Overview
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.6
USERS' SCORE
Good
Based on 23 Reviews
8.2
Supplement Facts
Serving Size: 2 Vegetable Capsules
Amount Per Serving
%DV
Choline (as choline bitartrate)
500 mg
91%
Inositol
500 mg
**
Top Medical Research Studies
8
We conducted a study to understand how inositol, a naturally occurring sugar alcohol, influences anxiety levels in laying hens. Our focus was on the behavior of Lohmann LSL lite hens, which were fed two different diets—one rich and one deficient in protein—while receiving either pure inositol or high levels of phytase.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Read More
8
We examined user sentiments surrounding treatments for Polycystic Ovary Syndrome (PCOS) through data collected from an extensive subreddit.
Our analysis revealed that lifestyle changes and supplements were viewed positively, while contraceptives often received negative feedback. Notably, inositol was associated with significant improvements in mental health, including reductions in anxiety.
This study highlights the potential of machine learning to analyze patient experiences, offering valuable insights that might complement traditional clinical research.
Our analysis revealed that lifestyle changes and supplements were viewed positively, while contraceptives often received negative feedback. Notably, inositol was associated with significant improvements in mental health, including reductions in anxiety.
This study highlights the potential of machine learning to analyze patient experiences, offering valuable insights that might complement traditional clinical research.
Read More
8
We explored how d-pinitol, a natural compound found in various fruits and legumes, could impact anxiety and related conditions. In our evaluation, we focused on its effects on mice to understand its potential as an anxiolytic agent.
During our study, we observed that when mice were given d-pinitol at doses ranging from 1 to 100 mg/kg, there was notable evidence of anxiolytic-like actions. In particular, at a dose of 70 mg/kg, d-pinitol showed significant effectiveness in reducing anxiety as assessed in specific behavioral tests.
We also investigated the possible mechanisms behind these effects. Our findings suggest that the GABAergic system may play a key role in mediating the anxiolytic benefits of d-pinitol, which indicates a promising direction for further research. It’s important to remember that while our results are encouraging, d-pinitol did not exhibit diuretic effects, which was a secondary focus of the study.
All in all, our study positions d-pinitol as a compelling candidate for alleviating anxiety, with mechanisms worth exploring further for therapeutic applications.
During our study, we observed that when mice were given d-pinitol at doses ranging from 1 to 100 mg/kg, there was notable evidence of anxiolytic-like actions. In particular, at a dose of 70 mg/kg, d-pinitol showed significant effectiveness in reducing anxiety as assessed in specific behavioral tests.
We also investigated the possible mechanisms behind these effects. Our findings suggest that the GABAergic system may play a key role in mediating the anxiolytic benefits of d-pinitol, which indicates a promising direction for further research. It’s important to remember that while our results are encouraging, d-pinitol did not exhibit diuretic effects, which was a secondary focus of the study.
All in all, our study positions d-pinitol as a compelling candidate for alleviating anxiety, with mechanisms worth exploring further for therapeutic applications.
Read More
Most Useful Reviews
7.5
Reduced anxiety
119 people found this helpful
Good product; I noticed results after a month. I read that Choline/Inositol helps reduce panic attacks. I take two capsules daily. It has been effective for my depressive disorder, and I've experienced fewer migraines. The anxiety that troubled me at night has vanished, and I feel more clarity in my mind.
Read More
9
Liver and calmness
102 people found this helpful
It's excellent for liver support and anxiety. After researching choline for NASH liver disease, I found evidence linking our diet to fatty liver. I took liver support supplements, and my liver enzyme levels returned to normal. This product is calming and significantly reduces my anxiety, making it great.
Read More
9
Boosted vitality
88 people found this helpful
On my doctor's advice, I purchased this from Solgar. After a week, my sleep, vitality, and overall mental performance significantly improved. Chronic fatigue and headaches vanished, and my mood lifted. This supplement enhances memory and concentration, which is vital for my demanding job. I highly recommend this quality product.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.6
- All Researches
8
We conducted a study to understand how inositol, a naturally occurring sugar alcohol, influences anxiety levels in laying hens. Our focus was on the behavior of Lohmann LSL lite hens, which were fed two different diets—one rich and one deficient in protein—while receiving either pure inositol or high levels of phytase.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Read More
8
We explored how d-pinitol, a natural compound found in various fruits and legumes, could impact anxiety and related conditions. In our evaluation, we focused on its effects on mice to understand its potential as an anxiolytic agent.
During our study, we observed that when mice were given d-pinitol at doses ranging from 1 to 100 mg/kg, there was notable evidence of anxiolytic-like actions. In particular, at a dose of 70 mg/kg, d-pinitol showed significant effectiveness in reducing anxiety as assessed in specific behavioral tests.
We also investigated the possible mechanisms behind these effects. Our findings suggest that the GABAergic system may play a key role in mediating the anxiolytic benefits of d-pinitol, which indicates a promising direction for further research. It’s important to remember that while our results are encouraging, d-pinitol did not exhibit diuretic effects, which was a secondary focus of the study.
All in all, our study positions d-pinitol as a compelling candidate for alleviating anxiety, with mechanisms worth exploring further for therapeutic applications.
During our study, we observed that when mice were given d-pinitol at doses ranging from 1 to 100 mg/kg, there was notable evidence of anxiolytic-like actions. In particular, at a dose of 70 mg/kg, d-pinitol showed significant effectiveness in reducing anxiety as assessed in specific behavioral tests.
We also investigated the possible mechanisms behind these effects. Our findings suggest that the GABAergic system may play a key role in mediating the anxiolytic benefits of d-pinitol, which indicates a promising direction for further research. It’s important to remember that while our results are encouraging, d-pinitol did not exhibit diuretic effects, which was a secondary focus of the study.
All in all, our study positions d-pinitol as a compelling candidate for alleviating anxiety, with mechanisms worth exploring further for therapeutic applications.
Read More
8
We examined user sentiments surrounding treatments for Polycystic Ovary Syndrome (PCOS) through data collected from an extensive subreddit.
Our analysis revealed that lifestyle changes and supplements were viewed positively, while contraceptives often received negative feedback. Notably, inositol was associated with significant improvements in mental health, including reductions in anxiety.
This study highlights the potential of machine learning to analyze patient experiences, offering valuable insights that might complement traditional clinical research.
Our analysis revealed that lifestyle changes and supplements were viewed positively, while contraceptives often received negative feedback. Notably, inositol was associated with significant improvements in mental health, including reductions in anxiety.
This study highlights the potential of machine learning to analyze patient experiences, offering valuable insights that might complement traditional clinical research.
Read More
7
Myo-Inositol improves anxiety behavior
We aimed to explore the impact of myo-inositol (MI) on anxiety in a mouse model of classic galactosemia. Our research involved a combination of acute and chronic evaluations of MI, particularly looking at its effects over a long-term treatment period. We observed that lower doses of MI suggested notable improvements in motor deficits and anxiety-driven hyperactivity among the GalT-KO mice, which are affected by this condition.
While we conducted a thorough assessment of motor-related behaviors and anxiety levels, it appears that MI holds potential as an adjunct treatment option. These findings indicate that MI may benefit not only physical symptoms but also emotional well-being, particularly in reducing anxiety-related behaviors in this genetically modified model, which helps us understand its role more clearly. The results could point to new avenues for managing anxiety, especially in conditions like classic galactosemia where traditional treatment methods fall short.
While we conducted a thorough assessment of motor-related behaviors and anxiety levels, it appears that MI holds potential as an adjunct treatment option. These findings indicate that MI may benefit not only physical symptoms but also emotional well-being, particularly in reducing anxiety-related behaviors in this genetically modified model, which helps us understand its role more clearly. The results could point to new avenues for managing anxiety, especially in conditions like classic galactosemia where traditional treatment methods fall short.
Read More
7
Inositol as potential anxiety treatment
We examined the potential of inositol as a treatment for anxiety disorders. While several treatments are currently available, many patients still struggle with symptoms, leading us to seek out alternatives like inositol.
Our findings suggest that inositol may have anti-panic effects, indicating it is worth considering for those who haven’t found success with other medications. We noted that it was generally well tolerated, which is essential for anyone looking for anxiety relief without unpleasant side effects.
While inositol shows promise, further research is necessary to firmly establish its efficacy. In this case, it's important to keep expectations grounded and recognize that individual responses may vary.
Overall, inositol presents itself as a intriguing option, especially for patients facing treatment-resistant conditions, highlighting the ongoing need for fresh approaches to managing anxiety.
Our findings suggest that inositol may have anti-panic effects, indicating it is worth considering for those who haven’t found success with other medications. We noted that it was generally well tolerated, which is essential for anyone looking for anxiety relief without unpleasant side effects.
While inositol shows promise, further research is necessary to firmly establish its efficacy. In this case, it's important to keep expectations grounded and recognize that individual responses may vary.
Overall, inositol presents itself as a intriguing option, especially for patients facing treatment-resistant conditions, highlighting the ongoing need for fresh approaches to managing anxiety.
Read More
User Reviews
USERS' SCORE
Good
Based on 23 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Reduced anxiety
119 people found this helpful
Good product; I noticed results after a month. I read that Choline/Inositol helps reduce panic attacks. I take two capsules daily. It has been effective for my depressive disorder, and I've experienced fewer migraines. The anxiety that troubled me at night has vanished, and I feel more clarity in my mind.
Read More
9
Liver and calmness
102 people found this helpful
It's excellent for liver support and anxiety. After researching choline for NASH liver disease, I found evidence linking our diet to fatty liver. I took liver support supplements, and my liver enzyme levels returned to normal. This product is calming and significantly reduces my anxiety, making it great.
Read More
9
Boosted vitality
88 people found this helpful
On my doctor's advice, I purchased this from Solgar. After a week, my sleep, vitality, and overall mental performance significantly improved. Chronic fatigue and headaches vanished, and my mood lifted. This supplement enhances memory and concentration, which is vital for my demanding job. I highly recommend this quality product.
Read More
7.5
Less panic attacks
29 people found this helpful
Wonderful! I took two capsules daily, and after two weeks, anxiety and panic attacks reduced significantly. After one month, my depression and apathy decreased. The drug effectively works gently without abrupt changes. It also improved clarity of thought when combined with ginkgo biloba.
Read More
9
Effective anxiety calmer
20 people found this helpful
Great anxiety calmer. This is an incredible nerve and anxiety calmer. I'm a firm believer in it.
Read More
Frequently Asked Questions
7.5
Less panic attacks
29 people found this helpful
Wonderful! I took two capsules daily, and after two weeks, anxiety and panic attacks reduced significantly. After one month, my depression and apathy decreased. The drug effectively works gently without abrupt changes. It also improved clarity of thought when combined with ginkgo biloba.
7.5
Reduced anxiety
6 people found this helpful
I took two capsules daily, and within two weeks, my anxiety and panic attacks became notably less intense. After a month, I experienced far less depression and apathy. The effects were gentle without sudden changes, and I noticed improvements in clarity of thought as well.
9
Boosted vitality
88 people found this helpful
On my doctor's advice, I purchased this from Solgar. After a week, my sleep, vitality, and overall mental performance significantly improved. Chronic fatigue and headaches vanished, and my mood lifted. This supplement enhances memory and concentration, which is vital for my demanding job. I highly recommend this quality product.
7.5
Reduced anxiety
119 people found this helpful
Good product; I noticed results after a month. I read that Choline/Inositol helps reduce panic attacks. I take two capsules daily. It has been effective for my depressive disorder, and I've experienced fewer migraines. The anxiety that troubled me at night has vanished, and I feel more clarity in my mind.
7.5
Anxiety relief
5 people found this helpful
I take two capsules daily, and my night shift work is now more manageable. The anxiety I previously experienced throughout the night has disappeared, leaving me with clarity of thought. The combined effect with Omega-3 may be the reason for my improvement.
8
Psychological lightness
11 people found this helpful
I experience less anxiety and feel more energetic upon waking. While I initially ordered it for my hair, I can't comment on that yet, but the relief from anxiety has been noticeable.
2
Dosage sensitivity
8 people found this helpful
Initially, I took one capsule at night and experienced restful sleep, but later I faced anxiety and restlessness. Perhaps the dosage was too high for me, as this isn't the first product from this brand that disagreed with me.
9
Enhanced focus
1 people found this helpful
I began taking Solgar's Choline and Inositol supplement daily and have been very pleased with its quality. The medium-sized capsules are easy to swallow and have improved my focus and organisation, significantly reducing my anxiety and stress levels. I plan to continue using it for cognitive support.
7
Myo-Inositol improves anxiety behavior
We aimed to explore the impact of myo-inositol (MI) on anxiety in a mouse model of classic galactosemia. Our research involved a combination of acute and chronic evaluations of MI, particularly looking at its effects over a long-term treatment period. We observed that lower doses of MI suggested notable improvements in motor deficits and anxiety-driven hyperactivity among the GalT-KO mice, which are affected by this condition.
While we conducted a thorough assessment of motor-related behaviors and anxiety levels, it appears that MI holds potential as an adjunct treatment option. These findings indicate that MI may benefit not only physical symptoms but also emotional well-being, particularly in reducing anxiety-related behaviors in this genetically modified model, which helps us understand its role more clearly. The results could point to new avenues for managing anxiety, especially in conditions like classic galactosemia where traditional treatment methods fall short.
While we conducted a thorough assessment of motor-related behaviors and anxiety levels, it appears that MI holds potential as an adjunct treatment option. These findings indicate that MI may benefit not only physical symptoms but also emotional well-being, particularly in reducing anxiety-related behaviors in this genetically modified model, which helps us understand its role more clearly. The results could point to new avenues for managing anxiety, especially in conditions like classic galactosemia where traditional treatment methods fall short.
4
We sought to understand the effects of inositol, a type of mitochondrial modulator, on anxiety as part of a broader examination of its role in treating obsessive-compulsive and related disorders. In this systematic review, we analyzed results from 17 double-blind, randomized, placebo-controlled trials involving 629 participants.
Our findings indicated that while inositol is included among several other treatments, its specific impact on anxiety-related scores did not surpass that of the placebo. Though overall symptoms improved with inositol and other mitochondrial modulators like N-acetylcysteine, the evidence for inositol alone does not demonstrate a significant advantage for anxiety relief.
Overall, while we enjoyed exploring the various treatments and their potential benefits, it is essential to note that inositol's effectiveness on its own concerning anxiety remains unproven when compared directly to placebo.
Our findings indicated that while inositol is included among several other treatments, its specific impact on anxiety-related scores did not surpass that of the placebo. Though overall symptoms improved with inositol and other mitochondrial modulators like N-acetylcysteine, the evidence for inositol alone does not demonstrate a significant advantage for anxiety relief.
Overall, while we enjoyed exploring the various treatments and their potential benefits, it is essential to note that inositol's effectiveness on its own concerning anxiety remains unproven when compared directly to placebo.
4
Myo-inositol shows no significant anxiety effects
Our study examined the effects of a combined supplement of myo-inositol, probiotics, and micronutrients on the mental wellbeing of women from preconception through pregnancy and into the post-delivery period. We designed a double-blind randomized trial to compare this specific supplement with a standard micronutrient supplement. Our goal was to see if the intervention could lead to reduced anxiety and improved mood in participants.
Throughout various stages of pregnancy and after delivery, we measured mood and anxiety levels using established scales. We found that while there were no significant differences between the supplement group and the control group in terms of anxiety and mood symptoms, there was a modest improvement in overall mental health functioning for those taking the combined supplement. Specifically, women in the intervention group experienced a slight uptick in their mental health scores by 1.21 points compared to the control group by six months post-delivery.
Ultimately, while our findings did not indicate a meaningful impact on anxiety levels, they do suggest that taking myo-inositol along with other nutrients could support overall mental health during the perinatal period, offering some benefits beyond mood and anxiety symptoms alone.
Throughout various stages of pregnancy and after delivery, we measured mood and anxiety levels using established scales. We found that while there were no significant differences between the supplement group and the control group in terms of anxiety and mood symptoms, there was a modest improvement in overall mental health functioning for those taking the combined supplement. Specifically, women in the intervention group experienced a slight uptick in their mental health scores by 1.21 points compared to the control group by six months post-delivery.
Ultimately, while our findings did not indicate a meaningful impact on anxiety levels, they do suggest that taking myo-inositol along with other nutrients could support overall mental health during the perinatal period, offering some benefits beyond mood and anxiety symptoms alone.
References
- Bellagamba O, Guo AJ, Senthilkumar S, Lillevik SH, De Biase D, et al. Assessment of Long-Term Safety and Efficacy of Purple Sweet Potato Color (PSPC) and Myo-Inositol (MI) Treatment for Motor Related and Behavioral Phenotypes in a Mouse Model of Classic Galactosemia. J Inherit Metab Dis. 2025;48:e70002. doi:10.1002/jimd.70002
- El-Heis S, Barton SJ, Chang HF, Nield H, Cox V, et al. Maternal mood, anxiety and mental health functioning after combined myo-inositol, probiotics, micronutrient supplementation from preconception: Findings from the NiPPeR RCT. Psychiatry Res. 2024;334:115813. doi:10.1016/j.psychres.2024.115813
- Kishi T, Sakuma K, Iwata N. Mitochondrial modulators for obsessive-compulsive and related disorders: a systematic review and meta-analysis. Transl Psychiatry. 2022;12:263. doi:10.1038/s41398-022-02026-5
- Herwig E, Classen HL, Walk CL, Bedford M, Schwean-Lardner K. Dietary Inositol Reduces Fearfulness and Avoidance in Laying Hens. Animals (Basel). 2019;9. doi:10.3390/ani9110938
- Alonso-Castro AJ, Alba-Betancourt C, Rocha-González E, Ruiz-Arredondo A, Zapata-Morales JR, et al. Neuropharmacological effects of d-pinitol and its possible mechanisms of action. J Food Biochem. 2019;43:e13070. doi:10.1111/jfbc.13070
- Zulfarina MS, Syarifah-Noratiqah SB, Nazrun SA, Sharif R, Naina-Mohamed I. Pharmacological Therapy in Panic Disorder: Current Guidelines and Novel Drugs Discovery for Treatment-resistant Patient. Clin Psychopharmacol Neurosci. 2019;17:145. doi:10.9758/cpn.2019.17.2.145
- Emanuel RHK, Docherty PD, Lunt H, Campbell RE. What do users in a polycystic ovary syndrome (PCOS) forum think about the treatments they tried: Analysing treatment sentiment using machine learning. Phys Eng Sci Med. 2025. doi:10.1007/s13246-025-01539-9
