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We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
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The micelles are made by combining vitamin D with polyethylene glycol, resulting in tiny structures that can release their drug load when interacting with enzymes typically found in pancreatic cancer cells. We observed that these micelles showed promising results in laboratory settings, enhancing the effectiveness of paclitaxel against aggressive pancreatic cancer cells compared to using paclitaxel alone.
Moreover, we noted that the vitamin D in the micelles may play a dual role: serving as both a hydrophobic core for drug delivery and a contributor to synergetic therapeutic effects. Our findings suggest that leveraging vitamin D in this way could increase the efficacy of existing treatment options for pancreatic cancer patients, which is particularly significant given the challenges currently faced in treating this disease.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
One significant finding was that combining this vitamin D analog with the chemotherapy drug docetaxel could overcome resistance seen in some prostate cancer cases. This combination showed promising results in primary cancer spheroids and xenografts from a patient whose cancer had resisted both docetaxel and androgen deprivation therapy.
These insights suggest that vitamin D analogs might offer new and effective strategies for managing advanced prostate cancer, particularly for those patients who have not responded well to standard treatments.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
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Frequently Asked Questions
Cancer is a complex group of diseases characterized by uncontrolled growth and spread of abnormal cells in the body. These cells can form tumors, invade nearby tissues, and metastasize to other parts of the body via the bloodstream or lymphatic system. While cancer can affect nearly any part of the body, it is classified into various types, including carcinomas, sarcomas, leukemia, and lymphomas, each originating from different types of cells. Risk factors for developing cancer can include genetic predisposition, lifestyle choices such as smoking and diet, environmental exposures, and certain infections.
Diagnosis typically involves medical imaging, biopsies, and a thorough review of personal and family health histories. Treatment options vary widely depending on the type and stage of cancer and may include surgery, chemotherapy, radiation therapy, immunotherapy, and targeted therapies. Early detection is crucial and can significantly improve treatment outcomes, leading to better survival rates. As awareness and research continue to advance, new methods for prevention, detection, and treatment of cancer are consistently being developed, offering hope to those affected by this challenging disease.
Vitamin D is a fat-soluble vitamin that's essential for maintaining healthy bones and teeth, supporting immune system function, and facilitating normal cell growth and development. It plays a crucial role in calcium absorption in the gut, which is vital for bone health. Unlike most vitamins, our bodies can produce Vitamin D when exposed to sunlight, specifically UVB rays, which is why it’s often referred to as the "sunshine vitamin." However, depending on your geographical location, lifestyle, and skin type, getting sufficient Vitamin D from the sun alone can be challenging, particularly during the winter months.
In addition to sunlight, Vitamin D can be obtained from certain foods such as fatty fish (like salmon and mackerel), fish liver oils, and fortified foods like milk and cereals. Some individuals may also consider supplements, especially if they're at risk for deficiency. Insufficient vitamin D levels are linked to various health issues, including rickets in children, osteomalacia in adults, and even an increased risk of chronic diseases. Regularly checking your vitamin D levels and consulting with a healthcare professional can help ensure you're meeting your needs for optimal health.
While there is ongoing research into the role of vitamin D in cancer prevention and treatment, the findings remain inconclusive. Some studies suggest that adequate levels of vitamin D may be associated with a lower risk of certain cancers, such as colorectal cancer and breast cancer, potentially due to its role in regulating cell growth and differentiation. However, definitive evidence proving that vitamin D supplements can prevent or successfully treat cancer is still lacking.
It’s important to approach the idea of using vitamin D as a cancer treatment with caution. Current guidelines recommend obtaining vitamin D primarily through safe sun exposure and diet. If you’re considering vitamin D supplementation, particularly for cancer-related purposes, it’s crucial to consult with a healthcare provider. They can provide personalized advice based on individual health needs and the latest research, ensuring that any approach to cancer management is both safe and effective.
Users report varying timelines when it comes to noticing the effects of vitamin D supplements, particularly in relation to cancer support. One user shared that after nearly three months of consistent use, they experienced a boost in energy and mood, along with a decrease in fatigue, though they noted that the overall impact on their quality of life still needed further evaluation (Read Review). Other users have indicated that they started feeling improvements within a few weeks to a couple of months of regular intake, especially in supporting general health and immune function, which can be critical for individuals dealing with cancer (Read Review).
Despite these positive reports, it's important to remember that the timeline can differ significantly between individuals, based on factors such as dosage, severity of deficiency, and overall health. Some reviews suggest a need for a higher intake (like 10,000 IU daily) for quicker results (Read Review). Regular monitoring and consultation with healthcare providers are advised to tailor the supplementation to meet personal health needs effectively.
Research suggests a promising role for vitamin D in cancer treatment and prevention across various types of cancer. One study indicated that a vitamin D analog, when combined with traditional chemotherapy, may help overcome resistance in advanced prostate cancer, highlighting its potential as a novel treatment strategy [1]. Additional evidence showed significant differences in vitamin D levels between patients with breast cancer and those with benign conditions, suggesting that adequate vitamin D could be linked to a lower risk of developing breast cancer [2].
Moreover, vitamin D's ability to impact cancer cell metabolism and growth is supported by multiple studies. For instance, treatment with active vitamin D3 showed promise in inhibiting the growth of colon cancer cells and modulating important metabolic pathways involved in cancer progression [4]. Other research demonstrated that a novel liposomal formulation of vitamin D3 effectively reduced tumor growth across several cancer types while minimizing potential side effects [5]. Overall, while the evidence is compelling, it is crucial to conduct larger and more controlled studies to further clarify vitamin D's full potential in cancer therapy.
Based on user reviews, many individuals have reported a range of symptom improvements after beginning vitamin D supplementation. Users indicate increased energy levels, improved mood, and reduced fatigue, particularly after several weeks to months of consistent usage. For example, one user noted a noticeable boost in energy and a decrease in fatigue after about three months of taking vitamin D following their cancer diagnosis (Read Review). Others have expressed feeling stronger and healthier overall, with some experiencing significant improvements in immune function and a reduction in the incidence of infections during low-sunlight seasons (Read Review).
Moreover, reviews highlight the importance of vitamin D in reducing the risk of serious conditions like cancer and improving overall health, showing promise in areas such as bone health and disease prevention (Read Review). However, individual results can vary significantly based on factors such as dosage, overall health status, and specific health conditions being addressed. Regular consultations with healthcare providers for tailored advice on dosage and monitoring can further enhance the effectiveness of supplementation (Read Review).
Based on user reviews, many individuals have reported positive experiences when combining vitamin D3 with other supplements, particularly for managing cancer. Users emphasize the importance of pairing vitamin D with K2, magnesium, and omega-3 fatty acids to enhance its effectiveness. One review highlights that this combination is especially vital for those dealing with cancer, as it improves immune function and supports overall health (Read Review). Another review reinforces the idea that vitamin D is crucial for maintaining bone health and overall wellness, suggesting that regular supplementation in conjunction with a balanced diet can lead to significant health improvements, particularly in cancer prevention (Read Review).
Furthermore, users underscore that adequate doses of vitamin D can play a role in reducing the risk of serious health conditions, including cancer. Some reviews recommend doses ranging from 2,000 to 10,000 IU daily, with many noting noticeable health benefits when consistently taken alongside vitamin K2 and magnesium (Read Review). Overall, users seem to support the theory that optimizing vitamin D levels through proper supplementation and dietary practices can play a crucial role in enhancing health outcomes for those battling cancer.
Based on user reviews, many individuals reported that Vitamin D, particularly in the form of D3, is crucial for maintaining health and potentially for cancer prevention. A commonly cited dosage among users is 2000 IU daily, which is highlighted to support immune function and overall well-being. For instance, one user noted that their daily intake of 2000 IU helped improve their health significantly, citing benefits in preventing diseases like cancer and osteoporosis (Read Review). Another user emphasized the importance of a higher dosage when dealing with health issues, suggesting that a daily intake of up to 10,000 IU could be beneficial, especially during illness (Read Review).
The consensus among reviewers suggests that achieving an optimal level of Vitamin D is essential, with some advocating for up to 10,000 IU in certain cases, particularly in individuals with cancer or those experiencing immunosuppression (Read Review). Additionally, users mentioned that taking Vitamin D with fatty meals can enhance absorption (Read Review). Overall, while the right dose may vary according to individual health needs, maintaining a daily intake of Vitamin D appears to be a widely agreed-upon strategy for enhancing health and potentially mitigating cancer risks.
One significant finding was that combining this vitamin D analog with the chemotherapy drug docetaxel could overcome resistance seen in some prostate cancer cases. This combination showed promising results in primary cancer spheroids and xenografts from a patient whose cancer had resisted both docetaxel and androgen deprivation therapy.
These insights suggest that vitamin D analogs might offer new and effective strategies for managing advanced prostate cancer, particularly for those patients who have not responded well to standard treatments.
During the study, we analyzed adult female patients admitted to a surgical department. Importantly, we excluded those who had taken vitamin D supplements recently or who had prior vitamin D deficiencies. By measuring serum vitamin D levels through a specific testing method, we were able to gather meaningful data about their relationship to breast health.
Our findings indicated a notable difference in average vitamin D levels when comparing the two groups. This suggests that inadequate vitamin D could be linked to an increased risk of developing breast cancer. Therefore, we explored the potential benefits of vitamin D supplementation as a preventive measure against breast cancer—though we acknowledge that larger and more controlled studies are essential to draw firm conclusions.
At the same time, we recognize that vitamin D has effects beyond bone health, and it is crucial to consider these broader impacts when discussing its role in cancer risk.
Our observations highlighted significant differences in metabolism between normal cells and cancerous ones, specifically noting increased glycolytic activity and higher lactate production in cancer cells. When we treated the cancer cells with 1,25-dihydroxyvitamin D3 (the active form of vitamin D3), we found that it suppressed glucose uptake and altered metabolic activity in one type of cancer cell, HCT116. This finding suggests that vitamin D3 could play a regulatory role in how cancer cells manage their energy and metabolize nutrients.
Overall, our study sheds light on the metabolic changes associated with cancer and points to vitamin D3 as a potential modulator of these processes. The insights gained could be valuable for developing new cancer therapies and understanding metabolic diseases better.
Our observations indicated that as part of this combination, vitamin D3 plays a supportive role. We found that using these loaded materials improved the survival of bone-forming cells (osteoblasts) over an 11-day period. Additionally, the combination treatment significantly increased new bone formation when compared to control groups.
However, it's important to note that the study's focus on the dual impact of curcumin and vitamin D3 limits our ability to assess the isolated effects of vitamin D3 alone. The results showed a decrease in the proliferation of osteosarcoma cells, highlighting the potential anti-cancer properties of the treatment combination. Yet, these findings suggest that while vitamin D3 contributes positively, more research is needed to fully understand its effectiveness on its own.
References
- Len-Tayon K, Metzger D, Laverny G. [New insights of vitamin D-based therapy for prostate cancer]. Med Sci (Paris). 2025;41:154. doi:10.1051/medsci/2025011
- Soni D, Tiwari A, Kushwah PS, Dubey S, Khan S. Levels of Serum 25-Hydroxy Vitamin D in Benign and Malignant Breast Disease Patients: An Observational Study. Cureus. 2025;17:e78283. doi:10.7759/cureus.78283
- Peixoto D, Ravasco JM, Blanco-Fernandez B, Veiga F, Concheiro A, et al. Enzyme-responsive vitamin D-based micelles for paclitaxel-controlled delivery and synergistic pancreatic cancer therapy. Mater Today Bio. 2025;31:101555. doi:10.1016/j.mtbio.2025.101555
- Xu N, Lin H, Ding X, Wang P, Lin JM. Isotope tracing-assisted chip-based solid-phase extraction mass spectrometry for monitoring metabolic changes and vitamin D3 regulation in cells. Talanta. 2025;288:127754. doi:10.1016/j.talanta.2025.127754
- Jo Y, Kushram P, Bose S. Curcumin and vitamin D3 release from calcium phosphate enhances bone regeneration. Biomater Sci. 2025. doi:10.1039/d4bm01188k
- Ezcurra-Hualde M, Zalba S, Bella Á, Arrizabalaga L, Risson A, et al. Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth. Front Immunol. 2025;16:1529007. doi:10.3389/fimmu.2025.1529007
- Wang L, Xu R, Wang M, Wang M, Su S, et al. Exploration and Identification of Vitamin D and Related Genes as Potential Biomarkers for Colorectal Tumors. Onco Targets Ther. 2025;18:129. doi:10.2147/OTT.S495066
- Evans H, Greenhough A, Perry L, Lasanta G, Gonzalez CM, et al. Hypoxia Compromises the Differentiation of Human Osteosarcoma Cells to CAR-R, a Hydroxylated Derivative of Lithocholic Acid and Potent Agonist of the Vitamin D Receptor. Int J Mol Sci. 2025;26. doi:10.3390/ijms26010365
- Kittaka A. Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities. Chem Pharm Bull (Tokyo). 2025;73:1. doi:10.1248/cpb.c24-00598
- He W, Lv W, Liu L, Gong Y, Song K, et al. Enhanced Antiglioma Effect by a Vitamin D3-Inserted Lipid Hybrid Neutrophil Membrane Biomimetic Multimodal Nanoplatform. ACS Nano. 2024;18:35559. doi:10.1021/acsnano.4c13470
- Almassri HF, Abdul Kadir A, Srour M, Foo LH. The Effects of Omega-3 Fatty Acids and Vitamin D Supplementation on the Nutritional Status of Women with Breast Cancer in Palestine: An Open-Label Randomized Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16223960
- Maturana-Ramiìrez A, Aitken-Saavedra J, Rojas-Zúñiga G, Rojas-Alcayaga G, Espinoza-Santander I, et al. Hypovitaminosis D in patients with oral squamous cell carcinoma: Is a risk factor of developing this neoplasia?. Med Oral Patol Oral Cir Bucal. 2025;30:e24. doi:10.4317/medoral.26692
- Almassri HF, Abdul Kadir A, Srour M, Foo LH. The effects of Omega-3 fatty acids and vitamin D supplementation on the quality of life and blood inflammation markers in newly diagnosed breast cancer women: An open-labelled randomised controlled trial. Clin Nutr ESPEN. 2025;65:64. doi:10.1016/j.clnesp.2024.11.014
- García-Martínez JM, Chocarro-Calvo A, Martínez-Useros J, Regueira-Acebedo N, Fernández-Aceñero MJ, et al. SIRT1 Mediates the Antagonism of Wnt/β-Catenin Pathway by Vitamin D in Colon Carcinoma Cells. Int J Biol Sci. 2024;20:5495. doi:10.7150/ijbs.95875
