Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8.3
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 5 Tablets
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol)
10 mcg (400 IU)
50%
Calcium (as calcium citrate)
1,000 mg
77%
Magnesium (as magnesium oxide, magnesium citrate)
500 mg
119%
Sodium
20 mg
<1%
Top Medical Research Studies
9
Vitamin D3 may reduce brain edema
We investigated whether preoperative serum levels of vitamin D3 could influence peritumoral brain edema in patients diagnosed with meningioma. This study included 112 patients who underwent assessments of serum 25(OH)D levels and magnetic resonance imaging (MRI) to evaluate brain edema.
Our findings revealed a significant correlation between lower vitamin D3 levels and higher edema index (EI) percentages. Patients with EI below 100% had a median serum vitamin D3 level of 65.58 ng/mL, whereas those with EI above 100% had a much lower median of 37.33 ng/mL.
We found that for every increase of 1 ng/mL in serum vitamin D3, the extent of brain edema decreased by approximately 4%. This suggests that maintaining adequate levels of vitamin D3 may serve as a protective factor against peritumoral brain edema in patients with meningioma.
Our findings revealed a significant correlation between lower vitamin D3 levels and higher edema index (EI) percentages. Patients with EI below 100% had a median serum vitamin D3 level of 65.58 ng/mL, whereas those with EI above 100% had a much lower median of 37.33 ng/mL.
We found that for every increase of 1 ng/mL in serum vitamin D3, the extent of brain edema decreased by approximately 4%. This suggests that maintaining adequate levels of vitamin D3 may serve as a protective factor against peritumoral brain edema in patients with meningioma.
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8
We investigated the effects of 1,25-dihydroxyvitamin D3, the active form of vitamin D3, on glioma cells to understand its potential role in brain tumor treatment. Our study showed that this compound can induce cellular senescence, a state where cells stop dividing and can no longer contribute to tumor growth.
Specifically, we observed that vitamin D3 increased the levels of key senescence markers, INK4A and CDKN1A, suggesting that it effectively slows down the progression of glioma. Additionally, vitamin D3 upregulated KDM6B, a histone demethylase that plays a crucial role in promoting the expression of INK4A by altering the chemical modifications on chromatin that repress its transcription.
By knocking down KDM6B, we found that the senescence induced by vitamin D3 was reduced, indicating that KDM6B is essential for this process. Overall, our findings reveal a new mechanism by which vitamin D3 could help inhibit the growth of glioma, paving the way for future prevention and treatment strategies.
Specifically, we observed that vitamin D3 increased the levels of key senescence markers, INK4A and CDKN1A, suggesting that it effectively slows down the progression of glioma. Additionally, vitamin D3 upregulated KDM6B, a histone demethylase that plays a crucial role in promoting the expression of INK4A by altering the chemical modifications on chromatin that repress its transcription.
By knocking down KDM6B, we found that the senescence induced by vitamin D3 was reduced, indicating that KDM6B is essential for this process. Overall, our findings reveal a new mechanism by which vitamin D3 could help inhibit the growth of glioma, paving the way for future prevention and treatment strategies.
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8
Vitamin D3 enhances surgery recovery
We evaluated the potential benefits of a high-dose vitamin D3 injection on patients with low vitamin D levels undergoing surgery for brain tumors. In our study, 60 patients with benign brain tumors and a serum level of 25-hydroxyvitamin D (25(OH)D) of 20 ng/mL or less were randomly divided into two equal groups.
The study group received a single injection of 300,000 IU of vitamin D3 before their craniotomy, while the control group did not receive any intervention. Following the surgery, we observed that the vitamin D3 treatment resulted in a significant increase in serum vitamin D levels for those in the study group.
Moreover, this boost in vitamin D was linked to better clinical outcomes. Specifically, patients who received the vitamin D3 injection experienced shorter stays in the Intensive Care Unit (ICU) and overall hospitalization compared to those who did not.
However, it's important to note that while we saw reductions in ICU and hospital stay lengths, there were no significant differences in the rates of perioperative complications between the two groups. Overall, our findings suggest that administering high doses of vitamin D3 is safe and can lead to improved recovery times for patients undergoing brain tumor surgery.
The study group received a single injection of 300,000 IU of vitamin D3 before their craniotomy, while the control group did not receive any intervention. Following the surgery, we observed that the vitamin D3 treatment resulted in a significant increase in serum vitamin D levels for those in the study group.
Moreover, this boost in vitamin D was linked to better clinical outcomes. Specifically, patients who received the vitamin D3 injection experienced shorter stays in the Intensive Care Unit (ICU) and overall hospitalization compared to those who did not.
However, it's important to note that while we saw reductions in ICU and hospital stay lengths, there were no significant differences in the rates of perioperative complications between the two groups. Overall, our findings suggest that administering high doses of vitamin D3 is safe and can lead to improved recovery times for patients undergoing brain tumor surgery.
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Most Useful Reviews
9
Boosted regeneration
This is an excellent supplement for teeth, bones and brain function. The addition of D3 aids in the processing of vitamins and proteins within cells, thereby enhancing regeneration.
Read More
7.5
Improved brain function
First of all, let me say that the quality of my well-being has improved noticeably. I felt weak and fatigued, but after taking these vitamins, the effect has been remarkable. Thanks to magnesium, my brain is receiving better nourishment.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 18 Researches
8.3
- All Researches
9.5
Magnesium's role in brain tumor treatment
We explored the relationship between low magnesium levels and the development of posterior reversible encephalopathy syndrome (PRES) in a patient with advanced breast cancer. After treatment with diuretics and chemotherapy, this patient experienced serious neurological symptoms alongside low magnesium levels.
Following intravenous magnesium supplementation, the patient showed remarkable improvement within 18 hours. This suggests that low magnesium, potentially linked to her treatment regimens, might have played a role in her condition. Thus, monitoring magnesium levels could be crucial in cancer care.
Following intravenous magnesium supplementation, the patient showed remarkable improvement within 18 hours. This suggests that low magnesium, potentially linked to her treatment regimens, might have played a role in her condition. Thus, monitoring magnesium levels could be crucial in cancer care.
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9
We explored the potential of calcitriol, the active form of vitamin D, in treating glioblastoma, one of the most aggressive brain tumors. Our research aimed to see if vitamin D could target the stem-like cells that contribute to tumor growth and resistance to treatment.
Through a combination of lab tests, including real-time PCR and organ transplant cultures, we found that calcitriol can effectively reduce the stem-like properties of glioblastoma stem cells. Interestingly, it also worked well alongside Temozolomide, a common chemotherapy drug, helping to improve its effectiveness. In some cases, the combination completely eliminated the tumor cells we analyzed.
These promising results suggest that calcitriol could serve as an important part of treatment for certain patients with glioblastoma. However, further studies will be essential to fully understand its potential and optimize its use in clinical settings.
Through a combination of lab tests, including real-time PCR and organ transplant cultures, we found that calcitriol can effectively reduce the stem-like properties of glioblastoma stem cells. Interestingly, it also worked well alongside Temozolomide, a common chemotherapy drug, helping to improve its effectiveness. In some cases, the combination completely eliminated the tumor cells we analyzed.
These promising results suggest that calcitriol could serve as an important part of treatment for certain patients with glioblastoma. However, further studies will be essential to fully understand its potential and optimize its use in clinical settings.
Read More
9
Vitamin D3 may reduce brain edema
We investigated whether preoperative serum levels of vitamin D3 could influence peritumoral brain edema in patients diagnosed with meningioma. This study included 112 patients who underwent assessments of serum 25(OH)D levels and magnetic resonance imaging (MRI) to evaluate brain edema.
Our findings revealed a significant correlation between lower vitamin D3 levels and higher edema index (EI) percentages. Patients with EI below 100% had a median serum vitamin D3 level of 65.58 ng/mL, whereas those with EI above 100% had a much lower median of 37.33 ng/mL.
We found that for every increase of 1 ng/mL in serum vitamin D3, the extent of brain edema decreased by approximately 4%. This suggests that maintaining adequate levels of vitamin D3 may serve as a protective factor against peritumoral brain edema in patients with meningioma.
Our findings revealed a significant correlation between lower vitamin D3 levels and higher edema index (EI) percentages. Patients with EI below 100% had a median serum vitamin D3 level of 65.58 ng/mL, whereas those with EI above 100% had a much lower median of 37.33 ng/mL.
We found that for every increase of 1 ng/mL in serum vitamin D3, the extent of brain edema decreased by approximately 4%. This suggests that maintaining adequate levels of vitamin D3 may serve as a protective factor against peritumoral brain edema in patients with meningioma.
Read More
9
We investigated how synthetic analogs of vitamin D, specifically tacalcitol and calcipotriol, impact the growth and movement of T98G human glioblastoma cells. This type of brain cancer is particularly aggressive and challenging to treat, making it vital to explore new therapeutic options.
Our findings revealed that both vitamin D analogs significantly decreased cell viability and reduced the rate at which these cancer cells proliferated. This was evident in our tests, where even low concentrations of the analogs, ranging from 1 nM to 10 μM, showed a notable suppression of cell growth.
We also conducted a wound-healing assay to assess the migration of T98G cells. Both tacalcitol and calcipotriol were effective in slowing down the movement of these cells compared to a control group. Interestingly, even though we saw these promising effects, the analogs did not appear to trigger apoptosis, as measured by caspase-3 and -7 activities.
Overall, our research supports the potential of vitamin D analogs as a promising avenue for the treatment of glioblastoma by significantly inhibiting both the growth and migration of cancer cells.
Our findings revealed that both vitamin D analogs significantly decreased cell viability and reduced the rate at which these cancer cells proliferated. This was evident in our tests, where even low concentrations of the analogs, ranging from 1 nM to 10 μM, showed a notable suppression of cell growth.
We also conducted a wound-healing assay to assess the migration of T98G cells. Both tacalcitol and calcipotriol were effective in slowing down the movement of these cells compared to a control group. Interestingly, even though we saw these promising effects, the analogs did not appear to trigger apoptosis, as measured by caspase-3 and -7 activities.
Overall, our research supports the potential of vitamin D analogs as a promising avenue for the treatment of glioblastoma by significantly inhibiting both the growth and migration of cancer cells.
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9
Our study investigated the role of calcium, specifically vitamin B5 calcium, as an inhibitor of GOLPH3L in treating glioblastoma, a challenging form of brain tumor. We found that this compound may have potential in improving the effectiveness of radiotherapy, especially in cases resistant to standard treatments.
By targeting GOLPH3L, which plays a role in creating an immunosuppressive tumor environment, we were able to observe that the vitamin enhanced the antitumor immune response. This suggests that calcium treatment could help shift the balance from tumor-promoting factors to those that boost the body's natural defenses against cancer.
Notably, our research revealed that patients with glioblastoma who received vitamin B5 calcium alongside radiotherapy showed improved responses. However, it’s essential to mention that while the outcomes are promising, the specific efficacy of vitamin B5 calcium as a standalone treatment needs further exploration and validation in clinical settings.
In summary, we might be looking at an exciting new avenue where calcium treatment could help reshape the outcomes of glioblastoma therapy, particularly when equipped with the knowledge of how it interacts with tumor biology.
By targeting GOLPH3L, which plays a role in creating an immunosuppressive tumor environment, we were able to observe that the vitamin enhanced the antitumor immune response. This suggests that calcium treatment could help shift the balance from tumor-promoting factors to those that boost the body's natural defenses against cancer.
Notably, our research revealed that patients with glioblastoma who received vitamin B5 calcium alongside radiotherapy showed improved responses. However, it’s essential to mention that while the outcomes are promising, the specific efficacy of vitamin B5 calcium as a standalone treatment needs further exploration and validation in clinical settings.
In summary, we might be looking at an exciting new avenue where calcium treatment could help reshape the outcomes of glioblastoma therapy, particularly when equipped with the knowledge of how it interacts with tumor biology.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Boosted regeneration
This is an excellent supplement for teeth, bones and brain function. The addition of D3 aids in the processing of vitamins and proteins within cells, thereby enhancing regeneration.
Read More
7.5
Improved brain function
First of all, let me say that the quality of my well-being has improved noticeably. I felt weak and fatigued, but after taking these vitamins, the effect has been remarkable. Thanks to magnesium, my brain is receiving better nourishment.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Rehbein S, Possmayer AL, Bozkurt S, Lotsch C, Gerstmeier J, et al. Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells. Cancers (Basel). 2023;15. 10.3390/cancers15215249
- Shahmohammadi M, Hajimohammadebrahim-Ketabforoush M, Shariatpanahi ZV. Optimal vitamin D status at admission appears to improve survival after craniotomy in patients with brain malignancies. Clin Nutr ESPEN. 2023;55:428. 10.1016/j.clnesp.2023.04.009
- Lo CS, Kiang KM, Leung GK. Anti-tumor effects of vitamin D in glioblastoma: mechanism and therapeutic implications. Lab Invest. 2022;102:118. 10.1038/s41374-021-00673-8
- Gerstmeier J, Possmayer AL, Bozkurt S, Hoffmann ME, Dikic I, et al. Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases Their Susceptibility to Temozolomide. Cancers (Basel). 2021;13. 10.3390/cancers13143577
- Ai M, Li SS, Chen H, Wang XT, Sun JN, et al. 1,25(OH) D attenuates sleep disturbance in mouse models of Lewis lung cancer, in silico and in vivo. J Cell Physiol. 2021;236:7473. 10.1002/jcp.30458
- Hajimohammadebrahim-Ketabforoush M, Shahmohammadi M, Keikhaee M, Eslamian G, Vahdat Shariatpanahi Z. Single high-dose vitamin D3 injection and clinical outcomes in brain tumor resection: A randomized, controlled clinical trial. Clin Nutr ESPEN. 2021;41:153. 10.1016/j.clnesp.2020.11.027
- Hajimohammadebrahim-Ketabforoush M, Shahmohammadi M, Vahdat Shariatpanahi Z, Zali A. Preoperative Serum Level of Vitamin D is a Possible Protective Factor for Peritumoral Brain Edema of Meningioma: A Cross Sectional Study. Nutr Cancer. 2021;73:2842. 10.1080/01635581.2020.1861311
- Norlin M. Effects of vitamin D in the nervous system: Special focus on interaction with steroid hormone signalling and a possible role in the treatment of brain cancer. J Neuroendocrinol. 2020;32:e12799. 10.1111/jne.12799
- Elmaci I, Ozpinar A, Ozpinar A, Perez JL, Altinoz MA. From epidemiology and neurometabolism to treatment: Vitamin D in pathogenesis of glioblastoma Multiforme (GBM) and a proposal for Vitamin D + all-trans retinoic acid + Temozolomide combination in treatment of GBM. Metab Brain Dis. 2019;34:687. 10.1007/s11011-019-00412-5
- Sui A, Xu Y, Pan B, Guo T, Wu J, et al. Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells. J Cell Physiol. 2019;234:17990. 10.1002/jcp.28431
- Hu P, Li S, Tian N, Wu F, Hu Y, et al. Acidosis enhances the self-renewal and mitochondrial respiration of stem cell-like glioma cells through CYP24A1-mediated reduction of vitamin D. Cell Death Dis. 2019;10:25. 10.1038/s41419-018-1242-1
- Emanuelsson I, Wikvall K, Friman T, Norlin M. Vitamin D Analogues Tacalcitol and Calcipotriol Inhibit Proliferation and Migration of T98G Human Glioblastoma Cells. Basic Clin Pharmacol Toxicol. 2018;123:130. 10.1111/bcpt.13007
- Sun S, Qian S, Wang R, Zhao M, Li R, et al. Targeting GOLPH3L improves glioblastoma radiotherapy by regulating STING-NLRP3-mediated tumor immune microenvironment reprogramming. Sci Transl Med. 2025;17:eado0020. 10.1126/scitranslmed.ado0020
- Dube CJ, Lai M, Zhang Y, Saha S, Yener U, et al. T-type calcium channels regulate medulloblastoma and can be targeted for therapy. J Neurooncol. 2025. 10.1007/s11060-025-04967-5
- Li S, Li W, Miao Y, Gao M, Jia Y, et al. Modeling craniopharyngioma for drug screening reveals a neuronal mechanism for tumor growth. Sci Transl Med. 2024;16:eadn6763. 10.1126/scitranslmed.adn6763
- Nalci OB, Nadaroglu H, Genc S, Hacimuftuoglu A, Alayli A. The effects of MgS nanoparticles-Cisplatin-bio-conjugate on SH-SY5Y neuroblastoma cell line. Mol Biol Rep. 2020;47:9715. 10.1007/s11033-020-05987-2
- Zappia F, Verzicco I, Simoni R, Ferrari M, Coghi P, et al. Posterior reversible encephalopathy syndrome in an oncological normotensive patient: evidence for a pathogenic role of concomitant low magnesium serum levels and chemotherapy treatment. Acta Biomed. 2020;91:365. 10.23750/abm.v91i2.8685
- Mirrahimi B, Mortazavi A, Nouri M, Ketabchi E, Amirjamshidi A, et al. Effect of magnesium on functional outcome and paraclinical parameters of patients undergoing supratentorial craniotomy for brain tumors: a randomized controlled trial. Acta Neurochir (Wien). 2015;157:985. 10.1007/s00701-015-2376-x
