We set out to explore the therapeutic impact of quercetin on psoriasis and how it interacts with a specific signaling pathway known as PI3K/AKT/GLUT1, which plays a critical role in inflammation and immune responses. Using a mouse model of psoriasis induced by imiquimod, we carefully assessed the effects of quercetin on skin lesions and associated histopathological features.
To deepen our understanding, we evaluated human keratinocyte cells (HaCaT) to see how quercetin influenced cell proliferation and apoptosis. Our findings indicated that quercetin appeared helpful in reducing the symptoms of psoriasis and that it had a notable effect on signaling through the PI3K/AKT/GLUT1 pathway.
Overall, the results suggest that quercetin could be a promising candidate for treating psoriasis, marking a step forward in potential therapeutic options. As we continue to investigate this area, these insights may pave the way for more targeted treatments in the future.
Read More
8
Quercetin reduces psoriasis inflammation
Quercetin mediates the therapeutic effect of on psoriasis by regulating STAT3 phosphorylation to inhibit the IL-23/IL-17A axis.
Our exploration focused on understanding how quercetin, along with other components, contributes to treating psoriasis. The study involved utilizing various databases to identify compounds and their targets, followed by creating a network to visualize these interactions.
We examined the effects of quercetin and found that it effectively reduces the production of inflammatory substances like NO, TNF-α, and IL-6. Additionally, quercetin appeared to impact critical inflammatory pathways, particularly by regulating the IL-23/IL-17A axis through the phospho-STAT3 pathway. This regulation is significant, as it suggests quercetin's potential in managing psoriasis symptoms by dampening the inflammatory response.
Overall, our findings highlight quercetin, along with asiaticoside and asiatic acid, as key players in addressing psoriasis. However, quercetin stands out for its specific impact on modulating inflammatory markers, which presents a promising direction for future treatments.
Read More
8
Quercetin's potential in psoriasis
Unveiling the molecular mechanisms of Haitang-Xiaoyin Mixture in psoriasis treatment based on bioinformatics, network pharmacology, machine learning, and molecular docking verification.
We examined the therapeutic effects of quercetin, a key component of the traditional Chinese medicine formulation known as Haitang-Xiaoyin Mixture (HXM), on psoriasis. The study utilized advanced approaches, including bioinformatics and network pharmacology, to identify the specific targets and mechanisms of action that quercetin may have in managing this skin condition.
Our findings illuminated that quercetin, along with another component called triptolide, interacts with important proteins in the body known to be involved in psoriasis. Notably, we pinpointed CXCL2 and CXCR4 as critical targets affected by quercetin, suggesting that this compound plays an essential role in modulating immune responses and inflammation associated with psoriasis.
By employing methods like machine learning and molecular docking, we strengthened the understanding of how quercetin acts at a molecular level. This research reveals the promising potential of quercetin in alleviating psoriasis symptoms, although we should carefully consider its effects in conjunction with other compounds present in HXM.
Read More
Most Useful Reviews
9
Psoriasis cleared unexpectedly
6 people found this helpful
My psoriasis suddenly disappeared. This is my second purchase. I had psoriasis and tried it, but it vanished unexpectedly. I cannot attribute this entirely to the product, as I did not change anything else. The expiration date is also good and long.
Read More
9
Significant improvement noted
I took this for my mother-in-law and will buy more. Surprisingly, her long-term psoriasis has diminished thanks to this product. No one believed it could have such an effect, but the result is evident. I highly recommend it; we will purchase again.
Read More
7.5
Helps psoriasis symptoms
119 people found this helpful
Quercetin and bromelain are powerful natural ingredients designed to suppress allergic and inflammatory disorders such as sinusitis, asthma, eczema, and hay fever. They help alleviate allergic conditions, relieve asthma symptoms, and promote phlegm elimination in bronchitis. These ingredients also combat atopic dermatitis and psoriasis, relieve sinusitis symptoms, and fight inflammation of cartilage and joints. As someone with arthritis, Raynaud's syndrome, and numerous allergies, Quercetin has been a salvation for me! I take it regularly and definitely recommend it.
Unveiling the molecular mechanisms of Haitang-Xiaoyin Mixture in psoriasis treatment based on bioinformatics, network pharmacology, machine learning, and molecular docking verification.
We examined the therapeutic effects of quercetin, a key component of the traditional Chinese medicine formulation known as Haitang-Xiaoyin Mixture (HXM), on psoriasis. The study utilized advanced approaches, including bioinformatics and network pharmacology, to identify the specific targets and mechanisms of action that quercetin may have in managing this skin condition.
Our findings illuminated that quercetin, along with another component called triptolide, interacts with important proteins in the body known to be involved in psoriasis. Notably, we pinpointed CXCL2 and CXCR4 as critical targets affected by quercetin, suggesting that this compound plays an essential role in modulating immune responses and inflammation associated with psoriasis.
By employing methods like machine learning and molecular docking, we strengthened the understanding of how quercetin acts at a molecular level. This research reveals the promising potential of quercetin in alleviating psoriasis symptoms, although we should carefully consider its effects in conjunction with other compounds present in HXM.
Read More
8
Quercetin reduces psoriasis inflammation
Quercetin mediates the therapeutic effect of on psoriasis by regulating STAT3 phosphorylation to inhibit the IL-23/IL-17A axis.
Our exploration focused on understanding how quercetin, along with other components, contributes to treating psoriasis. The study involved utilizing various databases to identify compounds and their targets, followed by creating a network to visualize these interactions.
We examined the effects of quercetin and found that it effectively reduces the production of inflammatory substances like NO, TNF-α, and IL-6. Additionally, quercetin appeared to impact critical inflammatory pathways, particularly by regulating the IL-23/IL-17A axis through the phospho-STAT3 pathway. This regulation is significant, as it suggests quercetin's potential in managing psoriasis symptoms by dampening the inflammatory response.
Overall, our findings highlight quercetin, along with asiaticoside and asiatic acid, as key players in addressing psoriasis. However, quercetin stands out for its specific impact on modulating inflammatory markers, which presents a promising direction for future treatments.
Read More
7
Quercetin shows promise for psoriasis
Inhibition of PI3K/AKT/GLUT1 Signaling Pathway by Quercetin in the Treatment of Psoriasis.
We set out to explore the therapeutic impact of quercetin on psoriasis and how it interacts with a specific signaling pathway known as PI3K/AKT/GLUT1, which plays a critical role in inflammation and immune responses. Using a mouse model of psoriasis induced by imiquimod, we carefully assessed the effects of quercetin on skin lesions and associated histopathological features.
To deepen our understanding, we evaluated human keratinocyte cells (HaCaT) to see how quercetin influenced cell proliferation and apoptosis. Our findings indicated that quercetin appeared helpful in reducing the symptoms of psoriasis and that it had a notable effect on signaling through the PI3K/AKT/GLUT1 pathway.
Overall, the results suggest that quercetin could be a promising candidate for treating psoriasis, marking a step forward in potential therapeutic options. As we continue to investigate this area, these insights may pave the way for more targeted treatments in the future.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8
All Reviews
Positive Reviews
Negative Reviews
9
Psoriasis cleared unexpectedly
6 people found this helpful
My psoriasis suddenly disappeared. This is my second purchase. I had psoriasis and tried it, but it vanished unexpectedly. I cannot attribute this entirely to the product, as I did not change anything else. The expiration date is also good and long.
Read More
9
Significant improvement noted
I took this for my mother-in-law and will buy more. Surprisingly, her long-term psoriasis has diminished thanks to this product. No one believed it could have such an effect, but the result is evident. I highly recommend it; we will purchase again.
Read More
7.5
Helps psoriasis symptoms
119 people found this helpful
Quercetin and bromelain are powerful natural ingredients designed to suppress allergic and inflammatory disorders such as sinusitis, asthma, eczema, and hay fever. They help alleviate allergic conditions, relieve asthma symptoms, and promote phlegm elimination in bronchitis. These ingredients also combat atopic dermatitis and psoriasis, relieve sinusitis symptoms, and fight inflammation of cartilage and joints. As someone with arthritis, Raynaud's syndrome, and numerous allergies, Quercetin has been a salvation for me! I take it regularly and definitely recommend it.
Read More
7.5
Psoriasis improved noticeably
1 people found this helpful
I'm taking this because it's beneficial. I have severe psoriasis and have used it for over a month, as it is said to support immunity and possesses antioxidant qualities. I’ve dealt with psoriasis on my elbows and knees for more than 10 years. While it worsened with itching and pain, my symptoms have improved significantly. There is almost no itching now, and although it remains slightly raised, it is manageable. I plan to continue taking it. I feel it’s better than not eating anything and hoping to improve. I am satisfied with this product.
Read More
7.5
Effective for inflammation
Excellent product with quality ingredients! I cannot do without Quercetin. I have psoriasis and this product greatly benefits my inflammation. It's wonderful for respiratory issues and boosts immunity. The bromelain enhances the antioxidant properties and improves the product's performance. The capsule size is fine, and there is no particular taste. I will continue to buy this product.
Psoriasis is a chronic autoimmune condition that primarily affects the skin, leading to the rapid growth of skin cells that accumulate, forming scales and red patches that can be itchy and sometimes painful. These changes occur due to an abnormal immune response that accelerates the skin renewal process. The disease can vary in severity, with some individuals experiencing mild flare-ups while others endure more severe symptoms. Psoriasis commonly appears on the elbows, knees, scalp, and lower back, but it can occur anywhere on the body.
There are several types of psoriasis, with plaque psoriasis being the most common form, characterized by raised, inflamed patches covered with silvery-white scales. Other types include guttate, inverse, pustular, and erythrodermic psoriasis. While the exact cause of psoriasis is still not entirely understood, it is believed to involve genetic, environmental, and immune system factors. Treatments vary widely and can range from topical medications and phototherapy to systemic treatments aimed at reducing inflammation and slowing skin cell turnover. If you suspect you have psoriasis, consulting a healthcare provider is advisable to explore the most appropriate treatment options.
Quercetin is a naturally occurring flavonoid that is found in a variety of fruits, vegetables, and grains. Known for its antioxidant properties, quercetin is believed to help combat oxidative stress in the body, which can contribute to various health issues. You can commonly find it in foods such as apples, onions, berries, and citrus fruits, as well as in leafy greens. This makes it a popular dietary supplement among health enthusiasts looking to enhance their overall wellness.
Beyond its antioxidant capacity, quercetin is also being researched for its potential anti-inflammatory effects and benefits for immune support. Some studies suggest that it may help reduce allergy symptoms and improve exercise performance by decreasing muscle fatigue. With its wide range of potential health benefits, quercetin is often marketed as a natural remedy for various ailments, although it’s essential to consult a healthcare professional before starting any new supplement regimen to ensure its safety and effectiveness for your specific needs.
Based on user reviews, the time it takes to see results from this supplement for psoriasis can vary, but many users report noticeable improvements within a month of use. For instance, one user mentions that after over a month of taking the product, their severe psoriasis symptoms improved significantly, with reduced itching and manageable raised areas on the skin Read Review. Another review highlights a longer-term benefit, noting that a user's long-term psoriasis diminished, suggesting that ongoing use can lead to substantial results over time Read Review.
While results can differ from person to person, consistent use seems to be key, as many users emphasize their plan to continue taking the supplement due to its positive effects on their psoriasis and inflammation levels Read Review. If you're considering this supplement, be prepared for a potential delay in seeing results, but remain hopeful as many others have experienced success.
Research indicates that quercetin may be a promising supplement for individuals dealing with psoriasis. In studies exploring its effectiveness, quercetin has been shown to reduce symptoms by interacting with critical inflammatory pathways and immune responses related to the condition. For instance, one study demonstrated that quercetin significantly inhibits the PI3K/AKT/GLUT1 signaling pathway, which is influential in inflammation, and effectively lessened skin lesions in a mouse model of psoriasis [1]. Additionally, quercetin appears to modulate inflammatory markers, such as TNF-α and IL-6, which are vital in managing psoriasis symptoms [3].
Moreover, quercetin has been studied in combination with other components found in traditional medicine formulations, underscoring its role in addressing psoriasis at a molecular level. One study specifically identified its interaction with critical targets like CXCL2 and CXCR4 as a mechanism for modulating immune responses linked to the skin condition [2]. Given these findings, quercetin could represent a valuable addition to psoriasis treatment regimens, although it is essential for patients to consult healthcare professionals before starting any new supplement.
Based on user reviews, many individuals have reported significant improvements in their psoriasis symptoms after using this supplement. One user experienced a complete disappearance of their psoriasis, attributing at least some of this positive change to the product Read Review. Another review details how a long-term psoriasis condition diminished remarkably, with the user's family expressing disbelief at the evident results, underscoring the supplement's potential effectiveness Read Review.
Additionally, several users have described reductions in itching and inflammation associated with psoriasis. For example, one reviewer shared their experience of significant symptom improvement after over a month of use, noting that while some symptoms persisted, they were now manageable and far less bothersome Read Review. Overall, while individual results can vary, there are numerous accounts of users experiencing relief from psoriasis symptoms, leading many to commit to continued use for ongoing benefits Read Review.
Based on user reviews, many individuals have found success in combining this supplement with other natural ingredients to enhance their experience managing psoriasis. Users have reported that the inclusion of Quercetin and Bromelain not only supports immune function but also alleviates inflammation linked to conditions such as psoriasis, eczema, and arthritis. For example, one reviewer mentions that Quercetin has been a "salvation" for their arthritis and psoriasis, backing its efficacy for inflammatory disorders Read Review.
Moreover, users have noted the synergistic effects between the ingredients, suggesting that the bromelain enhances the overall performance of the supplement, particularly in reducing inflammation related to psoriasis. One user highlighted that since incorporating this supplement, the inflammation from their psoriasis has noticeably decreased, while also benefiting their respiratory health post-COVID Read Review. Overall, it seems that users believe that combining this supplement with other supportive ingredients can lead to a more comprehensive approach in managing psoriasis symptoms effectively.
Based on user reviews, there seems to be considerable anecdotal support for the use of Quercetin in treating psoriasis, although specific dosage recommendations are not mentioned. One user, who has struggled with severe psoriasis for over a decade, reported significant improvement in symptoms after taking Quercetin regularly for more than a month. They noted a reduction in itching and pain, stating that the symptoms became more manageable over time Read Review. Another reviewer highlighted the benefits of Quercetin in reducing inflammation linked to psoriasis Read Review.
Moreover, users frequently reference the combination of Quercetin with bromelain as particularly effective in addressing inflammation and boosting immunity, which can be beneficial for those dealing with psoriasis Read Review. While individual experiences vary, the lack of detailed dosing information in the reviews suggests that users may be trying out different amounts to see what works best for their specific condition. Hence, it would be wise for potential users to consult with healthcare professionals regarding the appropriate dosing strategy for their unique situations.
7.5
Psoriasis improved noticeably
1 people found this helpful
I'm taking this because it's beneficial. I have severe psoriasis and have used it for over a month, as it is said to support immunity and possesses antioxidant qualities. I’ve dealt with psoriasis on my elbows and knees for more than 10 years. While it worsened with itching and pain, my symptoms have improved significantly. There is almost no itching now, and although it remains slightly raised, it is manageable. I plan to continue taking it. I feel it’s better than not eating anything and hoping to improve. I am satisfied with this product.
9
Significant improvement noted
I took this for my mother-in-law and will buy more. Surprisingly, her long-term psoriasis has diminished thanks to this product. No one believed it could have such an effect, but the result is evident. I highly recommend it; we will purchase again.
7.5
Effective for inflammation
Excellent product with quality ingredients! I cannot do without Quercetin. I have psoriasis and this product greatly benefits my inflammation. It's wonderful for respiratory issues and boosts immunity. The bromelain enhances the antioxidant properties and improves the product's performance. The capsule size is fine, and there is no particular taste. I will continue to buy this product.
9
Psoriasis cleared unexpectedly
6 people found this helpful
My psoriasis suddenly disappeared. This is my second purchase. I had psoriasis and tried it, but it vanished unexpectedly. I cannot attribute this entirely to the product, as I did not change anything else. The expiration date is also good and long.
7.5
Helps psoriasis symptoms
119 people found this helpful
Quercetin and bromelain are powerful natural ingredients designed to suppress allergic and inflammatory disorders such as sinusitis, asthma, eczema, and hay fever. They help alleviate allergic conditions, relieve asthma symptoms, and promote phlegm elimination in bronchitis. These ingredients also combat atopic dermatitis and psoriasis, relieve sinusitis symptoms, and fight inflammation of cartilage and joints. As someone with arthritis, Raynaud's syndrome, and numerous allergies, Quercetin has been a salvation for me! I take it regularly and definitely recommend it.
6
Reduced psoriasis inflammation
Good quercetin with a convenient dosage alongside bromelain. It helped my lungs and respiratory system recover quickly after COVID. The inflammation from my psoriasis has noticeably decreased due to the bromelain in the composition. I recommend it!
7
Quercetin shows promise for psoriasis
Inhibition of PI3K/AKT/GLUT1 Signaling Pathway by Quercetin in the Treatment of Psoriasis.
We set out to explore the therapeutic impact of quercetin on psoriasis and how it interacts with a specific signaling pathway known as PI3K/AKT/GLUT1, which plays a critical role in inflammation and immune responses. Using a mouse model of psoriasis induced by imiquimod, we carefully assessed the effects of quercetin on skin lesions and associated histopathological features.
To deepen our understanding, we evaluated human keratinocyte cells (HaCaT) to see how quercetin influenced cell proliferation and apoptosis. Our findings indicated that quercetin appeared helpful in reducing the symptoms of psoriasis and that it had a notable effect on signaling through the PI3K/AKT/GLUT1 pathway.
Overall, the results suggest that quercetin could be a promising candidate for treating psoriasis, marking a step forward in potential therapeutic options. As we continue to investigate this area, these insights may pave the way for more targeted treatments in the future.
8
Quercetin reduces psoriasis inflammation
Quercetin mediates the therapeutic effect of on psoriasis by regulating STAT3 phosphorylation to inhibit the IL-23/IL-17A axis.
Our exploration focused on understanding how quercetin, along with other components, contributes to treating psoriasis. The study involved utilizing various databases to identify compounds and their targets, followed by creating a network to visualize these interactions.
We examined the effects of quercetin and found that it effectively reduces the production of inflammatory substances like NO, TNF-α, and IL-6. Additionally, quercetin appeared to impact critical inflammatory pathways, particularly by regulating the IL-23/IL-17A axis through the phospho-STAT3 pathway. This regulation is significant, as it suggests quercetin's potential in managing psoriasis symptoms by dampening the inflammatory response.
Overall, our findings highlight quercetin, along with asiaticoside and asiatic acid, as key players in addressing psoriasis. However, quercetin stands out for its specific impact on modulating inflammatory markers, which presents a promising direction for future treatments.
8
Quercetin's potential in psoriasis
Unveiling the molecular mechanisms of Haitang-Xiaoyin Mixture in psoriasis treatment based on bioinformatics, network pharmacology, machine learning, and molecular docking verification.
We examined the therapeutic effects of quercetin, a key component of the traditional Chinese medicine formulation known as Haitang-Xiaoyin Mixture (HXM), on psoriasis. The study utilized advanced approaches, including bioinformatics and network pharmacology, to identify the specific targets and mechanisms of action that quercetin may have in managing this skin condition.
Our findings illuminated that quercetin, along with another component called triptolide, interacts with important proteins in the body known to be involved in psoriasis. Notably, we pinpointed CXCL2 and CXCR4 as critical targets affected by quercetin, suggesting that this compound plays an essential role in modulating immune responses and inflammation associated with psoriasis.
By employing methods like machine learning and molecular docking, we strengthened the understanding of how quercetin acts at a molecular level. This research reveals the promising potential of quercetin in alleviating psoriasis symptoms, although we should carefully consider its effects in conjunction with other compounds present in HXM.
References
Ma J, Wang F, Wang L, Wang Y, Wu D, et al. Inhibition of PI3K/AKT/GLUT1 Signaling Pathway by Quercetin in the Treatment of Psoriasis. Front Biosci (Landmark Ed). 2025;30:26884. doi:10.31083/FBL26884
Zhai M, Chen T, Shao M, Yang X, Qi Y, et al. Unveiling the molecular mechanisms of Haitang-Xiaoyin Mixture in psoriasis treatment based on bioinformatics, network pharmacology, machine learning, and molecular docking verification. Comput Biol Chem. 2025;115:108352. doi:10.1016/j.compbiolchem.2025.108352
Liu Q, Liu J, Zheng Y, Lei J, Huang J, et al. Quercetin mediates the therapeutic effect of on psoriasis by regulating STAT3 phosphorylation to inhibit the IL-23/IL-17A axis. Nan Fang Yi Ke Da Xue Xue Bao. 2025;45:90. doi:10.12122/j.issn.1673-4254.2025.01.12