psoriasis. Previous research has suggested a potential improvement in psoriasis symptoms when vitamin D3 is added to treatment regimens.
During our review of existing literature, we found that combining vitamin D3 with photodynamic therapy could enhance the overall effectiveness of treatment. Many studies indicate a significant improvement in psoriasis, with reported responses increasing by 6-30%, and in some cases, even up to 10 times greater than when photodynamic therapy is used alone.
It appears that vitamin D3 not only supports but potentially amplifies the effects of photodynamic therapy, which may lead to further research and clinical trials. Overall, the findings suggest a promising avenue for improving psoriasis treatment through vitamin D3 supplementation alongside traditional therapies.
During our review of existing literature, we found that combining vitamin D3 with photodynamic therapy could enhance the overall effectiveness of treatment. Many studies indicate a significant improvement in psoriasis, with reported responses increasing by 6-30%, and in some cases, even up to 10 times greater than when photodynamic therapy is used alone.
It appears that vitamin D3 not only supports but potentially amplifies the effects of photodynamic therapy, which may lead to further research and clinical trials. Overall, the findings suggest a promising avenue for improving psoriasis treatment through vitamin D3 supplementation alongside traditional therapies.
2
We investigated the relationship between vitamin D3 levels and psoriasis, a chronic inflammatory skin condition. In our review of the literature, we gathered data from 23 studies involving nearly 1,900 psoriasis patients and over 7,500 healthy individuals.
Our findings showed that psoriasis patients generally had lower levels of 25 hydroxyvitamin D (the form of vitamin D measured in blood tests) compared to healthy controls. Specifically, the average vitamin D level in psoriasis patients was 21.0 ng/mL, while it was 27.3 ng/mL in those without the condition.
However, when we looked at the impact of taking vitamin D3 supplements on psoriasis severity, the results were less promising. In four randomized controlled trials that included 173 psoriasis patients receiving vitamin D3 and 160 patients receiving a placebo, we found no significant improvements in the severity of psoriasis over 3, 6, or 12 months of treatment.
While the initial observation of lower vitamin D levels in psoriasis patients is intriguing and suggests a connection, the lack of improvement through supplementation indicates that vitamin D3 might not be the solution we hoped for in treating psoriasis.
Our findings showed that psoriasis patients generally had lower levels of 25 hydroxyvitamin D (the form of vitamin D measured in blood tests) compared to healthy controls. Specifically, the average vitamin D level in psoriasis patients was 21.0 ng/mL, while it was 27.3 ng/mL in those without the condition.
However, when we looked at the impact of taking vitamin D3 supplements on psoriasis severity, the results were less promising. In four randomized controlled trials that included 173 psoriasis patients receiving vitamin D3 and 160 patients receiving a placebo, we found no significant improvements in the severity of psoriasis over 3, 6, or 12 months of treatment.
While the initial observation of lower vitamin D levels in psoriasis patients is intriguing and suggests a connection, the lack of improvement through supplementation indicates that vitamin D3 might not be the solution we hoped for in treating psoriasis.
References
- Wang ZY, Zhao ZQ, Sheng YJ, Chen KJ, Chen BZ, et al. Dual-Action Psoriasis Therapy: Antiproliferative and Immunomodulatory Effects via Self-Locking Microneedles. Adv Sci (Weinh). 2024;11:e2409359. doi:10.1002/advs.202409359
- Zanghaneh AJ, Elmelid A, Gillstedt M, Ahmic O, Andersson B, et al. The Expression of Vitamin D Receptor on Peripheral Blood Mononuclear Cells in Patients with Psoriasis. Int J Mol Sci. 2024;25. doi:10.3390/ijms251910677
- Mehmood Y, Shahid H, Ahmed S, Khursheed A, Jamshaid T, et al. Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies. Sci Rep. 2024;14:23866. doi:10.1038/s41598-024-72951-6
- Elmelid A, Vandikas MS, Gillstedt M, Alsterholm M, Osmancevic A. The Effect of Phototherapy on Systemic Inflammation Measured with Serum Vitamin D-Binding Protein and hsCRP in Patients with Inflammatory Skin Disease. Int J Mol Sci. 2024;25. doi:10.3390/ijms25168632
- Das K, Ranjan R, Kumar P, Chandra S. A Comparative Study of the Effectiveness and Safety of Topical Calcipotriol and Topical Methotrexate in Chronic Plaque Psoriasis. Cureus. 2024;16:e59878. doi:10.7759/cureus.59878
- Formisano E, Proietti E, Borgarelli C, Pisciotta L. Comment to "Vitamin D in psoriatic arthritis - A systematic review and meta-analysis". Semin Arthritis Rheum. 2024;67:152457. doi:10.1016/j.semarthrit.2024.152457
- Curtis KL, Lipner SR. Vitamins for the Management of Nail Disease: A Literature Review. Skin Appendage Disord. 2024;10:104. doi:10.1159/000534972
- Formisano E, Proietti E, Borgarelli C, Pisciotta L. Psoriasis and Vitamin D: A Systematic Review and Meta-Analysis. Nutrients. 2023;15. doi:10.3390/nu15153387
- Zhao SS, Mason A, Gjekmarkaj E, Yanaoka H, Burgess S. Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis. Semin Arthritis Rheum. 2023;62:152238. doi:10.1016/j.semarthrit.2023.152238
- Chakraborty D, Aggarwal K. Comparative evaluation of efficacy and safety of calcipotriol versus calcitriol ointment, both in combination with narrow-band ultraviolet B phototherapy in the treatment of stable plaque psoriasis. Photodermatol Photoimmunol Photomed. 2023;39:512. doi:10.1111/phpp.12893
- Holmback J, Carlsson A, Rinwa P. Efficacy and Safety of Water-Free Lipid Formulation System Containing Calcipotriol Against Psoriasis Vulgaris. J Drugs Dermatol. 2023;22:197. doi:10.36849/JDD.7151
- Mazur A, Koziorowska K, Dynarowicz K, Aebisher D, Bartusik-Aebisher D. Vitamin D and Vitamin D3 Supplementation during Photodynamic Therapy: A Review. Nutrients. 2022;14. doi:10.3390/nu14183805
- Heim M, Irondelle M, Duteil L, Cardot-Leccia N, Rocchi S, et al. Impact of topical emollient, steroids alone or combined with calcipotriol, on the immune infiltrate and clinical outcome in psoriasis. Exp Dermatol. 2022;31:1764. doi:10.1111/exd.14657
