Solgar Zinc

Zinc protects heart function in OSA

Likely Very Effective

Zinc Is Indispensable in Exercise-Induced Cardioprotection against Intermittent Hypoxia-Induced Left Ventricular Function Impairment in Rats.

Most Relevant Research

We explored how zinc affects heart function in the context of obstructive sleep apnea (OSA), specifically focusing on cases of intermittent hypoxia (IH). In a detailed study using male rats, researchers set up different groups: a control group and one that underwent 10 weeks of exercise training. Half of the rats in both groups were exposed to IH conditions to simulate the effects of sleep apnea.

The results were eye-opening. Rats that experienced IH showed notable impairment in their heart's left ventricular function, characterized by reduced ejection fraction and increased inflammation. However, when treated with zinc, these negative effects were significantly countered. Notably, those who exercised and received zinc treatment displayed improved heart function and antioxidant capabilities compared to their counterparts that did not receive zinc.

On the flip side, exercise alone did not provide the same protective benefits when zinc was absent. The findings suggest that zinc is essential not only for the heart's protection against the damaging effects of IH but also enhances the benefits of physical exercise. This research indicates the importance of zinc in potentially managing heart health in individuals suffering from sleep apnea.

9.5

Deep sleep support

Most Useful Review

Perfect! This product really helps me to sleep deeply. I love it! In just a few days, I felt the full effect. I prefer this size. 👍

Bone Pain details

Great zinc! After three months of use, I noticed significant improvements. At 60 years old, I've had large transverse fossae on my nails since I was 30, but they've disappeared now and my nails have regained their structure. I've experienced pain in my small hand joints; however, after taking the chelating zinc, the bone pain has almost disappeared. I plan to continue using it with short breaks. My hair has grown extensively, reminiscent of when I was 15. This product is excellent.

Common Cold details

Zinc shortens cold duration variability

Based on 6 Researches

Quantile Treatment Effect of Zinc Lozenges on Common Cold Duration: A Novel Approach to Analyze the Effect of Treatment on Illness Duration.

Most Relevant Research

We explored how zinc lozenges affect the duration of the common cold through a detailed analysis of multiple trials. In particular, we focused on the Mossad (1996) trial involving zinc gluconate lozenges, which revealed an average reduction of cold duration by about 4.0 days. While that sounds promising, our findings through a quantile treatment effect (QTE) analysis tell a more nuanced story.

Interestingly, the QTE analysis showed that for individuals suffering from lengthy colds lasting 15 to 17 days, the zinc lozenges could shorten their illness by as much as 8 days. On the flip side, those with shorter, 2-day colds only experienced a 1-day reduction in sickness. This suggests that while zinc may help, its effectiveness varies significantly depending on the initial duration of the cold, making the overall average effect less informative than we might think.

Our examination extended to three trials that used zinc acetate lozenges, yielding a similar average reduction of around 2.7 days. However, again, those averages concealed varying effects for short and long colds, highlighting the importance of looking beyond simple averages in treatment studies.

Overall, we observed that zinc lozenges can indeed help with cold duration, but the extent of that help is very much dependent on how long a person has been suffering. This approach to understanding treatment effects through QTE analysis could have important implications not just for cold treatment but also for analyzing other health outcomes.

9.5

Cold prevention

Most Useful Review

My experience with chelated zinc has been very positive. I noticed improvements in my skin and a significant reduction in colds. Unlike traditional views emphasising vitamin C, zinc is now recognised for its effectiveness in combating the common cold and even reducing complications. The tablets are small and easy to swallow, with no side effects.

Eczema details

Zinc enhances eczema recovery

Transient symptomatic zinc deficiency in an exclusively breastfed infant.

Most Relevant Research

We investigated the relationship between zinc deficiency and eczema in a 3-month-old infant who was exclusively breastfed. The infant presented with symptoms like scaling erythematous dermatitis affecting her face and other areas, alongside irritability and poor weight gain. Her mother had been taking isoniazid for tuberculosis during pregnancy, which possibly contributed to the infant’s zinc deficiency.

After initial treatments for a suspected skin infection didn’t bring any changes, we found that the baby had low serum zinc levels and low zinc concentration in her breast milk. This led us to believe the skin condition was due to zinc deficiency rather than an infection. We started zinc supplementation, and the infant showed remarkable improvement in her skin condition and weight.

By 6 months, the infant had begun eating solid food, and we stopped the zinc supplements, with no signs of eczema returning. This case underscores the importance of monitoring zinc levels in breastfed infants, especially when mothers are on specific medications that might impact nutrient transfer through breast milk.

9.5

Improves immunity

Most Useful Review

We are eagerly awaiting the birth of our baby and I was advised by my gynaecologist to take a course of zinc. During pregnancy, my zinc levels decreased, leading to reduced immunity. Before taking this supplement, I fell ill frequently, and eczema developed on my hands. I split the tablet into two, as the dosage was quite large. After a few days of taking zinc, my hair loss ceased and my nails began to grow rapidly. Over the past three months, I have not caught any viruses. The results are noticeable, and although I can't say definitively if zinc is the cause, the improvement is apparent.

Headache details

Zinc reduces migraine symptoms

Based on 8 Researches

Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women.

Most Relevant Research

We conducted a randomized, double-blind, placebo-controlled trial to explore how zinc gluconate affects migraine symptoms in women. Sixty participants, with an average age of 35, were given either 15 mg of zinc per day or a placebo for 12 weeks, allowing us to measure the impact on headache frequency, duration, and intensity.

The results were quite promising; zinc supplementation significantly reduced how often headaches occurred, shortened their duration, and decreased the severity of the migraines reported. Participants in the zinc group experienced notable improvements, as indicated by their responses to the headache severity scale and a disability assessment questionnaire.

Furthermore, we found that zinc also had a positive effect on certain health markers. The serum levels of low-density lipoprotein (LDL), total cholesterol, and high-sensitivity C-reactive protein (hs-CRP) decreased with zinc supplementation. However, we didn’t observe significant changes in triglycerides or high-density lipoprotein (HDL) levels after adjusting for baseline values.

In conclusion, zinc supplementation appears to hold beneficial effects on migraine severity and frequency, offering a potential alternative for those who seek relief from these debilitating headaches.

9.5

No more headaches

Most Useful Review

Previously, I bought random zinc supplements, which led to persistent headaches without knowing the cause. Fortunately, a friend suggested "chelated" zinc, and it has made a remarkable difference. These supplements are much easier to digest, and I no longer experience headaches. I wholeheartedly recommend chelated zinc if you're seeking a beneficial zinc supplement.

Brain Tumor details

Zinc aids in glioblastoma treatment

Likely Very Effective

Ketogenic diet with oxyresveratrol and zinc inhibits glioblastoma and restores memory function and motor coordination.

Most Relevant Research

We evaluated the potential of zinc in combination with a ketogenic diet and oxyresveratrol in fighting glioblastoma, a highly aggressive brain tumor. Through a series of carefully designed experiments, we examined how these treatments affect tumor growth and overall brain function.

In our study, we induced brain tumors in Wistar rats and then applied our treatment regimen. We tracked various outcomes, including tumor size, proliferation rates, memory function, and motor coordination. By assessing glucose and ketone levels, we gained insights into the metabolic changes occurring as a result of the treatments.

The findings suggested that zinc played a supportive role alongside the ketogenic diet and oxyresveratrol in reducing tumor growth. Moreover, these treatments appeared to enhance memory and motor coordination, indicating a multi-faceted benefit. Overall, this progression offered valuable information about the role of diet and supplementary compounds in battling aggressive brain tumors like glioblastoma.

9.5

Essential for brain

Most Useful Review

This high-quality zinc supplement is fantastic; it increases immunity and is essential for brain function and physical activity.

Prostate cancer-selective anticancer action of an oxindole derivative via HO-1-mediated disruption of metabolic reprogramming.

Most Relevant Research

We explored the relationship between zinc levels and prostate cancer treatments, particularly focusing on a novel compound known as 3D. This compound showed a strong potential to target prostate cancer cells, contributing to a decrease in their proliferation rates.

Our analysis revealed that compound 3D selectively impacted key metabolic processes in prostate cancer cells by suppressing factors related to energy production, such as lactate levels. Interestingly, it also reduced the activity of transporters involved in zinc absorption while leaving those responsible for zinc export untouched.

We also found that the effectiveness of 3D could be reversed with zinc treatment, highlighting a complicated interaction between zinc and this therapeutic approach. While the compound successfully lowered zinc levels in cells and inhibited cancer growth, it is essential to note that we did not find significant benefits from zinc treatment by itself in the context of this study.

Overall, our findings suggest that targeting zinc metabolism and enhancing heme oxygenase-1 expression could be a promising strategy in prostate cancer therapy, more so than the direct application of zinc itself. The results illustrate the potential for combining innovative small molecules with an understanding of cancer metabolism in the development of treatment strategies.

9.5

Improves urination

Most Useful Review

The prostate truly improves. My urine flow is excellent! The effect is remarkable.

Allergies details

Zinc may relieve allergy symptoms

Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.

Most Relevant Research

We investigated how intranasal zinc (Zn) treatment affects symptoms of allergic rhinitis (AR), specifically focusing on individuals suffering from Japanese cedar pollinosis (JCP), a common seasonal allergy. In our study, we monitored 57 control subjects and 44 patients from preseason through the allergy season, observing the levels of Zn in both nasal fluid and serum.

Our findings showed that after exposure to pollen, the level of zinc in the nasal lining fluid of JCP patients significantly increased, while their serum zinc levels notably decreased compared to the control group during the JCP season. To delve deeper, we used model mice that could mimic these changes and the allergy symptoms of the patients.

The results from this mouse study were promising. We observed that treating these mice with a dose of zinc, similar to what humans might use, led to a notable improvement in their allergy symptoms. Additionally, the number of mucin-secreting goblet cells, which indicate a response to allergies, significantly decreased following the zinc treatment.

Our study points towards the potential of using intranasal zinc as a way to alleviate allergy symptoms, suggesting a new approach to managing allergic rhinitis.

9.5

Well-tolerated solution

Most Useful Review

Our paediatrician recommended a vitamin and mineral complex that includes zinc in high doses for my daughter, who has allergies. Finding the right one was challenging because all products with dyes and flavours were unsuitable for her. After several tries, we discovered this particular supplement that did not cause any allergies and was well tolerated. I highly recommend it!

Anemia details

Questionable

Zinc deficiency linked to anemia

Zinc Deficiency Presenting With Diverse Symptoms in a Young Patient: A Case Report.

Most Relevant Research

We explored the connection between zinc deficiency and anemia through the case of an 18-year-old woman who faced a series of health issues, including urinary tract infections and insulin dysfunction. After a thorough assessment, she was diagnosed with zinc deficiency, shedding light on how this overlooked issue can impact overall health.

What stood out to us was the rapid recovery the patient experienced after beginning oral zinc supplementation. Zinc plays a critical role in numerous bodily functions, including immune support and protein regulation. By addressing her deficiency, we observed significant improvement in her symptoms, including anemia.

The patient’s diet contained high levels of substances that were inhibiting her zinc absorption, which likely contributed to her condition. This case emphasizes the importance of recognizing zinc deficiency as a potential underlying cause for unexplained health issues, particularly anemia. Prompt diagnosis and treatment can lead to a complete turnaround in the patient's health.

By sharing this experience, we hope to raise awareness among clinicians about the vital role of zinc in managing anemia and encourage timely interventions for patients showing diverse symptoms.

9.5

Prevented iron deficiency

Most Useful Review

Chelated zinc and Spirulina provide essential iron, crucial for those lacking this element. Spirulina is not only popular in cosmetology but also positively impacts overall body function. Regular consumption helps prevent iron deficiency, alleviating anemia, enhancing stress resilience, and promoting healing.

Cancer details

Zinc's role in cancer immunity

Based on 6 Researches

cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance.

Most Relevant Research

We explored how zinc levels impact cancer cells and immune function, particularly focusing on macrophages, which are crucial for our body’s defense against tumors. Our research revealed that cancer cells often have decreased expression of specific genes tied to immune response, and this links to resistance against therapies designed to unblock immune checkpoints.

By upregulating a zinc importer known as SLC39A9, these cancer cells manage to hoard zinc for themselves, leaving the surrounding tumor microenvironment (TME) depleted of this vital nutrient. This competition for zinc results in macrophages becoming zinc-starved, which diminishes their ability to perform essential tasks like engulfing and destroying cancer cells.

Interestingly, we found that when we replenished zinc levels in the TME—through a dietary intervention—these macrophages could regain their pro-phagocytic function. This change significantly improved the response of certain tumors to immunotherapy treatments. Notably, T cells weren’t required for this transformation, indicating that macrophages alone play a pivotal role.

Our results are clinically relevant, showing that cancer patients with reduced zinc levels in their body tend to experience worse outcomes. Overall, we identified a new mechanism by which cancer cells can disrupt immune function, highlighting zinc’s critical role in both tumor environments and immunotherapy effectiveness.

7.5

Supports immune health

Most Useful Review

Zinc is essential for immune system activity. It aids in the maturation and functioning of white blood cells (T cells) that have immune memory, as well as participating in the creation of antibodies and natural killer cells that target infected and cancerous cells. Additionally, zinc is vital for skin, hair, nails, and eye health and assists with tissue recovery.

Chronic Fatigue Syndrome details

Zinc supplementation may benefit CFS

Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS.

Most Relevant Research

We explored the relationship between serum zinc levels and chronic fatigue syndrome (CFS) in a study that compared patients with CFS to normal volunteers. By using an atomic absorption method, we measured serum zinc concentrations and found that those suffering from CFS had significantly lower levels of zinc compared to healthy individuals.

Interestingly, we observed a trend indicating that lower zinc levels correlated with greater CFS severity. Patients also reported a negative correlation between their zinc levels and their subjective experiences of infection. This suggests that zinc plays a role in the immune dysfunction commonly seen in CFS.

Furthermore, we noted that lower serum zinc was associated with higher levels of inflammatory markers and certain defects in the early activation of T cells. Since zinc acts as a potent antioxidant, our findings indicate that CFS is linked to increased oxidative stress in these patients. Given this, it may be beneficial for some CFS patients to consider zinc supplements as part of their treatment approach.

Improved well-being

Most Useful Review

Solgar Chelated Zinc features a highly bioavailable form of zinc, chelated for optimal absorption. By incorporating it into my daily routine, I've noticed a significant improvement in my well-being. I feel more resilient against seasonal threats and experience fewer instances of fatigue, highlighting zinc's role in supporting energy metabolism. I truly appreciate Solgar's commitment to quality and purity, with their supplements undergoing rigorous testing for potency and safety. Knowing I'm getting a reliable product with each capsule brings me peace of mind. This high-quality formulation has made a great difference in my health and vitality, making Solgar Chelated Zinc an essential part of my immune support regimen. I wholeheartedly recommend it to anyone looking to enhance their immune system and overall well-being.

Tinnitus details

Zinc intake affects tinnitus risk

The Association between Dietary Intakes of Vitamins and Minerals with Tinnitus.

Most Relevant Research

We examined how dietary intakes of vitamins and minerals, particularly zinc, could influence the onset and presence of tinnitus, a condition characterized by phantom sounds in the ears. In a study involving nearly 3,000 participants over the age of 50, we identified cases of tinnitus to determine if their dietary habits played a role in their experience of this condition.

The findings indicated that while there were no significant associations between overall vitamin and mineral intake and existing tinnitus prevalence, zinc intake stood out in relation to developing tinnitus over time. Specifically, we observed that lower zinc consumption was linked to a 44% increased risk of experiencing tinnitus over a ten-year period.

Furthermore, we noted that iron intake also showed a significant correlation, with lower iron levels raising incident tinnitus risk by approximately 35%. These results highlight the potential importance of maintaining adequate zinc and iron levels in our diets to help reduce the risk of developing tinnitus.

9.5

Pain relief

Most Useful Review

Amazing! It helps me cope with various pains and provides relief for nearly non-existent tinnitus. A lifesaver!

Nausea details

Zinc treatment reduces nausea risk

Questionable

Based on 4 Researches

Randomized, multicenter, active-controlled open-label study of NPC-25, zinc histidine hydrate, (non-inferiority to NOBELZIN™, zinc acetate dihydrate) for patients with hypozincemia.

Most Relevant Research

We conducted a study to evaluate how effective NPC-25, a new form of zinc, is compared to a well-known treatment, NOBELZIN™, for patients with low zinc levels. Participants in this trial had their zinc levels checked and were grouped to receive either NPC-25 or NOBELZIN™.

For a period of up to 24 weeks, we aimed to maintain their zinc levels within a specific target range while closely monitoring for side effects. One of our main goals was to see if NPC-25 could maintain these target zinc levels similarly to NOBELZIN™.

Our findings revealed that NPC-25 was indeed non-inferior to NOBELZIN™, meaning it worked just as well. Importantly, we also observed that those taking NPC-25 reported fewer digestive issues, like nausea and vomiting. This suggests that while both treatments were effective, NPC-25 might be the gentler option.

9.5

No nausea

Most Useful Review

Very good and affordable! I've been using it for a year and find it beneficial to my health. It’s easy to take, and I have experienced no nausea when consumed after meals.

Cold Sores details

Zinc cream alleviates cold sores

Based on 9 Researches

A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine.

Most Relevant Research

We conducted a double-blind, placebo-controlled clinical trial to explore the effectiveness of a zinc oxide/glycine cream in treating cold sores caused by facial and circumoral herpes. By dividing 46 participants into two groups, one receiving the zinc treatment and the other a placebo, we aimed to measure how this formulation affected the duration and severity of cold sore symptoms.

Our results were quite promising! Participants who began using the zinc oxide/glycine cream within the first 24 hours of noticing symptoms experienced cold sore lesions that lasted only an average of 5 days, compared to 6.5 days for those on the placebo. Additionally, we noticed a significant reduction in the overall severity of their symptoms, including blistering, soreness, itching, and tingling.

As for side effects, subjects treated with the zinc cream experienced only minor and reversible issues typical of ionic zinc salt solutions. This indicates that the zinc oxide/glycine cream is not only effective but also safe for treating cold sores, presenting a valuable option for many people seeking relief from this common condition.

Improved male health

Most Useful Review

Helped me with a cold, and my boyfriend is thrilled with the result – these are excellent male vitamins. This Zinc delivers a good effect and helped him overcome a cold in two days. He noticed a significant difference after just five days, stating that men should monitor their zinc levels. However, we did notice some tingling in his side after taking it for five consecutive days, which we are monitoring. Overall, these vitamins are highly commendable.

Heartburn details

Zinc's role in heartburn relief

Likely Very Effective

Esophageal ulcer related to zinc deficiency following a total gastrectomy.

Most Relevant Research

We investigated how zinc affects heartburn through the case of a 76-year-old Japanese man who experienced significant discomfort after undergoing a total gastrectomy. For two weeks, he suffered from a sore throat, heartburn, and difficulty swallowing. Endoscopy revealed deep, craterlike ulcers in his esophagus, but tests for viral infections were negative.

After initial treatment, his symptoms returned, prompting further investigation. Eventually, we found that his serum zinc level was low at 38 µg/dL, which led to a diagnosis of zinc deficiency. Following oral zinc supplementation, the patient reported relief from his symptoms and a noticeable improvement in the esophageal ulcers observed during a follow-up endoscopy.

Over the five years since his treatment, the patient has continued to take zinc supplements and has not faced similar issues again. This case suggests that zinc can play a crucial role in treating heartburn issues related to ulcers, especially in those with a deficiency.

Relieved heartburn quickly

Most Useful Review

I took one tablet daily, along with Omega 3 and chelated magnesium from the same brand. After a month, I started feeling a heaviness in my stomach accompanied by heartburn. I ceased taking all supplements at once and soon after, my stomach condition returned to normal. I have no intention of taking these products again.

Autoimmune Disorder details