Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.4
USERS' SCORE
Good
Based on 16 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Proprietary Probiotic BlendProviding 1 billion CFUBifidobacterium longum BB536, HOWARU® Lactobacillus acidophilus NCFM®
11 mg
**
Top Medical Research Studies
9
Lactobacillus improves bloating symptoms
We conducted a double-blind, placebo-controlled trial to assess how Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 affect bloating in patients with functional bowel disorders.
Over eight weeks, patients reported a noticeable improvement in abdominal bloating when taking probiotics compared to those on a placebo.
Notably, results showed significant relief at four weeks and continued improvement by eight weeks, especially among those with irritable bowel syndrome. This suggests probiotics could be beneficial in managing bloating symptoms.
Over eight weeks, patients reported a noticeable improvement in abdominal bloating when taking probiotics compared to those on a placebo.
Notably, results showed significant relief at four weeks and continued improvement by eight weeks, especially among those with irritable bowel syndrome. This suggests probiotics could be beneficial in managing bloating symptoms.
Read More
9
Lactobacillus acidophilus reduces bloating
We examined how Lactobacillus acidophilus can help treat bloating in patients with dyspepsia due to imbalances in gut bacteria. In a study involving 30 participants, symptoms such as pain, pressure, and bloating were self-reported while objective measures like bowel movements and weight changes were also tracked.
Those affected by antibiotic-induced dysbiosis experienced rapid relief within days. Improvements were noted in symptoms of maldigestion over a week, and remarkable results were observed in patients with radiation enterocolitis. Overall, this probiotic showed promise for alleviating digestive discomfort without notable side effects.
Those affected by antibiotic-induced dysbiosis experienced rapid relief within days. Improvements were noted in symptoms of maldigestion over a week, and remarkable results were observed in patients with radiation enterocolitis. Overall, this probiotic showed promise for alleviating digestive discomfort without notable side effects.
Read More
4
We used a rigorous clinical trial to investigate the impact of Lactobacillus acidophilus on bloating and other IBS symptoms. Involving 80 patients diagnosed with IBS, we followed a double-blind, placebo-controlled approach over eight weeks.
While the treatment did not significantly relieve abdominal pain, we noted a marked decrease in flatus and overall symptom scores at eight weeks. This suggests that while lactobacillus acidophilus may not help with all IBS symptoms, it could be beneficial for reducing bloating-related discomfort.
While the treatment did not significantly relieve abdominal pain, we noted a marked decrease in flatus and overall symptom scores at eight weeks. This suggests that while lactobacillus acidophilus may not help with all IBS symptoms, it could be beneficial for reducing bloating-related discomfort.
Read More
Most Useful Reviews
9
Bloating resolved
141 people found this helpful
GREAT! Wish I had tried these years ago! After suffering from various digestive issues, I decided to try Pearls, and the difference is remarkable. Within two days, bowel regularity improved, bloating was gone, and my nausea significantly decreased. I now take it once in the morning and once after dinner, reducing my reliance on acid blockers, which can worsen constipation. I highly recommend trying Pearls for anyone with similar issues; they are worth the investment.
Read More
9
Effective for bloating
24 people found this helpful
These probiotics have been the most effective I've used. Despite trying various brands, I always return to these. I’ve found they significantly improve my digestive system, alleviating bloating, irregularity, and GIRD. While I’ve had Crohn's for about 40 years and opinions on probiotics vary, this brand has proven beneficial for me. They do interfere with certain medications, so consult your doctor if needed. Thank you for reading.
Read More
9
Works wonders
7 people found this helpful
These probiotics have significantly eased my IBS symptoms. I often bloat and feel uncomfortable after eating, yet taking one daily has made a noticeable difference. Even indulgent foods no longer affect me greatly. If I forget to take it, I immediately feel uncomfortable and irregular.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.4
- All Researches
9
Lactobacillus improves bloating symptoms
We conducted a double-blind, placebo-controlled trial to assess how Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 affect bloating in patients with functional bowel disorders.
Over eight weeks, patients reported a noticeable improvement in abdominal bloating when taking probiotics compared to those on a placebo.
Notably, results showed significant relief at four weeks and continued improvement by eight weeks, especially among those with irritable bowel syndrome. This suggests probiotics could be beneficial in managing bloating symptoms.
Over eight weeks, patients reported a noticeable improvement in abdominal bloating when taking probiotics compared to those on a placebo.
Notably, results showed significant relief at four weeks and continued improvement by eight weeks, especially among those with irritable bowel syndrome. This suggests probiotics could be beneficial in managing bloating symptoms.
Read More
9
We conducted a study examining the effects of a novel symbiotic treatment, SCM-III, on patients with irritable bowel syndrome (IBS). Sixty-eight adults were divided into two groups—one received SCM-III and the other a heat-inactivated version, both for 12 weeks.
Our findings showed that most patients reported significant improvements in bloating and abdominal pain compared to a control group. Over 80% felt the treatment was effective, while less than 5% labelled it ineffective.
Overall, this suggests that certain IBS patients could greatly benefit from symbiotic treatments like SCM-III, though it may require a cyclic use for best results.
Our findings showed that most patients reported significant improvements in bloating and abdominal pain compared to a control group. Over 80% felt the treatment was effective, while less than 5% labelled it ineffective.
Overall, this suggests that certain IBS patients could greatly benefit from symbiotic treatments like SCM-III, though it may require a cyclic use for best results.
Read More
9
Lactobacillus acidophilus reduces bloating
We examined how Lactobacillus acidophilus can help treat bloating in patients with dyspepsia due to imbalances in gut bacteria. In a study involving 30 participants, symptoms such as pain, pressure, and bloating were self-reported while objective measures like bowel movements and weight changes were also tracked.
Those affected by antibiotic-induced dysbiosis experienced rapid relief within days. Improvements were noted in symptoms of maldigestion over a week, and remarkable results were observed in patients with radiation enterocolitis. Overall, this probiotic showed promise for alleviating digestive discomfort without notable side effects.
Those affected by antibiotic-induced dysbiosis experienced rapid relief within days. Improvements were noted in symptoms of maldigestion over a week, and remarkable results were observed in patients with radiation enterocolitis. Overall, this probiotic showed promise for alleviating digestive discomfort without notable side effects.
Read More
We conducted a rigorous study to see how probiotic CECT 7347 (ES1) and its heat-treated version (HT-ES1) could help adults with diarrhea-predominant irritable bowel syndrome (IBS-D).
With 200 participants, we divided them into three groups, administering either the probiotic, the heat-treated version, or a placebo over 12 weeks.
Both ES1 and HT-ES1 showed significant improvements in symptom severity compared to placebo, making them promising options for those seeking relief from IBS-D symptoms.
With 200 participants, we divided them into three groups, administering either the probiotic, the heat-treated version, or a placebo over 12 weeks.
Both ES1 and HT-ES1 showed significant improvements in symptom severity compared to placebo, making them promising options for those seeking relief from IBS-D symptoms.
Read More
9
We examined the impact of Bifidobacterium longum BB536 combined with Lactobacillus rhamnosus HN001 on bloating in individuals with irritable bowel syndrome (IBS). In a controlled trial with 25 participants, we found that those treated with this probiotic formulation experienced a significant reduction in bloating, with a 36.35% decrease compared to an increase of 7.35% in the placebo group.
The treatment also led to improvements in abdominal pain and overall disease severity, pointing to its potential as an effective therapy for IBS symptoms.
The treatment also led to improvements in abdominal pain and overall disease severity, pointing to its potential as an effective therapy for IBS symptoms.
Read More
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Bloating resolved
141 people found this helpful
GREAT! Wish I had tried these years ago! After suffering from various digestive issues, I decided to try Pearls, and the difference is remarkable. Within two days, bowel regularity improved, bloating was gone, and my nausea significantly decreased. I now take it once in the morning and once after dinner, reducing my reliance on acid blockers, which can worsen constipation. I highly recommend trying Pearls for anyone with similar issues; they are worth the investment.
Read More
9
Effective for bloating
24 people found this helpful
These probiotics have been the most effective I've used. Despite trying various brands, I always return to these. I’ve found they significantly improve my digestive system, alleviating bloating, irregularity, and GIRD. While I’ve had Crohn's for about 40 years and opinions on probiotics vary, this brand has proven beneficial for me. They do interfere with certain medications, so consult your doctor if needed. Thank you for reading.
Read More
9
Works wonders
7 people found this helpful
These probiotics have significantly eased my IBS symptoms. I often bloat and feel uncomfortable after eating, yet taking one daily has made a noticeable difference. Even indulgent foods no longer affect me greatly. If I forget to take it, I immediately feel uncomfortable and irregular.
Read More
9
Highly effective
6 people found this helpful
Noticeable Results! These little pearls are significantly more effective than probiotic yogurts or drinks. Within 24 hours, they helped with my bloating and related issues that I’ve dealt with for nearly a decade. I should have started these sooner to replenish my gut flora! They work exceptionally well for beginners to probiotics in pill form.
Read More
7
Crohn's support
6 people found this helpful
This probiotic works! Having Crohn's disease, I tried two other probiotics with no success. After discovering these Pearls, I was truly impressed; they began working within days. While they don't cure Crohn's, they significantly aid my regularity, and I now handle high-fibre foods and dairy much better. My energy levels are higher, and my anxiety is diminished. I’ll be buying these for life!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Xie P, Luo M, Deng X, Fan J, Xiong L. Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis. Nutrients. 2023;15. 10.3390/nu15173856
- Wagner NRF, Ramos MRZ, de Oliveira Carlos L, da Cruz MRR, Taconeli CA, et al. Effects of Probiotics Supplementation on Gastrointestinal Symptoms and SIBO after Roux-en-Y Gastric Bypass: a Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. Obes Surg. 2021;31:143. 10.1007/s11695-020-04900-x
- Maixent JM, Pons O, Sennoune SR, Sadrin S. Clinical effects of Lactobacillus strains as probiotics in the treatment of irritable bowel syndrome. Results from the LAPIBSS trial: Future objectives. Cell Mol Biol (Noisy-le-grand). 2020;66:211.
- Sadrin S, Sennoune S, Gout B, Marque S, Moreau J, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis. 2020;52:534. 10.1016/j.dld.2019.12.009
- Wang MC, Zaydi AI, Lin WH, Lin JS, Liong MT, et al. Putative Probiotic Strains Isolated from Kefir Improve Gastrointestinal Health Parameters in Adults: a Randomized, Single-Blind, Placebo-Controlled Study. Probiotics Antimicrob Proteins. 2020;12:840. 10.1007/s12602-019-09615-9
- Airaksinen K, Yeung N, Lyra A, Lahtinen SJ, Huttunen T, et al. The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placebo controlled 2-week trial. Benef Microbes. 2019;10:617. 10.3920/BM2018.0163
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- Ringel-Kulka T, Goldsmith JR, Carroll IM, Barros SP, Palsson O, et al. Lactobacillus acidophilus NCFM affects colonic mucosal opioid receptor expression in patients with functional abdominal pain - a randomised clinical study. Aliment Pharmacol Ther. 2014;40:200. 10.1111/apt.12800
- Yoon JS, Sohn W, Lee OY, Lee SP, Lee KN, et al. Effect of multispecies probiotics on irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Gastroenterol Hepatol. 2014;29:52. 10.1111/jgh.12322
- Andresen V, Layer P, Menge D, Keller J. [Efficacy of freeze-dried Lactobacilli in functional diarrhoe: a pilot study]. Dtsch Med Wochenschr. 2012;137:1792. 10.1055/s-0032-1305295
- Ringel-Kulka T, Palsson OS, Maier D, Carroll I, Galanko JA, et al. Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders: a double-blind study. J Clin Gastroenterol. 2011;45:518. 10.1097/MCG.0b013e31820ca4d6
- Nova E, Viadel B, Wärnberg J, Carreres JE, Marcos A. Beneficial effects of a synbiotic supplement on self-perceived gastrointestinal well-being and immunoinflammatory status of healthy adults. J Med Food. 2011;14:79. 10.1089/jmf.2008.0328
- Tsuchiya J, Barreto R, Okura R, Kawakita S, Fesce E, et al. Single-blind follow-up study on the effectiveness of a symbiotic preparation in irritable bowel syndrome. Chin J Dig Dis. 2004;5:169.
- Molin G. Probiotics in foods not containing milk or milk constituents, with special reference to Lactobacillus plantarum 299v. Am J Clin Nutr. 2001;73:380S. 10.1093/ajcn/73.2.380s
- Gaón D, Doweck Y, Gómez Zavaglia A, Ruiz Holgado A, Oliver G. [Lactose digestion by milk fermented with Lactobacillus acidophilus and Lactobacillus casei of human origin]. Medicina (B Aires). 1995;55:237.
- Kocián J. [Lactobacilli in the treatment of dyspepsia due to dysmicrobia of various causes]. Vnitr Lek. 1994;40:79.
- Tanashat M, Abuelazm M, Abouzid M, Al-Ajlouni YA, Ramadan A, et al. Efficacy of probiotics regimens for Helicobacter pylori eradication: A systematic review, pairwise, and network meta-analysis of randomized controlled trials. Clin Nutr ESPEN. 2025;65:424. 10.1016/j.clnesp.2024.11.016
- Srivastava S, Basak U, Naghibi M, Vijayakumar V, Parihar R, et al. A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome. Gut Microbes. 2024;16:2338322. 10.1080/19490976.2024.2338322
- Lenoir M, Wienke J, Fardao-Beyler F, Roese N. An 8-Week Course of Bifidobacterium longum 35624 Is Associated with a Reduction in the Symptoms of Irritable Bowel Syndrome. Probiotics Antimicrob Proteins. 2025;17:315. 10.1007/s12602-023-10151-w
- Miyoshi M, Kadoguchi H, Usami M, Hori Y. Synbiotics Improved Stool Form via Changes in the Microbiota and Short-Chain Fatty Acids in Hemodialysis Patients. Kobe J Med Sci. 2021;67:E112.
- Zhang C, Jiang J, Tian F, Zhao J, Zhang H, et al. Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults. Clin Nutr. 2020;39:2960. 10.1016/j.clnu.2020.01.005
- Bonfrate L, Di Palo DM, Celano G, Albert A, Vitellio P, et al. Effects of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 in IBS patients. Eur J Clin Invest. 2020;50:e13201. 10.1111/eci.13201
- Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, et al. Effects of and on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. Nutrients. 2019;11. 10.3390/nu11040886
- Chen JC, Lee WJ, Tsou JJ, Liu TP, Tsai PL. Effect of probiotics on postoperative quality of gastric bypass surgeries: a prospective randomized trial. Surg Obes Relat Dis. 2016;12:57. 10.1016/j.soard.2015.07.010
- Colecchia A, Vestito A, La Rocca A, Pasqui F, Nikiforaki A, et al. Effect of a symbiotic preparation on the clinical manifestations of irritable bowel syndrome, constipation-variant. Results of an open, uncontrolled multicenter study. Minerva Gastroenterol Dietol. 2006;52:349.
