Overview

SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.7
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%

Top Medical Research Studies

7
Vitamin D3's role in anemia
We conducted a study to see how vitamin D3 might help improve iron levels in women of childbearing age who had marginally low iron stores. Our approach involved a carefully designed 8-week randomized controlled trial, where 120 women aged between 19 and 40 were divided into two groups. One group received fruit juice fortified with 4000 IU of vitamin D3 daily, while the other had a placebo juice.

Throughout the study, we collected blood samples and monitored various health indicators every four weeks. We aimed to find out if the vitamin D3 supplementation could positively influence the iron status of the participants compared to the placebo.

Given the promising role of vitamin D in enhancing iron absorption, we hoped to uncover new insights into dietary strategies for managing iron deficiency. By observing the interaction over time between vitamin D levels and iron status, we aimed to provide valuable information on whether this fortification could serve as a practical alternative to traditional iron supplements.

As we gathered data, we explored the potential of vitamin D3 beyond its usual role, assessing if it could indeed help improve the anemia indicators in our target group.
Read More
9
Vitamin D may reduce anemia risk
Our investigation centered on whether vitamin D levels play a significant role in iron deficiency anemia (IDA). We examined data from the National Health and Nutrition Examination Survey, which included over 3,700 participants, to explore the relationship between vitamin D and IDA.

Our findings indicated that higher levels of serum vitamin D are linked to a lower risk of developing IDA. Specifically, those in the highest quartile of vitamin D levels had a significantly reduced risk compared to those in the lowest quartile. Interestingly, this protective effect appeared to be more pronounced in women.

We also found a non-linear relationship, suggesting that the effects of vitamin D on anemia become more complex at different levels. This was further supported by a Mendelian randomization analysis, which provided genetic evidence for a causal connection between vitamin D and IDA.

Overall, our results suggest that adequate vitamin D levels could be important for preventing anemia, especially among women. However, further research is certainly needed to confirm these findings and to investigate the potential for vitamin D treatment in managing IDA directly.
Read More
9
Vitamin D3 improves iron status
We conducted an 8-week, double-blind randomized controlled trial to see how vitamin D3-fortified fruit drinks affect iron levels in women with low iron stores. Our subjects, a group of 45 healthy women aged between 18 and 40, received either the vitamin D3 drink or a placebo, helping us assess the impact of this nutrient on their health.

Throughout the study, we measured key biomarkers such as serum ferritin, which indicates iron stores, and 25-hydroxyvitamin D, the active form of vitamin D in the body. After the 8 weeks, we noted a significant increase in both vitamin D levels and serum ferritin among those who participated in the vitamin D3-fortified drink regimen. This suggests that supplementing with vitamin D3 can indeed help improve iron stores in women who are iron deficient.

Given these findings, it becomes clear that there is potential for vitamin D to play a role in managing anemia. However, we also recognize the need for further research to confirm these effects and explore the safety and practicality of such fortifications across different populations.
Read More

Most Useful Reviews

9
Effective treatment
I was vitamin D deficient and took this supplement. I checked my levels afterward, and to my surprise, they improved. I took it consistently before meals, though some may require higher dosages.
Read More
6
Improved health condition
255 people found this helpful
Vitamin D3 deficiency is widespread, affecting many due to factors like pollution and limited sun exposure. It's crucial to start with small doses if you have anemia, as it can enhance tissue nutrition. Elderly individuals or those post-surgery should opt for sublingual forms for better absorption. Breastfeeding mothers should ensure their levels are adequate before giving lower doses to their infants. Additionally, those with metabolism issues may need nearly double the standard dose. This particular supplement significantly increased my vitamin D3 levels as per my test results.
Read More
7.5
Enhanced wellbeing
7 people found this helpful
This vitamin D supplement of 2,000 IU is excellent. Most people are vitamin D deficient, which contributes to anaemia. I noticed my complexion improved and felt better after consuming it.
Read More

Medical Researches

SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.7
  • All Researches
9
Vitamin D may reduce anemia risk
Our investigation centered on whether vitamin D levels play a significant role in iron deficiency anemia (IDA). We examined data from the National Health and Nutrition Examination Survey, which included over 3,700 participants, to explore the relationship between vitamin D and IDA.

Our findings indicated that higher levels of serum vitamin D are linked to a lower risk of developing IDA. Specifically, those in the highest quartile of vitamin D levels had a significantly reduced risk compared to those in the lowest quartile. Interestingly, this protective effect appeared to be more pronounced in women.

We also found a non-linear relationship, suggesting that the effects of vitamin D on anemia become more complex at different levels. This was further supported by a Mendelian randomization analysis, which provided genetic evidence for a causal connection between vitamin D and IDA.

Overall, our results suggest that adequate vitamin D levels could be important for preventing anemia, especially among women. However, further research is certainly needed to confirm these findings and to investigate the potential for vitamin D treatment in managing IDA directly.
Read More
9
Vitamin D3 improves iron status
We conducted an 8-week, double-blind randomized controlled trial to see how vitamin D3-fortified fruit drinks affect iron levels in women with low iron stores. Our subjects, a group of 45 healthy women aged between 18 and 40, received either the vitamin D3 drink or a placebo, helping us assess the impact of this nutrient on their health.

Throughout the study, we measured key biomarkers such as serum ferritin, which indicates iron stores, and 25-hydroxyvitamin D, the active form of vitamin D in the body. After the 8 weeks, we noted a significant increase in both vitamin D levels and serum ferritin among those who participated in the vitamin D3-fortified drink regimen. This suggests that supplementing with vitamin D3 can indeed help improve iron stores in women who are iron deficient.

Given these findings, it becomes clear that there is potential for vitamin D to play a role in managing anemia. However, we also recognize the need for further research to confirm these effects and explore the safety and practicality of such fortifications across different populations.
Read More
8
Vitamin D improves anemia management
We examined the impact of cholecalciferol (vitamin D3) supplementation on anemia in hemodialysis patients suffering from vitamin D deficiency and secondary hyperparathyroidism. Our study included 122 patients who had low vitamin D levels and high parathyroid hormone (PTH) levels. We divided the participants into two groups: one received cholecalciferol supplements, while the other served as a control group.

In the group that received cholecalciferol, we observed significant improvements. PTH levels decreased notably, from an average of 476 to 296 pg/mL, indicating better regulation of calcium balance in the body. Alongside this, the 25-hydroxyvitamin D levels rose from 10.3 to 33.5 ng/mL, demonstrating a successful increase in vitamin D status.

More encouragingly, we noticed that hemoglobin levels, which reflect anemia status, increased from 11.6 to 12.2 g/dL in the supplemented group. This rise illustrates a potential benefit of vitamin D3 supplementation in managing anemia among hemodialysis patients. Additionally, the patients needed less paricalcitol, another medication used for managing PTH levels, revealing a positive overall impact on their treatment regimen.
Read More
7
Vitamin D3's role in anemia
We conducted a study to see how vitamin D3 might help improve iron levels in women of childbearing age who had marginally low iron stores. Our approach involved a carefully designed 8-week randomized controlled trial, where 120 women aged between 19 and 40 were divided into two groups. One group received fruit juice fortified with 4000 IU of vitamin D3 daily, while the other had a placebo juice.

Throughout the study, we collected blood samples and monitored various health indicators every four weeks. We aimed to find out if the vitamin D3 supplementation could positively influence the iron status of the participants compared to the placebo.

Given the promising role of vitamin D in enhancing iron absorption, we hoped to uncover new insights into dietary strategies for managing iron deficiency. By observing the interaction over time between vitamin D levels and iron status, we aimed to provide valuable information on whether this fortification could serve as a practical alternative to traditional iron supplements.

As we gathered data, we explored the potential of vitamin D3 beyond its usual role, assessing if it could indeed help improve the anemia indicators in our target group.
Read More
We explored the connection between vitamin D, particularly its epimer known as 3'-epi-25(OH)D, and anemia. The study analyzed data from 1,655 participants, examining how different forms of vitamin D relate to hemoglobin levels—a key indicator for anemia—while also considering other factors like age, sex, and body mass index (BMI).

Interestingly, we found that the total serum level of vitamin D didn't directly correlate with hemoglobin levels. However, when we focused on the 3'-epimeric form of vitamin D, we saw a significant association with hemoglobin levels, even when we accounted for age, sex, BMI, and high-sensitivity C-reactive protein (hsCRP). This suggests that 3'-epi-25(OH)D may have a unique role in improving hemoglobin levels, supporting its importance in red blood cell and iron metabolism.

On the other hand, the non-3'-epimeric form of vitamin D did not show a significant impact on hemoglobin levels. Overall, our findings highlight the potential benefits of vitamin D epimers in managing anemia and reinforce the need to look at vitamin D in its various forms when considering treatment options.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 6 Reviews
7.6
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Effective treatment
I was vitamin D deficient and took this supplement. I checked my levels afterward, and to my surprise, they improved. I took it consistently before meals, though some may require higher dosages.
Read More
6
Improved health condition
255 people found this helpful
Vitamin D3 deficiency is widespread, affecting many due to factors like pollution and limited sun exposure. It's crucial to start with small doses if you have anemia, as it can enhance tissue nutrition. Elderly individuals or those post-surgery should opt for sublingual forms for better absorption. Breastfeeding mothers should ensure their levels are adequate before giving lower doses to their infants. Additionally, those with metabolism issues may need nearly double the standard dose. This particular supplement significantly increased my vitamin D3 levels as per my test results.
Read More
7.5
Enhanced wellbeing
7 people found this helpful
This vitamin D supplement of 2,000 IU is excellent. Most people are vitamin D deficient, which contributes to anaemia. I noticed my complexion improved and felt better after consuming it.
Read More
9
Significant improvement
My anaemia didn't improve much with an iron supplement, so I tried this vitamin D. At my next health checkup, my values were significantly better and within the normal range!
Read More
8
Deficiency eliminated
The quality of this supplement is excellent, and it effectively eliminates deficiency. The symptoms of anaemia have lessened, and the taste is pleasant.
Read More

Frequently Asked Questions

9
Significant improvement
My anaemia didn't improve much with an iron supplement, so I tried this vitamin D. At my next health checkup, my values were significantly better and within the normal range!
7.5
Essential for health
I deal with various health issues and have been prescribed vitamin D and Omega consistently. These are crucial for everyone’s health. Since starting vitamin D3, I've noticed improvements with anaemia, fatigue, and overall well-being.
6
Improved health condition
255 people found this helpful
Vitamin D3 deficiency is widespread, affecting many due to factors like pollution and limited sun exposure. It's crucial to start with small doses if you have anemia, as it can enhance tissue nutrition. Elderly individuals or those post-surgery should opt for sublingual forms for better absorption. Breastfeeding mothers should ensure their levels are adequate before giving lower doses to their infants. Additionally, those with metabolism issues may need nearly double the standard dose. This particular supplement significantly increased my vitamin D3 levels as per my test results.
9
Effective treatment
I was vitamin D deficient and took this supplement. I checked my levels afterward, and to my surprise, they improved. I took it consistently before meals, though some may require higher dosages.
8
Deficiency eliminated
The quality of this supplement is excellent, and it effectively eliminates deficiency. The symptoms of anaemia have lessened, and the taste is pleasant.
7.5
Enhanced wellbeing
7 people found this helpful
This vitamin D supplement of 2,000 IU is excellent. Most people are vitamin D deficient, which contributes to anaemia. I noticed my complexion improved and felt better after consuming it.
9
Vitamin D may reduce anemia risk
Our investigation centered on whether vitamin D levels play a significant role in iron deficiency anemia (IDA). We examined data from the National Health and Nutrition Examination Survey, which included over 3,700 participants, to explore the relationship between vitamin D and IDA.

Our findings indicated that higher levels of serum vitamin D are linked to a lower risk of developing IDA. Specifically, those in the highest quartile of vitamin D levels had a significantly reduced risk compared to those in the lowest quartile. Interestingly, this protective effect appeared to be more pronounced in women.

We also found a non-linear relationship, suggesting that the effects of vitamin D on anemia become more complex at different levels. This was further supported by a Mendelian randomization analysis, which provided genetic evidence for a causal connection between vitamin D and IDA.

Overall, our results suggest that adequate vitamin D levels could be important for preventing anemia, especially among women. However, further research is certainly needed to confirm these findings and to investigate the potential for vitamin D treatment in managing IDA directly.
5
Impact of vitamin D on anemia
We conducted a study to investigate the impact of vitamin D3 in combination with iron-folic acid (IFA) on anemia among elderly individuals experiencing mild-to-moderate anemia. This community-based trial involved participants aged 60 and older, who were randomly assigned to receive either the combination of IFA and vitamin D3 or just IFA along with a placebo.

Our research aimed to understand how this supplementation could affect hemoglobin levels and other related markers. Given the complex nature of anemia in older adults—often linked to chronic diseases—Vitamin D3's potential role in enhancing iron utilization was particularly intriguing, especially as it has shown to lower hepcidin levels, a protein that inhibits iron absorption.

While our study design was robust, including a double-blinded and randomized approach, it’s important to note that the results regarding the effectiveness of Vitamin D3 alongside iron-folic acid are not yet confirmed. We hope to provide further insights into the relationship between these supplements and anemia in the elderly, contributing to better treatment options in the future.
9
Vitamin D3 improves iron status
We conducted an 8-week, double-blind randomized controlled trial to see how vitamin D3-fortified fruit drinks affect iron levels in women with low iron stores. Our subjects, a group of 45 healthy women aged between 18 and 40, received either the vitamin D3 drink or a placebo, helping us assess the impact of this nutrient on their health.

Throughout the study, we measured key biomarkers such as serum ferritin, which indicates iron stores, and 25-hydroxyvitamin D, the active form of vitamin D in the body. After the 8 weeks, we noted a significant increase in both vitamin D levels and serum ferritin among those who participated in the vitamin D3-fortified drink regimen. This suggests that supplementing with vitamin D3 can indeed help improve iron stores in women who are iron deficient.

Given these findings, it becomes clear that there is potential for vitamin D to play a role in managing anemia. However, we also recognize the need for further research to confirm these effects and explore the safety and practicality of such fortifications across different populations.
4
Vitamin D3's variable effects on anemia
We conducted a study to investigate how high doses of vitamin D3 affect anemia in patients with chronic kidney disease (CKD). In this randomized controlled trial, patients with CKD stages G3-G4 received either 8000 international units of vitamin D daily or a placebo for 12 weeks. We measured key markers related to hepcidin—an important hormone in iron metabolism—and erythropoiesis, which is the process of producing red blood cells.

Interestingly, our findings indicated that high-dose vitamin D supplementation did not show a significant impact on hepcidin levels or markers of anemia overall. However, we found that in patients who started with low levels of vitamin D, the supplementation appeared to improve both erythropoiesis and iron availability. On the other hand, those who had high baseline vitamin D levels seemed to experience a decrease in hepcidin, potentially due to a deterioration in their iron status.

In summary, while high-dose vitamin D3 might not be a universal fix for anemia in CKD patients, it could offer benefits for those with low initial vitamin D levels. This suggests the importance of checking vitamin D status before treatment to tailor approaches that may work best for individuals.

References

  1. Chen L, Gu N, Qiu K, Chen H, Tian F, et al. Serum Vitamin D Levels and Risk of Iron Deficiency Anemia in Adults: A Cross-Sectional Study and Mendelian Randomization Analysis. Food Sci Nutr. 2025;13:e4746. 10.1002/fsn3.4746
  2. Ahamed F, Jaiswal A, Sahoo S, Ghosh T, Kaur A, et al. Impact of supplementation with iron-folic acid (IFA) and vitamin D compared with IFA alone on haemoglobin levels in elderly people with mild-to-moderate anaemia: protocol for the double-blind, randomised, placebo-controlled Iron and vitamin D trial in Elderly Anemia (IDEA). BMJ Open. 2024;14:e080303. 10.1136/bmjopen-2023-080303
  3. Suhaimi NA, Loh SP, Ab Manan N, Zalbahar N, Mohamad Alwi MN, et al. An 8-Week Vitamin D3-Fortified Fruit Drink Supplementation Increases Serum Ferritin Concentration: A Randomized Controlled Trial in Malaysian Women With Low Iron Stores. J Acad Nutr Diet. 2024;124:1440. 10.1016/j.jand.2024.02.013
  4. Pistis KD, Westerberg PA, Qureshi AR, Beshara S, Sterner G, et al. The effect of high-dose vitamin D supplementation on hepcidin-25 and erythropoiesis in patients with chronic kidney disease. BMC Nephrol. 2023;24:20. 10.1186/s12882-022-03014-z
  5. Ahmad Fuzi SF, Su Peng L, Zabaha Zalbahar N, Ab Manan N, Mohamad Alwi MN. Effect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: Protocol for an 8-week, parallel group, double-blind randomized controlled trial. PLoS One. 2022;17:e0265772. 10.1371/journal.pone.0265772
  6. Chailurkit LO, Sritara P, Vathesatogkit P, Yamwong S, Thongmung N, et al. Vitamin D epimers are associated with circulating haemoglobin levels independently of C-reactive protein. Sci Rep. 2021;11:20747. 10.1038/s41598-021-00086-z
  7. Li M, Xu J, Wan Q, He Q, Ma Y, et al. Relationship between serum vitamin D3 concentration and anaemia in patients with chronic kidney disease in China. J Int Med Res. 2021;49:3000605211012231. 10.1177/03000605211012231
  8. Obi Y, Ichimaru N, Sakaguchi Y, Iwadoh K, Ishii D, et al. Correcting anemia and native vitamin D supplementation in kidney transplant recipients: a multicenter, 2 × 2 factorial, open-label, randomized clinical trial. Transpl Int. 2021;34:1212. 10.1111/tri.13885
  9. Obi Y, Yamaguchi S, Hamano T, Sakaguchi Y, Shimomura A, et al. Effect of cholecalciferol on serum hepcidin and parameters of anaemia and CKD-MBD among haemodialysis patients: a randomized clinical trial. Sci Rep. 2020;10:15500. 10.1038/s41598-020-72385-w
  10. Massimetti C, Bellasi A, Feriozzi S. [Cholecalciferol supplementation improves secondary hyperparathyroidism control in hemodialysis patients]. G Ital Nefrol. 2020;37.
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