Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 41 Researches
7.9
USERS' SCORE
Good
Based on 3 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Serving Per Container: 30
Amount Per Serving
%DV
Ultimate Care Probiotic Culture Blend 100 Billion CFU
301 mg
***
Bifido Probiotic BlendBifidobacterium lactis BI-04®, Bifidobacterium lactis HN019™, Bifidobacterium infantis Bi-26™, Bifidobacterium lactis Bi-07®
54 Billion CFU
Lacto Probiotic BlendLactobacillus plantarum Lp-115®, Lactobacillus rhamnosus GG, Lactococcus lactis LI-23™, Lactobacillus casei Lc-11®, Lactobacillus paracasei Lpc-37®, Lactobacillus acidophilus La-14®, Lactobacillus acidophilus NCFM®, Lactobacillus brevis Lbr-35™
46 Billion CFU
Top Medical Research Studies
9
We examined the potential of lactococcus lactis, a probiotic found in yogurt and cheese, in fighting colorectal cancer. Through a thorough review of recent studies, we found that this beneficial bacterium can suppress cancer cell proliferation and reduce inflammatory agents linked to cancer.
Specifically, lactococcus lactis was observed to lower levels of substances like interleukin-6 and tumor necrosis factor-alpha, which are involved in cancer development. However, while its effects appear promising, our findings indicate that more extensive research is necessary to confirm its overall effectiveness in cancer treatment without significant side effects.
Specifically, lactococcus lactis was observed to lower levels of substances like interleukin-6 and tumor necrosis factor-alpha, which are involved in cancer development. However, while its effects appear promising, our findings indicate that more extensive research is necessary to confirm its overall effectiveness in cancer treatment without significant side effects.
Read More
9
We explored the effects of Lactococcus lactis strain C60 on cancer growth, particularly its ability to enhance the immune response. In a study involving mice with melanoma, we found that C60 boosted the performance of immune cells called macrophages, leading to better tumor suppression.
Mice given C60 showed reduced tumor sizes, thanks to an increase in energy production from macrophages. These immune cells shifted to a state that promotes inflammation, which helped activate more T cells targeting cancer.
However, the study highlights that while promising, the benefits of C60 should be further examined in human contexts.
Mice given C60 showed reduced tumor sizes, thanks to an increase in energy production from macrophages. These immune cells shifted to a state that promotes inflammation, which helped activate more T cells targeting cancer.
However, the study highlights that while promising, the benefits of C60 should be further examined in human contexts.
Read More
9
We explored the potential of Lactococcus lactis in fighting colorectal cancer (CRC) through a detailed study with both healthy individuals and CRC patients. By isolating this probiotic from healthy human stools, we examined its effects on cancer in mice models.
Remarkably, Lactococcus lactis not only restores gut microbiota but also produces a key protein called α-mannosidase, which significantly slows down tumor growth. While we saw promising results in mice, it's important to note that further research is needed to fully understand its benefits for humans.
Remarkably, Lactococcus lactis not only restores gut microbiota but also produces a key protein called α-mannosidase, which significantly slows down tumor growth. While we saw promising results in mice, it's important to note that further research is needed to fully understand its benefits for humans.
Read More
Most Useful Reviews
9
Health improvements noticed
43 people found this helpful
I ordered this product in desperation. Due to chronic BV and the challenges of antibiotics, I sought a natural remedy as my wedding anniversary approached. After taking it, my yeast infection cleared up completely. I noticed an improvement in my digestion and overall health, especially regarding cancer lesions that had resolved completely!
Read More
9
Gut health support
1 people found this helpful
I received this product promptly. I’m pleased as I had previously struggled to find it. Having overcome cancer in 2016 without traditional treatments, I understand the importance of gut health, and this product is vital for my wellbeing.
Read More
7.5
Significant quality of life improvement
1 people found this helpful
After 11 years of digestive issues from metformin, I have never felt better since starting this probiotic. My mother now takes it for her rectal cancer, and I highly recommend it. My quality of life has drastically improved.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 41 Researches
7.9
- All Researches
9.5
Lactobacillus acidophilus improves cancer therapy
We explored how lactobacillus acidophilus can enhance chemodynamic therapy for cancer. By coupling the probiotic with specialized nanosheets loaded with calcium oxide nanoparticles, we observed a notable reduction in tumor size.
This innovative approach led to a significant boost in hydroxyl radical production within the tumor microenvironment, resulting in a remarkable tumor inhibition rate of 96.4%.
The findings suggest that probiotics can help target tumors more effectively and improve treatment outcomes.
This innovative approach led to a significant boost in hydroxyl radical production within the tumor microenvironment, resulting in a remarkable tumor inhibition rate of 96.4%.
The findings suggest that probiotics can help target tumors more effectively and improve treatment outcomes.
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9
We explored how Bifidobacterium lactis impacts bowel health, particularly regarding cancer. In a study involving mice with induced precancerous lesions, we found that B. lactis treatment helped reduce weight loss, intestinal damage, and the formation of polyps.
Both the probiotic and its cell-free supernatant improved gut microbiome health and decreased inflammatory responses. This suggests that B. lactis may play a beneficial role in combating bowel cancer through inflammation regulation and microbiome optimization.
Both the probiotic and its cell-free supernatant improved gut microbiome health and decreased inflammatory responses. This suggests that B. lactis may play a beneficial role in combating bowel cancer through inflammation regulation and microbiome optimization.
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9
Our exploration into the effects of Lactococcus lactis on cancer treatment revealed promising results. By genetically modifying Lactococcus lactis to produce HuFOLactis, we aimed to enhance immune responses against tumors. This modified variant, combined with the peptide iRGD, helped immune cells penetrate difficult tumor areas more effectively.
In tests, we saw significant immune cell activation and improved tumor-fighting abilities in mouse models, particularly against gastric cancer. When used alongside anti-PD-1 therapy, this combination successfully slowed tumor growth and improved survival rates.
In tests, we saw significant immune cell activation and improved tumor-fighting abilities in mouse models, particularly against gastric cancer. When used alongside anti-PD-1 therapy, this combination successfully slowed tumor growth and improved survival rates.
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9
We explored how a new approach using immunomodulator-boosted Lactococcus lactis can improve in situ cancer vaccination. By delivering specific immune-boosting agents directly into tumors, this treatment helped activate crucial immune cells, leading to a notable decrease in tumor growth and increased survival rates in mice.
The combination of this treatment with a myeloid-derived suppressor cell inhibitor showed even more promising results, allowing for complete tumor inhibition in certain cases. Overall, this innovative strategy appears to be a significant step towards effective cancer therapies.
The combination of this treatment with a myeloid-derived suppressor cell inhibitor showed even more promising results, allowing for complete tumor inhibition in certain cases. Overall, this innovative strategy appears to be a significant step towards effective cancer therapies.
Read More
9
We examined the potential of lactococcus lactis, a probiotic found in yogurt and cheese, in fighting colorectal cancer. Through a thorough review of recent studies, we found that this beneficial bacterium can suppress cancer cell proliferation and reduce inflammatory agents linked to cancer.
Specifically, lactococcus lactis was observed to lower levels of substances like interleukin-6 and tumor necrosis factor-alpha, which are involved in cancer development. However, while its effects appear promising, our findings indicate that more extensive research is necessary to confirm its overall effectiveness in cancer treatment without significant side effects.
Specifically, lactococcus lactis was observed to lower levels of substances like interleukin-6 and tumor necrosis factor-alpha, which are involved in cancer development. However, while its effects appear promising, our findings indicate that more extensive research is necessary to confirm its overall effectiveness in cancer treatment without significant side effects.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Health improvements noticed
43 people found this helpful
I ordered this product in desperation. Due to chronic BV and the challenges of antibiotics, I sought a natural remedy as my wedding anniversary approached. After taking it, my yeast infection cleared up completely. I noticed an improvement in my digestion and overall health, especially regarding cancer lesions that had resolved completely!
Read More
9
Gut health support
1 people found this helpful
I received this product promptly. I’m pleased as I had previously struggled to find it. Having overcome cancer in 2016 without traditional treatments, I understand the importance of gut health, and this product is vital for my wellbeing.
Read More
7.5
Significant quality of life improvement
1 people found this helpful
After 11 years of digestive issues from metformin, I have never felt better since starting this probiotic. My mother now takes it for her rectal cancer, and I highly recommend it. My quality of life has drastically improved.
Read More
Frequently Asked Questions
8
This study explored the effects of probiotic fermented milk containing Bifidobacterium animalis ssp. lactis BX-245 on mice with colorectal cancer.
We observed that this specific fermented milk led to changes in gut and intratumor microbiota, reduced gut barrier damage, and increased important immune markers.
Importantly, BX-245 was associated with a notable reduction in tumor size and quantity compared to regular fermented milk.
However, these findings are preliminary and more research is needed to firmly establish how this probiotic impacts cancer risk and progression.
We observed that this specific fermented milk led to changes in gut and intratumor microbiota, reduced gut barrier damage, and increased important immune markers.
Importantly, BX-245 was associated with a notable reduction in tumor size and quantity compared to regular fermented milk.
However, these findings are preliminary and more research is needed to firmly establish how this probiotic impacts cancer risk and progression.
7
We explored how probiotics, including Bifidobacterium lactis, can enhance recovery for patients undergoing surgery for stomach cancer. Our prospective study involved 74 patients divided into two groups—one receiving probiotics and the other a placebo.
We measured postoperative recovery by examining inflammation levels and overall outcomes. The results showed that probiotic patients experienced significantly reduced inflammation and faster recovery, leading to improved quality of life and reduced medical costs.
This suggests probiotics may play a beneficial role in recovery after gastric surgery.
We measured postoperative recovery by examining inflammation levels and overall outcomes. The results showed that probiotic patients experienced significantly reduced inflammation and faster recovery, leading to improved quality of life and reduced medical costs.
This suggests probiotics may play a beneficial role in recovery after gastric surgery.
9
We examined the potential of lactococcus lactis, a probiotic found in yogurt and cheese, in fighting colorectal cancer. Through a thorough review of recent studies, we found that this beneficial bacterium can suppress cancer cell proliferation and reduce inflammatory agents linked to cancer.
Specifically, lactococcus lactis was observed to lower levels of substances like interleukin-6 and tumor necrosis factor-alpha, which are involved in cancer development. However, while its effects appear promising, our findings indicate that more extensive research is necessary to confirm its overall effectiveness in cancer treatment without significant side effects.
Specifically, lactococcus lactis was observed to lower levels of substances like interleukin-6 and tumor necrosis factor-alpha, which are involved in cancer development. However, while its effects appear promising, our findings indicate that more extensive research is necessary to confirm its overall effectiveness in cancer treatment without significant side effects.
References
- Zhao Z, Fei K, Bai H, Wang Z, Duan J, et al. Metagenome association study of the gut microbiome revealed biomarkers linked to chemotherapy outcomes in locally advanced and advanced lung cancer. Thorac Cancer. 2021;12:66. 10.1111/1759-7714.13711
- Chan YL, Liao JC, Li TL, Wu CJ, Chiu YH. Bifidobacterium lactis ameliorates AOM/DSS-induced inflammation, dysbiosis, and colonic precancerous lesions. Appl Microbiol Biotechnol. 2025;109:69. 10.1007/s00253-025-13445-x
- Fedosova N, Cheremshenko N, Gogol S, Bezdieniezhnykh N, Tikhonov V, et al. THE INFLUENCE OF BIFIDOBACTERIUM ANIMALIS AND LECTIN OF B. SUBTILIS IMV B-7724 ON THE ANTITUMOR IMMUNE RESPONSE OF MICE WITH EHRLICH ADENOCARCINOMA. Exp Oncol. 2024;46:228. 10.15407/exp-oncology.2024.03.228
- Yang C, Zha M, Li L, Qiao J, Kwok LY, et al. Bifidobacterium animalis ssp. lactis BX-245-fermented milk alleviates tumor burden in mice with colorectal cancer. J Dairy Sci. 2025;108:1211. 10.3168/jds.2024-25614
- Xiong H, He Z, Wei Y, Li Q, Xiao Q, et al. Probiotic Compounds Enhanced Recovery after Surgery for Patients with Distal Gastric Cancer: A Prospective, Controlled Clinical Trial. Ann Surg Oncol. 2024;31:5240. 10.1245/s10434-024-15394-7
- Kozak T, Lykhova O, Serhiichuk T, Bezdieniezhnykh N, Chekhun V. OPTIMIZATION OF EXPERIMENTAL MODEL SYSTEMS FOR EVALUATING RECIPROCAL INFLUENCE OF BIFIDOBACTERIUM ANIMALIS AND HUMAN BREAST CANCER CELLS IN VITRO. Exp Oncol. 2024;45:504. 10.15407/exp-oncology.2023.04.504
- Reis SK, Socca EAR, de Souza BR, Genaro SC, Durán N, et al. Effects of probiotic supplementation on chronic inflammatory process modulation in colorectal carcinogenesis. Tissue Cell. 2024;87:102293. 10.1016/j.tice.2023.102293
- Yang X, Cao Q, Ma B, Xia Y, Liu M, et al. Probiotic powder ameliorates colorectal cancer by regulating Bifidobacterium animalis, Clostridium cocleatum, and immune cell composition. PLoS One. 2023;18:e0277155. 10.1371/journal.pone.0277155
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- Holkem AT, Favaro-Trindade CS, Lacroix M. Study of anticancer properties of proanthocyanidin-rich cinnamon extract in combination with Bifidobacterium animalis subsp. lactis BLC1 and resistance of these free and co-encapsulated materials under in vitro simulated gastrointestinal conditions. Food Res Int. 2020;134:109274. 10.1016/j.foodres.2020.109274
- An J, Kim H, Yang KM. An Aqueous Extract of a Species Induces Apoptosis and Inhibits Invasiveness of Non-Small Cell Lung Cancer Cells. J Microbiol Biotechnol. 2020;30:885. 10.4014/jmb.1912.12054
- Gholipour F, Entezar M, Amini M, Vandghanooni S, Baradaran B, et al. In vitro effects of crocin on the possible anticancer properties of Lactococcus lactis against colorectal adenocarcinoma cells. Naunyn Schmiedebergs Arch Pharmacol. 2024. 10.1007/s00210-024-03636-0
- Shang J, Liu L, Yang S, Duan B, Xie S, et al. A New Combination of and Strains with Synergistic Effects Alleviates Colitis-Associated Colorectal Cancer. Foods. 2024;13. 10.3390/foods13193054
- Ni X, Liu Y, Sun M, Jiang Y, Wang Y, et al. Oral Live-Carrier Vaccine of Recombinant Lactococcus lactis Inducing Prophylactic Protective Immunity Against Helicobacter pylori Infection. Probiotics Antimicrob Proteins. 2024. 10.1007/s12602-024-10360-x
- Shao J, Xin K, Qian Z, Liu F, Li L, et al. Combining iRGD with HuFOLactis enhances antitumor potency by facilitating immune cell infiltration and activation. Hum Vaccin Immunother. 2024;20:2375825. 10.1080/21645515.2024.2375825
- Sun M, Shi T, Tuerhong S, Li M, Wang Q, et al. An Immunomodulator-Boosted Lactococcus Lactis Platform For Enhanced In Situ Tumor Vaccine. Adv Healthc Mater. 2024;13:e2401635. 10.1002/adhm.202401635
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- Saito S, Cao DY, Maekawa T, Tsuji NM, Okuno A. subsp. C60 Upregulates Macrophage Function by Modifying Metabolic Preference in Enhanced Anti-Tumor Immunity. Cancers (Basel). 2024;16. 10.3390/cancers16101928
- Chen A, Zhu J, Liu R, Mei Y, Li L, et al. Injectable thermo-sensitive hydrogel enhances anti-tumor potency of engineered by activating dendritic cells and effective memory T cells. Bioact Mater. 2024;37:331. 10.1016/j.bioactmat.2024.03.023
- Su ACY, Ding X, Lau HCH, Kang X, Li Q, et al. suppresses colorectal tumourigenesis and restores gut microbiota through its generated alpha-mannosidase. Gut. 2024;73:1478. 10.1136/gutjnl-2023-330835
- Jastrząb R, Tomecki R, Jurkiewicz A, Graczyk D, Szczepankowska AK, et al. The strain-dependent cytostatic activity of Lactococcus lactis on CRC cell lines is mediated through the release of arginine deiminase. Microb Cell Fact. 2024;23:82. 10.1186/s12934-024-02345-w
- Liu R, Zhu J, Chen A, Fan Y, Li L, et al. Intra-bone marrow injection with engineered Lactococcus lactis for the treatment of metastatic tumors: Primary report. Biomed Pharmacother. 2024;173:116384. 10.1016/j.biopha.2024.116384
- Fan Y, Chen A, Zhu J, Liu R, Mei Y, et al. Engineered lactococcus lactis intrapleural therapy promotes regression of malignant pleural effusion by enhancing antitumor immunity. Cancer Lett. 2024;588:216777. 10.1016/j.canlet.2024.216777
- Lin Z, Tang Y, Chen Z, Li S, Xu X, et al. Soluble CD80 oral delivery by recombinant Lactococcus suppresses tumor growth by enhancing antitumor immunity. Bioeng Transl Med. 2023;8:e10533. 10.1002/btm2.10533
- Frey-Furtado L, Magalhães I, Azevedo MJ, Sampaio-Maia B. The Role of Biotics as a Therapeutic Strategy for Oral Mucositis - A Systematic Review. Probiotics Antimicrob Proteins. 2024;16:1313. 10.1007/s12602-023-10116-z
- Soleimanifar H, Mahmoodzadeh Hosseini H, Samavarchi Tehrani S, Mirhosseini SA. The Anti-Adhesion Effect of Nisin as a Robust Lantibiotic on the Colorectal Cancer Cells. Adv Biomed Res. 2023;12:113. 10.4103/abr.abr_267_21
- Mahmoudi M, Khomeiri M, Saeidi M, Davoodi H, Memarian A. Anticancer potential of fermented milk with autochthonous lactic acid bacteria. J Appl Microbiol. 2023;134. 10.1093/jambio/lxad041
- Mao L, Xarpidin B, Shi R, Lin Y, Hu H, et al. Natural Enzyme-Loaded Polymeric Stealth Coating-Armed Engineered Probiotics by Disrupting Tumor Lactate Homeostasis to Synergistic Metabolism-Immuno-Enzyme Dynamic Therapy. Adv Sci (Weinh). 2025. 10.1002/advs.202417172
- Nasri F, Alizadeh A, İncili GK, Hayaloğlu AA, Moradi M. Investigating Chemical Composition and Functionality of Lactobacillus acidophilus LA-5 Postbiotics Prepared in Classic and Cheese Whey Media. Probiotics Antimicrob Proteins. 2024. 10.1007/s12602-024-10435-9
- Si R, Hu T, Williams GR, Yang Y, Yang S, et al. Coupling Probiotics with CaO Nanoparticle-Loaded CoFeCe-LDH Nanosheets to Remodel the Tumor Microenvironment for Precise Chemodynamic Therapy. Adv Healthc Mater. 2025;14:e2403373. 10.1002/adhm.202403373
- Kumawat M, Une H. Effect of Lactobacillus acidophilus, Calcium, and Moringa oleifera leaves extract co-administration can prevent chemical-induced carcinogenesis. Arab J Gastroenterol. 2024;25:421. 10.1016/j.ajg.2024.07.015
- Karim MR, Iqbal S, Mohammad S, Kim JH, Ling L, et al. Upgrading Isoquercitrin Concentration via Submerge Fermentation of Mulberry Fruit Extract with Edible Probiotics to Suppress Gene Targets for Controlling Kidney Cancer and Inflammation. J Microbiol. 2024;62:919. 10.1007/s12275-024-00163-8
- Gad AI, Orabi MM, Abou-Taleb KA, Abdelghani DY, Amin SA. In vitro digestive system simulation and anticancer activity of soymilk fermented by probiotics and synbiotics immobilised on agro-industrial residues. Sci Rep. 2024;14:18518. 10.1038/s41598-024-68086-3
- Al-Asfour A, Bhardwaj RG, Karched M. Growth Suppression of Oral Squamous Cell Carcinoma Cells by Lactobacillus Acidophilus. Int Dent J. 2024;74:1151. 10.1016/j.identj.2024.03.017
- Mirzadeh MA, Eslami M, Ghanbari A, Zarbakhsh S, Yosefi S, et al. Coadministration of doxorubicin with vitamin D3, Lactobacillus acidophilus, and Lactobacillus casei in the 4T1 mouse model of breast cancer: anticancer and enteroprotective effects. Med Oncol. 2024;41:111. 10.1007/s12032-024-02346-0
- Saffar KN, Larypoor M, Torbati MB. Analyzing of colorectal cancerrelated genes and microRNAs expression profiles in response to probiotics Lactobacillus acidophilus and Saccharomyces cerevisiae in colon cancer cell lines. Mol Biol Rep. 2024;51:122. 10.1007/s11033-023-09008-w
- Lau HC, Zhang X, Ji F, Lin Y, Liang W, et al. Lactobacillus acidophilus suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma through producing valeric acid. EBioMedicine. 2024;100:104952. 10.1016/j.ebiom.2023.104952
- Erfanian N, Nasseri S, Miraki Feriz A, Safarpour H, Namaei MH. Characterization of Wnt signaling pathway under treatment of Lactobacillus acidophilus postbiotic in colorectal cancer using an integrated in silico and in vitro analysis. Sci Rep. 2023;13:22988. 10.1038/s41598-023-50047-x
- Zamani F, Khalighfard S, Kalhori MR, Poorkhani A, Amiriani T, et al. Expanding CYLD protein in NF-κβ/TNF-α signaling pathway in response to Lactobacillus acidophilus in non-metastatic rectal cancer patients. Med Oncol. 2023;40:302. 10.1007/s12032-023-02170-y
- Shen S, Ren F, Qin H, Bukhari I, Yang J, et al. NCFM and Lp-115 inhibit colonization and gastric inflammation in a murine model. Front Cell Infect Microbiol. 2023;13:1196084. 10.3389/fcimb.2023.1196084
- Abo-Zaid GA, Kenawy AM, El-Deeb NM, Al-Madboly LA. Improvement and enhancement of oligosaccharide production from Lactobacillus acidophilus using statistical experimental designs and its inhibitory effect on colon cancer. Microb Cell Fact. 2023;22:148. 10.1186/s12934-023-02153-8
