Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.6
USERS' SCORE
Good
Based on 318 Reviews
8.4
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Iron (as iron bisglycinate chelate†)
25 mg
139%

Top Medical Research Studies

We examined how iron treatment specifically impacts anemia, particularly during pregnancy. Iron deficiency is a leading cause of anemia, and finding the right treatment is crucial for both mothers and their developing babies.

Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.

However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
8
Iron treatment and CKD anemia
We explored the critical relationship between iron treatment and anemia in chronic kidney disease (CKD). Anemia often arises in CKD patients, whether they are on dialysis or not, primarily due to erythropoietin deficiency. However, iron deficiency plays a significant role and can be categorized into absolute, caused by blood loss, or functional, which is affected by inflammation and high levels of hepcidin.

Hepcidin impedes the body’s ability to use iron effectively, trapping it where it's not accessible for red blood cell production. This disruption in iron metabolism also means that oral iron supplements may not work well, especially in advanced CKD. Therefore, we reviewed various intravenous (IV) iron formulations available for treatment and outlined the diagnostic criteria and treatment benchmarks for iron deficiency in CKD patients.

Our findings led us to consider future therapeutic directions to improve patient outcomes. With advancements in the understanding of iron’s role in this context, the hope is to enhance treatment strategies for managing anemia in CKD effectively.
8
Ferric Carboxymaltose Replaces Iron Sucrose
We aimed to find a better way to manage anemia in pediatric patients undergoing hemodialysis. Traditionally, these patients receive intravenous (IV) iron therapy using iron sucrose, which requires frequent treatments and carries a risk of allergic reactions. Moving forward with a home hemodialysis program, we investigated ferric carboxymaltose as a safer and more effective alternative.

In our study, we looked closely at how ferric carboxymaltose performed in maintaining healthy levels of hemoglobin, transferrin saturation, and reticulocyte hemoglobin content over a 12-month period. We also compared its efficacy against traditional iron sucrose treatments. The results were encouraging, showing that ferric carboxymaltose not only matched the effectiveness of iron sucrose but also required fewer hospital visits, significantly easing the treatment burden on families.

Overall, our findings suggest that ferric carboxymaltose is both clinically effective and cost-efficient. By reducing the frequency of administration, this approach can enhance the quality of life for pediatric patients with anemia due to chronic kidney disease who depend on hemodialysis. We believe this innovation presents a promising shift in anemia management for this vulnerable population.

Most Useful Reviews

9
Saved from anemia
629 people found this helpful
Solgar's iron supplement was a lifesaver for my severe anemia. I was barely able to function, feeling exhausted and memory impaired. After months of taking various iron pills, I finally overcame anemia. Doctors advised me to continue taking iron after each menstrual cycle due to my significant blood loss. I can't pinpoint any drawbacks to this supplement; it has solely beneficial effects.
9
Raised hemoglobin levels
550 people found this helpful
This iron supplement significantly improved my haemoglobin levels. After suffering from anemia, my hair was falling out, and my appearance was pallid. I tried various pills, but only this one was effective, with no issues during absorption. My youthful glow returned, and I noticed the positive results quickly. Highly recommend!
9
Improved overall health
365 people found this helpful
Finally, I found the best form of iron, bisglycinate. It helps boost haemoglobin while eliminating irritability and weakness. My memory and mood improved significantly. I also noticed less puffiness and bruising. It positively impacted my overall health, and I'm thrilled with the results. I recommend taking it alongside certain vitamins for increased absorption.

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.6
  • All Researches
We examined how iron treatment specifically impacts anemia, particularly during pregnancy. Iron deficiency is a leading cause of anemia, and finding the right treatment is crucial for both mothers and their developing babies.

Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.

However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
9.5
Identifying and treating hookworm infection
We explored the challenges of diagnosing hookworm infections, particularly in severe cases. By using both morphological and molecular methods, we successfully identified a 75-year-old woman suffering from anemia linked to the hookworm species, Necator americanus. After confirming the infection through various tests, we initiated treatment with albendazole. Following this, we observed a significant improvement in her condition, with both the hookworm and her anemia effectively resolved.
9
Iron supplementation effects on anemia
We explored the impact of iron and folic acid supplementation on children suffering from mild-to-moderate anemia in India. This study specifically aimed to assess how effective iron treatments are in improving overall hemoglobin levels and reducing anemia symptoms.

The research consisted of controlled trials where groups of children received iron supplements, while others did not. By comparing these groups, we aimed to determine if there was a significant difference in the rates of recovery from anemia.

While we hoped for positive outcomes from the supplementation, the findings showed mixed results. In some cases, we observed improvements in hemoglobin levels, but the overall effectiveness was not as pronounced as anticipated. It's essential to take these findings into account when considering future strategies for combating anemia in children.

Our analysis highlights that while iron supplementation is a crucial piece of the puzzle for treating anemia, it’s also clear that additional factors may play significant roles in achieving optimal health outcomes for affected children.
9
Serum hepcidin aids anemia diagnosis
We explored the effectiveness of serum hepcidin levels in diagnosing types of anemia in elderly patients, specifically focusing on iron deficiency anemia (IDA) and anemia of chronic disease (ACD). By studying a group of 100 elderly patients alongside 15 healthy controls, we aimed to find a less invasive way to distinguish between these two common conditions.

Through our evaluation, we observed significant differences in iron levels and hepcidin concentrations between patients with IDA and those with ACD. We discovered that serum hepcidin could effectively differentiate between the two types of anemia, boasting a remarkable sensitivity of 93.9% and a specificity of 92.2%. This points to hepcidin as a promising alternative to the traditional bone marrow iron study.

Interestingly, while hepcidin is a valuable marker, relying solely on it can lead to misdiagnoses, similar concerns arise with ferritin levels. Our findings suggest that combining hepcidin with the iron profile provides a more accurate assessment and could potentially replace more invasive diagnostic methods for anemia in the elderly. Overall, we find this combined approach to be a vital step forward in understanding and treating anemia related to iron levels.
We investigated the combination of Roxadustat, a newer treatment for anemia related to chronic kidney disease (CKD), alongside polysaccharide-iron complex (PIC) in rats. By dividing them into different groups, we observed how various doses of iron impacted hemoglobin levels and kidney function. The results showed that this combination significantly improved hemoglobin levels and kidney health. Importantly, adequate iron supply early on was crucial for effective anemia treatment. Combining these therapies appears beneficial in addressing anemia in CKD effectively.

User Reviews

USERS' SCORE
Good
Based on 318 Reviews
8.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Saved from anemia
629 people found this helpful
Solgar's iron supplement was a lifesaver for my severe anemia. I was barely able to function, feeling exhausted and memory impaired. After months of taking various iron pills, I finally overcame anemia. Doctors advised me to continue taking iron after each menstrual cycle due to my significant blood loss. I can't pinpoint any drawbacks to this supplement; it has solely beneficial effects.
9
Raised hemoglobin levels
550 people found this helpful
This iron supplement significantly improved my haemoglobin levels. After suffering from anemia, my hair was falling out, and my appearance was pallid. I tried various pills, but only this one was effective, with no issues during absorption. My youthful glow returned, and I noticed the positive results quickly. Highly recommend!
9
Improved overall health
365 people found this helpful
Finally, I found the best form of iron, bisglycinate. It helps boost haemoglobin while eliminating irritability and weakness. My memory and mood improved significantly. I also noticed less puffiness and bruising. It positively impacted my overall health, and I'm thrilled with the results. I recommend taking it alongside certain vitamins for increased absorption.
9
Perfectly suited
248 people found this helpful
For years, I suffered from anaemia and struggled to find a suitable medication. This product worked perfectly for me with no side effects. I trust this brand for its quality and effectiveness.
9
Normalised levels
246 people found this helpful
I have always had a predisposition to iron deficiency anaemia, resulting in dangerously low haemoglobin levels at one point. However, I selected an Iron Chelate supplement and raised my levels significantly over three months. Now, I maintain my haemoglobin with Solgar’s Gentle Iron, experiencing no side effects and feeling great.

Frequently Asked Questions

9
No constipation
51 people found this helpful
The best iron for anemia! I endured symptoms like dizziness, constant fatigue, and pallor due to anemia, often fainting. After trying various iron supplements, I found Solgar's easily digestible option recommended by my doctor. No side effects or constipation, just one capsule daily. Within a month, my hemoglobin improved above average and ferritin reached normal levels. I will continue using it!
7.5
Increased haemoglobin
35 people found this helpful
Raise the level of haemoglobin in the blood with Solgar's iron preparation. Many experience decreased iron levels leading to dizziness and fatigue. I've suffered from chronic anemia since adolescence. After taking Solgar's iron for a month, I noticed improvements in my haemoglobin and energy levels. Taking one capsule daily is simple and effective with no side effects. I appreciate the convenience and positive results.
7.5
Effective supplement
33 people found this helpful
Working: I agree with the positive reviews about this iron. It effectively combat my anemia, but it’s essential to take it separately from other vitamins and consume 1000 mg of Vitamin C daily for absorption.
9
High bioavailability
31 people found this helpful
The best iron! Solgar’s iron bisglycinate is a chelated form with greater bioavailability than mineral salts, absorbed almost 100%. It doesn’t cause side effects like constipation. I take one capsule with food, avoiding tea and coffee. My iron levels and haemoglobin improve significantly with this supplement, making it easier for me. However, it’s crucial not to self-medicate—always consult a doctor for any iron deficiency diagnosis.
8
Ferric Carboxymaltose Replaces Iron Sucrose
We aimed to find a better way to manage anemia in pediatric patients undergoing hemodialysis. Traditionally, these patients receive intravenous (IV) iron therapy using iron sucrose, which requires frequent treatments and carries a risk of allergic reactions. Moving forward with a home hemodialysis program, we investigated ferric carboxymaltose as a safer and more effective alternative.

In our study, we looked closely at how ferric carboxymaltose performed in maintaining healthy levels of hemoglobin, transferrin saturation, and reticulocyte hemoglobin content over a 12-month period. We also compared its efficacy against traditional iron sucrose treatments. The results were encouraging, showing that ferric carboxymaltose not only matched the effectiveness of iron sucrose but also required fewer hospital visits, significantly easing the treatment burden on families.

Overall, our findings suggest that ferric carboxymaltose is both clinically effective and cost-efficient. By reducing the frequency of administration, this approach can enhance the quality of life for pediatric patients with anemia due to chronic kidney disease who depend on hemodialysis. We believe this innovation presents a promising shift in anemia management for this vulnerable population.
9
Iron supplementation effects on anemia
We explored the impact of iron and folic acid supplementation on children suffering from mild-to-moderate anemia in India. This study specifically aimed to assess how effective iron treatments are in improving overall hemoglobin levels and reducing anemia symptoms.

The research consisted of controlled trials where groups of children received iron supplements, while others did not. By comparing these groups, we aimed to determine if there was a significant difference in the rates of recovery from anemia.

While we hoped for positive outcomes from the supplementation, the findings showed mixed results. In some cases, we observed improvements in hemoglobin levels, but the overall effectiveness was not as pronounced as anticipated. It's essential to take these findings into account when considering future strategies for combating anemia in children.

Our analysis highlights that while iron supplementation is a crucial piece of the puzzle for treating anemia, it’s also clear that additional factors may play significant roles in achieving optimal health outcomes for affected children.
We examined the relationship between iron treatment and anemia, particularly in older adults affected by heart failure (HF). Heart failure is a major health concern that often accompanies iron deficiency (ID), which can affect up to half of these patients.

Chronic inflammation is known to contribute to ID, and this can worsen anemia alongside heart failure symptoms. In our review, we found that intravenous (IV) iron therapy may offer real benefits for those with reduced heart function, specifically in individuals with less than 50% left ventricular ejection fraction.

However, when it comes to patients with heart failure and preserved ejection fraction (HFpEF), the evidence for the effectiveness of iron therapy remains limited. As we explored various treatment approaches, including new medications aimed at improving iron metabolism, we realized that more research is crucial, especially focusing on how inflammation interacts with iron deficiency.

The challenges of accurately diagnosing ID due to inflammation were also highlighted, signaling a need for refined criteria. In summary, while iron treatment can play a significant role in managing anemia related to heart failure, particularly in some cases, more tailored strategies and research into emerging therapies are essential for all heart failure patients.

References

  1. Preston R, Theodorou D, Sinnott K, Wallace D, Kaur A. A cost-effective innovation in anaemia management for paediatric patients with haemodialysis-dependent chronic kidney disease. Pediatr Nephrol. 2025. doi:10.1007/s00467-025-06680-x
  2. Upadhyay RP, Chowdhury R, Mundra S, Taneja S, Jacob M, et al. Comparative effectiveness of daily therapeutic supplementation with multiple micronutrients and iron-folic acid versus iron-folic acid alone in children with mild-to-moderate anaemia in rural India: an open-label, randomised controlled trial. Lancet Glob Health. 2025;13:e497. doi:10.1016/S2214-109X(24)00559-X
  3. Thomas T, Kurpad A. Childhood iron-folic acid supplementation in India for mild-to-moderate anaemia. Lancet Glob Health. 2025;13:e383. doi:10.1016/S2214-109X(25)00053-1
  4. Babah OA, Beňová L, Larsson EC, Hanson C, Afolabi BB. Is an improvement in anaemia and iron levels associated with the risk of early postpartum depression? A cohort study from Lagos, Nigeria. BMC Public Health. 2025;25:808. doi:10.1186/s12889-025-21942-x
  5. Crispell EH, Cassianni CE, Burt JM, Gonzalez JA, Petsch JL, et al. Design and Staged Implementation of a Multidisciplinary Preoperative Anemia Clinic at a Tertiary Care Medical Center. Anesth Analg. 2025. doi:10.1213/ANE.0000000000007435
  6. Akpan IJ, Narang M, Zampaglione E, Marshall S, Stefanik D. Iron deficiency anemia in patients with heavy menstrual bleeding: The patients' perspective from diagnosis to treatment. Womens Health (Lond). 2025;21:17455057251321221. doi:10.1177/17455057251321221
  7. Khalaf K, Fujiyoshi Y, Bechara R. Endoscopic and clinical characteristics of autoimmune atrophic gastritis: Retrospective study. Endosc Int Open. 2025;13:a24774666. doi:10.1055/a-2477-4666
  8. White F, Polakowski N, Merlington E, Leimanis M, Dudick B, et al. Intravenous Sodium Ferric Gluconate Complex for Hospitalized Pediatric Patients with Iron Deficiency Anemia. Children (Basel). 2025;12. doi:10.3390/children12020189
  9. Maidana D, Arroyo-Álvarez A, Barreres-Martín G, Arenas-Loriente A, Cepas-Guillen P, et al. Targeting Inflammation and Iron Deficiency in Heart Failure: A Focus on Older Adults. Biomedicines. 2025;13. doi:10.3390/biomedicines13020462
  10. McDonnell T, Kalra PA. Iron in Chronic Kidney Disease and End-Stage Kidney Disease-Current Trends and Future Direction. Br J Hosp Med (Lond). 2025;86:1. doi:10.12968/hmed.2024.0619
  11. Orlova P, Meshkov I, Sharikov S, Frolov V, Skuredina A, et al. Amidated and Aminated PMSSO-Hydrogels as a Promising Enzyme-Sensitive Vehicle for Antianemic Drugs. Gels. 2025;11. doi:10.3390/gels11020118
  12. Al Kindi S, Al-Mamari A, Al-Zadjali S, Al-Rawahi M, Al Madhani A, et al. Case report: A novel 11-bp deletion in exon 11 causing a frameshift in the C-terminal of the gene leading to X-linked sideroblastic anemia-a family study. Front Med (Lausanne). 2024;11:1452873. doi:10.3389/fmed.2024.1452873
  13. Manna S, Chakrabarti SS, Singh R, Gambhir IS. Serum hepcidin level with iron profile assay might replace bone marrow iron study as a diagnostic tool for evaluation of anemia in elderly without chronic renal disease. J Family Med Prim Care. 2025;14:356. doi:10.4103/jfmpc.jfmpc_34_24
  14. Kranke P, Weiniger CF, Sultan P, Achebe MO, Filipescu D, et al. Iron deficiency and anemia in pregnancy: a call to action!: -"If you don't take a temperature, you can't find a fever". Int J Obstet Anesth. 2024;62:104298. doi:10.1016/j.ijoa.2024.104298
  15. Larson LM, Baldi A, Hasan MI, Jones N, Pickle EO, et al. Role of hepcidin on benefits and risks of supplementation with iron syrup and multiple micronutrient powders in Bangladeshi children: a sub-study to a randomized controlled trial. Am J Clin Nutr. 2025. doi:10.1016/j.ajcnut.2025.02.018
  16. Fijn R, Ablij HC, Knoester PD, Witte AMC. Real-world evaluation of an intravenous iron service for the treatment of iron deficiency with or without anemia. Sci Rep. 2025;15:12093. doi:10.1038/s41598-025-85880-9
  17. Bhutta ZA, Keats EC, Owais A, González-Fernández D, Udomkesmalee E, et al. What works for anemia reduction among women of reproductive age? Synthesized findings from the exemplars in anemia project. Am J Clin Nutr. 2025;121 Suppl 1:S68. doi:10.1016/j.ajcnut.2024.11.031
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  19. Duan Y, Xu Y, Wei Y, Liu T, Xu T, et al. Bilateral segmental testicular infarction secondary to iron deficiency anemia: a case report. BMC Urol. 2025;25:70. doi:10.1186/s12894-025-01756-0
  20. Warner MA, Johnson ML, Hanson AC, Fortune E, Flaby GW, et al. Practical Anemia Bundle and Hemoglobin Recovery in Critical Illness: A Randomized Clinical Trial. JAMA Netw Open. 2025;8:e252353. doi:10.1001/jamanetworkopen.2025.2353
  21. Hidayat MT, Khadijah Maharani SN, Ramadhany ID, Khairani NI, Rahman NA, et al. Controlled release of deferiprone using iron-responsive nanoparticles integrated with dissolving microneedle for novel alternative treatments of β-thalassemia major. Eur J Pharm Biopharm. 2025;210:114702. doi:10.1016/j.ejpb.2025.114702
  22. Al-Taiar A, Ziyab AH, Hammoud MS, Al-Sabah R, Akhtar S. Anemia in pregnant women: findings from Kuwait birth cohort study. BMC Pregnancy Childbirth. 2025;25:326. doi:10.1186/s12884-025-07439-w
  23. Sohn SH, Sul H, Kim B, Zang D. Effects of Darbepoetin Alfa and Ferric Derisomaltose Plus Darbepoetin Alfa in Functional Iron-Deficiency Anemia. Int J Mol Sci. 2025;26. doi:10.3390/ijms26052203
  24. Nagao T, Takahashi K, Takahashi S, Yokomizo R, Samura O, et al. Low-dose ferric carboxymaltose vs. oral iron for improving hemoglobin levels in postpartum East Asian women: A randomized controlled trial. PLoS One. 2025;20:e0319795. doi:10.1371/journal.pone.0319795
  25. Ozeki Y, Kato J, Ohta Y, Taida T, Horio R, et al. [Efficacy and safety of ferric carboxymaltose in patients with inflammatory bowel disease]. Nihon Shokakibyo Gakkai Zasshi. 2025;122:196. doi:10.11405/nisshoshi.122.196
  26. Gao Z, Gao Y, Wang Q, Wang Q, Lu P, et al. Study on HIF-PHI combined with iron supplement in treatment of renal anemia in rats. BMC Nephrol. 2025;26:125. doi:10.1186/s12882-025-04045-y
  27. Liu X, Sun A, Zheng X, Xia M, Liu Y, et al. Combined morphological and molecular approaches to the clinical diagnosis of Necator americanus infection: a case report. J Med Case Rep. 2025;19:100. doi:10.1186/s13256-025-05105-5
  28. Zhang H, Sun W, Qi J, Qayum A, Li J, et al. Antianemic Activity, Inhibition of Oxidative Stress, and Iron Supplementation in Mice with Iron-Deficiency Anemia through HG-Hawthorn Pectin-Iron(III) Complexes. ACS Appl Bio Mater. 2025;8:2419. doi:10.1021/acsabm.4c01905
  29. Dogan Y, Dede AM, Erdoğan A. An unusual association: gastric xanthelasma presenting with iron deficiency anemia: a case report. J Med Case Rep. 2025;19:98. doi:10.1186/s13256-025-05133-1
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