Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 32 Researches
8.2
USERS' SCORE
Moderately Good
Based on 45 Reviews
7.4
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Quercetin
800 mg
**
Bromelain (2,400 GDU/g)
165 mg
**
Top Medical Research Studies
9
Quercetin's role against colorectal cancer
We aimed to understand how quercetin and its derivatives, especially mono-methylated quercetins (MQs), might help in treating colorectal cancer. Using advanced techniques like tandem mass spectrometry, we identified specific structural features of these flavonoids that could enhance their anti-cancer activities.
Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.
We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.
Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.
Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.
We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.
Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.
Read More
9
We explored the effects of quercetin, a plant flavonoid, on KON oral cancer cells. Our aim was to understand how quercetin could potentially fight cancer by assessing its anti-growth, anti-migrative, and anti-invasive properties. Using various assays, we treated KON cells with quercetin and observed its impact on their viability compared to normal fibroblast cells.
After treatment, we noticed that quercetin significantly induced cell death and apoptosis. It did this by raising reactive oxygen species (ROS) levels, leading to the disruption of normal mitochondrial function. We also found that quercetin caused the cancer cells to halt their growth in both the S and G2/M phases of the cell cycle, which is a crucial factor in cancer progression.
Beyond its direct effects on cell viability, quercetin exhibited promising anti-metastatic properties. Our investigation also included detailed assessments of key markers associated with apoptosis and metastasis, which clarified the underlying mechanisms at play. This discovery presents exciting opportunities for quercetin as a potential treatment option for oral cancer, paving the way for further research and clinical trials.
After treatment, we noticed that quercetin significantly induced cell death and apoptosis. It did this by raising reactive oxygen species (ROS) levels, leading to the disruption of normal mitochondrial function. We also found that quercetin caused the cancer cells to halt their growth in both the S and G2/M phases of the cell cycle, which is a crucial factor in cancer progression.
Beyond its direct effects on cell viability, quercetin exhibited promising anti-metastatic properties. Our investigation also included detailed assessments of key markers associated with apoptosis and metastasis, which clarified the underlying mechanisms at play. This discovery presents exciting opportunities for quercetin as a potential treatment option for oral cancer, paving the way for further research and clinical trials.
Read More
8
Quercetin reduces oral cancer cell viability
We explored the effects of quercetin, a natural flavonoid, on oral cancer during a systematic review of existing studies. Our investigation included a thorough screening process, where we analyzed 193 articles and selected 18 that met our inclusion criteria.
Through this review, we observed that quercetin significantly reduced cancer cell proliferation and overall viability. It also appeared to decrease tumor volume, invasion, and metastasis, all of which are critical factors in cancer progression. Notably, quercetin seems to work by inducing oxidative stress and triggering apoptosis, the process of programmed cell death, in cancer cells.
However, while the findings are promising, we must exercise caution in suggesting quercetin as a standalone treatment for oral cancer. Its effectiveness is tempered by poor absorption rates in the body, and we still have much to uncover about the precise molecular mechanisms behind its anti-cancer properties. Therefore, further clinical studies are essential to determine how best to utilize quercetin in cancer therapy.
Through this review, we observed that quercetin significantly reduced cancer cell proliferation and overall viability. It also appeared to decrease tumor volume, invasion, and metastasis, all of which are critical factors in cancer progression. Notably, quercetin seems to work by inducing oxidative stress and triggering apoptosis, the process of programmed cell death, in cancer cells.
However, while the findings are promising, we must exercise caution in suggesting quercetin as a standalone treatment for oral cancer. Its effectiveness is tempered by poor absorption rates in the body, and we still have much to uncover about the precise molecular mechanisms behind its anti-cancer properties. Therefore, further clinical studies are essential to determine how best to utilize quercetin in cancer therapy.
Read More
Most Useful Reviews
7.5
Improved wellbeing
664 people found this helpful
I have multiple sclerosis, but this supplement has been stunningly effective. At 52, my health has improved significantly. Quercetin, a powerful antioxidant, along with bromelain, is helping my treatment against cancer. I only relied on these supplements and avoided antibiotics throughout my recovery. I consistently take them for ongoing health and quality of life.
Read More
7.5
Allergy relief
84 people found this helpful
After taking this supplement for two weeks, my chronic allergies and rhinitis improved remarkably. Quercetin effectively reduced blood viscosity and strengthened my immune system, while bromelain enhanced its properties. I am more resistant to infections, allowing me to focus more on my overall health and cancer prevention.
Read More
9
Cancer treatment
45 people found this helpful
I take this supplement as part of an anti-cancer regime, along with curcumin. Although it is challenging to digest with food, the anti-cancer properties of quercetin have proven effective. The bromelain significantly aids absorption. I believe this combination will help combat cancer cells over time.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 32 Researches
8.2
- All Researches
9.5
Quercetin enhances cancer treatment efficacy
We explored the impact of quercetin when used alongside doxorubicin in treating breast cancer. In our study, we delivered these two compounds using specialized polydimethylsiloxane nanoparticles, which were designed to enhance their effectiveness in targeting cancer cells.
Quercetin plays a crucial role by blocking the P-glycoprotein efflux pump. This action helps increase the intracellular levels of doxorubicin, leading to better cell death and more effective treatment outcomes. The combination of these two agents helps to tackle the problem of cancer cell resistance to drugs, making it easier for treatment to work.
Our research demonstrated that the sequential delivery of doxorubicin followed by quercetin significantly reduced tumor size in experimental models compared to using either treatment alone. We observed noticeable cell death and inhibited tumor growth in the tested breast cancer cells.
Overall, the findings suggest that quercetin can effectively support chemotherapy by reversing drug resistance and enhancing the anticancer effects of doxorubicin when they are delivered together. The approach not only shows promise in bolstering treatment efficacy but also indicates minimal toxicity to normal tissues.
Quercetin plays a crucial role by blocking the P-glycoprotein efflux pump. This action helps increase the intracellular levels of doxorubicin, leading to better cell death and more effective treatment outcomes. The combination of these two agents helps to tackle the problem of cancer cell resistance to drugs, making it easier for treatment to work.
Our research demonstrated that the sequential delivery of doxorubicin followed by quercetin significantly reduced tumor size in experimental models compared to using either treatment alone. We observed noticeable cell death and inhibited tumor growth in the tested breast cancer cells.
Overall, the findings suggest that quercetin can effectively support chemotherapy by reversing drug resistance and enhancing the anticancer effects of doxorubicin when they are delivered together. The approach not only shows promise in bolstering treatment efficacy but also indicates minimal toxicity to normal tissues.
Read More
9
We explored how quercetin, a natural compound, affects cancer cells, particularly in the context of oral squamous cell carcinoma (OSCC). This study focused on understanding the role of sirtuin 3 (SIRT3) and a specific form of cell death known as ferroptosis, as well as how quercetin influences these processes.
Using specially engineered SCC15 cell lines, we treated the cells with quercetin and observed significant changes. Our experiments revealed that overexpressing SIRT3 led to increased levels of harmful substances like malondialdehyde (MDA) and reactive oxygen species (ROS), which diminished cell viability and promoted ferroptosis. In contrast, knocking out SIRT3 produced the opposite effect, supporting the idea that SIRT3 plays a pivotal role in this process.
Notably, we found that quercetin treatment enhanced SIRT3 levels and other relevant markers, indicating its potential as a therapeutic agent. It actively triggered autophagy, particularly through a pathway involving AMPK and mTOR, thereby fostering ferroptosis. Our findings suggest that not only does quercetin have a direct impact on OSCC cells, but it enhances the cell death process that can be beneficial in cancer treatment.
Overall, our research highlights quercetin as a promising candidate for further investigation in the battle against oral squamous cell carcinoma.
Using specially engineered SCC15 cell lines, we treated the cells with quercetin and observed significant changes. Our experiments revealed that overexpressing SIRT3 led to increased levels of harmful substances like malondialdehyde (MDA) and reactive oxygen species (ROS), which diminished cell viability and promoted ferroptosis. In contrast, knocking out SIRT3 produced the opposite effect, supporting the idea that SIRT3 plays a pivotal role in this process.
Notably, we found that quercetin treatment enhanced SIRT3 levels and other relevant markers, indicating its potential as a therapeutic agent. It actively triggered autophagy, particularly through a pathway involving AMPK and mTOR, thereby fostering ferroptosis. Our findings suggest that not only does quercetin have a direct impact on OSCC cells, but it enhances the cell death process that can be beneficial in cancer treatment.
Overall, our research highlights quercetin as a promising candidate for further investigation in the battle against oral squamous cell carcinoma.
Read More
9
Quercetin's role against colorectal cancer
We aimed to understand how quercetin and its derivatives, especially mono-methylated quercetins (MQs), might help in treating colorectal cancer. Using advanced techniques like tandem mass spectrometry, we identified specific structural features of these flavonoids that could enhance their anti-cancer activities.
Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.
We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.
Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.
Our findings showed that methylation at specific positions on the quercetin molecule significantly improved its ability to fight cancer cells. Notably, 3-O-methylquercetin and 4'-O-methylquercetin were particularly effective. These compounds caused cancer cells to stop dividing and triggered programmed cell death, also known as apoptosis.
We observed that these MQs worked through several mechanisms, such as inducing oxidative stress, disrupting mitochondrial function, and inactivating cancer-related signaling pathways—all while being non-toxic to normal human colon cells. This makes them promising candidates for cancer therapy, especially for patients with colorectal cancer.
Ultimately, our research revealed that small modifications in flavonoid structures could lead to significant improvements in their anti-cancer effectiveness, providing a path for developing targeted treatments for colorectal cancer.
Read More
9
Quercetin combats cancer drug resistance
We explored the potential of quercetin, a natural compound found in various fruits and vegetables, in combating resistance to the cancer drug trastuzumab, particularly in patients with HER2-positive gastric cancer. Our study investigated how quercetin, as part of a mixture known as Jian Pi Hua Tan Fang (JPHTF), could enhance the effectiveness of this treatment.
Through a combination of network pharmacology and molecular docking techniques, we identified key targets and pathways linked to quercetin's action. Notably, the study revealed that quercetin might target vital proteins in the PI3K/AKT/mTOR pathway, which is crucial for cell growth and survival in cancer.
We validated our findings using laboratory models of gastric cancer cells, where JPHTF containing quercetin demonstrated the ability to reverse trastuzumab resistance effectively. The results indicated that quercetin not only helped in reducing cell proliferation but also promoted cell death in resistant cancer cells.
Overall, our findings suggest that integrating quercetin with trastuzumab could be a promising strategy for enhancing treatment outcomes in patients dealing with HER2-positive gastric cancer.
Through a combination of network pharmacology and molecular docking techniques, we identified key targets and pathways linked to quercetin's action. Notably, the study revealed that quercetin might target vital proteins in the PI3K/AKT/mTOR pathway, which is crucial for cell growth and survival in cancer.
We validated our findings using laboratory models of gastric cancer cells, where JPHTF containing quercetin demonstrated the ability to reverse trastuzumab resistance effectively. The results indicated that quercetin not only helped in reducing cell proliferation but also promoted cell death in resistant cancer cells.
Overall, our findings suggest that integrating quercetin with trastuzumab could be a promising strategy for enhancing treatment outcomes in patients dealing with HER2-positive gastric cancer.
Read More
9
Our research delved into the effects of quercetin, a flavonoid commonly found in plants, on hepatocellular carcinoma (HCC), a prevalent form of liver cancer. We focused on the role of the Farnesoid X receptor (FXR), which is crucial for maintaining liver health and metabolism. By investigating how quercetin influences the glycolysis pathway through FXR signaling, we sought to uncover its anti-cancer properties.
Utilizing various methods like RNA sequencing, molecular docking, and cell proliferation assays, we found that quercetin significantly impacted several genes associated with HCC and glycolysis. Our analysis revealed that quercetin inhibits the growth of liver cancer cells by triggering an accumulation of these cells in the S-phase of the cell cycle.
Furthermore, quercetin reduced the expression of key glycolysis-related enzymes and regulated metabolite levels. This suggests that quercetin can effectively disrupt the cancer-promoting processes in the liver by altering energy metabolism. Overall, our findings illustrate quercetin's potential as an anti-cancer agent specifically targeting the glycolysis pathway in liver cancer.
Utilizing various methods like RNA sequencing, molecular docking, and cell proliferation assays, we found that quercetin significantly impacted several genes associated with HCC and glycolysis. Our analysis revealed that quercetin inhibits the growth of liver cancer cells by triggering an accumulation of these cells in the S-phase of the cell cycle.
Furthermore, quercetin reduced the expression of key glycolysis-related enzymes and regulated metabolite levels. This suggests that quercetin can effectively disrupt the cancer-promoting processes in the liver by altering energy metabolism. Overall, our findings illustrate quercetin's potential as an anti-cancer agent specifically targeting the glycolysis pathway in liver cancer.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 45 Reviews
7.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved wellbeing
664 people found this helpful
I have multiple sclerosis, but this supplement has been stunningly effective. At 52, my health has improved significantly. Quercetin, a powerful antioxidant, along with bromelain, is helping my treatment against cancer. I only relied on these supplements and avoided antibiotics throughout my recovery. I consistently take them for ongoing health and quality of life.
Read More
7.5
Allergy relief
84 people found this helpful
After taking this supplement for two weeks, my chronic allergies and rhinitis improved remarkably. Quercetin effectively reduced blood viscosity and strengthened my immune system, while bromelain enhanced its properties. I am more resistant to infections, allowing me to focus more on my overall health and cancer prevention.
Read More
9
Cancer treatment
45 people found this helpful
I take this supplement as part of an anti-cancer regime, along with curcumin. Although it is challenging to digest with food, the anti-cancer properties of quercetin have proven effective. The bromelain significantly aids absorption. I believe this combination will help combat cancer cells over time.
Read More
9
Prostate cancer
25 people found this helpful
I chose this quercetin supplement due to its popularity, and it's helping me manage my advanced prostate cancer. I'm experiencing less pain in my legs and feet. Despite my oncologist's grim prognosis, I am finding relief and am pleased with the effects of this product.
Read More
9
Irritation soothing
11 people found this helpful
Initially prescribed to reduce inflammation after my cancer diagnosis, I stopped taking quercetin. However, upon experiencing throat irritation, I resumed it, and within three days, my coughing subsided. This has greatly relieved my anxiety about recurring cancer symptoms.
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Frequently Asked Questions
9
Irritation soothing
11 people found this helpful
Initially prescribed to reduce inflammation after my cancer diagnosis, I stopped taking quercetin. However, upon experiencing throat irritation, I resumed it, and within three days, my coughing subsided. This has greatly relieved my anxiety about recurring cancer symptoms.
7.5
Supportive treatment
9 people found this helpful
My spouse has been using this supplement for over a year in combination with prescribed treatment for breast cancer. We believe it significantly aids in the positive dynamics of her treatment, providing support alongside curcumin. We feel optimistic about her recovery journey.
9
Cancer treatment
45 people found this helpful
I take this supplement as part of an anti-cancer regime, along with curcumin. Although it is challenging to digest with food, the anti-cancer properties of quercetin have proven effective. The bromelain significantly aids absorption. I believe this combination will help combat cancer cells over time.
7.5
Cancer support
2 people found this helpful
Quercetin, with its antioxidant and anti-inflammatory properties, effectively reduces inflammation and boosts immunity. It also supports respiratory health and may protect against certain cancers and neurodegenerative diseases, while protease aids digestion and reduces bloating.
7.5
Improved wellbeing
664 people found this helpful
I have multiple sclerosis, but this supplement has been stunningly effective. At 52, my health has improved significantly. Quercetin, a powerful antioxidant, along with bromelain, is helping my treatment against cancer. I only relied on these supplements and avoided antibiotics throughout my recovery. I consistently take them for ongoing health and quality of life.
7.5
Allergy relief
84 people found this helpful
After taking this supplement for two weeks, my chronic allergies and rhinitis improved remarkably. Quercetin effectively reduced blood viscosity and strengthened my immune system, while bromelain enhanced its properties. I am more resistant to infections, allowing me to focus more on my overall health and cancer prevention.
9
Prostate cancer
25 people found this helpful
I chose this quercetin supplement due to its popularity, and it's helping me manage my advanced prostate cancer. I'm experiencing less pain in my legs and feet. Despite my oncologist's grim prognosis, I am finding relief and am pleased with the effects of this product.
7.5
Cancer resistance
11 people found this helpful
Quercetin's anti-inflammatory, anti-cancer, and antioxidant properties have impressed me. It helps prevent viral infections and reduces allergies as well. I appreciate its benefits, especially against cancer and improving overall health. I recommend it for maintaining immune health, particularly during allergy seasons and cold months.
7.5
Natural cancer relief
5 people found this helpful
Many overlook quercetin's benefits as a natural anti-inflammatory and antihistamine. Research links inflammation to various diseases, including cancer. By pairing quercetin with vitamin C, I enhance its effects, relieving allergies and supporting overall health.
9
Overall health benefits
6 people found this helpful
Quercetin is a powerful supplement I take regularly. With strong antioxidant, anti-inflammatory, and anti-cancer effects, I find it essential for my health. I take two tablets twice daily, firmly believing in its capability to support my overall wellbeing and resist chronic conditions, including cancer.
7.5
Combating cancer risks
6 people found this helpful
Quercetin supports the immune system by reducing inflammation, combating allergies, and lowering cancer risk. It inhibits enzymes that trigger inflammation and some histamines linked to it. However, quercetin is better absorbed when combined with digestive enzymes or vitamin C, such as bromelain included in my supplement.
References
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- Wang J, Yang JH, Xiong D, Chen L. Activation of SIRT3/AMPK/mTOR-mediated autophagy promotes quercetin-induced ferroptosis in oral squamous cell carcinoma. Hum Exp Toxicol. 2025;44:9603271251323753. doi:10.1177/09603271251323753
- Saadh MJ, Ahmed HH, Chandra M, Al-Hussainy AF, Hamid JA, et al. Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis. Cancer Cell Int. 2025;25:66. doi:10.1186/s12935-025-03694-1
- Mukherjee S, Banik SK, Chakraborty S, Das T, Choudhury MD, et al. Bryophyllum pinnatum Induces p53-Dependent Apoptosis of Colorectal Cancer Cells via Increased Intracellular ROS and G2/M Cell-Cycle Arrest In Vitro and Validated in Silico by Molecular Docking. Cell Biol Int. 2025. doi:10.1002/cbin.70004
- Alsaab J, Sarawi WS, Alhusaini AM, Hasan IH, Alturaif S, et al. Procyanidin B2 mitigates methotrexate-induced hepatic pyroptosis by suppressing TLR4/NF-κB and caspase-3/GSDME pathways. Food Chem Toxicol. 2025;199:115341. doi:10.1016/j.fct.2025.115341
- Sun J, Sha M, Zhou J, Huang Y. Quercetin affects apoptosis and autophagy in pediatric acute myeloid leukaemia cells by inhibiting PI3K/AKT signaling pathway activation through regulation of miR-224-3p/PTEN axis. BMC Cancer. 2025;25:318. doi:10.1186/s12885-025-13709-9
- Han S, Yi YW, Kim H, Lee MY, Choi H, et al. Structure-activity relationship analysis of mono-methylated quercetins by comprehensive MS/MS analysis and anti-proliferative efficacy in human colorectal cancer cells. Biomed Pharmacother. 2025;184:117930. doi:10.1016/j.biopha.2025.117930
- Martínez-Esquivias F, Guzmán-Flores JM, Pech-Santiago EO, Guerrero-Barrera AL, Delgadillo-Aguirre CK, et al. Therapeutic Role of Quercetin in Prostate Cancer: A Study of Network Pharmacology, Molecular Docking, and Dynamics Simulation. Cell Biochem Biophys. 2025. doi:10.1007/s12013-025-01697-3
- Chuang CH, Tai YA, Wu TJ, Ho YJ, Yeh SL. Quercetin attenuates cisplatin-induced fatigue through mechanisms associated with the regulation of the HPA axis and MCP-1 signaling. Front Nutr. 2025;12:1530132. doi:10.3389/fnut.2025.1530132
- Singh T, Rastogi M, Thakur K. Network pharmacology and in silico approach to study the mechanism of quercetin against breast cancer. In Silico Pharmacol. 2025;13:22. doi:10.1007/s40203-025-00306-8
- Hu J, Bu W, Ding Y, Li X, Zhang B, et al. Jian Pi Hua Tan Fang Reverses Trastuzumab Resistance of HER2-Positive Gastric Cancer Through PI3K/AKT/mTOR Pathway: Integrating Network Pharmacology, Molecular Docking and Experimental Validation. Immun Inflamm Dis. 2025;13:e70154. doi:10.1002/iid3.70154
- Zhong W, Chen T, Chen L, Xing Y, Lin H, et al. Crippled Hepatocarcinogenesis Inhibition of Quercetin in Glycolysis Pathway with Hepatic Farnesoid X Receptor Deficiency. Curr Pharm Des. 2025. doi:10.2174/0113816128342642250111055339
- Qiu C, Xia F, Tu Q, Tang H, Liu Y, et al. Multimodal lung cancer theranostics via manganese phosphate/quercetin particle. Mol Cancer. 2025;24:43. doi:10.1186/s12943-025-02242-9
- Tubtimsri S, Chuenbarn T, Manmuan S. Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells. BMC Complement Med Ther. 2025;25:34. doi:10.1186/s12906-025-04782-5
- Wen C, Tang J, Wu M, Liu H, Lin X, et al. Preparation, characterization, and stability of pectin-whey protein isolate-based nanoparticles with mitochondrial targeting ability. Int J Biol Macromol. 2025;301:140383. doi:10.1016/j.ijbiomac.2025.140383
- Wang G, Wang D, Xia L, Lian J, Zhang Q, et al. Metal-Phenolic Nanomedicines Targeting Fatty Acid Metabolic Reprogramming to Overcome Immunosuppression in Radiometabolic Cancer Therapy. ACS Appl Mater Interfaces. 2025;17:7478. doi:10.1021/acsami.4c21028
- Velásquez Bravo A, Martínez Medina JJ, López Tevez LL, Restrepo AG, Huamaní ÁL, et al. Structural related oxidovanadium(IV)-flavonoid complexes. Influence on their anticancer effects. J Inorg Biochem. 2025;268:112915. doi:10.1016/j.jinorgbio.2025.112915
- Zhang J, Qi S, Du Y, Dai H, Liu N. Effect of quercetin on inhibiting gefitinib‑activated non‑small cell lung cancer‑induced cell pyroptosis in cardiomyocytes via modulating mitochondrial autophagy mediated by the SHP2/ROS/AMPK/XBP‑1/DJ‑1 signaling pathway. Oncol Rep. 2025;53. doi:10.3892/or.2025.8890
- Ramadan DR, Osman HA, Madhy SA, Teleb M, Darwish AI, et al. A tailored 4G -triazine-based dendrimer vehicle for quercetin endowed with MMP-2/9 inhibition and VEGF downregulation for targeting breast cancer progression and liver metastasis. RSC Adv. 2025;15:10426. doi:10.1039/d5ra01588j
- El Gendy SN, Elmotayam AK, Samir R, Ezzat MI, Abo-Elfadl MT, et al. Biotransformation of quercetin by Bacillus subtilis and anticancer activity evaluation: in vitro and in Silico. AMB Express. 2025;15:58. doi:10.1186/s13568-025-01860-2
- Wu J, Zhang J, Shu W, Feng W, Meng R, et al. Kitag. (Binpu-3) root extract inhibits tumor invasion via Notch signaling in and human breast cancer MDA-MB-231 cells. Front Pharmacol. 2025;16:1494545. doi:10.3389/fphar.2025.1494545
- Mukherjee A, Ghosh S, Ganguli S, Basu J, Basu B. Antiproliferative and Apoptotic Efficacy of Nano-PLGA Encapsulated Quercetin Molecules by Downregulation of Akt in K-ras Mutated NSCLC Cell Lines, A549 and H460. J Biochem Mol Toxicol. 2025;39:e70240. doi:10.1002/jbt.70240
- Siddiqui AJ, Elkahoui S, Alshammari AM, Patel M, Ghoniem AEM, et al. Mechanistic Insights into the Anticancer Potential of Willd. Against Triple-Negative Breast Cancer: A Network Pharmacology and Experimental Validation Study. Pharmaceuticals (Basel). 2025;18. doi:10.3390/ph18030433
- Hussein SA, Ababneh NA, Tarawneh N, Ismail MA, Awidi A, et al. Antitumor Effects of Quercetin and Luteolin in A375 Cutaneous Melanoma Cell Line Are Mediated by Upregulation of P-ERK, c-Myc, and the Upstream GPER. Life (Basel). 2025;15. doi:10.3390/life15030417
- Pawar CS, Balamurugan K, Baskar S, Prasad NR, Khan HA. Enhancing Chemosensitivity in Drug-Resistant Breast Cancer Cells Using β-Cyclodextrin-Loaded Quercetin and Doxorubicin Inclusion Complex via Modulating SRC/PI3K/Akt Pathway. Appl Biochem Biotechnol. 2025. doi:10.1007/s12010-025-05219-y
- Ma S, Zhang X, Zhu X, Yan K, Wang Q, et al. Dual-modality immune nano-activator harnessing Mn⁺ and quercetin to potentiate the cGAS-STING pathway for advanced cancer metalloimmunotherapy. J Nanobiotechnology. 2025;23:248. doi:10.1186/s12951-025-03336-8
- Sun G, Wu Y, Li J, Yang M, Xu H, et al. Quercetin liposomes conjugated with hyaluronidase: An efficient drug delivery system to block pancreatic cancer. J Control Release. 2025;382:113642. doi:10.1016/j.jconrel.2025.113642
- Yang C, Ma H, Liang Z, Zhuang Y, Hu L, et al. Cyclic RGD modified dextran-quercetin polymer micelles for targeted therapy of breast cancer. Int J Biol Macromol. 2025;308:142272. doi:10.1016/j.ijbiomac.2025.142272
- Silva-Pinto PA, de Pontes JTC, Aguilar-Morón B, Canales CSC, Pavan FR, et al. Phytochemical insights into flavonoids in cancer: Mechanisms, therapeutic potential, and the case of quercetin. Heliyon. 2025;11:e42682. doi:10.1016/j.heliyon.2025.e42682
- Zafar M, Anwar S, Hussain MA, Iqbal N, Ali A, et al. Elucidation of -derived natural compounds in STAT 3 pathway against human cancer cells: and studies. Front Pharmacol. 2025;16:1507002. doi:10.3389/fphar.2025.1507002
- Tiburzi S, Lezcano V, Principe G, Montiel Schneider MG, Miravalles AB, et al. Quercetin-loaded magnetic nanoparticles: a promising tool for antitumor treatment in human breast cancer cells. J Drug Target. 2025. doi:10.1080/1061186X.2025.2477764
- Mehrabadi S. Quercetin's Potential Therapeutic Role in Human Colorectal Cancer: An Effective Strategy for Prevention and Treatment. Anticancer Agents Med Chem. 2025. doi:10.2174/0118715206354948250226103832
