Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
USERS' SCORE
Good
Based on 1 Review
8.4
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin D2 (as Ergocalciferol)
25 mcg (1,000 IU)
125%
Top Medical Research Studies
8
High-dose vitamin D reduces anxiety
We conducted a study to understand how high-dose vitamin D supplementation might impact anxiety levels, particularly in patients experiencing post-COVID symptoms. In our double-blind, randomized controlled trial, we enrolled 80 individuals dealing with fatigue or neuropsychiatric issues after COVID-19.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Read More
8
We examined if there is a connection between vitamin D levels and anxiety among US adults, utilizing data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2012. The study included over 12,000 participants and employed sophisticated statistical methods to determine the relationship between serum vitamin D and anxiety.
Our analyses revealed that higher levels of serum vitamin D were associated with a lower risk of experiencing anxiety. Specifically, we found a significant inverse relationship; as vitamin D levels increased, the likelihood of anxiety decreased. This connection remained strong even after adjusting for various factors that could influence the results.
Furthermore, smooth curve fitting techniques confirmed a negative association between vitamin D and anxiety risk. Nonetheless, while these findings are promising, we emphasize the need for further prospective studies to validate these results and fully understand the implications of vitamin D on mental health.
Our analyses revealed that higher levels of serum vitamin D were associated with a lower risk of experiencing anxiety. Specifically, we found a significant inverse relationship; as vitamin D levels increased, the likelihood of anxiety decreased. This connection remained strong even after adjusting for various factors that could influence the results.
Furthermore, smooth curve fitting techniques confirmed a negative association between vitamin D and anxiety risk. Nonetheless, while these findings are promising, we emphasize the need for further prospective studies to validate these results and fully understand the implications of vitamin D on mental health.
Read More
8
Vitamin D2 reduces noise-induced anxiety
We conducted an investigation into how vitamin D2 can help reduce anxiety caused by noise stress. In this study, thirty-six albino rats were segregated into six groups, some experiencing noise stress while others served as controls. The exposed rats received corn oil or vitamin D2, with the latter being administered to explore its effects on anxiety, depression, and cognitive abilities.
The results were quite revealing. We observed that those rats treated with vitamin D2 showed less anxiety. In particular, they spent less time in open areas known to induce anxiety and demonstrated reduced signs of depression compared to their counterparts. Importantly, their memory and cognitive capabilities, assessed through maze tests, also improved.
Moreover, vitamin D2 appeared to boost antioxidant enzyme activity in the brain and reduce harmful lipid peroxidation. This suggests that the protective effects of vitamin D2 may be linked to its ability to combat oxidative stress. Histological examinations further indicated that vitamin D2 treatment normalized brain changes associated with noise stress.
In conclusion, our findings highlight that vitamin D2 can significantly protect against anxiety and other stress-related impairments induced by noise through its antioxidative capabilities.
The results were quite revealing. We observed that those rats treated with vitamin D2 showed less anxiety. In particular, they spent less time in open areas known to induce anxiety and demonstrated reduced signs of depression compared to their counterparts. Importantly, their memory and cognitive capabilities, assessed through maze tests, also improved.
Moreover, vitamin D2 appeared to boost antioxidant enzyme activity in the brain and reduce harmful lipid peroxidation. This suggests that the protective effects of vitamin D2 may be linked to its ability to combat oxidative stress. Histological examinations further indicated that vitamin D2 treatment normalized brain changes associated with noise stress.
In conclusion, our findings highlight that vitamin D2 can significantly protect against anxiety and other stress-related impairments induced by noise through its antioxidative capabilities.
Read More
Most Useful Reviews
7.5
Major difference
11 people found this helpful
After starting this product five days ago, my long-standing anxiety and depression have improved. Despite prior prescriptions, this supplement has made a noticeable difference, lowering my anxiety level significantly. I take it alongside vitamin D3 and plan to purchase it again.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
- All Researches
8
High-dose vitamin D reduces anxiety
We conducted a study to understand how high-dose vitamin D supplementation might impact anxiety levels, particularly in patients experiencing post-COVID symptoms. In our double-blind, randomized controlled trial, we enrolled 80 individuals dealing with fatigue or neuropsychiatric issues after COVID-19.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Read More
8
Vitamin D mitigates anxiety symptoms
We explored the impact of changing levels of a specific enzyme, CYP11A1, in the placenta and how it might influence anxiety and social behavior in offspring. Using a unique mouse model, we found that higher levels of this enzyme are associated with behaviors similar to those seen in autism spectrum disorders (ASD), such as reduced social interaction and increased anxiety.
Interestingly, we observed that these anxiety-related behaviors improved significantly after administering vitamin D3. Behavioral tests, including open field and elevated plus maze assessments, showed that the mice exhibited less anxiety when given this supplement.
Additionally, our study highlighted that vitamin D3 could help correct some of the hormonal imbalances linked to CYP11A1 overexpression. Higher progesterone levels and increased inflammation were noted in the affected mice, and these issues seemed to reverse with vitamin D3 treatment.
This research underscores not only the potential role of vitamin D in managing anxiety but also suggests that examining CYP11A1 levels could be important for understanding and perhaps preventing some neurodevelopmental disorders. Overall, it appears vitamin D3 may serve as a useful tool in mitigating anxiety linked to hormonal changes during development.
Interestingly, we observed that these anxiety-related behaviors improved significantly after administering vitamin D3. Behavioral tests, including open field and elevated plus maze assessments, showed that the mice exhibited less anxiety when given this supplement.
Additionally, our study highlighted that vitamin D3 could help correct some of the hormonal imbalances linked to CYP11A1 overexpression. Higher progesterone levels and increased inflammation were noted in the affected mice, and these issues seemed to reverse with vitamin D3 treatment.
This research underscores not only the potential role of vitamin D in managing anxiety but also suggests that examining CYP11A1 levels could be important for understanding and perhaps preventing some neurodevelopmental disorders. Overall, it appears vitamin D3 may serve as a useful tool in mitigating anxiety linked to hormonal changes during development.
Read More
8
We examined if there is a connection between vitamin D levels and anxiety among US adults, utilizing data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2012. The study included over 12,000 participants and employed sophisticated statistical methods to determine the relationship between serum vitamin D and anxiety.
Our analyses revealed that higher levels of serum vitamin D were associated with a lower risk of experiencing anxiety. Specifically, we found a significant inverse relationship; as vitamin D levels increased, the likelihood of anxiety decreased. This connection remained strong even after adjusting for various factors that could influence the results.
Furthermore, smooth curve fitting techniques confirmed a negative association between vitamin D and anxiety risk. Nonetheless, while these findings are promising, we emphasize the need for further prospective studies to validate these results and fully understand the implications of vitamin D on mental health.
Our analyses revealed that higher levels of serum vitamin D were associated with a lower risk of experiencing anxiety. Specifically, we found a significant inverse relationship; as vitamin D levels increased, the likelihood of anxiety decreased. This connection remained strong even after adjusting for various factors that could influence the results.
Furthermore, smooth curve fitting techniques confirmed a negative association between vitamin D and anxiety risk. Nonetheless, while these findings are promising, we emphasize the need for further prospective studies to validate these results and fully understand the implications of vitamin D on mental health.
Read More
8
We evaluated the effectiveness of a treatment combining probiotics and vitamin D on patients suffering from irritable bowel syndrome, particularly focusing on those who experience anxiety. The study involved adult participants diagnosed with diarrhea-predominant IBS or mixed bowel movements, who took a daily sachet containing specific probiotic strains and vitamin D for 42 days.
At the end of the treatment period, we saw that a significant percentage of patients reported relief from their symptoms. Specifically, many in the study reported a marked decrease in the severity of their IBS symptoms, which was linked to improved quality of life and reductions in both anxiety and depression scores.
However, while vitamin D was part of the treatment regimen, it was used alongside probiotics, making it challenging to pinpoint the individual effect of vitamin D alone on anxiety. Still, the findings suggest that the combination might beneficially impact gut-related anxiety among IBS patients.
At the end of the treatment period, we saw that a significant percentage of patients reported relief from their symptoms. Specifically, many in the study reported a marked decrease in the severity of their IBS symptoms, which was linked to improved quality of life and reductions in both anxiety and depression scores.
However, while vitamin D was part of the treatment regimen, it was used alongside probiotics, making it challenging to pinpoint the individual effect of vitamin D alone on anxiety. Still, the findings suggest that the combination might beneficially impact gut-related anxiety among IBS patients.
Read More
8
Vitamin D2 reduces noise-induced anxiety
We conducted an investigation into how vitamin D2 can help reduce anxiety caused by noise stress. In this study, thirty-six albino rats were segregated into six groups, some experiencing noise stress while others served as controls. The exposed rats received corn oil or vitamin D2, with the latter being administered to explore its effects on anxiety, depression, and cognitive abilities.
The results were quite revealing. We observed that those rats treated with vitamin D2 showed less anxiety. In particular, they spent less time in open areas known to induce anxiety and demonstrated reduced signs of depression compared to their counterparts. Importantly, their memory and cognitive capabilities, assessed through maze tests, also improved.
Moreover, vitamin D2 appeared to boost antioxidant enzyme activity in the brain and reduce harmful lipid peroxidation. This suggests that the protective effects of vitamin D2 may be linked to its ability to combat oxidative stress. Histological examinations further indicated that vitamin D2 treatment normalized brain changes associated with noise stress.
In conclusion, our findings highlight that vitamin D2 can significantly protect against anxiety and other stress-related impairments induced by noise through its antioxidative capabilities.
The results were quite revealing. We observed that those rats treated with vitamin D2 showed less anxiety. In particular, they spent less time in open areas known to induce anxiety and demonstrated reduced signs of depression compared to their counterparts. Importantly, their memory and cognitive capabilities, assessed through maze tests, also improved.
Moreover, vitamin D2 appeared to boost antioxidant enzyme activity in the brain and reduce harmful lipid peroxidation. This suggests that the protective effects of vitamin D2 may be linked to its ability to combat oxidative stress. Histological examinations further indicated that vitamin D2 treatment normalized brain changes associated with noise stress.
In conclusion, our findings highlight that vitamin D2 can significantly protect against anxiety and other stress-related impairments induced by noise through its antioxidative capabilities.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Major difference
11 people found this helpful
After starting this product five days ago, my long-standing anxiety and depression have improved. Despite prior prescriptions, this supplement has made a noticeable difference, lowering my anxiety level significantly. I take it alongside vitamin D3 and plan to purchase it again.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Charoenporn V, Tungsukruthai P, Teacharushatakit P, Hanvivattanakul S, Sriyakul K, et al. Effects of an 8-week high-dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post-COVID syndrome: A randomized controlled trial. Psychiatry Clin Neurosci. 2024;78:595. doi:10.1111/pcn.13716
- Yin H, Zhang J, Chen Y, Guo J, Li Q, et al. Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention. Brain Behav Immun. 2024;121:13. doi:10.1016/j.bbi.2024.07.012
- Domacassé D, de Rooij SR, Vrijkotte T, de Jonge A, Henrichs J. Associations Between Early-Pregnancy Vitamin D Status and Postpartum Depressive and Anxiety Symptoms. Psychosom Med. 2024;86:648. doi:10.1097/PSY.0000000000001328
- Wen Z, Bai L, Wu S, Chen J, Jama HA, et al. Association of serum vitamin D with anxiety in US adults: a cross-sectional study. Front Nutr. 2024;11:1371170. doi:10.3389/fnut.2024.1371170
- Zhao W, Zhu DM, Shen Y, Zhang Y, Chen T, et al. The protective effect of vitamin D supplementation as adjunctive therapy to antidepressants on brain structural and functional connectivity of patients with major depressive disorder: a randomized controlled trial. Psychol Med. 2024;54:2403. doi:10.1017/S0033291724000539
- Jouët P, Altman C, Bruley DES Varannes S, Juhel C, Henri F. Probiotics plus vitamin D in irritable bowel syndrome: a prospective multicentric non-interventional study. Minerva Gastroenterol (Torino). 2024;70:332. doi:10.23736/S2724-5985.24.03581-2
- Renteria KM, Constantine E, Teoh CM, Cooper A, Lozano N, et al. Combination of vitamin D and fructooligosaccharides upregulates colonic vitamin D receptor in C57BL/6J mice and affects anxiety-related behavior in a sex-specific manner. Nutr Res. 2024;125:16. doi:10.1016/j.nutres.2024.02.003
- Gammoh O, Ibrahim A, Yehya A, Alqudah A, Qnais E, et al. Exploring the Roles of Vitamins C and D and Etifoxine in Combination with Citalopram in Depression/Anxiety Model: A Focus on ICAM-1, SIRT1 and Nitric Oxide. Int J Mol Sci. 2024;25. doi:10.3390/ijms25041960
- Samad N, Imran A, Bhatti SA, Imran I, Alqahtani F, et al. Vitamin D2 protects acute and repeated noise stress induced behavioral, biochemical, and histopathological alterations: Possible antioxidant effect. Saudi J Biol Sci. 2022;29:601. doi:10.1016/j.sjbs.2021.09.018
- Aygun H, Ayyildiz M, Agar E. Effects of vitamin D and paricalcitol on epileptogenesis and behavioral properties of WAG/Rij rats with absence epilepsy. Epilepsy Res. 2019;157:106208. doi:10.1016/j.eplepsyres.2019.106208
