Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal.
We explored the effects of quercetin (QCT) on constipation induced by loperamide in rats. The study involved multiple treatment groups receiving different doses of QCT after the constipation model was established.
After treatment, we found significant improvements in gastrointestinal motility and stool frequency in the rats that received QCT compared to those who didn’t.
Moreover, we observed that QCT activates certain messenger pathways in the gut, highlighting its potential as a valuable option for managing chronic constipation.
Read More
8
Quercetin's effect on constipation explored
Efficacy and Molecular Mechanism of Quercetin on Constipation Induced by Berberine via Regulating Gut Microbiota.
We investigated the effects of quercetin in alleviating constipation caused by berberine. Using a small intestine propulsion experiment on constipated mice, we identified quercetin as the key ingredient in alleviating this condition.
Quercetin appears to positively influence gut microbiota and boost levels of certain substances linked to digestion. However, we noted that when combined with berberine, quercetin's efficacy in reducing constipation was less significant. These findings provide new insights into managing berberine-related constipation.
Read More
7
Euphorbia hirta supports gut health
The use of Euphorbia hirta L. (Euphorbiaceae) in diarrhea and constipation involves calcium antagonism and cholinergic mechanisms.
We investigated the traditional use of Euphorbia hirta in treating gastrointestinal issues, particularly diarrhea and constipation. Through various tests on mice and rabbits, we observed that the crude extract of E. hirta demonstrated significant antidiarrheal effects, while also acting as a laxative in constipated mice. Notably, quercetin was identified as a key component responsible for these effects. Overall, our findings lend credence to the folk medicine practices surrounding E. hirta, showing it has both benefits for diarrhea and gentle stimulation for constipation.
Read More
Most Useful Reviews
9
Relieved constipation
11 people found this helpful
Taking 50 mg of chelated iron significantly eased my stubborn constipation. Combined with probiotics, it helped promote regularity. I initially took quercetin before lunch to improve my gut health, and I recommend it for anyone struggling with iron-related constipation.
Read More
9
Constipation relief
The quality of this supplement is excellent, with good ingredients that enhance health. It has notably improved my digestion, and I no longer experience constipation. The overall benefits are substantial.
Read More
9
Daily regularity
This quercetin has significantly helped my eczema, and its quality is high. My constipation has improved, and I now enjoy daily bowel movements. I plan to repurchase after finishing my current supply.
Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal.
We explored the effects of quercetin (QCT) on constipation induced by loperamide in rats. The study involved multiple treatment groups receiving different doses of QCT after the constipation model was established.
After treatment, we found significant improvements in gastrointestinal motility and stool frequency in the rats that received QCT compared to those who didn’t.
Moreover, we observed that QCT activates certain messenger pathways in the gut, highlighting its potential as a valuable option for managing chronic constipation.
Read More
8
Quercetin's effect on constipation explored
Efficacy and Molecular Mechanism of Quercetin on Constipation Induced by Berberine via Regulating Gut Microbiota.
We investigated the effects of quercetin in alleviating constipation caused by berberine. Using a small intestine propulsion experiment on constipated mice, we identified quercetin as the key ingredient in alleviating this condition.
Quercetin appears to positively influence gut microbiota and boost levels of certain substances linked to digestion. However, we noted that when combined with berberine, quercetin's efficacy in reducing constipation was less significant. These findings provide new insights into managing berberine-related constipation.
Read More
7
Euphorbia hirta supports gut health
The use of Euphorbia hirta L. (Euphorbiaceae) in diarrhea and constipation involves calcium antagonism and cholinergic mechanisms.
We investigated the traditional use of Euphorbia hirta in treating gastrointestinal issues, particularly diarrhea and constipation. Through various tests on mice and rabbits, we observed that the crude extract of E. hirta demonstrated significant antidiarrheal effects, while also acting as a laxative in constipated mice. Notably, quercetin was identified as a key component responsible for these effects. Overall, our findings lend credence to the folk medicine practices surrounding E. hirta, showing it has both benefits for diarrhea and gentle stimulation for constipation.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 12 Reviews
7.8
All Reviews
Positive Reviews
Negative Reviews
9
Relieved constipation
11 people found this helpful
Taking 50 mg of chelated iron significantly eased my stubborn constipation. Combined with probiotics, it helped promote regularity. I initially took quercetin before lunch to improve my gut health, and I recommend it for anyone struggling with iron-related constipation.
Read More
9
Constipation relief
The quality of this supplement is excellent, with good ingredients that enhance health. It has notably improved my digestion, and I no longer experience constipation. The overall benefits are substantial.
Read More
9
Daily regularity
This quercetin has significantly helped my eczema, and its quality is high. My constipation has improved, and I now enjoy daily bowel movements. I plan to repurchase after finishing my current supply.
Read More
7.5
Improved digestion
142 people found this helpful
I used quercetin for my allergies and found it beneficial. After a week, my allergy symptoms lessened and my digestion improved, eliminating constipation. Quercetin also strengthens blood vessels and lowers cholesterol, reducing stroke and heart attack risks, while supporting respiratory health.
Read More
6
Unexpected improvement
2 people found this helpful
I’ve dealt with allergies and eczema for some time. Although quercetin didn’t show immediate effects on my allergies, it surprisingly helped alleviate my constipation, which I hadn’t anticipated.
Constipation is a common condition characterized by infrequent bowel movements or difficulty passing stools. It is typically defined as having fewer than three bowel movements per week, leading to hard, dry stools that are painful or difficult to expel. This condition can be caused by a variety of factors, including diet, dehydration, lack of physical activity, and certain medications. Stress and lifestyle changes can also contribute, making it essential for individuals to identify the root causes of their constipation for effective relief.
To alleviate constipation, it’s recommended to increase fiber intake by consuming more fruits, vegetables, whole grains, and legumes, as well as ensuring adequate hydration throughout the day. Regular exercise can also promote healthy bowel function. If over-the-counter solutions such as fiber supplements or laxatives aren't effective, it's advisable to consult a healthcare provider, as chronic constipation can lead to complications and indicate underlying health issues. Keeping a consistent eating and bathroom schedule can also help regulate bowel movements.
Quercetin is a naturally occurring flavonoid that is found in a variety of fruits, vegetables, and grains. Known for its antioxidant properties, quercetin is believed to help combat oxidative stress in the body, which can contribute to various health issues. You can commonly find it in foods such as apples, onions, berries, and citrus fruits, as well as in leafy greens. This makes it a popular dietary supplement among health enthusiasts looking to enhance their overall wellness.
Beyond its antioxidant capacity, quercetin is also being researched for its potential anti-inflammatory effects and benefits for immune support. Some studies suggest that it may help reduce allergy symptoms and improve exercise performance by decreasing muscle fatigue. With its wide range of potential health benefits, quercetin is often marketed as a natural remedy for various ailments, although it’s essential to consult a healthcare professional before starting any new supplement regimen to ensure its safety and effectiveness for your specific needs.
Based on user reviews, the timeline for seeing results from this supplement when taken for constipation varies but often ranges from a few days to a couple of weeks. For example, one user reported significant relief from constipation within just one week of use (Read Review), while another noted improved bowel movements after starting the supplement and plans to repurchase (Read Review). Additionally, a user observed benefits in digestion and constipation improvement shortly after starting the supplement (Read Review). However, individual experiences can vary significantly.
It's also worth noting that some users had delayed responses, with one indicating a lack of significant change after two weeks of use, leading to discontinuation due to persistent constipation (Read Review). Ultimately, while many users found relief relatively quickly, it seems that consistent use for at least a week or two is commonly necessary to gauge the supplement's effectiveness for constipation.
Research indicates that quercetin, a compound found in various plants, has potential benefits for relieving constipation. A study involving rats showed that quercetin significantly improved gastrointestinal motility and stool frequency in those with constipation induced by loperamide, suggesting its effectiveness in managing this condition ([3]). Furthermore, quercetin's role in enhancing gut health and positively influencing gut microbiota also supports its potential as a remedy for constipation, particularly when combined with certain other substances ([1]).
In addition to quercetin, Euphorbia hirta has been evaluated for its dual effects on both diarrhea and constipation. This plant demonstrated laxative properties in constipated mice, further substantiating the traditional use of this herb for gastrointestinal issues ([2]). Overall, the scientific evidence does lend support to the use of quercetin and Euphorbia hirta for addressing constipation. However, as always, it's crucial to consult with a healthcare professional before starting any new supplement regimen.
Users report a variety of positive outcomes regarding their constipation symptoms after using this supplement. Many have noted significant improvements in stool regularity and overall digestion. For example, one user highlighted that taking 50 mg of chelated iron alongside probiotics significantly eased their persistent constipation (Read Review). Others have similarly reported daily bowel movements and overall digestive health after incorporating quercetin into their routines (Read Review, Read Review).
Anecdotal experiences indicate that additional benefits may come from the supplement's formulation; for instance, one user experienced relief from constipation due to the combination of bromelain and quercetin (Read Review). However, it is important to note that individual results can vary widely, with some users reporting no significant effects after extended use.Read Review
Users report a variety of positive outcomes when combining this supplement with others, particularly for handling constipation. For instance, one user noted that taking 50 mg of chelated iron along with probiotics significantly improved their stubborn constipation, promoting regularity (Read Review). Similarly, the combination of bromelain and quercetin was highlighted for its effectiveness not only in reducing inflammation but also in improving digestion and alleviating constipation (Read Review). Other users have reported enhanced digestive health and regular bowel movements after integrating quercetin into their daily routines, suggesting that this combination can be particularly beneficial (Read Review).
However, the user experiences do vary. While many have found the combination of quercetin with other supplements to be effective, a few users reported less desirable responses, including persistent constipation that led them to discontinue use (Read Review). Overall, the feedback indicates that while combining quercetin with other supplements may enhance its effectiveness for digestion and constipation relief, individual results can differ widely.
Based on user reviews, the optimal dose for Quercetin to treat constipation appears to vary among individuals, with some reporting significant improvements at fairly standard amounts. Many reviewers note that taking Quercetin alongside meals, typically around the 50 mg dose, can effectively alleviate constipation issues while also enhancing overall digestion. For instance, one user mentioned they felt increased regularity after using Quercetin in conjunction with probiotics, indicating that dosing and time of consumption might be critical for success in relieving constipation (Read Review).
Others highlight the importance of combining Quercetin with other supportive ingredients, like bromelain. Users have reported that such combinations have led to improved digestive health and reduced constipation symptoms, suggesting the synergy between these components may play a key role in effectiveness. For example, one user found that taking both Quercetin and bromelain has significantly helped improve their digestion and alleviate constipation, reinforcing the idea that multitasking supplements could enhance outcomes (Read Review). While a specific universal dosage is not clearly established from user feedback, these insights may assist others in determining an effective personal regimen.
7.5
Improved digestion
142 people found this helpful
I used quercetin for my allergies and found it beneficial. After a week, my allergy symptoms lessened and my digestion improved, eliminating constipation. Quercetin also strengthens blood vessels and lowers cholesterol, reducing stroke and heart attack risks, while supporting respiratory health.
9
Daily regularity
This quercetin has significantly helped my eczema, and its quality is high. My constipation has improved, and I now enjoy daily bowel movements. I plan to repurchase after finishing my current supply.
7.5
Helps with constipation
I purchased this product to aid digestion and take two tablets, one of this and one of a bromelain product, alongside meals. It has been effective for digestion and seems to help with constipation as well!
2
Minimal effect
10 people found this helpful
I purchased quercetin for my mother’s seasonal allergic cough. After two weeks of usage, we haven’t observed significant effects on her condition, and I experienced constipation, leading me to discontinue its use.
9
Relieved constipation
11 people found this helpful
Taking 50 mg of chelated iron significantly eased my stubborn constipation. Combined with probiotics, it helped promote regularity. I initially took quercetin before lunch to improve my gut health, and I recommend it for anyone struggling with iron-related constipation.
9
Constipation relief
The quality of this supplement is excellent, with good ingredients that enhance health. It has notably improved my digestion, and I no longer experience constipation. The overall benefits are substantial.
7.5
Eliminated inflammation
1 people found this helpful
The combination of bromelain and quercetin in this supplement is excellent for reducing inflammation and boosting immunity. It's effective in improving digestion and has helped eliminate my constipation.
9
Quercetin improves gastrointestinal function
Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal.
We explored the effects of quercetin (QCT) on constipation induced by loperamide in rats. The study involved multiple treatment groups receiving different doses of QCT after the constipation model was established.
After treatment, we found significant improvements in gastrointestinal motility and stool frequency in the rats that received QCT compared to those who didn’t.
Moreover, we observed that QCT activates certain messenger pathways in the gut, highlighting its potential as a valuable option for managing chronic constipation.
8
Quercetin's effect on constipation explored
Efficacy and Molecular Mechanism of Quercetin on Constipation Induced by Berberine via Regulating Gut Microbiota.
We investigated the effects of quercetin in alleviating constipation caused by berberine. Using a small intestine propulsion experiment on constipated mice, we identified quercetin as the key ingredient in alleviating this condition.
Quercetin appears to positively influence gut microbiota and boost levels of certain substances linked to digestion. However, we noted that when combined with berberine, quercetin's efficacy in reducing constipation was less significant. These findings provide new insights into managing berberine-related constipation.
7
Euphorbia hirta supports gut health
The use of Euphorbia hirta L. (Euphorbiaceae) in diarrhea and constipation involves calcium antagonism and cholinergic mechanisms.
We investigated the traditional use of Euphorbia hirta in treating gastrointestinal issues, particularly diarrhea and constipation. Through various tests on mice and rabbits, we observed that the crude extract of E. hirta demonstrated significant antidiarrheal effects, while also acting as a laxative in constipated mice. Notably, quercetin was identified as a key component responsible for these effects. Overall, our findings lend credence to the folk medicine practices surrounding E. hirta, showing it has both benefits for diarrhea and gentle stimulation for constipation.
References
Cui M, Li Y, Zheng T, Chen H, Wang J, et al. Efficacy and Molecular Mechanism of Quercetin on Constipation Induced by Berberine via Regulating Gut Microbiota. Int J Mol Sci. 2024;25. doi:10.3390/ijms25116228
Ali MZ, Mehmood MH, Saleem M, Gilani AH. The use of Euphorbia hirta L. (Euphorbiaceae) in diarrhea and constipation involves calcium antagonism and cholinergic mechanisms. BMC Complement Med Ther. 2020;20:14. doi:10.1186/s12906-019-2793-0
Kim JE, Lee MR, Park JJ, Choi JY, Song BR, et al. Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal. Pharm Biol. 2018;56:309. doi:10.1080/13880209.2018.1474932