NOW Supplements Zinc Picolinate

Zinc shortens cold duration variability

Based on 6 Researches

Hemilä H, Chalker E, Tukiainen J. Quantile Treatment Effect of Zinc Lozenges on Common Cold Duration: A Novel Approach to Analyze the Effect of Treatment on Illness Duration. Front Pharmacol. 2022;13:817522. doi:10.3389/fphar.2022.817522

We explored how zinc lozenges affect the duration of the common cold through a detailed analysis of multiple trials. In particular, we focused on the Mossad (1996) trial involving zinc gluconate lozenges, which revealed an average reduction of cold duration by about 4.0 days. While that sounds promising, our findings through a quantile treatment effect (QTE) analysis tell a more nuanced story.

Interestingly, the QTE analysis showed that for individuals suffering from lengthy colds lasting 15 to 17 days, the zinc lozenges could shorten their illness by as much as 8 days. On the flip side, those with shorter, 2-day colds only experienced a 1-day reduction in sickness. This suggests that while zinc may help, its effectiveness varies significantly depending on the initial duration of the cold, making the overall average effect less informative than we might think.

Our examination extended to three trials that used zinc acetate lozenges, yielding a similar average reduction of around 2.7 days. However, again, those averages concealed varying effects for short and long colds, highlighting the importance of looking beyond simple averages in treatment studies.

Overall, we observed that zinc lozenges can indeed help with cold duration, but the extent of that help is very much dependent on how long a person has been suffering. This approach to understanding treatment effects through QTE analysis could have important implications not just for cold treatment but also for analyzing other health outcomes.

9.5

Instant relief

Most Useful Review

This form of zinc works instantly at the first signs of a common cold. I combine one tablet of zinc with 1000mg of vitamin C, and I feel healthy by morning. It’s essential during winter, and I struggled to find this form as it was quickly sold out. I'm grateful for the chance to stay healthy!

Hair Loss details

Matsuoka N, Mizutani T, Kawakami K. Symptom Profile of Patients With Post-COVID-19 Conditions and Influencing Factors for Recovery. J Clin Med Res. 2023;15:116. doi:10.14740/jocmr4855

Zinc shows promise for hair loss

We explored how zinc acetate hydrate impacts hair loss for patients experiencing symptoms after COVID-19. In our analysis, we looked at 120 symptomatic outpatients over 12 weeks, observing their recovery patterns and any improvements in their symptoms. The focus was on various lingering effects, including fatigue and hair loss, particularly how zinc could potentially alleviate these issues.

Our findings highlighted significant improvements in hair loss for those treated with zinc acetate hydrate at multiple checkpoints (4, 8, and 12 weeks) compared to those who did not receive this treatment. The results were statistically significant and suggested that zinc could be a useful option for those struggling with hair loss post-COVID-19.

Additionally, we noted improvements in fatigue among those receiving zinc, although this was not as pronounced at all time intervals. As a whole, our study emphasized zinc's beneficial effects, particularly for hair loss, providing promising insights for anyone dealing with these challenging post-viral symptoms.

9.5

Tremendous impact

Most Useful Review

An excellent Zinc form for absorption. I've been using it for hair loss, and it has helped tremendously. Through research, I realised I have Copper overload. After taking this with Manganese and Vitamin C, my hair is growing back, my nervousness decreased, and I feel much more energetic and clear-headed.

We explored how zinc might help in treating and preventing the common cold. The study focused on zinc's effects, isolating it from other treatments to understand its true impact on cold symptoms. By doing this, the researchers aimed to clarify whether zinc could genuinely shorten the duration of a cold or alleviate its symptoms.

The findings were intriguing but showed that zinc might not yield significant benefits for everyone. While some individuals reported a slight reduction in cold symptoms, the evidence did not strongly support zinc as an effective treatment overall.

This means that, for those seeking relief from a nasty cold, zinc alone might not be the go-to solution we hoped it would be. It’s essential to consider this information when deciding on a cold treatment plan and to approach zinc with realistic expectations.

9.5

Works instantly

Most Useful Review

This zinc is the best form, acting immediately at the first sign of a cold. I take one tablet combined with 1000mg of vitamin C, and I feel perfectly well by morning. It's indispensable during winter. I struggled to find this particular form of zinc as it sells out rapidly. Thank you for keeping me healthy!

Ear Infection details

Zinc's mixed impact on ear infections

Based on 8 Researches

Abba K, Gulani A, Sachdev HS. Zinc supplements for preventing otitis media. Cochrane Database Syst Rev. 2010. doi:10.1002/14651858.CD006639.pub2

We explored whether zinc supplements could help prevent otitis media, which is a common ear infection affecting many, especially young children. Our examination included several randomized, placebo-controlled trials where participants received zinc supplements at least once a week for a minimum of a month.

In total, we identified 12 trials, but only 10 provided sufficient data for analysis. Among healthy children from low-income communities, most studies did not show a clear benefit of zinc on reducing ear infections. However, one trial with over 1600 participants did find a significantly lower incidence of otitis media in those taking zinc, suggesting that it might help. Additionally, a small study focusing on infants with severe malnutrition hinted at potential benefits, yet it is important to note this was based on limited data.

Overall, the evidence isn't definitive—while some results point towards positive effects, particularly in specific groups, many trials did not support the effectiveness of zinc in healthy children. Furthermore, zinc supplements appeared safe, with minimal reports of adverse effects.

Restored sense of smell

Most Useful Review

I purchased zinc to restore my sense of smell, taking 50 mg per day for a month with food. This zinc is well-absorbed and contributes significantly to immunity, helping to combat infections. With its use, my hair has stopped falling out, my skin is clearer, my nails are stronger, and my sense of smell has returned. I wholeheartedly recommend it for overall health!

Flu details

Zinc treatment impacts flu virus entry

Nishi K, Yoshimoto S, Nishi S, Nishi T, Nishi R, et al. Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry. In Vivo. 2022;36:2357. doi:10.21873/invivo.12967

In our study, we examined how epipharyngeal abrasive therapy (EAT), which includes the use of zinc chloride, affects the expression of a key molecule known as Cav1.2. This molecule is essential for the influenza virus to enter cells, making it a crucial target in flu prevention strategies.

We compared two groups of patients: those who received EAT and those who did not. Our findings revealed that the levels of Cav1.2 were significantly lower in the EAT group, at a striking 4.19 times less than in the non-treated group. This suggests that the squamous metaplasia induced by EAT—which is a process of changing the epithelium—could be a beneficial approach to limiting flu infections.

The results of the study highlight zinc's potential indirect role in flu prevention by remarking on its contribution to lowering the expression of a critical receptor for the virus. Although we didn't isolate the effects of zinc alone, the findings indicate that treatments involving zinc, like EAT, may offer a straightforward way to help limit the impact of influenza.

8.8

Effective against flu

Most Useful Review

This supplement is incredible! I've realised how zinc helps maintain my immune system. After being in close quarters with those suffering from flu, I remained unaffected thanks to zinc. It effectively reduced symptoms for my son too, while others around struggled. I highly recommend zinc as a preventative measure during flu season.

Herpes details

Eases herpes outbreaks

Super thing! I only take them when I feel unwell, usually two capsules at once. Although often exposed to sick individuals, I’ve never fallen ill. Recently, I took a shock dose when I noticed herpes on my lip. Two blisters had appeared, but by morning, they were gone! What a relief, as neither acyclovir nor valacyclovir have worked for me. I also applied zinc paste on my lip, which may benefit others suffering from herpes during times of reduced immunity.

Influenza details

Zinc may prevent influenza entry

We investigated how zinc, delivered through epipharyngeal abrasive therapy (EAT), might impact the expression of a key molecule known as Cav1.2, which plays a crucial role in allowing the influenza A virus to enter cells. The study included two groups of patients: one group that received EAT, which involved scratching the epipharyngeal mucosa with a zinc chloride-treated swab, and another group that did not receive this treatment.

By analyzing tissue samples, we observed that the levels of Cav1.2 were significantly lower in the EAT-treated patients compared to those who were not treated. In fact, the expression of Cav1.2 in the patients who underwent EAT was measured to be 4.19 times lower than in the non-treated group. This suggests that the squamous metaplasia induced by EAT might help reduce the entry of the influenza virus by down-regulating this key protein.

Our findings indicate that EAT, through its zinc content, could serve as a simple and effective method to potentially prevent influenza infection by limiting the virus's ability to enter cells.

9.5

Strengthens hair

Most Useful Review

Zinc is vital for strengthening my hair as it boosts immunity, aids wound healing, and alleviates influenza symptoms.

Insomnia details

Cherasse Y, Saito H, Nagata N, Aritake K, Lazarus M, et al. Zinc-containing yeast extract promotes nonrapid eye movement sleep in mice. Mol Nutr Food Res. 2015;59:2087. doi:10.1002/mnfr.201500082

Zinc promotes sleep in mice

We explored the effects of zinc on sleep by looking at how it might help with insomnia. In our study, we gave mice a zinc-containing yeast extract and monitored their behavior and brain activity. The results were quite promising.

We found that administering zinc at doses of 40 and 80 mg/kg led to a significant increase in non-rapid eye movement (NREM) sleep. This means that the mice were not only sleeping longer but also showed less activity, which is a good indicator of effective sleep. Interestingly, we did not observe any changes in rapid eye movement (REM) sleep, a crucial sleep phase for dreaming and deep rest.

Importantly, we didn’t see any negative side effects, such as rebound insomnia, within 24 hours after treating the mice. This suggests that zinc could be a safe option for those struggling with sleep issues, unlike other mineral extracts we tested, such as manganese, iron, and copper, which did not affect locomotor activity at all.

Overall, our findings provide the first evidence that zinc has a direct role in promoting sleep, opening up exciting possibilities for new sleep supplements featuring this essential mineral.

9.5

Minimises insomnia symptoms

Most Useful Review

Antioxidant possesses a stabilising effect in cases of insomnia, depression, autonomic dysfunction, and other conditions, particularly during menopause or old age. The quality of the ingredients is natural, aiding in relieving excess stress while stimulating brain function, improving concentration, and enhancing mood and sleep. The capsules are of medium size. GABA, as a neurotransmitter of the central nervous system, is key to improving sleep quality, with the greatest growth hormone release occurring at night. This component minimises stress influences, facilitating deeper, more effective sleep. The dosage is optimal.

Sore Throat details

Zinc reduces postoperative sore throat

Sarkar T, Mandal T. Preoperative oral zinc tablet decreases incidence of postoperative sore throat. Indian J Anaesth. 2020;64:409. doi:10.4103/ija.IJA_959_19

We investigated the impact of dispersible zinc tablets on postoperative sore throat (POST) experienced by patients after endotracheal intubation. In our study, 88 patients were divided into two groups. One group received a 40 mg zinc tablet, while the other received a placebo 30 minutes before their surgery.

Our findings revealed that the zinc group reported significantly fewer instances of POST at the 4-hour mark compared to the placebo group. Specifically, only 6.8% of patients in the zinc group experienced POST, while a higher 31.8% in the placebo group did. Furthermore, none of the patients taking zinc reported severe sore throat, a stark contrast to three patients in the placebo group who did.

Additionally, we noted lower severity ratings for sore throat in the zinc group at various time intervals post-surgery. The results emphasize that taking zinc tablets before surgery can effectively mitigate the incidence and discomfort of sore throat following intubation, presenting a simple solution for a common postoperative issue.

9.5

Immunity boost

Most Useful Review

I ordered this on the advice of my doctors after having Covid to boost my immunity. I am pleased with the results; the symptoms bothering me, such as sore throat and fatigue, have gone.

Anxiety details

Zinc may alleviate anxiety symptoms

Based on 8 Researches

Azargoonjahromi A. A systematic review of the association between zinc and anxiety. Nutr Rev. 2024;82:612. doi:10.1093/nutrit/nuad076

We explored the connection between zinc intake and anxiety in adults through a systematic review of nine original studies. Two of these studies looked at how zinc consumption impacts anxiety, while the other seven focused on the relationship between serum zinc levels and anxiety symptoms. Our analysis included studies published in English within peer-reviewed journals, ensuring a solid foundation for understanding this potential link.

What we discovered was quite illuminating. The data indicated that individuals experiencing anxiety often had lower levels of zinc in their serum compared to those who did not suffer from anxiety. Additionally, we observed an inverse association between zinc intake and anxiety levels. This suggests that higher consumption of zinc may contribute to reduced anxiety symptoms.

In conclusion, the evidence points towards zinc playing a positive role in treating anxiety, although we acknowledge some limitations in the available studies. This means zinc supplementation could be a beneficial strategy for those looking to manage their anxiety, but more research is needed to confirm these findings and understand the underlying mechanisms better.

9.5

Anxiety reduction

Most Useful Review

This zinc supplement has dramatically reduced my anxiety symptoms. I was on the verge of increasing my Zoloft dose but now I have hope that I can wean off my medication entirely in the future.

Athlete’s Foot details

Chretien JH, Esswein JG, Sharpe LM, Kiely JJ, Lyddon FE. Efficacy of undecylenic acid-zinc undecylenate powder in culture positive tinea pedis. Int J Dermatol. 1980;19:51.

Zinc aids athlete's foot treatment

We explored the effectiveness of a powder containing 2% undecylenic acid and 20% zinc undecylenate for treating athlete's foot, also known as tinea pedis. In a double-blind study, 151 participants were assigned to apply either the active powder or a placebo twice daily for four weeks. The results were telling.

From the 85 patients with confirmed fungal infections, a remarkable 88% of those using the active powder had negative cultures after the treatment, compared to only 17% in the placebo group. Additionally, 80% of those on the active treatment were found to be free of fungus in KOH skin scrapings after four weeks, while only 49% of placebo users achieved this. Furthermore, we observed significant improvement in symptoms like itching, burning, erythema, and scaling, with no side effects reported.

Overall, our findings indicate that the combination of undecylenic acid and zinc may offer a robust solution for individuals suffering from athlete's foot, effectively reducing fungal presence and alleviating uncomfortable symptoms. However, it is important to note that while zinc played a role in this combination treatment, we cannot fully assess its isolated effect on its own without further studies.

9.5

Odour elimination

Most Useful Review

ZINC IN CAPSULES! HOORAY! It’s crucial to take supplements, especially minerals, in capsule form. Tablets often contain too many binders. Zinc has greatly improved hygiene for my family by eliminating foot and scalp odours. Just one capsule a day does the job!

Bloating details

This zinc is remarkable. It’s easy to digest and does not cause any bloating or eructation. I truly appreciated it.

Chest Pain details

Eby GA, Halcomb WW. High-dose zinc to terminate angina pectoris: a review and hypothesis for action by ICAM inhibition. Med Hypotheses. 2006;66:169.

Zinc treatment for angina pectoris

We delved into an intriguing question: Can high doses of zinc help relieve chest pain caused by angina pectoris? Our research reviewed studies that highlight how zinc may play a role in managing this condition. Angina pectoris often results from arteriosclerosis, where the arteries become narrowed due to cholesterol buildup and other factors.

We discovered that patients with severe atherosclerosis showed promising improvements when treated with high-dose zinc. Specifically, a treatment regimen involved raising serum zinc levels significantly, resulting in symptom relief for many individuals. In one notable case, 12 out of 16 patients experienced measurable benefits, including one patient who also suffered from Raynaud's disease.

Furthermore, our analysis noted that long-term exposure to zinc in the environment correlated with reduced incidence of angina and ischemic events during exercise. Zinc appears to possess antioxidant properties, which may protect against the oxidation of LDL cholesterol, a key player in artery damage. By blocking certain inflammatory factors and promoting better circulation, zinc might enhance heart function and alleviate chest pain.

Based on these findings, we propose that zinc treatment should be considered a fundamental option in both prevention and therapy for atherosclerosis-related chest pain. This could lead to a renewed focus on restoring a healthier cardiac function among those affected by these conditions.

9.5

Life-saving zinc

Most Useful Review

Very excellent; I felt inspired to purchase this a month before I had corona when I was already suffering from chest allergies and was immunocompromised. The doctor assured me that the zinc I took is what saved my life.

Cold Sores details

Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med. 2001;7:49.

Zinc cream alleviates cold sores

We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.

Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.

As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.

9.5

Prevented infections

Most Useful Review

I often fall ill, but since taking Zinc, I have noticed a significant improvement. A recent visit from my mother-in-law brought the flu, yet I remained unaffected! My son also followed my advice and took Zinc along with Kagocel, recovering quickly. I am truly amazed by the effectiveness of Zinc.

Constipation details

Zinc may mitigate granisetron constipation

Nacci C, Fanelli M, Potenza MA, Leo V, Montagnani M, et al. Carbon monoxide contributes to the constipating effects of granisetron in rat colon. World J Gastroenterol. 2016;22:9333.

We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.

Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.

Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.

9.5

Improved digestion

Most Useful Review

The quality of this supplement is excellent. The balanced ingredients have improved my health as they contain natural substances. The capsules are conveniently sized and easy to swallow, with a neutral taste. It has notably helped my digestion and alleviated constipation. I highly recommend purchasing it!

Cough details

Balasubramanian A, Holbrook JT, Canning BJ, Que LG, Castro M, et al. Efficacy and tolerability of zinc acetate for treatment of chronic refractory cough: pilot randomised futility trial. ERJ Open Res. 2023;9. doi:10.1183/23120541.00678-2022

Zinc acetate ineffective for cough

We conducted a pilot trial to explore the effectiveness of zinc acetate in treating chronic refractory cough, a condition that causes significant discomfort for many people. In this study, we compared zinc acetate against a placebo over a period of six weeks, with the aim of measuring improvements in quality of life and cough symptoms using several established questionnaires.

Our group included 34 participants who were primarily white females suffering from moderate to severe cough. Throughout the trial, we noted that those taking zinc acetate did experience a rise in serum zinc levels, which indicates that the treatment was effective in that regard. However, when assessing the overall impact on cough symptoms and quality of life, both the zinc and placebo groups showed improvements, but those improvements were minimal.

Importantly, the treatment effects observed did not reach the clinically meaningful thresholds that would suggest zinc acetate significantly benefits cough management. Therefore, we concluded that there is no substantial advantage to using zinc therapy over placebo for people dealing with chronic cough, and suggest that larger trials are unnecessary at this time.

8.3

Prevents cough effects

Most Useful Review

My husband has been working overtime for 3 months and I believe that zinc helps keep viruses at bay—he hasn’t had a single sniffle or cough despite the bug circulating in his office and his sleep deprivation.

Migraine details

Mazaheri M, Aghdam AM, Heidari M, Zarrin R. Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women. Clin Nutr Res. 2021;10:127. doi:10.7762/cnr.2021.10.2.127

Zinc reduces migraine symptoms

This study was designed as a randomized double-blind, placebo-controlled trial to examine how zinc gluconate supplementation might alleviate migraine symptoms in adult women. We followed 60 women, averaging about 35 years old, who either received 15 mg of zinc per day or a placebo for a duration of 12 weeks.

Over the trial, we observed significant improvements in those taking zinc. The frequency of migraine attacks, as well as the duration and severity of the headaches, drastically decreased for participants receiving zinc. We used various assessments, such as a numerical rating scale and the Migraine Disability Assessment test, to evaluate these changes.

Additionally, zinc supplementation showed a notable reduction in levels of low-density lipoprotein (LDL) cholesterol and high-sensitivity C-reactive protein (hs-CRP), both of which are associated with inflammation. However, no significant changes in triglycerides or high-density lipoprotein (HDL) levels were seen. After taking initial values into account, the changes in lipid levels and hs-CRP weren’t significant.

Overall, we found that zinc supplementation can beneficially impact migraine symptoms, reducing their severity and frequency among women. This offers a promising direction for migraine management without the side effects often associated with traditional medications.

9.5

Improved migraine frequency

Most Useful Review

Great! It normalises sleep when I take 2 capsules regularly. It has greatly improved my migraines, which now pass in a couple of hours instead of taking half a day. I have also found that PMS and menstruation are easier to endure with regular magnesium intake. Chronic nasal pain has not worsened either. I suspect the magnesium, along with my other supplements, has been beneficial, but I was pleasantly surprised by the result. No allergies or stomach issues, and the quality is excellent.

Polycystic Ovary Syndrome details

Serves its purpose! I began taking this as I was diagnosed with PCOS and experiencing severe hair loss. After researching, I decided to try it, and IT WORKED! My hair fall has significantly decreased.

Adenoiditis details

Effective throat relief

I use this dosage when the first symptoms of a cold arise. In the initial days, I take 2 capsules. If my throat is sore, I take one capsule whole and open another to pour it onto my tongue. No throat lozenges have provided such relief until now. This has become an essential part of my regimen.

Adrenal Gland Disorder details

Maintains health effectively

Adrenal/Immune support has been vital for me during the cold season, particularly while working in hospitality within a hospital setting where many around me fell ill. I took this specific Zinc product and successfully maintained my health, avoiding any sickness. I combine it with a Vitamin C botanical each morning before work.

Blurred Vision details

I always take zinc with joy. It assists me in restoring my vision and boosting my immunity.

Celiac details

NOW Foods Zinc Picolinate is produced by a reputable brand that prioritises high-quality ingredients. Each capsule contains 50mg of a highly absorbable zinc form. I’ve found that it supports my immune system and leaves me feeling energised. Free from gluten, soy, and dairy, it suits individuals with dietary sensitivities. I could easily swallow the capsules and experienced no stomach issues. Highly recommend this product for overall health support.

Frozen Shoulder details

I followed the instructions closely, and initially experienced a surge of energy and mental clarity. My skin, which had been dry with a rash on my shoulders for years, has begun to recover. I am incredibly happy with the results.

Gastritis details

Zinc protects against gastritis damage

Based on 8 Researches

Sun X, Xu S, Liu T, Wu J, Yang J, et al. Zinc supplementation alleviates oxidative stress to inhibit chronic gastritis the ROS/NF-κB pathway in a mouse model. Food Funct. 2024;15:7136. doi:10.1039/d4fo01142b

We investigated how zinc supplementation impacts chronic gastritis, particularly in the context of oxidative stress and inflammation. By establishing models of inflammatory injury in C57BL/6 mice, we were able to analyze the effects of zinc on the gastric mucosa, which is crucial for maintaining digestive health.

Our findings revealed that when the mice were exposed to a compound known to induce inflammation, there was a noticeable rise in reactive oxygen species (ROS), signaling an increase in oxidative stress. This stress resulted in an uptick in certain harmful factors related to inflammation and cell death. However, when we introduced zinc as a supplement, it effectively reduced these damaging factors, alleviating inflammation and the resulting cell death in both the mouse stomach and cultured cells.

Overall, our study indicates that zinc supplementation can play a significant role in controlling inflammation and protecting against cellular damage caused by oxidative stress in chronic gastritis. By modulating the ROS/NF-κB signaling pathway, zinc demonstrates potential as a protective agent for gastric health.

9.5

Gentle on stomach

Most Useful Review

I frequently buy dietary supplements from Now Foods. This zinc form does not irritate my stomach, which is a relief as I have gastritis.

High Cholesterol details

Khajeh M, Hassanizadeh S, Pourteymour Fard Tabrizi F, Hassanizadeh R, Vajdi M, et al. Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients with Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis. Biol Trace Elem Res. 2024;202:4877. doi:10.1007/s12011-024-04059-x

Zinc improves cholesterol levels

We explored how zinc supplementation affects cholesterol levels and body composition in patients with type 2 diabetes. By reviewing data from nineteen randomized controlled trials, involving 1,357 participants, we uncovered significant findings regarding lipid profiles.

Our results revealed that zinc supplementation leads to reduced levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C). Specifically, we noted reductions of 17.41 mg/dL in triglycerides, 19.60 mg/dL in total cholesterol, and 8.80 mg/dL in LDL-C. Furthermore, we observed an increase in high-density lipoprotein cholesterol (HDL-C) by 4.82 mg/dL, which is often termed "good" cholesterol.

While zinc appears to positively influence cholesterol levels, it's interesting to note that it did not have a significant impact on body weight. The body mass index (BMI) did show a slight decrease of 0.53 kg/m², but overall body weight remained unchanged.

In conclusion, our findings suggest that zinc supplementation could be a beneficial strategy for improving cholesterol levels in individuals with type 2 diabetes, thus contributing positively to their overall health and well-being.

9.5

Heart health improves

Most Useful Review

Excellent quality supplement, great dosage ratio. My high cholesterol hasn't increased while taking it, and my heart feels fantastic.

Leg Cramps details

Zinc Picolinate has been beneficial for my condition, Pyroluria. After switching from "NOW" zinc supplements, I experienced better absorption and have not suffered from leg cramps that I previously endured.

Obesity details

Zinc improves prostate health in obesity

Li Y, Wu Z, Ma J, Liu X, Zhang C, et al. Zinc Attenuates Prostate Hyperplasia and Inflammatory Injury in Obese Rats by Regulating Zinc Homeostasis and Inhibiting the JAK1/STAT3 Pathway. Prostate. 2025. doi:10.1002/pros.24883

We explored how zinc supplementation affects prostate health in obese rats, particularly in terms of prostate inflammation and cell proliferation. The study involved a well-structured experiment with control and treatment groups over eight weeks. Obese rats were given either zinc sulfate or a saline solution, allowing us to compare the effects of zinc directly.

Our findings revealed that obese rats experienced reduced sperm health and increased inflammatory markers in prostate tissue. Upon zinc supplementation, these rats showed improved sperm motility and count, alongside a notable reduction in inflammatory cytokines and insulin growth factors.

We observed significant changes in the expression of zinc transporters, which regulate zinc levels in the body, after supplementation. The results also indicated that zinc negatively affected the JAK1/STAT3 signaling pathway, which is often linked to inflammation and cancer, suggesting a potential mechanism by which zinc supports prostate health.

Overall, our study presents compelling evidence that zinc can be an effective tool in managing obesity-related prostate issues, highlighting its role in promoting healthier reproductive function in males.

8.8

Supports men’s hormones

Most Useful Review

Zinc picolinate is an inexpensive supplement that can help strengthen male hormones and prevent obesity. I recommend it.

Osteoporosis details

Fang D, Jiang D, Shi G, Song Y. The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis. BMC Musculoskelet Disord. 2024;25:710. doi:10.1186/s12891-024-07768-5

Based on 10 Researches

Zinc intake may protect bones

We investigated the connection between dietary zinc intake and the prevalence of osteoporosis and osteopenia in patients with rheumatoid arthritis (RA). Using data from the National Health and Nutrition Examination Survey collected over several years, we applied various statistical methods to analyze how zinc impacts bone health in these patients.

Our findings revealed that higher dietary zinc intake appears to be linked with a lower incidence of osteopenia and osteoporosis among individuals with RA. This suggests that consuming adequate amounts of zinc might support better bone health for those suffering from this chronic condition.

Despite our positive findings, we acknowledge that further research, including longitudinal and randomized trials, is essential for confirming these results and understanding the underlying mechanisms at play. However, the evidence from our analysis encourages a focus on dietary zinc as a possible factor in maintaining bone health for patients with RA.

8.8

Aids immunity and osteoporosis

Most Useful Review

I chose this zinc picolinate as it is quickly absorbed and essential for proper immune function. Zinc is vital for bone health, helping to prevent osteoporosis and healing wounds. It effectively lowers the risk of age-related chronic diseases.

Pneumonia details

Effective during illness

This zinc is excellent for colds. My husband and I took it daily during our illness, and thankfully, we avoided pneumonia. I highly recommend zinc picolinate for effective recovery.

Prostate Cancer details

Zinc's complex role in prostate cancer

Ghimire K, Awasthi BP, Yadav K, Lee J, Kim H, et al. Prostate cancer-selective anticancer action of an oxindole derivative via HO-1-mediated disruption of metabolic reprogramming. Chem Biol Interact. 2025;408:111393. doi:10.1016/j.cbi.2025.111393

We explored the relationship between zinc levels and prostate cancer treatments, particularly focusing on a novel compound known as 3D. This compound showed a strong potential to target prostate cancer cells, contributing to a decrease in their proliferation rates.

Our analysis revealed that compound 3D selectively impacted key metabolic processes in prostate cancer cells by suppressing factors related to energy production, such as lactate levels. Interestingly, it also reduced the activity of transporters involved in zinc absorption while leaving those responsible for zinc export untouched.

We also found that the effectiveness of 3D could be reversed with zinc treatment, highlighting a complicated interaction between zinc and this therapeutic approach. While the compound successfully lowered zinc levels in cells and inhibited cancer growth, it is essential to note that we did not find significant benefits from zinc treatment by itself in the context of this study.

Overall, our findings suggest that targeting zinc metabolism and enhancing heme oxygenase-1 expression could be a promising strategy in prostate cancer therapy, more so than the direct application of zinc itself. The results illustrate the potential for combining innovative small molecules with an understanding of cancer metabolism in the development of treatment strategies.

8.8

Zinc benefits prostate

Most Useful Review

Zinc is essential for combating viruses like herpes and supports prostate health, playing a crucial role in preventing prostate cancer. It helps in protein synthesis and promotes healing; additionally, my skin and nails improved, and my cravings for sweets diminished. I highly recommend this zinc supplement.

Sleep Apnea details

Zinc protects heart function in OSA

Chen TI, Chen MY. Zinc Is Indispensable in Exercise-Induced Cardioprotection against Intermittent Hypoxia-Induced Left Ventricular Function Impairment in Rats. PLoS One. 2016;11:e0168600. doi:10.1371/journal.pone.0168600

We explored how zinc affects heart function in the context of obstructive sleep apnea (OSA), specifically focusing on cases of intermittent hypoxia (IH). In a detailed study using male rats, researchers set up different groups: a control group and one that underwent 10 weeks of exercise training. Half of the rats in both groups were exposed to IH conditions to simulate the effects of sleep apnea.

The results were eye-opening. Rats that experienced IH showed notable impairment in their heart's left ventricular function, characterized by reduced ejection fraction and increased inflammation. However, when treated with zinc, these negative effects were significantly countered. Notably, those who exercised and received zinc treatment displayed improved heart function and antioxidant capabilities compared to their counterparts that did not receive zinc.

On the flip side, exercise alone did not provide the same protective benefits when zinc was absent. The findings suggest that zinc is essential not only for the heart's protection against the damaging effects of IH but also enhances the benefits of physical exercise. This research indicates the importance of zinc in potentially managing heart health in individuals suffering from sleep apnea.

9.5

Improved mood

Most Useful Review

I’ve been taking 1000 mg each night for over a month and have noticed significant changes. My mood has improved, my energy levels have increased, and I’m sleeping better than ever, which has positively affected my sleep apnea.

Swollen Lymph Nodes details

Improved skin condition

I felt a symptomatic lack of zinc in my body and decided to order a supplement. With weekly intake, effects became evident. My skin improved, and swelling under my eyes reduced significantly. Men’s health has also somewhat improved, and this is just after a week. I’m currently taking one capsule a day, but I may switch to one capsule every 1-2 days.

Weight Loss details

I take zinc on the advice of my cosmetologist for tissue renewal. Insufficient zinc leads to acne and inflammation. After taking it for 1-2 months, my skin has become more elastic, and the sebaceous gland secretion has normalised. Additionally, combined with picolinic acid, it enhances metabolism and supports my weight loss journey.

Arthritis details

Hasan M, Yadav P, Ansari MA, Ali S, Khan HA. Therapeutic Dose of Zinc Aspartate and Zinc Citrate Attenuates Disease Activity Indices in Rheumatoid Arthritis. Biol Trace Elem Res. 2024. doi:10.1007/s12011-024-04439-3

Zinc alleviates arthritis symptoms

We explored the effects of zinc supplements—specifically zinc aspartate and zinc citrate—on reducing the symptoms of rheumatoid arthritis. In our study, we induced arthritis in male Wistar rats using a collagen-related method and then treated the rats with these zinc compounds over a four-week period. Our objective was to evaluate how these compounds could impact the disease's severity and markers associated with rheumatoid arthritis.

The results were quite promising. Both zinc aspartate and zinc citrate, administered at a therapeutic dose of 50 mg of elemental zinc per day, showed a significant reduction in the clinical symptoms associated with arthritis. Furthermore, these compounds displayed antibacterial properties against Escherichia coli, which is notable since rheumatoid arthritis patients often suffer from increased sensitivity to bacterial infections.

Importantly, we found no adverse effects on liver or kidney function in the rats that received the zinc treatment. This highlights the potential of zinc compounds not only as anti-inflammatory agents but also as preventive measures against microbial growth that can complicate rheumatoid arthritis.

9.5

Improved sleep

Most Useful Review

I purchased these vitamins to strengthen my immune system and support my joints, as I suffer from arthritis. I have recently started taking them and have noticed no negative effects. My sleep has improved, and there’s new hair growth in bald patches. Overall, I’m pleased with the vitamins and would recommend them for arthritis.

Asthma details

Cheng C, Lin J, Zhang Z, Zhang L. Association between dietary zinc intake and asthma in overweight or obese children and adolescents: A cross-sectional analysis of NHANES. World Allergy Organ J. 2024;17:100900. doi:10.1016/j.waojou.2024.100900

Dietary zinc may reduce asthma

We explored the relationship between dietary zinc intake and asthma in overweight or obese children and adolescents. This research utilized data from the National Health and Nutrition Examination Survey, focusing on those aged 20 and younger who had both asthma and dietary zinc consumption.

Our findings indicate that there is an inverse association between zinc intake and the occurrence of asthma. In simpler terms, higher dietary zinc appears to be linked with lower asthma rates in these children. This suggests that zinc could play an important role in respiratory health, especially for kids struggling with their weight.

While our study sheds light on this potential protective effect of zinc, we recognize that the results in existing literature have been mixed. Some research indicates benefits, while other studies don’t show significant effects. Therefore, while we have uncovered a correlation worth noting, further research is required to fully understand zinc’s role in asthma management.

9.5

Strengthened immunity

Most Useful Review

I've been using Now Foods Zinc Picolinate for about a year due to my asthma and frequent illness. Since taking it, I've only been ill once in the past year, as it has bolstered my immune system. I highly recommend this product!

Autoimmune Disorder details

Zinc supplementation benefits MS models

Based on 6 Researches

Bayiroglu AF, Acar G, Gulbahce-Mutlu E, Baltaci SB, Mogulkoc R, et al. Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model. J Trace Elem Med Biol. 2024;86:127540. doi:10.1016/j.jtemb.2024.127540

We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.

After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.

Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.

9.5

Aids conception

Most Useful Review

I ordered zinc picolinate to improve my husband's sperm quality when we faced conceiving challenges. After three months of use with other vitamins, he had noticeable improvements. I recommend this supplement for those struggling with male-factor infertility; it worked for us when we wanted to conceive.

Bone Pain details

Zinc plays a crucial role in various bodily processes, including the prevention of inflammatory conditions and support for bone and teeth strength, which is essential for overall wellness.

Bronchitis details

Zinc accelerates bronchiolitis recovery

Mahyar A, Ayazi P, Ahmadi NK, Pour Nikoo ST, Hamzehloo S, et al. Zinc sulphate for acute bronchiolitis: A double-blind placebo-controlled trial. Infez Med. 2016;24:331.

We investigated the effectiveness of zinc sulphate in treating acute bronchiolitis in children, aiming to uncover whether this supplement could help speed recovery. In our study, we closely examined 100 young patients diagnosed with the condition. Half of the children received oral zinc sulphate while the other half received a placebo.

Over the course of the treatment, we compared the clinical signs and symptoms between the two groups at several intervals: 24, 48, 72, 96, and 120 hours after starting. Encouragingly, we observed that those in the zinc group showed a more favorable trend in recovery compared to the placebo group across all time points. Notably, significant differences were noted in improvements of coughing and wheezing at the 48 and 72-hour marks.

Remarkably, we found that 98% of the children who received zinc sulphate achieved full recovery within 72 hours of treatment—indicating a rapid response to the therapy. Our findings suggest that zinc sulphate can notably accelerate the improvement of clinical symptoms in acute bronchiolitis. Therefore, we feel confident recommending zinc sulphate as a helpful treatment option for this condition.

8.8

Improved immunity

Most Useful Review

At the first signs of a cold, I found zinc invaluable. It has been a part of our family’s regimen for years, especially as my eldest son previously suffered from severe illnesses, including bronchitis. Now, our family's health has significantly improved. I do divide the capsule for my children during illness and take it regularly during the cold season for prevention.

Eczema details

Crisóstomo M, Santos MC, Tavares E, Cunha F. Transient symptomatic zinc deficiency in an exclusively breastfed infant. BMJ Case Rep. 2021;14. doi:10.1136/bcr-2021-241754

Zinc enhances eczema recovery

We investigated the relationship between zinc deficiency and eczema in a 3-month-old infant who was exclusively breastfed. The infant presented with symptoms like scaling erythematous dermatitis affecting her face and other areas, alongside irritability and poor weight gain. Her mother had been taking isoniazid for tuberculosis during pregnancy, which possibly contributed to the infant’s zinc deficiency.

After initial treatments for a suspected skin infection didn’t bring any changes, we found that the baby had low serum zinc levels and low zinc concentration in her breast milk. This led us to believe the skin condition was due to zinc deficiency rather than an infection. We started zinc supplementation, and the infant showed remarkable improvement in her skin condition and weight.

By 6 months, the infant had begun eating solid food, and we stopped the zinc supplements, with no signs of eczema returning. This case underscores the importance of monitoring zinc levels in breastfed infants, especially when mothers are on specific medications that might impact nutrient transfer through breast milk.

Notable skin improvement

Most Useful Review

I am really pleased so far! I've noticed that the eczema on my face has vanished completely, leaving my skin feeling more supple and plump. Additionally, breakouts have considerably decreased. Though it’s been a few weeks, I haven’t tracked any changes with my hair yet. I took before pictures, so we shall see. I'm also taking flaxseed oil pills for hair and skin, which I adore for promoting hair growth, but for now, the zinc seems to be more effective for my skin!

Heart Disease details

Zinc benefits heart health post-cisplatin

Based on 4 Researches

Al-Lbban AM. Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats. Braz J Biol. 2025;84:e287764. doi:10.1590/1519-6984.287764

We explored the potential benefits of zinc oxide nanoparticles (ZnONPs) in preventing heart damage caused by cisplatin, a powerful chemotherapy drug known for its efficacy but also for its side effects, particularly cardiotoxicity.

In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.

As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.

Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.

8.3

Heart symptoms improved

Most Useful Review

The quality of California Gold Nutrition is trustworthy. After a month of use, I noticed improvements including reduced cholesterol and better hair health. My heart feels relieved, and the general immunity has improved significantly. I recommend giving it a try without fear.

Knee Pain details

Effective immunity support

Vitamin for immunity I purchased for the cold season as advised by my doctor. Recently, I began to feel unwell and took one capsule daily for two days, which alleviated my symptoms. My immunity managed well. I have now ordered a lower dosage of zinc picolinate for my child. This was bought specifically for short-term support during the cold season, and I intend to undergo tests after a course.

Psoriasis details

Zinc conditioner benefits scalp psoriasis

Yu C, Yu N, Jiang X, Gao X, Lv S, et al. Efficacy and safety of supramolecular active zinc in the treatment of scalp psoriasis: a multicentre, randomized, observed-blind, parallel-group, placebo- and active-controlled noninferiority trial. Clin Exp Dermatol. 2023;48:1138. doi:10.1093/ced/llad168

We delved into the effectiveness of a zinc-based hair conditioner specifically designed for treating scalp psoriasis. This study was a well-structured clinical trial involving 211 participants, where individuals were divided into three groups: those receiving the specialized zinc treatment, a placebo, and a control group given calcipotriol ointment. Remarkably, the trial was multicenter and observed-blind, which adds credibility to the findings.

Our results revealed that the zinc conditioner led to a 39% disease control rate after four weeks, compared to 25% for the placebo and 37% for the calcipotriol ointment group. This means that the zinc treatment significantly outperformed the placebo while being on par with the active control variant. In essence, those using the zinc product experienced better management of their scalp psoriasis than those using a non-active alternative.

Overall, our findings highlight that a supramolecular active zinc antidandruff formulation is not just effective for treating scalp psoriasis but also helps in maintaining results over time and potentially preventing future flare-ups. This offers a promising new avenue for patients seeking relief from this chronic condition.

9.5

Psoriasis relief

Most Useful Review

I've taken zinc for three years; it's been instrumental for my psoriasis management. During flare-ups, I take a daily tablet, and the itching and redness have drastically reduced, with several spots cleared up completely.

Allergies details

Xu H, Tong K, Iwasaki N, Ohgami N, Tazaki A, et al. Alleviating effect of intranasal zinc on symptoms of allergic rhinitis. J Allergy Clin Immunol Glob. 2025;4:100408. doi:10.1016/j.jacig.2025.100408

Zinc may relieve allergy symptoms

We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.

Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.

The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.

Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.

9.5

Skin condition improvement

Most Useful Review

I bought these pills for my atopic dermatitis. After struggling with various treatments, I tried zinc picolinate, as it’s better absorbed. Amazingly, the itching has now gone, and my skin is no longer dry. My husband even remarked on how delicate my skin looks!

Candidiasis details

Zinc's preventive role in candidiasis

Based on 6 Researches

Roselletti E, Pericolini E, Nore A, Takacs P, Kozma B, et al. Zinc prevents vaginal candidiasis by inhibiting expression of an inflammatory fungal protein. Sci Transl Med. 2023;15:eadi3363. doi:10.1126/scitranslmed.adi3363

We set out to understand how zinc impacts vaginal candidiasis, a common condition affecting millions. The research highlighted that the fungus responsible for this infection responds to low zinc levels by producing a protein called Pra1. This protein is linked to inflammation and worsens symptoms of the infection.

Our findings revealed that increased levels of Pra1 corresponded to higher amounts of inflammatory markers in women with recurrent infections. By genetically altering mice to eliminate Pra1, we successfully reduced vaginal inflammation in these models. Moreover, when we applied a zinc solution, we noticed a decrease in Pra1 and a mitigation of inflammatory responses.

Excitingly, our research extended to women suffering from recurring infections, showing that using a zinc gel not only alleviated symptoms but also prevented reinfections. This opens doors for preventive strategies that leverage zinc’s ability to modulate inflammation, targeting the root cause of painful symptoms.

9.5

Essential for immune support

Most Useful Review

I adore this zinc due to its large dosage of 50 mg (that's the maximum per day). The picolinate form is ideal for quick and effective absorption. Its price is reasonable as not everything is affordable. Many amino acids and substances like zinc are inexpensive to produce. Zinc from Nau performs exceptionally well. Before I drink alcohol, I take NAC, zinc, vitamin C, and B vitamins since alcohol metabolism relies on zinc-dependent enzyme alcohol dehydrogenase. Zinc is crucial during "anti" courses (anti-parasitic, anti-Candidiasis, etc.), as most immune reactions depend on it. I consistently give zinc to my child during illness, and it is vital for men's health. The appearance of white spots on nails indicates a zinc deficiency.

Chronic Fatigue Syndrome details

Zinc supplementation may benefit CFS

Maes M, Mihaylova I, De Ruyter M. Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS. J Affect Disord. 2006;90:141.

We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.

Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.

Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.

9.5

Zinc improves wellbeing

Most Useful Review

This zinc is fantastic! After a month of use, I've experienced positive changes, especially regarding my chronic fatigue syndrome. My anxiety has lessened, cravings decreased, and my skin and nails have improved significantly. I feel healthier overall!

Depression details

Zinc deficiency impacts brain function

Gąsior Ł, Pochwat B, Zaręba-Kozioł M, Włodarczyk J, Grabrucker AM, et al. Proteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency. Pharmacol Rep. 2025;77:145. doi:10.1007/s43440-024-00681-7

We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.

We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.

Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.

These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health.

9.5

Improves mood

Most Useful Review

I've been taking zinc picolinate for several months as a preventive measure against depression. It has helped me manage my anxiety and irritability due to stress, leaving me feeling calmer, more confident, and productive.

Diabetes details

Zinc alleviates diabetic muscle atrophy

Yu X, Chen X, Wu W, Tang H, Su Y, et al. Zinc Alleviates Diabetic Muscle Atrophy via Modulation of the SIRT1/FoxO1 Autophagy Pathway Through GPR39. J Cachexia Sarcopenia Muscle. 2025;16:e13771. doi:10.1002/jcsm.13771

Our investigation aimed to understand how zinc affects muscle atrophy in diabetes, a serious complication that leads to muscle loss. Using diabetes-induced mice, we treated them with zinc sulfate for six weeks and observed notable improvements in their muscle condition.

We conducted various analyses to evaluate the impact of zinc on autophagy—the process that helps manage muscle mass. The results were promising; zinc appeared to enhance muscle recovery by regulating specific molecular pathways connected to muscle health.

Additionally, our in vitro studies with diabetic muscle cells revealed similar results, with zinc supplementation proving beneficial in reducing excessive autophagy. Overall, this suggests that incorporating zinc into treatment plans could be a promising approach to counteract muscle deterioration in diabetic patients.

9.5

Supports diabetes management

Most Useful Review

This supplement significantly improved my health regarding diabetes in just a month. I plan to repurchase as it's greatly helped me manage my condition.

Irritable Bowel Syndrome details

Zinc intake may reduce IBS risk

Zhuang Y, Li L, Ran Y, Zhang Y, Chen J, et al. Dietary copper, zinc, copper/zinc ratio intakes and irritable bowel syndrome risk: a large-scale prospective cohort study from UK Biobank. Am J Epidemiol. 2024. doi:10.1093/aje/kwae412

We explored the potential connection between dietary zinc intake and the risk of developing irritable bowel syndrome (IBS) through a large-scale analysis of participants from the UK Biobank. By assessing the dietary habits of 175,421 individuals who did not have IBS at the start of the study, we sought to understand how various levels of zinc, as well as copper and their ratio, might influence the onset of this troublesome condition.

Over an average follow-up period of 13.3 years, we observed that 2,240 participants were diagnosed with new-onset IBS. Notably, our findings revealed a U-shaped relationship between zinc intake and IBS incidence. For those consuming less than 10 mg of zinc per day, an increase in intake was linked to a decreased risk of IBS. Specifically, individuals taking less than 10 mg of zinc daily experienced a reduced risk with higher zinc consumption.

However, the relationship shifted for individuals who had higher intakes of copper and zinc; no significant benefits were noted when intakes reached or exceeded established thresholds. This suggests that there's a delicate balance to maintain when it comes to zinc and copper in the diet.

Importantly, subgroup analysis indicated that younger individuals, particularly those under 60, could benefit more from slight increases in zinc. Overall, our study highlights the significance of dietary management, emphasizing that reasonable zinc intake may contribute to lowering IBS risk while keeping copper and the copper/zinc ratio in a sensible range.

Improved immune system

Most Useful Review

Excellent zinc! I’ve been using it for about a month and noticed positive changes. It has calmed my nerves, and I’ve even lost my craving for sweets. My hair loss has decreased, skin condition improved, and nails strengthened. While I cannot speak on all fronts, I take it after meals to avoid nausea. The capsule is small, easy to take, and I appreciate the quality and reasonable price from iHerb.

Pancreatitis details

Helpful for pancreatitis

Zinc is crucial, especially for pancreatitis and diabetes. I take 40-100 mg (2-5 tablets) daily with meals and alternate between a couple of months of use and breaks.

Reflux details

Relieved reflux symptoms

A nutritionist informed me that zinc can enhance gastric acid secretion. A deficiency in gastric acid may lead to malabsorption of trace elements, proteins, and vitamins, resulting in health issues. I experience reflux and decided to supplement with zinc picolinate, which the nutritionist recommended as the best option. After taking it for some time, my reflux has improved. I plan to continue this supplement to further boost gastric acid production and support my nutrition.

Tonsillitis details

Zinc in supplement reduces tonsillitis symptoms

Cardinale F, Barattini DF, Martinucci V, Bordea MM, Barattini L, et al. The Effectiveness of a Dietary Supplement with Honey, Propolis, Extract, and Zinc in Children Affected by Acute Tonsillopharyngitis: An Open, Randomized, and Controlled Trial. Pharmaceuticals (Basel). 2024;17. doi:10.3390/ph17060804

This study took a closer look at the effects of a dietary supplement, PediaFlù, which includes honey, propolis, and zinc, on children suffering from acute tonsillopharyngitis, a common throat infection. We explored how well this supplement worked alongside standard care compared to standard care alone over six days.

The results were quite encouraging! We found that children who received the supplement alongside standard treatment reported lower throat pain and erythema (redness of the throat) by day six. There were also improvements in swallowing and overall throat severity scores by days four and six. Interestingly, only one child in the standard care group needed additional treatment with ibuprofen, suggesting that the supplement may help alleviate symptoms effectively.

However, it's important to note that while zinc was part of this combination treatment, the study focused on the overall effect of all components together. We couldn't isolate zinc's individual impact on tonsillitis specifically. That said, the findings point to the possibility of using this dietary supplement as a helpful adjunct in treating upper respiratory tract infections, which may reduce unnecessary antibiotic use in pediatric care.

9.5

Stronger nails

Most Useful Review

I didn't expect much, mainly wanting to reduce the frequency of tonsillitis episodes. However, my hair has stopped falling out, now shining beautifully. My nails, which often broke, have become stronger and are growing quickly.

Cardiovascular Disease details

Guo J, Ma T, Wang B, Xing B, Huang L, et al. Zn protects H9C2 cardiomyocytes by alleviating MAMs-associated apoptosis and calcium signaling dysregulation. Cell Signal. 2025;127:111629. doi:10.1016/j.cellsig.2025.111629

Zinc counters heart cell injury

We set out to investigate how zinc might help protect heart cells from damage caused by a lack of blood flow, known as myocardial ischemia-reperfusion injury (MIRI). Using H9C2 cells, which are derived from rat heart tissue, we simulated this injury by depriving these cells of oxygen and then reintroducing it while treating them with zinc.

Through this process, we found that zinc treatment significantly increased cell viability compared to those that did not receive zinc. Cells exposed to ischemia showed typical signs of trauma, like heightened levels of apoptosis—or programmed cell death—and calcium overload, which can further damage cells.

Interestingly, zinc seemed to tackle these issues by lowering the levels of certain proteins related to cell death. It also played a role in regulating calcium levels by interacting with various cellular pathways. In fact, when we silenced specific proteins involved in these pathways, the protective benefits of zinc were even more pronounced.

Our findings suggest that zinc can relieve the harmful effects of ischemia by mitigating cell death and regulating calcium overload, which offers hope for future treatments for heart-related conditions impacted by blood flow interruptions.

Glucose metabolism support

Most Useful Review

Ok, I started taking it as it is beneficial for glucose metabolism. I haven't noticed significant changes yet, but I appreciate how easily I can take it alongside my supplements.

Hypothyroidism details

Zinc's uncertain role in hypothyroidism

Nikkhah M, Vafa M, Abiri B, Golgiri F, Sarbakhsh P, et al. The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial. Med J Islam Repub Iran. 2024;38:133. doi:10.47176/mjiri.38.133

We conducted a study to investigate the effects of micronutrient supplementation, including zinc, on thyroid function and overall quality of life in patients with hypothyroidism. Our trial involved 104 participants who were receiving levothyroxine and vitamin D. They were randomly assigned to either a group that received a mix of essential nutrients or a placebo group over eight weeks.

We measured various health markers before and after this period, including thyroid hormone levels, cholesterol, insulin resistance, and blood pressure. Our findings suggested that the group receiving the micronutrient supplement experienced improvements in insulin resistance and overall quality of life. However, it’s important to note that the specific effects of zinc alone are somewhat difficult to isolate, as it was part of a combination of nutrients being tested.

Ultimately, while the study indicates potential benefits of micronutrient supplementation for thyroid function in hypothyroid patients, further trials are necessary to clearly define the role of zinc and other nutrients in this context.

7.5

Prevented hormone decline

Most Useful Review

I bought this after learning that zinc aids in improving and preventing hypothyroidism. I previously took thyroxine for years, but since starting this supplement, my thyroid hormone levels have remained normal. Zinc also boosts immunity and protects against infections. I manage intake carefully to avoid side effects.

Ulcer details

Hayashi A, Taki Y, Arai K, Sato S, Higashizono K, et al. Esophageal ulcer related to zinc deficiency following a total gastrectomy. Nutrition. 2023;110:111999. doi:10.1016/j.nut.2023.111999

Based on 16 Researches

Zinc helps heal esophageal ulcers

We delved into an interesting case of a 76-year-old man who developed severe esophageal ulcers, likely due to zinc deficiency following a total gastrectomy. His symptoms included sore throat, heartburn, and difficulty swallowing.

After the diagnosis of zinc deficiency, he began oral zinc treatment. Remarkably, this led to significant symptom relief and visible healing of the ulcers during follow-up imaging. Impressively, he has maintained his zinc supplementation for five years without any recurrence of symptoms. This unique case shines a light on the potential role of zinc in ulcer healing.

9.5

Ulcer improvement noted

Most Useful Review

After starting this product due to my zinc deficiency and mouth ulcers, I noticed my ulcers subsided within a week. I'm thrilled with the results!

Hashimoto details

Zinc's link to Hashimoto's thyroiditis

Rostami R, Beiranvand A, Nourooz-Zadeh S, Rostami M, Mohammadi A, et al. Association Between Essential Trace Elements and Thyroid Antibodies in the Blood of Women with Newly Diagnosed Hashimoto's Thyroiditis. Int J Endocrinol Metab. 2024;22:e145599. doi:10.5812/ijem-145599

We explored the connection between essential trace elements, particularly zinc, and Hashimoto’s thyroiditis (HT) in women who were newly diagnosed. In this study, we looked at a group of 56 women with HT and compared them to 64 matched controls.

The results showed that women with HT had significantly lower levels of selenium, iron, and zinc in their blood compared to the controls. Interestingly, their copper levels were higher. We examined the relationships between these trace elements and thyroid autoantibodies, which can indicate the presence of autoimmune activity affecting the thyroid.

While we noted a significant correlation between lower zinc (and other elements) and higher levels of thyroid antibodies, the study did not specifically focus on zinc treatment. This means that while zinc levels appear to be linked to autoantibody levels in HT, we can't definitively state that zinc treatment will improve the condition without further dedicated research.

Overall, the study indicates that lower zinc levels in conjunction with selenium and iron deficiencies might be involved in the autoimmune response seen in Hashimoto’s thyroiditis. Thus, this provides an avenue for future exploration into zinc's role as a potential supplement for women diagnosed with this condition.

9.5

Improves cold tolerance

Most Useful Review

This excellent drug is well absorbed. When I catch a cold, I find I endure it easily. I have Hashimoto's, hypothyroidism, and I require zinc continually.

Menopause details

Zinc enhances vitamin D in menopause

Vázquez-Lorente H, Molina-López J, Herrera-Quintana L, Gamarra-Morales Y, López-González B, et al. Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial. J Trace Elem Med Biol. 2021;65:126730. doi:10.1016/j.jtemb.2021.126730

We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.

Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.

Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.

Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.

8.8

Energy boost

Most Useful Review

As a 63-year-old male, I began taking this due to a decline in energy and male function, which I attribute to menopause. The capsules are easy to swallow, and I noticed immediate effects. I have been using them daily since their arrival, and the packaging is compact.

Low Libido details

Essential mineral benefits

Zinc is a vital mineral involved in numerous bodily processes. It regulates the synthesis of crucial hormones such as testosterone and oestrogen in women, increases libido, aids conception issues, enhances sleep quality, and strengthens immunity. It helps regulate mood and improves skin quality for those with conditions like psoriasis and eczema, while also enhancing hair growth and reducing chronic inflammation. Care should be taken with dosage, as overdose can lead to toxicity. Picolinate is among the best zinc forms.

Heartburn details

Hayashi A, Taki Y, Arai K, Sato S, Higashizono K, et al. Esophageal ulcer related to zinc deficiency following a total gastrectomy. Nutrition. 2023;110:111999. doi:10.1016/j.nut.2023.111999

Zinc's role in heartburn relief

We investigated how zinc affects heartburn through the case of a 76-year-old Japanese man who experienced significant discomfort after undergoing a total gastrectomy. For two weeks, he suffered from a sore throat, heartburn, and difficulty swallowing. Endoscopy revealed deep, craterlike ulcers in his esophagus, but tests for viral infections were negative.

After initial treatment, his symptoms returned, prompting further investigation. Eventually, we found that his serum zinc level was low at 38 µg/dL, which led to a diagnosis of zinc deficiency. Following oral zinc supplementation, the patient reported relief from his symptoms and a noticeable improvement in the esophageal ulcers observed during a follow-up endoscopy.

Over the five years since his treatment, the patient has continued to take zinc supplements and has not faced similar issues again. This case suggests that zinc can play a crucial role in treating heartburn issues related to ulcers, especially in those with a deficiency.

Supports wound healing

Most Useful Review

A must for wound healing. After extensive research, I chose picolinate and have no regrets. It alleviates heartburn and is essential for those with a compromised immune system, alongside vitamin C like sodium ascorbate powder.

Indigestion details

Zinc-enhanced therapy improves eradication

Ibrahim N, El Said H, Choukair A. Zinc carnosine-based modified bismuth quadruple therapy standard triple therapy for eradication: A randomized controlled study. World J Clin Cases. 2022;10:227. doi:10.12998/wjcc.v10.i1.227

We explored the effectiveness of a modified bismuth quadruple therapy that includes zinc carnosine, in comparison to the traditional triple therapy for treating indigestion caused by Helicobacter pylori infection. In our study, 92 patients with symptoms of dyspepsia and positive breath tests were randomly assigned to receive either the conventional treatment of esomeprazole, amoxicillin, and clarithromycin for 14 days, or a shorter 10-day course of the new therapy that also included bismuth subcitrate and zinc carnosine.

The results were quite revealing. Our findings showed that the modified bismuth quadruple therapy group had a significantly higher eradication rate of 93.5%, compared to 69.6% in the standard treatment group. This suggests that the addition of zinc carnosine to the treatment regimen could enhance the effectiveness of indigestion relief. Importantly, the side effects reported between the two groups were similar, with only mild dizziness noted in those receiving the new therapy.

Overall, the study indicates that a shorter course of therapy that includes zinc carnosine may be a superior option for individuals suffering from indigestion related to Helicobacter pylori. This approach not only appears to work better but also does not lead to more serious side effects, making it an appealing alternative to traditional treatment methods.

Improved wellbeing

Most Useful Review

This is the only zinc picolinate that does not cause me indigestion or nausea, especially on an empty stomach. I love it! I feel a difference within hours of taking it – feeling calmer and overall better.

Nausea details

Asaoka D, Ishihara T, Ezoe S, Hamada I, Kitamura M, et al. Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia. J Trace Elem Med Biol. 2025;87:127558. doi:10.1016/j.jtemb.2024.127558

Based on 4 Researches

Zinc treatment reduces nausea risk

We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.

For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.

Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.

9.5

No nausea experienced

Most Useful Review

This zinc is exceptional and far better than the expensive duds sold in pharmacies. I experienced no nausea or stomach pain with this product, unlike others. I recommend taking it during meals, and I've noticed positive effects on my skin and hair. Just avoid taking it with calcium for best results.

Anemia details

Inoue M. Zinc Deficiency Presenting With Diverse Symptoms in a Young Patient: A Case Report. Cureus. 2024;16:e66034. doi:10.7759/cureus.66034

Zinc deficiency linked to anemia

We explored the connection between zinc deficiency and anemia through the case of an 18-year-old woman who faced a series of health issues, including urinary tract infections and insulin dysfunction. After a thorough assessment, she was diagnosed with zinc deficiency, shedding light on how this overlooked issue can impact overall health.

What stood out to us was the rapid recovery the patient experienced after beginning oral zinc supplementation. Zinc plays a critical role in numerous bodily functions, including immune support and protein regulation. By addressing her deficiency, we observed significant improvement in her symptoms, including anemia.

The patient’s diet contained high levels of substances that were inhibiting her zinc absorption, which likely contributed to her condition. This case emphasizes the importance of recognizing zinc deficiency as a potential underlying cause for unexplained health issues, particularly anemia. Prompt diagnosis and treatment can lead to a complete turnaround in the patient's health.

By sharing this experience, we hope to raise awareness among clinicians about the vital role of zinc in managing anemia and encourage timely interventions for patients showing diverse symptoms.

8.8

Improved immunity

Most Useful Review

One of the best forms of zinc. The capsule size is average and easy to swallow. I noticed significant improvements; my hair grows faster, my skin looks healthier, and my sebum production has decreased. Additionally, my immunity has enhanced, and I no longer catch colds from my sick child. However, it's essential not to overdo it, as too much zinc can lead to copper deficiency and subsequent anaemia.

Dizziness details

Zinc's limited effect on dizziness

Libonati GA, Leone A, Martellucci S, Gallo A, Albera R, et al. Prevention of Recurrent Benign Paroxysmal Positional Vertigo: The Role of Combined Supplementation with Vitamin D and Antioxidants. Audiol Res. 2022;12:445. doi:10.3390/audiolres12040045

This study examined the effectiveness of a nutritional supplement containing zinc, among other ingredients, in preventing the recurrence of benign paroxysmal positional vertigo (BPPV), a condition that can cause intense dizziness. We followed a diverse group of 128 patients with a history of frequent BPPV episodes. They were divided into three groups based on their vitamin D levels and received different treatment plans.

In one group, those with low vitamin D received a daily supplement containing zinc, along with other antioxidants and vitamin D3. We noticed a remarkable decrease in BPPV relapses in this group after six months compared to where they started. However, for the groups that had sufficient vitamin D and particularly those receiving zinc without vitamin D, we did not find significant benefits in reducing dizziness recurrence.

While zinc was part of a combined treatment approach, it didn’t demonstrate a standalone positive impact on dizziness. Our findings suggest that while zinc might play a role alongside other supplements, it shouldn't be solely relied upon for preventing BPPV relapses in patients with sufficient vitamin D levels.

9.5

Reduced dizziness

Most Useful Review

Excellent! I used to feel nauseous with other zinc types, but switching to picolinate salt has meant I can take it without experiencing dizziness or discomfort.

Back Pain details

Bhardwaj A, Swe KMM, Sinha NK. Treatment for osteoporosis in people with beta-thalassaemia. Cochrane Database Syst Rev. 2023;5:CD010429. doi:10.1002/14651858.CD010429.pub3

Zinc may boost bone density

We explored how zinc supplementation might help with back pain in individuals with beta-thalassaemia. The research included a randomized controlled trial with 42 participants, where some received zinc while others were given a placebo.

Results showed that zinc supplementation likely increased the bone mineral density (BMD) at the lumbar spine and hip after 12 to 18 months of treatment. This improvement in bone health could suggest potential benefits in pain relief, although the study didn’t directly measure back pain outcomes.

Even though the findings about BMD improvements are promising, we should be cautious. The trial didn't provide direct evidence on whether zinc specifically alleviates back pain. It’s essential to recognize that while we observed positive changes in bone density, interpreting this as a definitive solution for back pain would be premature.

Thus, further research is necessary to connect zinc's effects on bone health to actual pain relief in order to offer clearer guidance on its use as a treatment for back pain.

Great improvement

Most Useful Review

I took this vitamin alongside others for my father, who experienced a significant improvement, particularly regarding back pain, stress, and fatigue. After researching, I found the ingredients to be of high quality. May everyone enjoy good health.

Liver Disease details

Chim SM, Howell K, Dronzek J, Wu W, Van Hout C, et al. Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings. Elife. 2024;12. doi:10.7554/eLife.90419

Zinc's Role in Liver Health

We focused on the connection between zinc and liver health, particularly how it may influence conditions like non-alcoholic fatty liver disease (NAFLD) and metabolic issues, including type II diabetes (T2D). Our analysis of data from a large genetics cohort revealed a significant finding: rare genetic variants that reduce the function of the zinc transporter SLC39A5 were linked to better metabolic profiles and lower T2D risk.

To delve deeper into these results, we used both laboratory and animal models. We developed mice that completely lacked SLC39A5 and observed promising outcomes. These mice showcased improved liver function and lower blood sugar levels after being subjected to obesity challenges, whether congenital or diet-induced.

Notably, this improvement seemed to be associated with increased levels of zinc in the liver, which activated key signaling pathways involved in metabolism, such as AMPK and AKT. Furthermore, these mice exhibited less liver inflammation and fibrosis in models of diet-induced non-alcoholic steatohepatitis (NASH).

Together, these findings position SLC39A5 as a potentially valuable target for treating liver-related metabolic disorders, emphasizing zinc's crucial role in managing liver health and blood sugar regulation.

9.5

Effective during illness

Most Useful Review

For a year, I’ve taken this zinc as advised by a trichologist, and I’m pleased with the results, particularly during the coronavirus period. My relatives now take it too. When unwell, it helps me recover from illness rapidly, including concerns related to liver disease.

Food Poisoning details