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In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
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In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
The treatments explored included a combination of Calcipotriol (a vitamin D3 analogue) and Betamethasone (a steroid), as well as Betamethasone alone and Clobetasol Propionate ointment. Through the analysis of skin biopsies before and after four weeks of treatment, we observed changes in skin inflammation, cellular infiltrate, and patients’ clinical scores for psoriasis severity.
While we noted that all treatments helped reduce skin thickness and improved patient scores, the greatest impact was seen with the combination of Calcipotriol and Betamethasone. This specific treatment effectively diminished the number of harmful immune cells that contribute to psoriasis flare-ups. However, the isolated effect of vitamin D3 alone wasn’t clearly established, as the most significant outcomes were tied to its use in combination with steroids.
Ultimately, our findings suggest that while vitamin D3 plays a role in psoriasis treatment, its benefits are most pronounced when paired with corticosteroids. This combination could potentially lead to enhanced long-term management of the disease, although the specific contribution of vitamin D3 alone remains uncertain.
Through a review of existing studies, we found strong evidence supporting the use of topical vitamin D analogs alongside tazarotene for managing nail psoriasis effectively. This means that for individuals dealing with nail psoriasis, there is a credible therapeutic option that can assist in reducing symptoms and improving overall nail health.
However, when we looked at other nail disorders and broader treatments involving vitamin D, the evidence was limited. We didn’t uncover significant benefits for many conditions when relying solely on vitamins, suggesting that while vitamin D can be helpful, more robust research is needed to ascertain its full potential across various nail disorders.
In conclusion, while there’s promising news for nail psoriasis patients, the journey for solid, proven treatments for other nail conditions could use further exploration.
Throughout the trial, we observed significant improvements in skin conditions such as erythema, scaling, and overall plaque thickness with both treatments. Remarkably, those using calcipotriol showed quicker clearance of plaques and experienced fewer relapses compared to those using calcitriol.
Both treatments were found to be safe and well-tolerated, making them cosmetically appealing options. However, calcipotriol not only demonstrated a rapid onset of action but also maintained its efficacy more consistently over the treatment period.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
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Frequently Asked Questions
Psoriasis is a chronic autoimmune condition that primarily affects the skin, leading to the rapid growth of skin cells that accumulate, forming scales and red patches that can be itchy and sometimes painful. These changes occur due to an abnormal immune response that accelerates the skin renewal process. The disease can vary in severity, with some individuals experiencing mild flare-ups while others endure more severe symptoms. Psoriasis commonly appears on the elbows, knees, scalp, and lower back, but it can occur anywhere on the body.
There are several types of psoriasis, with plaque psoriasis being the most common form, characterized by raised, inflamed patches covered with silvery-white scales. Other types include guttate, inverse, pustular, and erythrodermic psoriasis. While the exact cause of psoriasis is still not entirely understood, it is believed to involve genetic, environmental, and immune system factors. Treatments vary widely and can range from topical medications and phototherapy to systemic treatments aimed at reducing inflammation and slowing skin cell turnover. If you suspect you have psoriasis, consulting a healthcare provider is advisable to explore the most appropriate treatment options.
Vitamin D is a fat-soluble vitamin that's essential for maintaining healthy bones and teeth, supporting immune system function, and facilitating normal cell growth and development. It plays a crucial role in calcium absorption in the gut, which is vital for bone health. Unlike most vitamins, our bodies can produce Vitamin D when exposed to sunlight, specifically UVB rays, which is why it’s often referred to as the "sunshine vitamin." However, depending on your geographical location, lifestyle, and skin type, getting sufficient Vitamin D from the sun alone can be challenging, particularly during the winter months.
In addition to sunlight, Vitamin D can be obtained from certain foods such as fatty fish (like salmon and mackerel), fish liver oils, and fortified foods like milk and cereals. Some individuals may also consider supplements, especially if they're at risk for deficiency. Insufficient vitamin D levels are linked to various health issues, including rickets in children, osteomalacia in adults, and even an increased risk of chronic diseases. Regularly checking your vitamin D levels and consulting with a healthcare professional can help ensure you're meeting your needs for optimal health.
Vitamin D has been studied for its potential benefits in managing psoriasis, a chronic skin condition characterized by red, scaly patches. Research indicates that vitamin D can play a role in skin cell regulation and may help reduce the rapid skin cell turnover that is a hallmark of psoriasis. Topical treatments that contain vitamin D, such as calcipotriene, are commonly prescribed and can help to alleviate symptoms and improve skin appearance for many patients.
Moreover, maintaining adequate levels of vitamin D through sun exposure, diet, or supplementation may contribute to overall skin health, although the results can vary from person to person. It is essential to consult with a healthcare professional for personalized advice and treatment options if you or someone you know is dealing with psoriasis. While vitamin D might aid in symptom management, it is typically used as part of a broader treatment plan.
Many users report seeing improvements in their psoriasis symptoms after starting Vitamin D supplementation, although the time frame for noticeable results can vary. Some individuals state that they began to see healing of affected areas shortly after starting the supplement, with one user mentioning that their scalp psoriasis calmed down significantly after beginning their regimen (Read Review). Others, however, note that while they experienced improvement, it may not lead to complete healing right away; one review highlights that the user saw the affected area drying and healing over time without total resolution (Read Review).
Overall, the general consensus among users seems to suggest that improvements can start within a few weeks of consistent use, though complete healing may take longer. It is recommended to maintain regular dosing and possibly consult a healthcare professional for personalized advice, especially regarding the appropriate dosage for managing psoriasis effectively (Read Review).
The use of vitamin D, particularly in its analogs like Calcipotriol, is supported by various scientific studies as a treatment option for psoriasis. For instance, a study demonstrated that Calcipotriol combined with a novel delivery method significantly reduces skin lesions associated with psoriasis, indicating its potential in managing localized symptoms and inflammation [1]. Additionally, clinical trials have shown that both Calcipotriol and Methotrexate are effective in reducing the severity of psoriasis lesions, making vitamin D treatments a promising avenue for therapy [5].
However, while there is evidence supporting the use of vitamin D for psoriasis treatment, some studies suggest that its overall impact may not be as robust as once believed. In a systematic review, researchers found inconsistent results concerning the effectiveness of vitamin D in alleviating psoriasis symptoms, underscoring the necessity for further examination of its role in treatment [6]. Moreover, while vitamin D levels are often lower in psoriasis patients, supplementation alone has shown minimal effect on improving symptom severity [9]. Overall, while vitamin D treatments show promise, they are often most effective when used in combination with other therapeutic approaches.
Users have reported a range of improvements in their psoriasis symptoms after incorporating Vitamin D into their regimen. Many individuals have noted enhancement in specific areas, indicating that even if full healing isn't achieved right away, there are considerable benefits. For example, a user observed that their scalp psoriasis calmed down significantly and areas that had previously resisted healing for months began to show improvement after starting Vitamin D (Read Review). Additionally, another user mentioned that their affected area dried and started healing after they began supplementation, suggesting a positive response even in the absence of a complete cure (Read Review).
The general sentiment among users is that consistent use of Vitamin D may lead to noticeable improvements within weeks, highlighting its potential role in managing psoriasis symptoms. Users have also emphasized the importance of finding the right dosage, with one user expressing great results at higher doses for a family member while maintaining a lower personal dosage (Read Review). Overall, while individual experiences can vary, many users report a favorable impact on their skin health thanks to Vitamin D.
Users have shared positive experiences regarding the combination of Vitamin D with other supplements while managing psoriasis. Some individuals, like the reviewer who reported a significant improvement in their scalp psoriasis after starting Vitamin D, also mentioned taking MSM (Methylsulfonylmethane) alongside it, suggesting that this combination may enhance the benefits (Read Review). The combined approach seems to contribute to better skin health, as evidenced by reports of areas that had resisted healing for months finally showing improvement after the introduction of these supplements into their regimen.
Moreover, another user noted that higher dosages of Vitamin D, such as 10,000 IU, were beneficial for their husband's psoriasis management, while they found success at a lower dose of 2,000 IU. This highlights the potential for tailored supplementation strategies based on individual needs (Read Review). Overall, users express a consistent sentiment that combining Vitamin D with other supplements can support better management of psoriasis, emphasizing the importance of adjusting dosages to achieve optimal results.
Users report varying effective doses of Vitamin D for treating psoriasis, indicating that individual needs may differ significantly. One user noted that their husband benefits from a higher dosage of 10,000 IU, while they personally take 2,000 IU, both experiencing positive effects on skin health (Read Review). Another user advocates for testing to find the right dosage, as Vitamin D deficiency is common, which can exacerbate psoriasis symptoms (Read Review).
Additionally, some users mention taking Vitamin D regularly, reporting improvements in their skin condition. One user observed that their scalp psoriasis calmed down with a routine of taking one soft gel each morning and evening (Read Review). The overall consensus suggests that while Vitamin D can aid psoriasis management, determining the right dosage is crucial and often requires personalized adjustments based on individual health needs and response to treatment.
Calcipotriol is known for its effectiveness in psoriasis treatment, especially for reducing thickened skin lesions, yet it shines when paired with advanced drug delivery systems. The microneedle patch design allows for quick penetration and localized action, showing promise not only in reducing inflammation but also in improving localized skin retention of the medication.
We observed that this dual-action approach not only targets the specific lesions directly but may also play a role in reducing overall systemic inflammation by inhibiting the differentiation of certain immune cells. This offers an exciting new option for those suffering from psoriasis and reflects a significant step toward more effective and specifically targeted therapies.
Our findings revealed that both calcipotriol and methotrexate were effective in reducing the severity of psoriasis lesions. At the start of the study, both groups had similar PASI scores, but by the eighth week, both treatments had significantly lowered these scores. Interestingly, while six patients in the calcipotriol group experienced complete clearance of their lesions, three patients in the methotrexate group did as well.
When it came to safety, the adverse effects from both treatments were generally mild and transient. A few patients reported skin irritation with calcipotriol and a burning sensation with methotrexate, but these issues were not severe and did not significantly impact overall well-being. We conclude that topical calcipotriol and methotrexate treatment options are effective and well-tolerated for those dealing with chronic plaque psoriasis.
Our analysis revealed some interesting patterns regarding vitamin D levels and psoriasis severity. However, we observed that the overall results did not demonstrate a consistent, significant benefit of vitamin D in alleviating psoriasis symptoms across the different studies analyzed. It appeared that, while vitamin D is vital for overall skin health, its direct impact on treating psoriasis may not be as strong as previously thought.
Ultimately, this research sheds light on the need for further investigation into vitamin D's role, considering the mixed outcomes found. Understanding its potential will be crucial in guiding future treatment options for psoriasis patients.
Our findings showed that psoriasis patients generally had lower levels of 25 hydroxyvitamin D (the form of vitamin D measured in blood tests) compared to healthy controls. Specifically, the average vitamin D level in psoriasis patients was 21.0 ng/mL, while it was 27.3 ng/mL in those without the condition.
However, when we looked at the impact of taking vitamin D3 supplements on psoriasis severity, the results were less promising. In four randomized controlled trials that included 173 psoriasis patients receiving vitamin D3 and 160 patients receiving a placebo, we found no significant improvements in the severity of psoriasis over 3, 6, or 12 months of treatment.
While the initial observation of lower vitamin D levels in psoriasis patients is intriguing and suggests a connection, the lack of improvement through supplementation indicates that vitamin D3 might not be the solution we hoped for in treating psoriasis.
References
- Wang ZY, Zhao ZQ, Sheng YJ, Chen KJ, Chen BZ, et al. Dual-Action Psoriasis Therapy: Antiproliferative and Immunomodulatory Effects via Self-Locking Microneedles. Adv Sci (Weinh). 2024;11:e2409359. doi:10.1002/advs.202409359
- Zanghaneh AJ, Elmelid A, Gillstedt M, Ahmic O, Andersson B, et al. The Expression of Vitamin D Receptor on Peripheral Blood Mononuclear Cells in Patients with Psoriasis. Int J Mol Sci. 2024;25. doi:10.3390/ijms251910677
- Mehmood Y, Shahid H, Ahmed S, Khursheed A, Jamshaid T, et al. Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies. Sci Rep. 2024;14:23866. doi:10.1038/s41598-024-72951-6
- Elmelid A, Vandikas MS, Gillstedt M, Alsterholm M, Osmancevic A. The Effect of Phototherapy on Systemic Inflammation Measured with Serum Vitamin D-Binding Protein and hsCRP in Patients with Inflammatory Skin Disease. Int J Mol Sci. 2024;25. doi:10.3390/ijms25168632
- Das K, Ranjan R, Kumar P, Chandra S. A Comparative Study of the Effectiveness and Safety of Topical Calcipotriol and Topical Methotrexate in Chronic Plaque Psoriasis. Cureus. 2024;16:e59878. doi:10.7759/cureus.59878
- Formisano E, Proietti E, Borgarelli C, Pisciotta L. Comment to "Vitamin D in psoriatic arthritis - A systematic review and meta-analysis". Semin Arthritis Rheum. 2024;67:152457. doi:10.1016/j.semarthrit.2024.152457
- Curtis KL, Lipner SR. Vitamins for the Management of Nail Disease: A Literature Review. Skin Appendage Disord. 2024;10:104. doi:10.1159/000534972
- Mehmood Y, Shahid H, Ahmed S, Khursheed A, Jamshaid T, et al. Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies. Sci Rep. 2024;14:23866. doi:10.1038/s41598-024-72951-6
- Formisano E, Proietti E, Borgarelli C, Pisciotta L. Psoriasis and Vitamin D: A Systematic Review and Meta-Analysis. Nutrients. 2023;15. doi:10.3390/nu15153387
- Zhao SS, Mason A, Gjekmarkaj E, Yanaoka H, Burgess S. Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis. Semin Arthritis Rheum. 2023;62:152238. doi:10.1016/j.semarthrit.2023.152238
- Chakraborty D, Aggarwal K. Comparative evaluation of efficacy and safety of calcipotriol versus calcitriol ointment, both in combination with narrow-band ultraviolet B phototherapy in the treatment of stable plaque psoriasis. Photodermatol Photoimmunol Photomed. 2023;39:512. doi:10.1111/phpp.12893
- Holmback J, Carlsson A, Rinwa P. Efficacy and Safety of Water-Free Lipid Formulation System Containing Calcipotriol Against Psoriasis Vulgaris. J Drugs Dermatol. 2023;22:197. doi:10.36849/JDD.7151
- Mazur A, Koziorowska K, Dynarowicz K, Aebisher D, Bartusik-Aebisher D. Vitamin D and Vitamin D3 Supplementation during Photodynamic Therapy: A Review. Nutrients. 2022;14. doi:10.3390/nu14183805
- Heim M, Irondelle M, Duteil L, Cardot-Leccia N, Rocchi S, et al. Impact of topical emollient, steroids alone or combined with calcipotriol, on the immune infiltrate and clinical outcome in psoriasis. Exp Dermatol. 2022;31:1764. doi:10.1111/exd.14657
