' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 7 Researches
7.6
USERS' SCORE
Very Good
Based on 7 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%
Top Medical Research Studies
9.5
Vitamin D3 ethosomes for psoriasis
Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies.
Strong focus on vitamin D3 effectiveness
We aimed to explore the effectiveness of a special gel infused with vitamin D3, known as an ethosome, in managing psoriasis. This inflammatory skin condition is driven by an overactive immune response, and vitamin D3 plays a crucial role in the growth and development of skin cells called keratinocytes, making it a promising treatment option.
In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
Read More
8
Vitamin D supports psoriasis management
Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis.
Strong evidence for psoriasis impact
We explored how vitamin D influences psoriasis, a persistent skin condition marked by red, flaky patches. Our study analyzed data from a significant number of participants in the UK Biobank, including those diagnosed with various autoimmune diseases, with a focus on individuals suffering from psoriasis.
Through a unique approach known as Mendelian randomization, we looked into the causal relationship between vitamin D levels and psoriasis risk. This method allowed us to consider genetic variations linked to vitamin D metabolism, helping us predict how these levels could affect the likelihood of developing psoriasis.
The results we observed were quite promising. We found that higher genetically-predicted vitamin D levels were associated with a lower risk of developing psoriasis. Specifically, for every 10 ng/ml increase in vitamin D, the risk of psoriasis decreased significantly, suggesting a beneficial influence of vitamin D in this context.
While we also examined other autoimmune diseases, evidence supporting a similar protective effect for conditions like systemic lupus erythematosus was not as strong. However, our findings highlight the potential of vitamin D in managing psoriasis, paving the way for future prevention and treatment strategies.
Through a unique approach known as Mendelian randomization, we looked into the causal relationship between vitamin D levels and psoriasis risk. This method allowed us to consider genetic variations linked to vitamin D metabolism, helping us predict how these levels could affect the likelihood of developing psoriasis.
The results we observed were quite promising. We found that higher genetically-predicted vitamin D levels were associated with a lower risk of developing psoriasis. Specifically, for every 10 ng/ml increase in vitamin D, the risk of psoriasis decreased significantly, suggesting a beneficial influence of vitamin D in this context.
While we also examined other autoimmune diseases, evidence supporting a similar protective effect for conditions like systemic lupus erythematosus was not as strong. However, our findings highlight the potential of vitamin D in managing psoriasis, paving the way for future prevention and treatment strategies.
Read More
8
Calcipotriol formulation shows promise
Efficacy and Safety of Water-Free Lipid Formulation System Containing Calcipotriol Against Psoriasis Vulgaris.
Relevant for vitamin D3 research
We evaluated the effectiveness of a new treatment involving calcipotriol, a vitamin D3 analogue, specifically designed to combat psoriasis vulgaris. This clinical trial included 24 participants, who underwent treatment with a water-free lipid-based formulation once daily for 12 days, allowing us to see how this innovative delivery system could enhance the medication's effects.
Our findings were promising, showing a significant reduction in psoriatic infiltrates—about 34% to 37%—after treatment with calcipotriol compared to a minimal change with the vehicle formulations. This suggests that the lipid-based formulations can effectively tackle the symptoms of psoriasis. However, it was essential to note that the improvement wasn't superior to the effects seen with marketed calcipotriol solutions and creams.
Participants reported some mild and non-serious side effects, but overall, the treatment was well-tolerated. In conclusion, the new lipid-based calcipotriol formulations showed efficacy and displayed an acceptable safety profile, making them a viable option for patients seeking relief from psoriasis symptoms.
Our findings were promising, showing a significant reduction in psoriatic infiltrates—about 34% to 37%—after treatment with calcipotriol compared to a minimal change with the vehicle formulations. This suggests that the lipid-based formulations can effectively tackle the symptoms of psoriasis. However, it was essential to note that the improvement wasn't superior to the effects seen with marketed calcipotriol solutions and creams.
Participants reported some mild and non-serious side effects, but overall, the treatment was well-tolerated. In conclusion, the new lipid-based calcipotriol formulations showed efficacy and displayed an acceptable safety profile, making them a viable option for patients seeking relief from psoriasis symptoms.
Read More
Most Useful Reviews
9.5
Reduced psoriasis impact
I prefer NOW brand vitamins for my family. Vitamin D3 is essential. My brother benefited greatly from it for his psoriasis, which has improved significantly. I take it regularly, and it's advisable to test for the right dosage, as deficiency is common.
Read More
8.8
Supports skin health
I've had diabetes for nearly 30 years and became interested in Vitamin D after learning its roles in many conditions. Its deficiency can lead to issues like obesity, autoimmune diseases, and psoriasis. Surprisingly, even sunny countries face deficiency issues, so exposure to sunlight is vital.
Read More
8.8
Alleviated psoriasis symptoms
Vitamin D has been effective for my psoriasis. While it hasn’t completely healed yet, the affected area has dried and is healing since I began taking it. I will continue using it.
Read More
Most Recommended Products for Psoriasis
Solgar Evening Primrose Oil
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 14 Reviews
8.9
NOW Foods Sweet Almond Oil
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 13 Reviews
8.8
NOW Foods Zinc Picolinate
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 10 Reviews
8.5
Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 7 Researches
7.6
9.5
Vitamin D3 ethosomes for psoriasis
Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies.
Strong focus on vitamin D3 effectiveness
We aimed to explore the effectiveness of a special gel infused with vitamin D3, known as an ethosome, in managing psoriasis. This inflammatory skin condition is driven by an overactive immune response, and vitamin D3 plays a crucial role in the growth and development of skin cells called keratinocytes, making it a promising treatment option.
In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
Read More
9.5
Vitamin D3's role in psoriasis
Impact of topical emollient, steroids alone or combined with calcipotriol, on the immune infiltrate and clinical outcome in psoriasis.
Combined treatment effects evaluated
We conducted a study to better understand how topical treatments, particularly those involving vitamin D3, affect psoriasis. In our investigation, we focused on a group of 30 psoriasis patients, using a double-blind, randomized approach. This means neither the patients nor the researchers knew who received which treatment, ensuring an unbiased evaluation of their effects.
The treatments explored included a combination of Calcipotriol (a vitamin D3 analogue) and Betamethasone (a steroid), as well as Betamethasone alone and Clobetasol Propionate ointment. Through the analysis of skin biopsies before and after four weeks of treatment, we observed changes in skin inflammation, cellular infiltrate, and patients’ clinical scores for psoriasis severity.
While we noted that all treatments helped reduce skin thickness and improved patient scores, the greatest impact was seen with the combination of Calcipotriol and Betamethasone. This specific treatment effectively diminished the number of harmful immune cells that contribute to psoriasis flare-ups. However, the isolated effect of vitamin D3 alone wasn’t clearly established, as the most significant outcomes were tied to its use in combination with steroids.
Ultimately, our findings suggest that while vitamin D3 plays a role in psoriasis treatment, its benefits are most pronounced when paired with corticosteroids. This combination could potentially lead to enhanced long-term management of the disease, although the specific contribution of vitamin D3 alone remains uncertain.
The treatments explored included a combination of Calcipotriol (a vitamin D3 analogue) and Betamethasone (a steroid), as well as Betamethasone alone and Clobetasol Propionate ointment. Through the analysis of skin biopsies before and after four weeks of treatment, we observed changes in skin inflammation, cellular infiltrate, and patients’ clinical scores for psoriasis severity.
While we noted that all treatments helped reduce skin thickness and improved patient scores, the greatest impact was seen with the combination of Calcipotriol and Betamethasone. This specific treatment effectively diminished the number of harmful immune cells that contribute to psoriasis flare-ups. However, the isolated effect of vitamin D3 alone wasn’t clearly established, as the most significant outcomes were tied to its use in combination with steroids.
Ultimately, our findings suggest that while vitamin D3 plays a role in psoriasis treatment, its benefits are most pronounced when paired with corticosteroids. This combination could potentially lead to enhanced long-term management of the disease, although the specific contribution of vitamin D3 alone remains uncertain.
Read More
9
Calcipotriol more effective than calcitriol
Comparative evaluation of efficacy and safety of calcipotriol versus calcitriol ointment, both in combination with narrow-band ultraviolet B phototherapy in the treatment of stable plaque psoriasis.
Study confirms vitamin D3's role
We explored the effectiveness of two vitamin D analogues, calcipotriol and calcitriol, in treating stable plaque psoriasis when combined with narrow-band ultraviolet B (NBUVB) phototherapy. Our study involved thirty patients who were treated for 12 weeks, applying calcitriol ointment to one side and calcipotriol ointment to the other.
Throughout the trial, we observed significant improvements in skin conditions such as erythema, scaling, and overall plaque thickness with both treatments. Remarkably, those using calcipotriol showed quicker clearance of plaques and experienced fewer relapses compared to those using calcitriol.
Both treatments were found to be safe and well-tolerated, making them cosmetically appealing options. However, calcipotriol not only demonstrated a rapid onset of action but also maintained its efficacy more consistently over the treatment period.
Throughout the trial, we observed significant improvements in skin conditions such as erythema, scaling, and overall plaque thickness with both treatments. Remarkably, those using calcipotriol showed quicker clearance of plaques and experienced fewer relapses compared to those using calcitriol.
Both treatments were found to be safe and well-tolerated, making them cosmetically appealing options. However, calcipotriol not only demonstrated a rapid onset of action but also maintained its efficacy more consistently over the treatment period.
Read More
8
Vitamin D supports psoriasis management
Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis.
Strong evidence for psoriasis impact
We explored how vitamin D influences psoriasis, a persistent skin condition marked by red, flaky patches. Our study analyzed data from a significant number of participants in the UK Biobank, including those diagnosed with various autoimmune diseases, with a focus on individuals suffering from psoriasis.
Through a unique approach known as Mendelian randomization, we looked into the causal relationship between vitamin D levels and psoriasis risk. This method allowed us to consider genetic variations linked to vitamin D metabolism, helping us predict how these levels could affect the likelihood of developing psoriasis.
The results we observed were quite promising. We found that higher genetically-predicted vitamin D levels were associated with a lower risk of developing psoriasis. Specifically, for every 10 ng/ml increase in vitamin D, the risk of psoriasis decreased significantly, suggesting a beneficial influence of vitamin D in this context.
While we also examined other autoimmune diseases, evidence supporting a similar protective effect for conditions like systemic lupus erythematosus was not as strong. However, our findings highlight the potential of vitamin D in managing psoriasis, paving the way for future prevention and treatment strategies.
Through a unique approach known as Mendelian randomization, we looked into the causal relationship between vitamin D levels and psoriasis risk. This method allowed us to consider genetic variations linked to vitamin D metabolism, helping us predict how these levels could affect the likelihood of developing psoriasis.
The results we observed were quite promising. We found that higher genetically-predicted vitamin D levels were associated with a lower risk of developing psoriasis. Specifically, for every 10 ng/ml increase in vitamin D, the risk of psoriasis decreased significantly, suggesting a beneficial influence of vitamin D in this context.
While we also examined other autoimmune diseases, evidence supporting a similar protective effect for conditions like systemic lupus erythematosus was not as strong. However, our findings highlight the potential of vitamin D in managing psoriasis, paving the way for future prevention and treatment strategies.
Read More
8
Calcipotriol formulation shows promise
Efficacy and Safety of Water-Free Lipid Formulation System Containing Calcipotriol Against Psoriasis Vulgaris.
Relevant for vitamin D3 research
We evaluated the effectiveness of a new treatment involving calcipotriol, a vitamin D3 analogue, specifically designed to combat psoriasis vulgaris. This clinical trial included 24 participants, who underwent treatment with a water-free lipid-based formulation once daily for 12 days, allowing us to see how this innovative delivery system could enhance the medication's effects.
Our findings were promising, showing a significant reduction in psoriatic infiltrates—about 34% to 37%—after treatment with calcipotriol compared to a minimal change with the vehicle formulations. This suggests that the lipid-based formulations can effectively tackle the symptoms of psoriasis. However, it was essential to note that the improvement wasn't superior to the effects seen with marketed calcipotriol solutions and creams.
Participants reported some mild and non-serious side effects, but overall, the treatment was well-tolerated. In conclusion, the new lipid-based calcipotriol formulations showed efficacy and displayed an acceptable safety profile, making them a viable option for patients seeking relief from psoriasis symptoms.
Our findings were promising, showing a significant reduction in psoriatic infiltrates—about 34% to 37%—after treatment with calcipotriol compared to a minimal change with the vehicle formulations. This suggests that the lipid-based formulations can effectively tackle the symptoms of psoriasis. However, it was essential to note that the improvement wasn't superior to the effects seen with marketed calcipotriol solutions and creams.
Participants reported some mild and non-serious side effects, but overall, the treatment was well-tolerated. In conclusion, the new lipid-based calcipotriol formulations showed efficacy and displayed an acceptable safety profile, making them a viable option for patients seeking relief from psoriasis symptoms.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 7 Reviews
8.2
9.5
Reduced psoriasis impact
I prefer NOW brand vitamins for my family. Vitamin D3 is essential. My brother benefited greatly from it for his psoriasis, which has improved significantly. I take it regularly, and it's advisable to test for the right dosage, as deficiency is common.
8.8
Calmed psoriasis symptoms
I take 1 soft gel of Vitamin D each morning and evening. Since starting, I've noticed that my scalp psoriasis has calmed down, and areas that hadn't healed for months have improved. I'm also taking MSM, which may help. Vitamin D is important!
8.8
Supports skin health
I've had diabetes for nearly 30 years and became interested in Vitamin D after learning its roles in many conditions. Its deficiency can lead to issues like obesity, autoimmune diseases, and psoriasis. Surprisingly, even sunny countries face deficiency issues, so exposure to sunlight is vital.
Read More
8.8
Alleviated psoriasis symptoms
Vitamin D has been effective for my psoriasis. While it hasn’t completely healed yet, the affected area has dried and is healing since I began taking it. I will continue using it.
8
Strengthened immune response
Vitamin D3 is effective! It regulates calcium and phosphorus metabolism, improves insulin sensitivity, and strengthens the immune system. It also helps combat inflammation and prevents psoriasis. I take it regularly, and my analysis results indicate it works wonderfully. Wishing you all good health!
Read More
