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Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.4
USERS' SCORE
Good
Based on 13 Reviews
8.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Proprietary Probiotic BlendProviding 1 billion CFUBifidobacterium longum BB536, HOWARU® Lactobacillus acidophilus NCFM®
11 mg
**
Top Medical Research Studies
7
We evaluated the impact of Bifidobacterium longum BB536 on chronic constipation in elderly individuals through a randomized, double-blind trial in Japan, involving 80 participants.
Although the primary outcomes showed no significant improvement, we did observe noteworthy enhancements in bowel movements among those taking the probiotics compared to the placebo group.
This suggests that while not a complete solution, B. longum BB536 may still provide safe and beneficial effects for older adults struggling with constipation.
Although the primary outcomes showed no significant improvement, we did observe noteworthy enhancements in bowel movements among those taking the probiotics compared to the placebo group.
This suggests that while not a complete solution, B. longum BB536 may still provide safe and beneficial effects for older adults struggling with constipation.
Read More
9
Probiotics improve constipation symptoms
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
Read More
8
Synbiotics improve constipation symptoms
We conducted a double-blinded, randomized controlled trial to explore the effects of synbiotics on constipation among chronic haemodialysis patients. While our study found that the synbiotic treatment did not significantly reduce indoxyl sulphate toxin levels, it notably improved constipation symptoms and the overall quality of life related to constipation.
This suggests that Lactobacillus acidophilus and Bifidobacterium longum may be beneficial for enhancing digestive comfort in individuals facing these challenges, even if they don't directly affect certain toxic levels in the body.
This suggests that Lactobacillus acidophilus and Bifidobacterium longum may be beneficial for enhancing digestive comfort in individuals facing these challenges, even if they don't directly affect certain toxic levels in the body.
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Most Useful Reviews
10
Constipation relief
141 people found this helpful
GREAT! I wish I had tried these years ago! After an endoscopy that revealed "burns" in my stomach, I decided to try Pearls. They have made such a difference! I suffered from constipation for 7 years following thyroid removal, and nothing seemed to help. Within just two days of starting Pearls, I began to have regular bathroom visits. The bloating and nausea disappeared, and while my reflux isn't completely gone, it's significantly improved. I recommend Pearls for anyone struggling with constipation.
Read More
9
Miralax alternative
71 people found this helpful
Better than Miralax! My family relied on Miralax for years due to severe constipation. I decided to try Pearls after researching alternatives. Within a few days, I noticed a difference and began reducing our reliance on Miralax. It's been nearly two years now, and they work well for both my kids and me, with only occasional adjustments during my menstrual cycle.
Read More
7.5
Regular bowel movements
13 people found this helpful
I can't imagine going without Pearls ever again! My husband found these after taking antibiotics, and I have struggled with constipation all my life. I used to rely on daily fibre, but it often made me feel bloated. After taking Pearls regularly for a few days, I started having regular and more frequent bowel movements and felt less bloated. They’re convenient as they don’t require refrigeration, and I appreciate the ease of taking them any time. Missing a dose is noticeable for me.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.4
- All Researches
9.5
Lactobacillus improves IBS-C symptoms
We investigated how a cultured milk drink containing Lactobacillus acidophilus affects symptoms of constipation in individuals with irritable bowel syndrome (IBS-C). Over 30 days, participants consumed the drink daily.
At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
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9
Probiotics improve constipation symptoms
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
Read More
9
We evaluated how lactobacillus acidophilus, both alone and in a mix with other bacteria, might relieve constipation caused by loperamide in rats. Over 14 days, we noticed that the groups receiving probiotics had significantly heavier and wetter stools compared to control animals.
Notably, the CKDBP group, a blend of multiple bacteria, showed the greatest improvement in intestinal transit. Measures like mucosal length and mucus secretion were also significantly enhanced in all probiotic-treated groups, highlighting their potential to alleviate constipation symptoms effectively.
Notably, the CKDBP group, a blend of multiple bacteria, showed the greatest improvement in intestinal transit. Measures like mucosal length and mucus secretion were also significantly enhanced in all probiotic-treated groups, highlighting their potential to alleviate constipation symptoms effectively.
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9
We investigated the impact of Bifidobacterium animalis subsp. lactis XLTG11 on functional constipation in children using a randomized, double-blind, placebo-controlled design.
Our findings showed that children receiving this probiotic experienced a significant increase in their weekly fecal frequency compared to those on conventional treatment without probiotics.
Additionally, the introduction of XLTG11 altered gut microbiota positively and influenced the metabolism of short-chain fatty acids. These results suggest that Bifidobacterium can benefit children suffering from constipation.
Our findings showed that children receiving this probiotic experienced a significant increase in their weekly fecal frequency compared to those on conventional treatment without probiotics.
Additionally, the introduction of XLTG11 altered gut microbiota positively and influenced the metabolism of short-chain fatty acids. These results suggest that Bifidobacterium can benefit children suffering from constipation.
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9
We explored the effectiveness of Bifidobacterium longum W11 in treating constipation, particularly in patients with irritable bowel syndrome (IBS). Our research included rigorous reviews and clinical trials, one of which was randomized and placebo-controlled.
The findings were promising—B. longum W11 significantly reduced constipation symptoms, especially in those experiencing reduced gut motility due to calorie-restricted diets.
Additionally, its non-transmissible antibiotic resistance may offer advantages when used alongside antibiotics like rifaximin, showing improved outcomes in certain conditions like diverticular disease.
The findings were promising—B. longum W11 significantly reduced constipation symptoms, especially in those experiencing reduced gut motility due to calorie-restricted diets.
Additionally, its non-transmissible antibiotic resistance may offer advantages when used alongside antibiotics like rifaximin, showing improved outcomes in certain conditions like diverticular disease.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
10
Constipation relief
141 people found this helpful
GREAT! I wish I had tried these years ago! After an endoscopy that revealed "burns" in my stomach, I decided to try Pearls. They have made such a difference! I suffered from constipation for 7 years following thyroid removal, and nothing seemed to help. Within just two days of starting Pearls, I began to have regular bathroom visits. The bloating and nausea disappeared, and while my reflux isn't completely gone, it's significantly improved. I recommend Pearls for anyone struggling with constipation.
Read More
9
Miralax alternative
71 people found this helpful
Better than Miralax! My family relied on Miralax for years due to severe constipation. I decided to try Pearls after researching alternatives. Within a few days, I noticed a difference and began reducing our reliance on Miralax. It's been nearly two years now, and they work well for both my kids and me, with only occasional adjustments during my menstrual cycle.
Read More
7.5
Regular bowel movements
13 people found this helpful
I can't imagine going without Pearls ever again! My husband found these after taking antibiotics, and I have struggled with constipation all my life. I used to rely on daily fibre, but it often made me feel bloated. After taking Pearls regularly for a few days, I started having regular and more frequent bowel movements and felt less bloated. They’re convenient as they don’t require refrigeration, and I appreciate the ease of taking them any time. Missing a dose is noticeable for me.
Read More
9
Improved gut health
9 people found this helpful
These make me feel so much better. After researching acidophilus, I ordered these and was very excited to try them. I had been in significant pain and suffered from severe constipation. Cutting out grains helped, but I felt my gut was damaged. I've been taking Acidophilus Pearls for just over a week, and within the first couple of days, I noticed a difference. My gut feels smooth and easy. I no longer struggle in the bathroom, and each day is better. I'm impressed with the convenience and no need for refrigeration. I highly recommend these Pearls for anyone with tummy troubles.
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9
Pain relief
8 people found this helpful
These pearls worked wonders for me! I had discomfort on the left side of my waist, which I thought was unrelated. However, an article I read suggested it could be due to constipation. After taking one pearl daily for three months, that discomfort completely vanished. They are a convenient option for someone like me, who is lactose-sensitive and looking for a reliable source of acidophilus.
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Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Liao Y, Wang Y, Huang W, Wang J, Guo M, et al. L. acidophilus/L. johnsonii ratio affects slow transit constipation in rats. Sci Rep. 2024;14:21088. 10.1038/s41598-024-71945-8
- Mitelmão FCR, Häckel K, Bergamaschi CC, Gerenutti M, Silva MT, et al. The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. Medicine (Baltimore). 2022;101:e31185. 10.1097/MD.0000000000031185
- Gan D, Chen J, Tang X, Xiao L, Martoni CJ, et al. Impact of a probiotic chewable tablet on stool habits and microbial profile in children with functional constipation: A randomized controlled clinical trial. Front Microbiol. 2022;13:985308. 10.3389/fmicb.2022.985308
- Šola KF, Vladimir-Knežević S, Hrabač P, Mucalo I, Saso L, et al. The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial. Eur J Clin Nutr. 2022;76:1675. 10.1038/s41430-022-01189-0
- Lydia A, Indra TA, Rizka A, Abdullah M. The effects of synbiotics on indoxyl sulphate level, constipation, and quality of life associated with constipation in chronic haemodialysis patients: a randomized controlled trial. BMC Nephrol. 2022;23:259. 10.1186/s12882-022-02890-9
- Lin B, Zhao F, Liu Y, Wu X, Feng J, et al. Randomized Clinical Trial: Probiotics Alleviated Oral-Gut Microbiota Dysbiosis and Thyroid Hormone Withdrawal-Related Complications in Thyroid Cancer Patients Before Radioiodine Therapy Following Thyroidectomy. Front Endocrinol (Lausanne). 2022;13:834674. 10.3389/fendo.2022.834674
- Mokhtar NM, Jaafar NM, Alfian E, Mohd Rathi ND, Abdul Rani R, et al. Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink. Acta Gastroenterol Belg. 2021;84:585. 10.51821/84.4.009
- Martoni CJ, Evans M, Chow CT, Chan LS, Leyer G. Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: A randomized controlled trial. J Dig Dis. 2019;20:435. 10.1111/1751-2980.12797
- Airaksinen K, Yeung N, Lyra A, Lahtinen SJ, Huttunen T, et al. The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placebo controlled 2-week trial. Benef Microbes. 2019;10:617. 10.3920/BM2018.0163
- Leventogiannis K, Gkolfakis P, Spithakis G, Tsatali A, Pistiki A, et al. Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Probiotics Antimicrob Proteins. 2019;11:627. 10.1007/s12602-018-9401-3
- Kim BK, Choi IS, Kim J, Han SH, Suh HJ, et al. Effects of Fermented Milk with Mixed Strains as a Probiotic on the Inhibition of Loperamide-Induced Constipation. Korean J Food Sci Anim Resour. 2017;37:906. 10.5851/kosfa.2017.37.6.906
- Magro DO, de Oliveira LM, Bernasconi I, Ruela Mde S, Credidio L, et al. Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation. Nutr J. 2014;13:75. 10.1186/1475-2891-13-75
- Ohigashi S, Hoshino Y, Ohde S, Onodera H. Functional outcome, quality of life, and efficacy of probiotics in postoperative patients with colorectal cancer. Surg Today. 2011;41:1200. 10.1007/s00595-010-4450-6
- Choi SC, Kim BJ, Rhee PL, Chang DK, Son HJ, et al. Probiotic Fermented Milk Containing Dietary Fiber Has Additive Effects in IBS with Constipation Compared to Plain Probiotic Fermented Milk. Gut Liver. 2011;5:22. 10.5009/gnl.2011.5.1.22
- Nova E, Viadel B, Wärnberg J, Carreres JE, Marcos A. Beneficial effects of a synbiotic supplement on self-perceived gastrointestinal well-being and immunoinflammatory status of healthy adults. J Med Food. 2011;14:79. 10.1089/jmf.2008.0328
- Jeon JR, Choi JH. Lactic acid fermentation of germinated barley fiber and proliferative function of colonic epithelial cells in loperamide-induced rats. J Med Food. 2010;13:950. 10.1089/jmf.2009.1307
- Chen K, Zhou Z, Nie Y, Cao Y, Yang P, et al. Adjunctive efficacy of Bifidobacterium animalis subsp. lactis XLTG11 for functional constipation in children. Braz J Microbiol. 2024;55:1317. 10.1007/s42770-024-01276-3
- Chang YH, Choi YJ, Shin CM, Moon JS, Kim TY, et al. Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. J Neurogastroenterol Motil. 2024;30:73. 10.5056/jnm23036
- Zhang C, Yu L, Ma C, Jiang S, Zhang Y, et al. A key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation. Cell Host Microbe. 2023;31:1989. 10.1016/j.chom.2023.10.011
- Lenoir M, Wienke J, Fardao-Beyler F, Roese N. An 8-Week Course of Bifidobacterium longum 35624 Is Associated with a Reduction in the Symptoms of Irritable Bowel Syndrome. Probiotics Antimicrob Proteins. 2025;17:315. 10.1007/s12602-023-10151-w
- Nakamura Y, Suzuki S, Murakami S, Nishimoto Y, Higashi K, et al. Integrated gut microbiome and metabolome analyses identified fecal biomarkers for bowel movement regulation by BB536 supplementation: A RCT. Comput Struct Biotechnol J. 2022;20:5847. 10.1016/j.csbj.2022.10.026
- Takeda T, Asaoka D, Nojiri S, Yanagisawa N, Nishizaki Y, et al. Usefulness of Bifidobacterium longum BB536 in Elderly Individuals With Chronic Constipation: A Randomized Controlled Trial. Am J Gastroenterol. 2023;118:561. 10.14309/ajg.0000000000002028
- Moreno-Muñoz JA, Martín-Palomas M, Jiménez López J. [Bifidobacterium longum subsp. infantis CECT 7210 (B. infantis IM-1®) shows activity against intestinal pathogens]. Nutr Hosp. 2022;39:65. 10.20960/nh.04315
- Wang L, Chai M, Wang J, Yu Q, Wang G, et al. relieves constipation by regulating the intestinal barrier of mice. Food Funct. 2022;13:5037. 10.1039/d1fo04151g
- Miyoshi M, Kadoguchi H, Usami M, Hori Y. Synbiotics Improved Stool Form via Changes in the Microbiota and Short-Chain Fatty Acids in Hemodialysis Patients. Kobe J Med Sci. 2021;67:E112.
- Ito D, Yamamoto Y, Maekita T, Yamagishi N, Kawashima S, et al. Do synbiotics really enhance beneficial synbiotics effect on defecation symptoms in healthy adults?: Randomized, double-blind, placebo-controlled trial. Medicine (Baltimore). 2022;101:e28858. 10.1097/MD.0000000000028858
- Astó E, Huedo P, Altadill T, Aguiló García M, Sticco M, et al. Probiotic Properties of KABP042 and KABP041 Show Potential to Counteract Functional Gastrointestinal Disorders in an Observational Pilot Trial in Infants. Front Microbiol. 2021;12:741391. 10.3389/fmicb.2021.741391
- Di Pierro F, Pane M. Bifidobacterium longum W11: Uniqueness and individual or combined clinical use in association with rifaximin. Clin Nutr ESPEN. 2021;42:15. 10.1016/j.clnesp.2020.12.025
- Zhang C, Jiang J, Tian F, Zhao J, Zhang H, et al. Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults. Clin Nutr. 2020;39:2960. 10.1016/j.clnu.2020.01.005
