Overview

SCIENTIFIC SCORE
Questionable
Based on 25 Researches
6.4
USERS' SCORE
Good
Based on 3 Reviews
8.7
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%

Top Medical Research Studies

We aimed to explore the effectiveness of vitamin D supplementation in alleviating the symptoms of fibromyalgia—a condition marked by chronic pain, fatigue, and cognitive challenges. Our research included a group of 180 women, aged 18 to 65, who met the criteria for fibromyalgia. We administered a high-dose vitamin D3 supplement of 50,000 IU over a span of 12 weeks and assessed the impact on their quality of life through the Fibromyalgia Impact Questionnaire (FIQ) and the Visual Analog Scale (VAS).

After the treatment, we observed significant improvements in both FIQ and VAS scores, indicating a notable positive effect of vitamin D on the quality of life and pain reduction in these patients. Particularly, the results suggested that many of the participants had a pre-existing vitamin D deficiency, which is more common among individuals with fibromyalgia.

Overall, this study highlights the potential benefits of vitamin D supplementation for those suffering from fibromyalgia and encourages further investigation into its role in managing this challenging condition.
Read More
We explored the potential benefits of vitamin D supplementation for individuals suffering from fibromyalgia, a condition known for causing widespread pain and fatigue. Our review involved examining various studies, including randomized controlled trials and observational studies, focusing on those published between early 2011 and May 2021.

After a thorough search, we found a total of 2,651 studies, narrowing it down to 12 high-quality studies that met our criteria. Remarkably, 11 of these studies presented clear evidence of improvement in clinical status and various related outcomes after participants received vitamin D supplements. This suggests that vitamin D could play a key role in alleviating fibromyalgia symptoms.

Our findings highlight a promising link between vitamin D supplementation and the enhancement of health in fibromyalgia patients. As we move forward, we recognize the need for continued research to further standardize how we detect and treat this complex condition, potentially offering cost-effective solutions that incorporate vitamin D.
Read More
We conducted a thorough review of the existing literature to understand how vitamin D3 supplementation affects those suffering from fibromyalgia. This condition is often marked by widespread pain and fatigue, and we wanted to see if vitamin D3 could help alleviate these troubling symptoms.

In our search, we scoured various databases for studies published between January 2011 and May 2021. This included randomized controlled trials, observational studies, and other well-documented research focused explicitly on fibromyalgia. Out of the 2,651 studies retrieved, 12 met our strict criteria for inclusion, of which 11 were of high quality, showing minimal bias.

The results were promising, as 11 of those high-quality studies indicated a significant positive impact on the clinical status of fibromyalgia patients who received vitamin D3. This suggests that vitamin D3 might play an important role in managing fibromyalgia symptoms.

While our findings point towards the benefits of vitamin D3 supplementation, they also highlight the need for further research. As we continue to explore effective treatments for fibromyalgia, vitamin D3 stands out as a potentially beneficial option worth considering for patients seeking relief.
Read More

Most Useful Reviews

10
Significant health recovery
I discovered vitamin D, which saved my mother from severe pain caused by fibromyalgia and osteoporosis. Despite ineffective treatments, her condition drastically improved after her vitamin D levels rose from critical deficiency. After taking 2,000 units daily, her health greatly improved, allowing her to regain strength. I urge anyone with elderly loved ones to consider vitamin D for unexplained ailments, as it can be life-changing.
Read More
9.5
Improved overall health
At over 50 and having experienced a stroke, I find this vitamin D3 essential. It comes in a great dosage, is easily absorbed, and reasonably priced. It's not only vital for bones and skin but can also prevent conditions like fibromyalgia and multiple sclerosis, which are linked to D3 deficiency. Taking it alongside vitamin E has positively impacted my health within days.
Read More
8.8
Reduced negative emotions
I take this medicine to alleviate withdrawal symptoms from fibromyalgia after stopping benzodiazepines for depression. Since starting this treatment, my negative emotions have diminished and my depression appears to be improving. A recent blood test confirmed an increase in vitamin levels, indicating effectiveness. Given my limited sun exposure and dislike for fish, this supplement has been very beneficial.
Read More

Medical Researches

SCIENTIFIC SCORE
Questionable
Based on 25 Researches
6.4
  • All Researches
We aimed to explore the effectiveness of vitamin D supplementation in alleviating the symptoms of fibromyalgia—a condition marked by chronic pain, fatigue, and cognitive challenges. Our research included a group of 180 women, aged 18 to 65, who met the criteria for fibromyalgia. We administered a high-dose vitamin D3 supplement of 50,000 IU over a span of 12 weeks and assessed the impact on their quality of life through the Fibromyalgia Impact Questionnaire (FIQ) and the Visual Analog Scale (VAS).

After the treatment, we observed significant improvements in both FIQ and VAS scores, indicating a notable positive effect of vitamin D on the quality of life and pain reduction in these patients. Particularly, the results suggested that many of the participants had a pre-existing vitamin D deficiency, which is more common among individuals with fibromyalgia.

Overall, this study highlights the potential benefits of vitamin D supplementation for those suffering from fibromyalgia and encourages further investigation into its role in managing this challenging condition.
Read More
We explored the potential benefits of vitamin D supplementation for individuals suffering from fibromyalgia, a condition known for causing widespread pain and fatigue. Our review involved examining various studies, including randomized controlled trials and observational studies, focusing on those published between early 2011 and May 2021.

After a thorough search, we found a total of 2,651 studies, narrowing it down to 12 high-quality studies that met our criteria. Remarkably, 11 of these studies presented clear evidence of improvement in clinical status and various related outcomes after participants received vitamin D supplements. This suggests that vitamin D could play a key role in alleviating fibromyalgia symptoms.

Our findings highlight a promising link between vitamin D supplementation and the enhancement of health in fibromyalgia patients. As we move forward, we recognize the need for continued research to further standardize how we detect and treat this complex condition, potentially offering cost-effective solutions that incorporate vitamin D.
Read More
9
Fibromyalgia treatment approach explored
We examined a unique case involving a 61-year-old woman with Chagas' disease who was also diagnosed with fibromyalgia. This patient had been suffering from severe gastrointestinal issues for years, alongside diffuse body pain and sleep difficulties. She was treated with a combination of psychotherapy, vitamin D supplementation, and physical exercise, specifically Pilates and walking.

Remarkably, after six months of this treatment regimen, the patient showed significant improvement. Her pain was greatly reduced, anxiety levels were controlled, and her vitamin D levels became normal. This raises an interesting point about the role of vitamin D in treating fibromyalgia, although we must note that the positive effects could not be attributed solely to vitamin D, as other treatments were also involved.

Our exploration of related literature revealed various connections between infections and fibromyalgia; however, there was no specific mention of Trypanosoma cruzi, the parasite responsible for Chagas' disease, being linked to fibromyalgia symptoms. This suggests that while infectious agents might play a role in fibromyalgia, the relationship with T. cruzi in this context remains uncertain.

Overall, this case highlights a promising alternative treatment approach for fibromyalgia using vitamin D, alongside other supportive measures but also cautions us to consider the multifaceted nature of the condition.
Read More
We conducted a thorough review of the existing literature to understand how vitamin D3 supplementation affects those suffering from fibromyalgia. This condition is often marked by widespread pain and fatigue, and we wanted to see if vitamin D3 could help alleviate these troubling symptoms.

In our search, we scoured various databases for studies published between January 2011 and May 2021. This included randomized controlled trials, observational studies, and other well-documented research focused explicitly on fibromyalgia. Out of the 2,651 studies retrieved, 12 met our strict criteria for inclusion, of which 11 were of high quality, showing minimal bias.

The results were promising, as 11 of those high-quality studies indicated a significant positive impact on the clinical status of fibromyalgia patients who received vitamin D3. This suggests that vitamin D3 might play an important role in managing fibromyalgia symptoms.

While our findings point towards the benefits of vitamin D3 supplementation, they also highlight the need for further research. As we continue to explore effective treatments for fibromyalgia, vitamin D3 stands out as a potentially beneficial option worth considering for patients seeking relief.
Read More
9
Vitamin D3 improves fibromyalgia symptoms
We aimed to understand how vitamin D3 replacement therapy could help alleviate symptoms for those suffering from chronic widespread musculoskeletal pain (CWP) and fibromyalgia (FM). Our research included patients who had low levels of vitamin D and experienced significant musculoskeletal discomfort.

To see if vitamin D3 could make a difference, we administered a treatment of 50,000 IU of oral vitamin D3 weekly for three months. Before and after this treatment, we assessed various health markers, like pain severity, fatigue levels, depression, and quality of life.

The results were quite promising. Patients showed a significant increase in vitamin D levels post-treatment, rising from an average of 10.6 ng/mL to 46.5 ng/mL. Alongside this improvement, there was a marked reduction in pain, fatigue, and depressive symptoms, along with enhanced overall quality of life. A notable number of patients reported satisfaction with the treatment, and the percentage of those meeting the criteria for fibromyalgia decreased after vitamin D3 therapy.

Overall, this study suggests that vitamin D3 replacement can lead to meaningful improvements for individuals with fibromyalgia and chronic pain, emphasizing the need to check for vitamin D deficiency in these patients.
Read More

User Reviews

USERS' SCORE
Good
Based on 3 Reviews
8.7
  • All Reviews
  • Positive Reviews
  • Negative Reviews
10
Significant health recovery
I discovered vitamin D, which saved my mother from severe pain caused by fibromyalgia and osteoporosis. Despite ineffective treatments, her condition drastically improved after her vitamin D levels rose from critical deficiency. After taking 2,000 units daily, her health greatly improved, allowing her to regain strength. I urge anyone with elderly loved ones to consider vitamin D for unexplained ailments, as it can be life-changing.
Read More
9.5
Improved overall health
At over 50 and having experienced a stroke, I find this vitamin D3 essential. It comes in a great dosage, is easily absorbed, and reasonably priced. It's not only vital for bones and skin but can also prevent conditions like fibromyalgia and multiple sclerosis, which are linked to D3 deficiency. Taking it alongside vitamin E has positively impacted my health within days.
Read More
8.8
Reduced negative emotions
I take this medicine to alleviate withdrawal symptoms from fibromyalgia after stopping benzodiazepines for depression. Since starting this treatment, my negative emotions have diminished and my depression appears to be improving. A recent blood test confirmed an increase in vitamin levels, indicating effectiveness. Given my limited sun exposure and dislike for fish, this supplement has been very beneficial.
Read More

Frequently Asked Questions

Fibromyalgia is a chronic condition characterized by widespread musculoskeletal pain, fatigue, and tenderness in localized areas. Individuals with fibromyalgia often experience a variety of symptoms, including sleep disturbances, cognitive difficulties (often referred to as "fibro fog"), and heightened sensitivity to pain. This condition affects the way the brain processes pain signals, leading to an increased perception of pain from stimuli that would normally be considered mild. Though the exact cause of fibromyalgia is still not fully understood, it may be linked to genetics, infections, physical or emotional trauma, and changes in how the brain and nervous system process pain signals.

Diagnosis of fibromyalgia typically relies on the presence of specific symptoms and the exclusion of other conditions that may cause similar symptoms. There is no definitive laboratory test for the condition, which can make it challenging to diagnose. Treatment often involves a combination of medication, physical therapy, lifestyle changes, and stress management techniques. Patients may benefit from medications aimed at reducing pain and improving sleep, alongside engaging in regular physical activity and practicing mindfulness techniques. While fibromyalgia is a lifelong condition, effective management can significantly improve quality of life for those affected.

Vitamin D is a fat-soluble vitamin that's essential for maintaining healthy bones and teeth, supporting immune system function, and facilitating normal cell growth and development. It plays a crucial role in calcium absorption in the gut, which is vital for bone health. Unlike most vitamins, our bodies can produce Vitamin D when exposed to sunlight, specifically UVB rays, which is why it’s often referred to as the "sunshine vitamin." However, depending on your geographical location, lifestyle, and skin type, getting sufficient Vitamin D from the sun alone can be challenging, particularly during the winter months.

In addition to sunlight, Vitamin D can be obtained from certain foods such as fatty fish (like salmon and mackerel), fish liver oils, and fortified foods like milk and cereals. Some individuals may also consider supplements, especially if they're at risk for deficiency. Insufficient vitamin D levels are linked to various health issues, including rickets in children, osteomalacia in adults, and even an increased risk of chronic diseases. Regularly checking your vitamin D levels and consulting with a healthcare professional can help ensure you're meeting your needs for optimal health.

While there is no definitive cure for fibromyalgia, some studies suggest that vitamin D may play a role in managing symptoms associated with the condition. Vitamin D is essential for various bodily functions, including bone health and immune system regulation. Since individuals with fibromyalgia often report pain sensitivity and fatigue, maintaining adequate levels of vitamin D could potentially help alleviate some of these symptoms. Research indicates that many fibromyalgia patients have lower levels of vitamin D, which has led some healthcare professionals to recommend supplementation.

That said, it’s important to approach vitamin D supplementation cautiously. The effectiveness of vitamin D in treating fibromyalgia may vary from person to person, and not all patients will experience relief. If you suspect you have a vitamin D deficiency or are considering supplementation, it’s crucial to speak with a healthcare provider. They can recommend appropriate testing and the right dosage based on your individual needs. Overall, while vitamin D may provide some benefits for fibromyalgia sufferers, it should be viewed as a potential adjunct to a comprehensive treatment plan rather than a standalone solution.

Based on user reviews, the time it takes to see results from vitamin D supplementation for Fibromyalgia can vary among individuals. One user reported significant improvement in their mother's condition after her vitamin D levels increased through supplementation, indicating that results can be quite effective when deficiencies are addressed ((Read Review)). However, another user mentioned experiencing positive health impacts "within days" of taking vitamin D3, which suggests that some may notice changes relatively quickly ((Read Review)).

Additionally, some users have described ongoing benefits that improve over time, especially when combined with other therapies, such as vitamin E. For those who are deficient in vitamin D, it appears that once supplementation begins, noticeable improvements might come quite rapidly, though individual experiences can differ widely based on personal health status and dosage ((Read Review)). Overall, while some users report immediate relief, others might need a longer duration of supplementation to feel the full effects.

Research surrounding vitamin D supplementation for fibromyalgia (FM) is revealing, albeit nuanced. Several studies suggest that individuals with fibromyalgia tend to have lower levels of vitamin D compared to healthy individuals, indicating a potential link between vitamin D deficiency and increased symptoms of the condition [2]. Additionally, a systematic review of randomized controlled trials showed that vitamin D supplementation could help improve certain quality-of-life metrics, although results were inconsistent regarding pain relief [7].

Despite some positive findings, the relationship between vitamin D and symptom management in fibromyalgia remains complex. While some studies report improvements in pain levels and overall well-being with vitamin D supplementation [1], others have found minimal or no significant impact on the severity of pain [19]. More robust clinical trials are necessary to better understand how vitamin D might specifically aid those suffering from fibromyalgia. Therefore, while current evidence indicates that vitamin D could play a supportive role in managing symptoms, definitive recommendations for its use in treatment still warrant further investigation.

Users have reported various improvements in symptoms related to vitamin D supplementation for fibromyalgia, highlighting its potential as a game-changer for those suffering from the condition. One user shared a transformative experience where their mother's severe pain from both fibromyalgia and osteoporosis drastically improved after addressing a critical vitamin D deficiency, showcasing how significant health benefits can follow an increase in vitamin levels ((Read Review)). Another user, who has health concerns stemming from their age and a previous stroke, noted that taking vitamin D3 not only provides essential health benefits but has also led to noticeable positive impacts on their health within days, particularly when combined with vitamin E ((Read Review)).

Additionally, some users have reported using vitamin D to alleviate symptoms associated with withdrawal from other medications, such as benzodiazepines, connected to fibromyalgia and depression. One reviewer experienced a diminishment of negative emotions and improvement in their depressive symptoms after starting supplementation, which underscores the multifaceted benefits of vitamin D for emotional health alongside its physical benefits ((Read Review)). However, it is essential to note that individual results can vary significantly, and what works for one person may not yield the same results for another.

Users have reported positive experiences when combining vitamin D supplementation with other supplements for managing fibromyalgia symptoms. One reviewer specifically noted that taking vitamin D3 alongside vitamin E led to noticeable health improvements within just a few days, emphasizing the potential synergistic effects of these supplements ((Read Review)). Another user shared their journey of using vitamin D to help alleviate withdrawal symptoms from benzodiazepines, which are connected to both fibromyalgia and depression. This user observed improvements in their emotional state and felt the vitamin D supplementation contributed significantly to their recovery from these symptoms ((Read Review)).

Overall, the combination of vitamin D with other interventions appears to enhance some users' health outcomes. Given the individual nature of fibromyalgia and the varied responses to different treatments, it's essential for those affected to explore how supplement combinations may work for them, as results can differ substantially from person to person.

The optimal dose of Vitamin D for treating Fibromyalgia appears to lean toward higher supplementation levels, specifically 50,000 IU weekly. Several studies suggest beneficial effects with this dosage, highlighting significant improvements in symptoms and overall quality of life for patients. For instance, a study involving 180 women with Fibromyalgia showed that administering 50,000 IU weekly over 12 weeks resulted in marked enhancements in both quality of life and pain levels as measured by the Fibromyalgia Impact Questionnaire (FIQ) [5]. Similarly, another study indicated that this high-dose regimen could also lead to meaningful improvements, particularly in younger patients when combined with rehabilitation [17].

However, while many findings appear positive, the overall consensus within the research community reflects a need for larger studies and further investigation into maintaining optimal Vitamin D levels tailored for individual patients. Some studies noted that while Vitamin D levels increased following supplementation, the direct correlation with pain relief remained inconsistent [19]. This suggests a complex interaction between Vitamin D and Fibromyalgia symptoms, implying that while high doses may assist, they should be part of a broader, multi-faceted approach to treatment.

10
Significant health recovery
I discovered vitamin D, which saved my mother from severe pain caused by fibromyalgia and osteoporosis. Despite ineffective treatments, her condition drastically improved after her vitamin D levels rose from critical deficiency. After taking 2,000 units daily, her health greatly improved, allowing her to regain strength. I urge anyone with elderly loved ones to consider vitamin D for unexplained ailments, as it can be life-changing.
9.5
Improved overall health
At over 50 and having experienced a stroke, I find this vitamin D3 essential. It comes in a great dosage, is easily absorbed, and reasonably priced. It's not only vital for bones and skin but can also prevent conditions like fibromyalgia and multiple sclerosis, which are linked to D3 deficiency. Taking it alongside vitamin E has positively impacted my health within days.
8.8
Reduced negative emotions
I take this medicine to alleviate withdrawal symptoms from fibromyalgia after stopping benzodiazepines for depression. Since starting this treatment, my negative emotions have diminished and my depression appears to be improving. A recent blood test confirmed an increase in vitamin levels, indicating effectiveness. Given my limited sun exposure and dislike for fish, this supplement has been very beneficial.
4
Vitamin D levels lower in fibromyalgia
We conducted a comprehensive review to explore how vitamin D levels differ between individuals with fibromyalgia and healthy controls. Our systematic investigation included a total of 25 studies, with a focus on various micronutrients including vitamin D, ferritin, and vitamin B12.

Through our analysis, we found that individuals suffering from fibromyalgia generally had lower levels of vitamin D and ferritin compared to healthy individuals. Specifically, the mean difference was notable, with vitamin D showing a decrease of approximately 3.86 units and ferritin levels significantly lower by around 14.78 units.

Interestingly, we observed that vitamin B12 levels did not demonstrate a significant difference between the two groups. This means that, while vitamin D and ferritin appear linked to fibromyalgia, the efficacy of vitamin D supplementation in easing symptoms remains uncertain and debated within the medical community.

We recommend routine testing of ferritin levels and considering vitamin D supplementation as a general best practice for patients with fibromyalgia. However, more research is needed to fully understand the role of lower vitamin B12 levels in the context of this condition.
7
Vitamin D may boost wellness in fibromyalgia
We aimed to understand how vitamin D supplementation might influence fibromyalgia patients, particularly focusing on psychological outcomes and overall quality of life. Our evaluation included a thorough meta-analysis of 8 randomized controlled trials, encompassing a total of 694 participants.

We found that vitamin D showed positive effects on several areas, such as physical function and emotional health. Notably, improvements were seen in role limitations due to emotional health and social function, indicating that vitamin D could play a role in enhancing these aspects of health.

However, while we noted a slight improvement in overall wellness measured by the Fibromyalgia Impact Questionnaire, there were no significant changes observed in pain levels or depressive symptoms. Therefore, while vitamin D supplements may be beneficial for certain psychological facets and quality of life in fibromyalgia patients, they are not a cure-all solution for pain management or depression.
We conducted a rigorous clinical trial to explore whether vitamin D supplementation could help alleviate symptoms in patients with fibromyalgia (FM). Over 12 weeks, female participants aged 18 and older, who met established criteria for FM, were randomly assigned to receive either a weekly dose of 50,000 IU of vitamin D or a placebo.

This study was designed to be double-blind, ensuring that neither the participants nor the researchers knew who received the vitamin D or placebo to eliminate bias in the results. At the beginning of the study, we measured pain levels and quality of life using validated tools, specifically focusing on the Visual Analog Scale (VAS) and the Fibromyalgia Impact Questionnaire (FIQ).

However, our findings indicated that there was no significant difference between the vitamin D group and the placebo group in terms of pain relief or overall improvement in FM symptoms. Despite confirming that vitamin D levels increased in those receiving the supplement, this did not translate into better outcomes for the patients involved.

Overall, the study clearly suggests that vitamin D supplementation may not be effective in improving symptoms for fibromyalgia patients, challenging the existing beliefs around vitamin D’s role in treating this condition.
We aimed to explore the effectiveness of vitamin D supplementation in alleviating the symptoms of fibromyalgia—a condition marked by chronic pain, fatigue, and cognitive challenges. Our research included a group of 180 women, aged 18 to 65, who met the criteria for fibromyalgia. We administered a high-dose vitamin D3 supplement of 50,000 IU over a span of 12 weeks and assessed the impact on their quality of life through the Fibromyalgia Impact Questionnaire (FIQ) and the Visual Analog Scale (VAS).

After the treatment, we observed significant improvements in both FIQ and VAS scores, indicating a notable positive effect of vitamin D on the quality of life and pain reduction in these patients. Particularly, the results suggested that many of the participants had a pre-existing vitamin D deficiency, which is more common among individuals with fibromyalgia.

Overall, this study highlights the potential benefits of vitamin D supplementation for those suffering from fibromyalgia and encourages further investigation into its role in managing this challenging condition.
We conducted a study to explore the effects of vitamin D3 supplementation coupled with rehabilitation on fibromyalgia symptoms among different age groups. The research involved 80 patients, split into two age groups: those aged 50 and younger, and those over 50. Each group received a high dose of vitamin D (50,000 IU) weekly for three months, alongside a structured rehabilitation protocol.

Through regular assessments over six months, we noted distinct improvements based on age. For younger patients, high-dose vitamin D led to impressive short-term relief from musculoskeletal pain and enhanced long-term functional capacity. On the other hand, older patients experienced significant improvements in their overall quality of life and management of musculoskeletal pain over time.

These findings suggest that vitamin D can play a beneficial role in managing fibromyalgia symptoms, emphasizing the importance of considering age in treatment approaches. Essentially, while the young benefited in terms of functionality, the elderly saw improvements in their quality of life and pain management after vitamin D supplementation.

References

  1. Saija C, Bertuccio MP, Scoglio A, Macaione V, Cacciola F, et al. Role of Vitamin D Status and Alterations in Gut Microbiota Metabolism in Fibromyalgia-Associated Chronic Inflammatory Pain. Biomedicines. 2025;13. doi:10.3390/biomedicines13010139
  2. Ismail O, Albdour K, Albdour Z, Jaber K. Differences in Ferritin, Vitamin D, and Vitamin B12 Between Fibromyalgia Patients and Healthy Individuals: A Systematic Review and Meta-Analysis. Musculoskeletal Care. 2025;23:e70057. doi:10.1002/msc.70057
  3. Tarsitano MG, Dolcini G, Pandozzi C, Greco F, Iannuncelli C, et al. Role of micronutrients in the symptoms of fibromyalgia: a review of the literature and analysis of an Italian female sample. Eur Rev Med Pharmacol Sci. 2024;28:4038. doi:10.26355/eurrev_202407_36579
  4. Badaeva A, Danilov A, Kosareva A, Lepshina M, Novikov V, et al. Neuronutritional Approach to Fibromyalgia Management: A Narrative Review. Pain Ther. 2024;13:1047. doi:10.1007/s40122-024-00641-2
  5. Ersoy S, Kesiktas FN, Sirin B, Bugdayci D, Paker N. The effect of vitamin D treatment on quality of life in patients with fibromyalgia. Ir J Med Sci. 2024;193:1111. doi:10.1007/s11845-023-03521-4
  6. Zabihiyeganeh M, Amini Kadijani A, Akbari A, Yahyazadeh H, Mirzaei A. Association of serum vitamin D status with serum pro-inflammatory cytokine levels and clinical severity of fibromyalgia patients. Clin Nutr ESPEN. 2023;55:71. doi:10.1016/j.clnesp.2023.03.006
  7. Yang CC, Tsai ST, Ting B, Cheng YC, Wang CK, et al. Psychological Outcomes and Quality of Life of Fibromyalgia Patients with Vitamin D Supplementation-A Meta-Analysis. J Clin Med. 2023;12. doi:10.3390/jcm12072750
  8. Erkilic B, Dalgic GS. The preventive role of vitamin D in the prevention and management of Fibromyalgia syndrome. Nutr Health. 2023;29:223. doi:10.1177/02601060221144801
  9. Lombardo M, Feraco A, Ottaviani M, Rizzo G, Camajani E, et al. The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musculoskeletal Pain. Nutrients. 2022;14. doi:10.3390/nu14153010
  10. Scaturro D, Vitagliani F, Tomasello S, Filippetti M, Picelli A, et al. Can the Combination of Rehabilitation and Vitamin D Supplementation Improve Fibromyalgia Symptoms at All Ages?. J Funct Morphol Kinesiol. 2022;7. doi:10.3390/jfmk7020051
  11. Qu K, Li MX, Zhou YL, Yu P, Dong M. The efficacy of vitamin D in treatment of fibromyalgia: a meta-analysis of randomized controlled studies and systematic review. Expert Rev Clin Pharmacol. 2022;15:433. doi:10.1080/17512433.2022.2081151
  12. Venkatesan N, Gyawali M, Botleroo RA, Ahmed R, Kareem R, et al. Efficacy of Vitamin D Supplementation in the Improvement of Clinical Status in Patients Diagnosed with Fibromyalgia Syndrome: A Systematic Review. Curr Rheumatol Rev. 2022;18:317. doi:10.2174/1573397118666220307122152
  13. Haddad HW, Jumonville AC, Stark KJ, Temple SN, Dike CC, et al. The Role of Vitamin D in the Management of Chronic Pain in Fibromyalgia: A Narrative Review. Health Psychol Res. 2021;9:25208. doi:10.52965/001c.25208
  14. Ali OME. Prevalence of Vitamin D Deficiency and Its Relationship with Clinical Outcomes in Patients with Fibromyalgia: a Systematic Review of the Literature. SN Compr Clin Med. 2022;4:38. doi:10.1007/s42399-021-01105-w
  15. Kucuk A, Baykara RA, Tuzcu A, Omma A, Cure MC, et al. Could ferritin, vitamin B, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?. Rom J Intern Med. 2021;59:384. doi:10.2478/rjim-2021-0022
  16. de Carvalho JF, Lerner A. Fibromyalgia associated with Chagas' disease treated with nutraceuticals. Clin Nutr ESPEN. 2021;42:212. doi:10.1016/j.clnesp.2021.01.037
  17. Scaturro D, Vitagliani F, Tomasello S, Filippetti M, Picelli A, et al. Can the Combination of Rehabilitation and Vitamin D Supplementation Improve Fibromyalgia Symptoms at All Ages?. J Funct Morphol Kinesiol. 2022;7. doi:10.3390/jfmk7020051
  18. Venkatesan N, Gyawali M, Botleroo RA, Ahmed R, Kareem R, et al. Efficacy of Vitamin D Supplementation in the Improvement of Clinical Status in Patients Diagnosed with Fibromyalgia Syndrome: A Systematic Review. Curr Rheumatol Rev. 2022;18:317. doi:10.2174/1573397118666220307122152
  19. Lozano-Plata LI, Vega-Morales D, Esquivel-Valerio JA, Garza-Elizondo MA, Galarza-Delgado DA, et al. Efficacy and safety of weekly vitamin D in patients with fibromyalgia: 12-week, double-blind, randomized, controlled placebo trial. Clin Rheumatol. 2021;40:3257. doi:10.1007/s10067-021-05640-8
  20. Yong WC, Sanguankeo A, Upala S. Effect of vitamin D supplementation in chronic widespread pain: a systematic review and meta-analysis. Clin Rheumatol. 2017;36:2825. doi:10.1007/s10067-017-3754-y
  21. Yilmaz R, Salli A, Cingoz HT, Kucuksen S, Ugurlu H. Efficacy of vitamin D replacement therapy on patients with chronic nonspecific widespread musculoskeletal pain with vitamin D deficiency. Int J Rheum Dis. 2016;19:1255. doi:10.1111/1756-185X.12960
  22. Wepner F, Scheuer R, Schuetz-Wieser B, Machacek P, Pieler-Bruha E, et al. Effects of vitamin D on patients with fibromyalgia syndrome: a randomized placebo-controlled trial. Pain. 2014;155:261. doi:10.1016/j.pain.2013.10.002
  23. Chaudhari SA, Sacerdote A, Bahtiyar G. 1-α hydroxylation defect in postural orthostatic tachycardia syndrome: remission with calcitriol supplementation. BMJ Case Rep. 2012;2012. doi:10.1136/bcr.02.2012.5730
  24. Harari M, Dramsdahl E, Shany S, Baumfeld Y, Ingber A, et al. Increased vitamin D serum levels correlate with clinical improvement of rheumatic diseases after Dead Sea climatotherapy. Isr Med Assoc J. 2011;13:212.
  25. Arvold DS, Odean MJ, Dornfeld MP, Regal RR, Arvold JG, et al. Correlation of symptoms with vitamin D deficiency and symptom response to cholecalciferol treatment: a randomized controlled trial. Endocr Pract. 2009;15:203.
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