Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 42 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size:  1 Softgel
Amount Per Serving
%DV
Proprietary Probiotic BlendProviding 1 billion CFU:Bifidobacterium longum BB536, B. bifidum/lactis Bb-02™, B. breve M-16V, B. infantis M-63
15 mg
**

Top Medical Research Studies

9.5
Bifidobacterium lactis reduced diarrhea duration
We explored the impact of Bifidobacterium animalis subsp. lactis BLa80 on diarrhea in young children through a well-structured, randomized, double-blinded, placebo-controlled study.

Our findings show that children receiving the probiotic experienced a significantly shorter duration of diarrhea and a higher recovery rate compared to those given a placebo.

Notably, we also observed beneficial changes in gut microbiome composition and gene functions that promote immune response.

This evidence suggests that Bifidobacterium lactis can effectively support recovery from acute diarrhea in children.
Read More
9.5
Probiotics improve H. pylori treatments
We analyzed various studies on incorporating probiotics into treatments for Helicobacter pylori (H. pylori) infection. Our findings revealed that adding probiotics like Bifidobacterium longum improved the eradication rate significantly.

Specifically, we noted that the probiotic group experienced fewer side effects, including diarrhea, nausea, and abdominal pain. This suggests that probiotics could not only enhance the effectiveness of H. pylori treatment but also make it more comfortable for patients. Overall, these results support the use of probiotics in gastric therapies.
Read More
9.5
Bifidobacterium longum shows promise
We conducted a randomized double-blind, placebo-controlled trial with 200 participants to see how well the probiotic CECT 7347 (ES1) and its heat-treated version (HT-ES1) could help those suffering from diarrhea-predominant irritable bowel syndrome (IBS-D). After 12 weeks of treatment, both ES1 and HT-ES1 showed significant improvements in symptom severity, with marked reductions in IBS-SSS scores compared to the placebo.

Secondary benefits included better stool consistency and quality of life, making these treatments promising options for managing IBS-D symptoms. These findings reflect meaningful advancements in probiotic and postbiotic solutions.
Read More

Most Useful Reviews

9
Diarrhea stopped immediately
17 people found this helpful
WORKS GREAT. I needed a probiotic and after much consideration, I chose this small size with over 50 pills. The first time I tried it, it stopped my diarrhea immediately. I was convinced right away! I plan to reorder.
Read More
7.5
Balanced intestinal health
2 people found this helpful
Intestinal balance means a better life. Pearls 50+ has significantly helped my intestinal issues, alleviating gas, diarrhea, and constipation experienced in the past. After one hospitalisation for diverticulitis, I hope to keep these problems at bay. Maintaining intestinal balance has noticeably improved my daily life.
Read More
7.5
Less stomach pain
2 people found this helpful
PEARLS DIGESTIVE AND COLON SUPPORT. For three months, I've taken Pearls Probiotics to relieve terrible stomach pains and diarrhoea. After a few weeks, I noticed significant improvement. I occasionally experience stomach upsets, but not as severe as before. This product doesn’t require food or refrigeration and only one needs to be taken daily. I’ve also lost weight and feel fuller quicker; I am very pleased with it.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 42 Researches
8
  • All Researches
9.5
Probiotics improve H. pylori treatments
We analyzed various studies on incorporating probiotics into treatments for Helicobacter pylori (H. pylori) infection. Our findings revealed that adding probiotics like Bifidobacterium longum improved the eradication rate significantly.

Specifically, we noted that the probiotic group experienced fewer side effects, including diarrhea, nausea, and abdominal pain. This suggests that probiotics could not only enhance the effectiveness of H. pylori treatment but also make it more comfortable for patients. Overall, these results support the use of probiotics in gastric therapies.
Read More
9.5
Bifidobacterium longum shows promise
We conducted a randomized double-blind, placebo-controlled trial with 200 participants to see how well the probiotic CECT 7347 (ES1) and its heat-treated version (HT-ES1) could help those suffering from diarrhea-predominant irritable bowel syndrome (IBS-D). After 12 weeks of treatment, both ES1 and HT-ES1 showed significant improvements in symptom severity, with marked reductions in IBS-SSS scores compared to the placebo.

Secondary benefits included better stool consistency and quality of life, making these treatments promising options for managing IBS-D symptoms. These findings reflect meaningful advancements in probiotic and postbiotic solutions.
Read More
9.5
Bifidobacterium lactis reduced diarrhea duration
We explored the impact of Bifidobacterium animalis subsp. lactis BLa80 on diarrhea in young children through a well-structured, randomized, double-blinded, placebo-controlled study.

Our findings show that children receiving the probiotic experienced a significantly shorter duration of diarrhea and a higher recovery rate compared to those given a placebo.

Notably, we also observed beneficial changes in gut microbiome composition and gene functions that promote immune response.

This evidence suggests that Bifidobacterium lactis can effectively support recovery from acute diarrhea in children.
Read More
We investigated how multistrain probiotics, specifically Sensi-Biome, impact diarrhea through the gut-brain connection. In a controlled rat study, various concentrations of these probiotics were given to evaluate their effectiveness against diarrhea triggered by acetic acid.

Our findings suggest that Sensi-Biome significantly improved stool moisture content, intestinal movement rates, and pH levels. Additionally, the probiotics influenced serotonin levels and reduced inflammation-related cytokines. This indicates their potential to effectively manage diarrhea by modifying important metabolic pathways.
Read More
9
Bifidobacterium improves diarrhea relief
We explored how the probiotic Neobiotic Lactobalance®, which includes bifidobacterium bifidum, impacts diarrhea in patients with irritable bowel syndrome and antibiotic-associated diarrhea. Over 21 days, 54 participants took one capsule daily. The results were promising—patients with IBS experienced notable reductions in diarrhea symptoms and abdominal pain. Similarly, those with antibiotic-associated diarrhea reported significant symptom relief. Our findings indicate that this probiotic can effectively normalize gut bacteria and alleviate diarrhea symptoms.
Read More

User Reviews

USERS' SCORE
Good
Based on 3 Reviews
8.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Diarrhea stopped immediately
17 people found this helpful
WORKS GREAT. I needed a probiotic and after much consideration, I chose this small size with over 50 pills. The first time I tried it, it stopped my diarrhea immediately. I was convinced right away! I plan to reorder.
Read More
7.5
Balanced intestinal health
2 people found this helpful
Intestinal balance means a better life. Pearls 50+ has significantly helped my intestinal issues, alleviating gas, diarrhea, and constipation experienced in the past. After one hospitalisation for diverticulitis, I hope to keep these problems at bay. Maintaining intestinal balance has noticeably improved my daily life.
Read More
7.5
Less stomach pain
2 people found this helpful
PEARLS DIGESTIVE AND COLON SUPPORT. For three months, I've taken Pearls Probiotics to relieve terrible stomach pains and diarrhoea. After a few weeks, I noticed significant improvement. I occasionally experience stomach upsets, but not as severe as before. This product doesn’t require food or refrigeration and only one needs to be taken daily. I’ve also lost weight and feel fuller quicker; I am very pleased with it.
Read More

Frequently Asked Questions

4
Bifidobacterium bifidum aids stroke recovery
We explored the benefits of Bifidobacterium bifidum supplementation in enhancing the health of elderly patients who suffered ischemic strokes. By analyzing data from 153 patients, we separated them into two groups: one receiving the supplement and the other with standard treatment.

The group receiving Bifidobacterium bifidum showed notable improvements in several health measures, including cognitive function and emotional well-being. Even better, we noted decreased instances of diarrhea and constipation. This underscores the potential of gut health interventions in recovery following strokes, integrating both neurological and digestive health strategies.
8
Bifidobacterium improves diarrhea outcomes
We explored how effective bifidobacterium bifidum, alongside zinc, is for treating children with acute gastroenteritis. This double-blind study involved infants divided into groups receiving either dietary recommendations, probiotics, or zinc.

Notably, those who received both probiotics and zinc saw significantly faster recovery times. For example, they experienced a dramatic reduction in the time it took for their diarrhea to resolve, compared to the control group.

While probiotics alone showed some benefit, the combination therapy emerged as the most effective treatment option.
We aimed to understand how a multispecies probiotic, including Bifidobacterium bifidum, impacts antibiotic-associated diarrhea (AAD) in children.

In a rigorous trial involving 350 children, we found that while the probiotic did not effectively lower AAD risks by strict standards, it did reduce general diarrhea during and after antibiotic treatment.

This indicates that how we define AAD significantly influences the results of such studies.
9
Bifidobacterium Longum aids in diarrhea
We explored the impact of Bifidobacterium animalis sp. Lactis XLTG11 on acute diarrhea in children through a randomized, double-blinded, placebo-controlled study. Children received either conventional treatment plus the probiotic or conventional treatment alone.

Our findings revealed that the probiotic group experienced shorter diarrhea duration and hospital stays compared to the control group. Additionally, a greater percentage of these children showed improvement, along with significant changes in gut microbiome composition.

These results suggest that XLTG11 can effectively enhance treatment outcomes for diarrhea in children.
9
Probiotics beneficial for antibiotic diarrhea
We examined the effectiveness of probiotics in preventing antibiotic-associated diarrhea (AAD) among adult patients. Conducted across several hospitals, our study included 340 participants who received either probiotics or a placebo soon after starting antibiotics.

The results showed that probiotics, specifically Lactobacillus rhamnosus GG and Bifidobacterium longum BB536, significantly reduced both the incidence and duration of AAD. High adherence rates and positive patient feedback added to the supportive findings for probiotics' role in gut health during antibiotic treatment.

References

  1. Xin H, Zhang X, Li P, Li H, Feng G, et al. Bifidobacterium bifidum supplementation improves ischemic stroke outcomes in elderly patients: A retrospective study. Medicine (Baltimore). 2024;103:e37682. 10.1097/MD.0000000000037682
  2. Jeong JJ, Jin YJ, Ganesan R, Park HJ, Min BH, et al. Multistrain Probiotics Alleviate Diarrhea by Modulating Microbiome-Derived Metabolites and Serotonin Pathway. Probiotics Antimicrob Proteins. 2024. 10.1007/s12602-024-10232-4
  3. Hashimoto Y, Kobayashi G, Kitagawa N, Okada H, Hamaguchi M, et al. Protocol of efficacy of bifidobacteria intake on gastrointestinal symptoms in symptomatic type 2 diabetes mellitus patients in abdominis: An open-label, randomized controlled trial (Binary STAR study). PLoS One. 2024;19:e0295998. 10.1371/journal.pone.0295998
  4. Drozdov VN, Shikh EV, Astapovskii AA, Khalaidzheva KN, Solovieva SA, et al. [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea]. Vopr Pitan. 2023;92:92. 10.33029/0042-8833-2023-92-4-92-103
  5. Tomita T, Fukui H, Okugawa T, Nakanishi T, Mieno M, et al. Effect of G9-1 on the Intestinal Environment and Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)-like Symptoms in Patients with Quiescent Crohn's Disease: A Prospective Pilot Study. J Clin Med. 2023;12. 10.3390/jcm12103368
  6. Yalcin G, Demirbas F, Bacalan F, Toy EB. Evaluation of treatment in acute gastroenteritis: A comparative study. J Pak Med Assoc. 2022;72:2019. 10.47391/JPMA.4438
  7. Lukasik J, Dierikx T, Besseling-van der Vaart I, de Meij T, Szajewska H. Multispecies Probiotic for the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Clinical Trial. JAMA Pediatr. 2022;176:860. 10.1001/jamapediatrics.2022.1973
  8. Kang S, Lin Z, Xu Y, Park M, Ji GE, et al. A recombinant Bifidobacterium bifidum BGN4 strain expressing the streptococcal superoxide dismutase gene ameliorates inflammatory bowel disease. Microb Cell Fact. 2022;21:113. 10.1186/s12934-022-01840-2
  9. Hata S, Nakajima H, Hashimoto Y, Miyoshi T, Hosomi Y, et al. Effects of probiotic Bifidobacterium bifidum G9-1 on the gastrointestinal symptoms of patients with type 2 diabetes mellitus treated with metformin: An open-label, single-arm, exploratory research trial. J Diabetes Investig. 2022;13:489. 10.1111/jdi.13698
  10. Ivashkin V, Fomin V, Moiseev S, Brovko M, Maslennikov R, et al. Efficacy of a Probiotic Consisting of Lacticaseibacillus rhamnosus PDV 1705, Bifidobacterium bifidum PDV 0903, Bifidobacterium longum subsp. infantis PDV 1911, and Bifidobacterium longum subsp. longum PDV 2301 in the Treatment of Hospitalized Patients with COVID-19: a Randomized Controlled Trial. Probiotics Antimicrob Proteins. 2023;15:460. 10.1007/s12602-021-09858-5
  11. Yang B, Huang Z, He Z, Yue Y, Zhou Y, et al. Protective effect of Bifidobacterium bifidum FSDJN7O5 and Bifidobacterium breve FHNFQ23M3 on diarrhea caused by enterotoxigenic Escherichia coli. Food Funct. 2021;12:7271. 10.1039/d1fo00504a
  12. Meskina ER, Tselipanova EE, Khadisova MK, Galkina LA, Stashko TV. [Efficiency of application of sorbed probiotics in complex therapy of pneumonia caused by SARS-CoV-2. Part 1. Heating clinical displays period]. Ter Arkh. 2021;93:456. 10.26442/00403660.2021.04.200835
  13. Skrzydło-Radomańska B, Prozorow-Król B, Cichoż-Lach H, Majsiak E, Bierła JB, et al. The Effectiveness of Synbiotic Preparation Containing and Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant Irritable Bowel Syndrome-A Randomized Double-Blind, Placebo-Controlled Study. Nutrients. 2020;12. 10.3390/nu12071999
  14. Makizaki Y, Maeda A, Oikawa Y, Tamura S, Tanaka Y, et al. Probiotic Bifidobacterium bifidum G9-1 ameliorates phytohemagglutinin-induced diarrhea caused by intestinal dysbiosis. Microbiol Immunol. 2019;63:481. 10.1111/1348-0421.12743
  15. Renaud DL, Kelton DF, Weese JS, Noble C, Duffield TF. Evaluation of a multispecies probiotic as a supportive treatment for diarrhea in dairy calves: A randomized clinical trial. J Dairy Sci. 2019;102:4498. 10.3168/jds.2018-15793
  16. Huang L, Chiang Chiau JS, Cheng ML, Chan WT, Jiang CB, et al. SCID/NOD mice model for 5-FU induced intestinal mucositis: Safety and effects of probiotics as therapy. Pediatr Neonatol. 2019;60:252. 10.1016/j.pedneo.2018.07.007
  17. Tanashat M, Abuelazm M, Abouzid M, Al-Ajlouni YA, Ramadan A, et al. Efficacy of probiotics regimens for Helicobacter pylori eradication: A systematic review, pairwise, and network meta-analysis of randomized controlled trials. Clin Nutr ESPEN. 2025;65:424. 10.1016/j.clnesp.2024.11.016
  18. Chen K, Zeng K, Jin S, Ma Y, Cai L, et al. LRa05 in the treatment of acute diarrhea in children: a randomized controlled trial. Front Nutr. 2024;11:1479186. 10.3389/fnut.2024.1479186
  19. Shah J, Adnan SH, Yousaf MS, Din SJU, Haq MU, et al. A Multi-Hospital Comparative Study on the Efficacy of Probiotics Versus Placebo in Preventing Antibiotic-Associated Diarrhea in Adult Patients. Cureus. 2024;16:e70881. 10.7759/cureus.70881
  20. Moreno-Muñoz JA, Ojeda JD, López JJ. A Probiotic Bacterium with Activity against the Most Frequent Bacteria and Viruses Causing Pediatric Diarrhea: subsp. CECT 7210 ( IM1). Microorganisms. 2024;12. 10.3390/microorganisms12061183
  21. Srivastava S, Basak U, Naghibi M, Vijayakumar V, Parihar R, et al. A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome. Gut Microbes. 2024;16:2338322. 10.1080/19490976.2024.2338322
  22. Lenoir M, Wienke J, Fardao-Beyler F, Roese N. An 8-Week Course of Bifidobacterium longum 35624 Is Associated with a Reduction in the Symptoms of Irritable Bowel Syndrome. Probiotics Antimicrob Proteins. 2025;17:315. 10.1007/s12602-023-10151-w
  23. Chen K, Jin S, Ma Y, Cai L, Xu P, et al. Adjunctive efficacy of Lactis XLTG11 for Acute diarrhea in children: A randomized, blinded, placebo-controlled study. Nutrition. 2023;111:112052. 10.1016/j.nut.2023.112052
  24. Li W, Zhang S, Wang Y, Bian H, Yu S, et al. Complex probiotics alleviate ampicillin-induced antibiotic-associated diarrhea in mice. Front Microbiol. 2023;14:1156058. 10.3389/fmicb.2023.1156058
  25. Mizutani Y, Kawamoto S, Takahashi M, Doi H, Wakida K, et al. Efficacy and Safety of Synbiotics in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation: A Randomized, Double-blinded, Placebo-controlled Pilot Study. Intern Med. 2023;62:2949. 10.2169/internalmedicine.1314-22
  26. Li W, Kai L, Jiang Z, He H, Yang M, et al. , and Reversed ETEC-Inducing Intestinal Inflammation in Mice. Microorganisms. 2022;10. 10.3390/microorganisms10122350
  27. Yakovenko EP, Strokova TV, Ivanov AN, Iakovenko AV, Gioeva IZ, et al. [The effectiveness of a probiotic containing Bifidobacterium longum BB-46 and Enterococcus faecium ENCfa-68 in the treatment of post-infectious irritable bowel syndrome. Prospective randomized comparative study]. Ter Arkh. 2022;94:180. 10.26442/00403660.2022.02.201368
  28. Shin SY, Park S, Moon JM, Kim K, Kim JW, et al. Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: A Post Hoc Analysis of a Randomized Clinical Trial. J Neurogastroenterol Motil. 2022;28:642. 10.5056/jnm21202
  29. Álvarez-Mercado AI, Plaza-Díaz J, de Almagro MC, Gil Á, Moreno-Muñoz JA, et al. subsp. CECT 7210 Reduces Inflammatory Cytokine Secretion in Caco-2 Cells Cultured in the Presence of CECT 515. Int J Mol Sci. 2022;23. 10.3390/ijms231810813
  30. Moreno-Muñoz JA, Martín-Palomas M, Jiménez López J. [Bifidobacterium longum subsp. infantis CECT 7210 (B. infantis IM-1®) shows activity against intestinal pathogens]. Nutr Hosp. 2022;39:65. 10.20960/nh.04315
  31. Uttarwar RG, Mekonnen SA, Van Beeck W, Wang A, Finnegan P, et al. Effects of Bifidobacterium animalis subsp. lactis BB-12 and yogurt on mice during oral antibiotic administration. Microbiol Res. 2024;286:127794. 10.1016/j.micres.2024.127794
  32. Chen K, Jin S, Ma Y, Cai L, Xu P, et al. Adjudicative efficacy of Bifidobacterium animalis subsp. lactis BLa80 in treating acute diarrhea in children: a randomized, double-blinded, placebo-controlled study. Eur J Clin Nutr. 2024;78:501. 10.1038/s41430-024-01428-6
  33. Pang J, Liu Y, Kang L, Ye H, Zang J, et al. Bifidobacterium animalis Promotes the Growth of Weaning Piglets by Improving Intestinal Development, Enhancing Antioxidant Capacity, and Modulating Gut Microbiota. Appl Environ Microbiol. 2022;88:e0129622. 10.1128/aem.01296-22
  34. Şahin K, Şahintürk Y, Köker G, Özçelik Köker G, Bostan F, et al. Metformin with Versus without Concomitant Probiotic Therapy in Newly Diagnosed Patients with Type 2 Diabetes or Prediabetes: A Comparative Analysis in Relation to Glycemic Control, Gastrointestinal Side Effects, and Treatment Compliance. Turk J Gastroenterol. 2022;33:925. 10.5152/tjg.2022.211063
  35. Xu B, Liang S, Zhao J, Li X, Guo J, et al. subsp. XLTG11 improves antibiotic-related diarrhea by alleviating inflammation, enhancing intestinal barrier function and regulating intestinal flora. Food Funct. 2022;13:6404. 10.1039/d1fo04305f
  36. Liu B, Wang C, Huasai S, Han A, Zhang J, et al. Compound Probiotics Improve the Diarrhea Rate and Intestinal Microbiota of Newborn Calves. Animals (Basel). 2022;12. 10.3390/ani12030322
  37. Michels M, Córneo E, Cucker L, Simon CS, de Jesus GFA, et al. Bifidobacterium lactis CCT 7858 Improves Gastrointestinal Symptoms by Antibiotics Treatment: a Double-Blind, Randomized, Placebo-Controlled Trial. Probiotics Antimicrob Proteins. 2023;15:738. 10.1007/s12602-021-09900-6
  38. Cheng J, Laitila A, Ouwehand AC. subsp. HN019 Effects on Gut Health: A Review. Front Nutr. 2021;8:790561. 10.3389/fnut.2021.790561
  39. Li Z, Zhu G, Li C, Lai H, Liu X, et al. Which Probiotic Is the Most Effective for Treating Acute Diarrhea in Children? A Bayesian Network Meta-Analysis of Randomized Controlled Trials. Nutrients. 2021;13. 10.3390/nu13124319
  40. Guo Y, Li Z, Deng M, Li Y, Liu G, et al. Effects of a multi-strain probiotic on growth, health, and fecal bacterial flora of neonatal dairy calves. Anim Biosci. 2022;35:204. 10.5713/ab.21.0084
  41. Merenstein D, Fraser CM, Roberts RF, Liu T, Grant-Beurmann S, et al. subsp. BB-12 Protects against Antibiotic-Induced Functional and Compositional Changes in Human Fecal Microbiome. Nutrients. 2021;13. 10.3390/nu13082814
  42. Kluijfhout S, Trieu TV, Vandenplas Y. Efficacy of the Probiotic Probiotical Confirmed in Acute Gastroenteritis. Pediatr Gastroenterol Hepatol Nutr. 2020;23:464. 10.5223/pghn.2020.23.5.464
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