Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.4
USERS' SCORE
Good
Based on 8 Reviews
8.5
Supplement Facts
Serving Size: 3 tablets
Serving Per Container: 83
Amount Per Serving
%DV
Calcium (as calcium carbonate, calcium gluconate, calcium citrate)
1,000 mg
77%
Magnesium (as magnesium oxide, magnesium gluconate, magnesium citrate)
400 mg
95%
Zinc (as zinc gluconate)
15 mg
136%
Sodium†
15 mg
<1%

Top Medical Research Studies

8
Zinc may alleviate anxiety symptoms
We explored the connection between zinc intake and anxiety in adults through a systematic review of nine original studies. Two of these studies looked at how zinc consumption impacts anxiety, while the other seven focused on the relationship between serum zinc levels and anxiety symptoms. Our analysis included studies published in English within peer-reviewed journals, ensuring a solid foundation for understanding this potential link.

What we discovered was quite illuminating. The data indicated that individuals experiencing anxiety often had lower levels of zinc in their serum compared to those who did not suffer from anxiety. Additionally, we observed an inverse association between zinc intake and anxiety levels. This suggests that higher consumption of zinc may contribute to reduced anxiety symptoms.

In conclusion, the evidence points towards zinc playing a positive role in treating anxiety, although we acknowledge some limitations in the available studies. This means zinc supplementation could be a beneficial strategy for those looking to manage their anxiety, but more research is needed to confirm these findings and understand the underlying mechanisms better.
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7
Zinc alleviates acrylamide-induced anxiety
We explored the effects of zinc treatment on anxiety caused by exposure to acrylamide, a harmful chemical found in some foods that can lead to cognitive decline and emotional distress. In our study, twenty male Wistar rats were divided into four groups; one group received water, while the other groups were given a daily oral dose of acrylamide.

Among those exposed to acrylamide, some were treated with low and high doses of zinc for eight weeks. We observed that zinc significantly improved anxiety-like behavior in the treated groups. This suggests that zinc acts not only as a protector against cognitive impairment but also helps in alleviating anxiety symptoms associated with acrylamide exposure.

Furthermore, zinc demonstrated antioxidant and anti-inflammatory effects, which could contribute to its ability to improve mood and mental function. Overall, zinc emerged as a promising contender in mitigating anxiety and cognitive challenges posed by acrylamide, leading to better mental clarity and emotional well-being.
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8
Magnesium treats anxiety in MS
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.

We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.

Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.

In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
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Most Useful Reviews

10
Feeling happier
18 people found this helpful
Absolutely amazing. I ordered this product for anxiety, and it is simply remarkable. I've been using it for two weeks now and couldn't be happier.
Read More
7.5
Heart health improvement
15 people found this helpful
For the heart, this is excellent! I consumed all 250 tablets, and the effect was immediate. My heart rate normalised, with tachycardia disappearing. It alleviates stress and anxiety, and now I take it as required. I am very satisfied with the medication.
Read More
9
Restores strength effectively
Helps to restore strength after illness! After having contracted covid for the second time, my doctor advised me to take zinc long-term, particularly Solgar in combination with magnesium and calcium. There is an effective form and dosage for long-term use. We all take it as a family. Immediately, my sleep returned to normal and anxiety diminished—thanks to magnesium. My strength was quickly restored, vigour returned, and we all take a pill before bedtime. A great product, especially during discounts.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.4
  • All Researches
We examined how magnesium, in combination with ibogaine, affects anxiety in veterans with traumatic brain injuries. This was part of a larger study focusing on the wellbeing of Special Operations Forces veterans, who often suffer from mental health issues like anxiety and PTSD after experiencing head trauma.

The study involved 30 male veterans, primarily with mild brain injuries. Researchers used various assessments, including scales for anxiety, to measure changes before treatment and then again one month afterward. The findings were promising, showing considerable improvements in anxiety levels, as well as in depression and PTSD symptoms.

However, it’s important to note that since magnesium was administered alongside ibogaine, we can’t isolate the effects of magnesium alone on anxiety. Although the results were encouraging, we need more controlled clinical trials to fully understand the safety and effectiveness of magnesium treatment on its own.

Overall, while magnesium may play a role in improving anxiety, further research is essential to clarify its specific impact without the influence of other treatments.
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9
Zinc shows promise for anxiety
We aimed to understand how zinc chloride may help reduce anxiety, particularly when combined with diazepam. In our study, we organized Wistar albino rats into five groups, with each group receiving different combinations of zinc chloride and diazepam. The dosages included two different levels of diazepam (1 and 2 mg/kg) paired with a consistent dose of zinc chloride (10 mg/kg).

To assess the anxiety levels of the rats, we employed four established models: the Elevated Plus Maze, the hole board, the light and dark box, and the mirror chamber. Our observations indicated that when combined, zinc chloride and diazepam produced more potent anxiolytic effects compared to when either treatment was used alone. This suggests a possible synergistic effect that could enhance anxiety relief.

Overall, we found that zinc chloride, especially when combined with diazepam, can significantly improve anxiety outcomes in these animal models. This research opens the door to further studies on zinc's role in anxiety management and its potential as a supplementary treatment option alongside traditional medications.
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9
Zinc reduces anxiety in treatment
In a recent study, we investigated how zinc supplementation could impact anxiety levels among patients undergoing methadone maintenance treatment for opioid use disorder. The research involved a randomized controlled trial with 68 participants. We divided them into two groups: one received zinc supplements along with their usual methadone treatment, while the other group only received methadone.

Our findings revealed some encouraging results regarding anxiety reduction. Specifically, we noted a significant decrease in anxiety levels among those who took zinc, with a marked difference when compared to the control group. This was assessed using the Depression, Anxiety, and Stress Scale 21 (DASS-21), where we observed a notable reduction in anxiety scores following the treatment period.

Overall, it appears that zinc supplementation may contribute positively to reducing anxiety in this particular patient demographic. However, since zinc was combined with methadone treatment, it's essential we approach these findings with caution and encourage further research to clarify the role of zinc supplementation alone.
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8
Calcium blockers reduce cocaine withdrawal anxiety
We explored how blocking L-type calcium channels (LTCCs) could influence anxiety-like behaviors during cocaine abstinence in both female and male rats. In this study, rats were trained to self-administer cocaine or saline, followed by a two-week abstinence period. Throughout this withdrawal phase, we examined their behavior using several tests designed to measure anxiety and mood, notably the elevated plus maze and forced swim test, while also checking for changes in their preference for a sweet solution.

Our findings revealed that cocaine-abstinent rats exhibited increased anxiety, as indicated by reduced time spent in open arms of the maze and heightened immobility in the forced swim test. Administering isradipine—a calcium channel blocker—could reverse some anxiety-like behaviors, with varied efficacy based on sex and dosage. For instance, the lower dose effectively reduced anxiety in female rats, while males required a higher dose to obtain similar results. In terms of immobility during stress tests, both sexes benefited from the lower dose of isradipine, while the higher dose affected both groups regardless of their abstinence condition.

This research emphasizes the potential of LTCCs in managing mood-related symptoms linked to cocaine abstinence, though results suggest a more complex relationship that requires further investigation. Overall, our study presents a hopeful look at calcium channel blockade as a possible avenue for treating anxiety disorders that may arise from substance withdrawal.
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8
Magnesium's role in anxiety treatment
We explored the effects of magnesium sulfate and labetalol on managing pregnancy-induced hypertension (PIH) and their potential influence on anxiety and depression among patients. In our study, we examined data from patients diagnosed with PIH from July 2020 to July 2023 at two hospitals in Chengdu, China.

Among the 219 participants, we found that 36.1% experienced anxiety and depression. We divided patients into two groups based on treatment: one group received magnesium sulfate and labetalol, while the other group received standard treatment. It was notable that those in the magnesium sulfate and labetalol group reported significant improvements in anxiety and depression levels, as measured by the Edinburgh Postnatal Depression Scale and the Generalized Anxiety Disorder 7 scale.

However, when evaluating blood pressure control, the effectiveness was similar across both groups, which means the treatment did not significantly impact blood pressure outcomes. Overall, this research points to the possibility that magnesium sulfate and labetalol can not only help manage high blood pressure in pregnant women but may also indirectly alleviate feelings of anxiety and depression.
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User Reviews

USERS' SCORE
Good
Based on 8 Reviews
8.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
10
Feeling happier
18 people found this helpful
Absolutely amazing. I ordered this product for anxiety, and it is simply remarkable. I've been using it for two weeks now and couldn't be happier.
Read More
7.5
Heart health improvement
15 people found this helpful
For the heart, this is excellent! I consumed all 250 tablets, and the effect was immediate. My heart rate normalised, with tachycardia disappearing. It alleviates stress and anxiety, and now I take it as required. I am very satisfied with the medication.
Read More
9
Restores strength effectively
Helps to restore strength after illness! After having contracted covid for the second time, my doctor advised me to take zinc long-term, particularly Solgar in combination with magnesium and calcium. There is an effective form and dosage for long-term use. We all take it as a family. Immediately, my sleep returned to normal and anxiety diminished—thanks to magnesium. My strength was quickly restored, vigour returned, and we all take a pill before bedtime. A great product, especially during discounts.
Read More
9
Anxiety relief noted
I absolutely adore this magnesium; it's a good dosage and works quickly as soon as I start taking it. My sleep has improved, anxiety has vanished, and overall, I feel much better.
Read More
9
Immediate sleep improvement
This is a fantastic tool! My sleep improved immediately, and anxiety disappeared. The quality of the product is excellent, and the ingredients are superbly chosen!
Read More

Frequently Asked Questions

9
Immediate sleep improvement
This is a fantastic tool! My sleep improved immediately, and anxiety disappeared. The quality of the product is excellent, and the ingredients are superbly chosen!
9
Restores strength effectively
Helps to restore strength after illness! After having contracted covid for the second time, my doctor advised me to take zinc long-term, particularly Solgar in combination with magnesium and calcium. There is an effective form and dosage for long-term use. We all take it as a family. Immediately, my sleep returned to normal and anxiety diminished—thanks to magnesium. My strength was quickly restored, vigour returned, and we all take a pill before bedtime. A great product, especially during discounts.
9
Anxiety relief noted
I absolutely adore this magnesium; it's a good dosage and works quickly as soon as I start taking it. My sleep has improved, anxiety has vanished, and overall, I feel much better.
7.5
Heart health improvement
15 people found this helpful
For the heart, this is excellent! I consumed all 250 tablets, and the effect was immediate. My heart rate normalised, with tachycardia disappearing. It alleviates stress and anxiety, and now I take it as required. I am very satisfied with the medication.
7
Magnesium shows potential for anxiety
We conducted a systematic review to evaluate how magnesium might help with anxiety. As self-treatment with supplements grows in popularity, we focused on the clinical evidence surrounding magnesium’s effects on anxiety and sleep disorders.

Through our thorough search, we found 15 studies that fit our strict criteria. Most of these studies showed at least some improvement in either anxiety levels or sleep quality. In fact, five out of eight studies looking at sleep-related outcomes noted positive changes, while five out of seven studies focused on anxiety reported improvements in self-reported anxiety.

Despite the encouraging findings, we have to approach these results with caution. The studies varied in terms of dosage, formulation, and duration of magnesium treatment. Plus, some included other active ingredients that make it hard to know magnesium’s exact impact. Interestingly, two of the studies that didn’t show improvement involved populations with other health concerns, highlighting the need for further investigation.

Overall, it seems like magnesium might be a useful supplement for those dealing with mild anxiety, especially if they have low magnesium levels to begin with. However, larger and more rigorous trials are essential to truly confirm its effectiveness and determine the best types and doses for use.
We investigated how magnesium might influence anxiety, particularly when triggered by oxidative stress from hydrogen peroxide. The study involved eighteen Wistar rats divided into three groups: a control group, a group treated with hydrogen peroxide, and a group receiving both hydrogen peroxide and magnesium sulphate.

Our findings revealed that the rats exposed to hydrogen peroxide exhibited increased anxiety and signs of oxidative damage in the brain. However, those that received magnesium showed significant improvements. They not only had reduced levels of anxiety but also demonstrated less oxidative stress.

This suggests that magnesium could play a beneficial role in counteracting anxiety and the negative effects of oxidative stress. Though the results are promising, it's important to remember that further research is needed to fully understand magnesium's potential effects on anxiety in humans.
7
Magnesium's transient anxiety relief
In our quest to understand how magnesium influences anxiety, we conducted a randomized double-blind controlled trial involving 120 adults diagnosed with major depressive disorder (MDD). Participants took either a combination of probiotics, magnesium orotate, and coenzyme Q10 or a placebo for eight weeks.

At the end of the treatment period, we observed that those taking the combination showed significantly lower rates of major depressive episodes compared to those taking the placebo. However, this difference did not persist by the 8-week follow-up. While there was a notable reduction in self-reported symptoms of anxiety and stress during the treatment, this result also lacks long-term significance.

Ultimately, while our findings suggest that magnesium in combination with probiotics and coenzyme Q10 might help alleviate anxiety symptoms for a brief period, the persistent effects are unclear as we found no enduring benefits in the longer term.

References

  1. Nunes EJ, Kimble V, Rajadhyaksha AM, Addy NA. L-type calcium channel blockade attenuates the anxiogenic-like effects of cocaine abstinence in female and male rats. Neuroscience. 2025;568:314. doi:10.1016/j.neuroscience.2025.01.003
  2. Strodl E, Bambling M, Parnam S, Ritchie G, Cramb S, et al. Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial. Sci Rep. 2024;14:20841. doi:10.1038/s41598-024-71093-z
  3. Coffman CN, Carroll-Portillo A, Alcock J, Singh SB, Rumsey K, et al. Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria. Microorganisms. 2024;12. doi:10.3390/microorganisms12071429
  4. Rawji A, Peltier MR, Mourtzanakis K, Awan S, Rana J, et al. Examining the Effects of Supplemental Magnesium on Self-Reported Anxiety and Sleep Quality: A Systematic Review. Cureus. 2024;16:e59317. doi:10.7759/cureus.59317
  5. Wang S, Zhang J, Zhu T, Xie X, Xia X, et al. Efficacy of Magnesium Sulfate and Labetalol in the Treatment of Pregnancy-Induced Hypertension and Its Effect on Anxiety and Depression: A Retrospective Cohort Study. Alpha Psychiatry. 2024;25:243. doi:10.5152/alphapsychiatry.2024.231342
  6. Abdel Rady MM, Osman AM, Abo Elfadl GM, Ahmed HM, Sayed S, et al. Effects of intravenous single-bolus lidocaine infusion versus intravenous single-bolus magnesium sulfate infusion on postoperative pain, emotional status, and quality of life in patients undergoing spine fusion surgery: a randomized study. Minerva Anestesiol. 2024;90:397. doi:10.23736/S0375-9393.24.17868-6
  7. Cetin A, Ozdemir E, Golgeli A, Taskiran AS, Karabulut S, et al. The effect of magnesium sulfate on memory and anxiety-like behavior in a rat model: an investigation of its neuronal molecular mechanisms. Neurol Res. 2024;46:752. doi:10.1080/01616412.2024.2352234
  8. Mititelu-Tartau L, Bogdan M, Pavel LL, Rezus C, Foia CI, et al. Anxiolytic-like Activity, Antioxidant Properties, and Facilitatory Effects on the Short-Term Memory Retention of Molsidomine in Rats. Life (Basel). 2024;14. doi:10.3390/life14030306
  9. Cherian KN, Keynan JN, Anker L, Faerman A, Brown RE, et al. Magnesium-ibogaine therapy in veterans with traumatic brain injuries. Nat Med. 2024;30:373. doi:10.1038/s41591-023-02705-w
  10. Pickering G, Noah L, Pereira B, Goubayon J, Leray V, et al. Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study. Front Nutr. 2023;10:1211321. doi:10.3389/fnut.2023.1211321
  11. Hajri L, Othman H, Ghodbane S, Sakly M, Abdelmelek H, et al. Neuroprotective effects of magnesium against stress induced by hydrogen peroxide in Wistar rat. Biomarkers. 2023;28:538. doi:10.1080/1354750X.2023.2246104
  12. Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. doi:10.1186/s12974-023-02696-y
  13. Proskurnina EV, Liaukovich KM, Bychkovskaya LS, Mikheev IV, Alshanskaia EI, et al. Salivary Antioxidant Capacity and Magnesium in Generalized Anxiety Disorder. Metabolites. 2023;13. doi:10.3390/metabo13010073
  14. Ajibare AJ, Akintoye OO, Oriowo OA, Asuku AO, Oriyomi IA, et al. Zinc Ameliorates Acrylamide-Induced Cognitive Impairment in Male Wistar Rats: Modulation of Oxidative Stress, Neuro-inflammation, and Neurotrophic Pathways. Biol Trace Elem Res. 2024. doi:10.1007/s12011-024-04490-0
  15. Apryatin S, Lopachev A, Zhukov I, Efimova E, Apryatina V. BEHAVIORAL AND NEUROCHEMICAL CHANGES DURING INTRANASAL ADMINISTRATION OF ALPHA-GLUTAMYL-TRYPTOPHAN AND CHELATE COMPLEX OF ZINC ARGINYL-GLYCINATE ON MONOAMINE SYSTEMS DYSFUNCTIONS KNOCK-OUT MODELS. Georgian Med News. 2024.
  16. Naik VV, Desai VH, Noronha S. Synergistic anxiolytic efficacy exploring the combined effects of diazepam and zinc chloride in wistar albino rats. Drug Res (Stuttg). 2024;74:220. doi:10.1055/a-2308-9192
  17. Tomas-Sanchez C, Blanco-Alvarez VM, Gonzalez-Barrios JA, Martinez-Fong D, Soto-Rodriguez G, et al. Prophylactic zinc and therapeutic selenium administration in adult rats prevents long-term cognitive and behavioral sequelae by a transient ischemic attack. Heliyon. 2024;10:e30017. doi:10.1016/j.heliyon.2024.e30017
  18. Sameei P, Fatehfar S, Abdollahzadeh N, Chodari L, Saboory E, et al. The effects of forced exercise and zinc supplementation during pregnancy on prenatally stress-induced behavioral and neurobiological consequences in adolescent female rat offspring. Dev Psychobiol. 2023;65:e22411. doi:10.1002/dev.22411
  19. Azargoonjahromi A. A systematic review of the association between zinc and anxiety. Nutr Rev. 2024;82:612. doi:10.1093/nutrit/nuad076
  20. Hamdi E, Muñiz-Gonzalez AB, Hidouri S, Bermejo AM, Sakly M, et al. Prevention of neurotoxicity and cognitive impairment induced by zinc nanoparticles by oral administration of saffron extract. J Anim Physiol Anim Nutr (Berl). 2023;107:1473. doi:10.1111/jpn.13848
  21. Amini Z, HeidariFarsani E. Investigating the effect of zinc supplementation on probability of relapse and mental health in patients with opioid use disorder undergoing methadone maintenance treatment. Subst Abuse Treat Prev Policy. 2023;18:1. doi:10.1186/s13011-023-00514-5
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